Gene Symbol: BC0671
Description: sphingomyelin phosphodiesterase
Species: Bacillus cereus ATCC 14579
Granum P, Nissen H. Sphingomyelinase is part of the 'enterotoxin complex' produced by Bacillus cereus. FEMS Microbiol Lett. 1993;110:97-100 pubmed
Nishiwaki H, Ito K, Otsuki K, Yamamoto H, Komai K, Matsuda K. Purification and functional characterization of insecticidal sphingomyelinase C produced by Bacillus cereus. Eur J Biochem. 2004;271:601-6 pubmed
Gilmore M, Cruz Rodz A, Leimeister W chter M, Kreft J, Goebel W. A Bacillus cereus cytolytic determinant, cereolysin AB, which comprises the phospholipase C and sphingomyelinase genes: nucleotide sequence and genetic linkage. J Bacteriol. 1989;171:744-53 pubmed
..subtilis host. The 3' open reading frame encoded a sphingomyelinase. The two tandemly encoded activities, phospholipase C and sphingomyelinase, constitute a biologically functional cytolytic determinant of B. cereus termed cereolysin AB...
Ago H, Oda M, Takahashi M, Tsuge H, Ochi S, Katunuma N, et al
. Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus. J Biol Chem. 2006;281:16157-67 pubmed publisher
..In addition, the structural features and site-directed mutagenesis suggest that the specific beta-hairpin with the aromatic amino acid residues participates in binding to the membrane-bound sphingomyelin substrate...
Yamada A, Tsukagoshi N, Udaka S, Sasaki T, Makino S, Nakamura S, et al
. Nucleotide sequence and expression in Escherichia coli of the gene coding for sphingomyelinase of Bacillus cereus. Eur J Biochem. 1988;175:213-20 pubmed
..The enzymatic activity toward sphingomyelin was enhanced 20-30-fold in the presence of MgCl2, and the adsorption of the enzyme onto erythrocyte membranes was accelerated in the presence of CaCl2...
Tomita M, Nakai K, Yamada A, Taguchi R, Ikezawa H. Secondary structure of sphingomyelinase from Bacillus cereus. J Biochem. 1990;108:811-5 pubmed
..The partial homologies between the amino acid sequences of SMPLC and Clostridium perfringens alpha-toxin (phospholipase C) are discussed. ..
Johansen T, Haugli F, Ikezawa H, Little C. Bacillus cereus strain SE-1: nucleotide sequence of the sphingomyelinase C gene. Nucleic Acids Res. 1988;16:10370 pubmed
Johansen T, Holm T, Guddal P, Sletten K, Haugli F, Little C. Cloning and sequencing of the gene encoding the phosphatidylcholine-preferring phospholipase C of Bacillus cereus. Gene. 1988;65:293-304 pubmed
..coli. The cloning and sequencing described here complete the first step toward using in vitro mutagenesis for investigations of the structure-function relationships of B. cereus phospholipase C. ..
Gavrilenko I, Baida G, Karpov A, Kuz min N. [Nucleotide sequence of phospholipase C and sphingomyelinase genes from Bacillus cereus BKM-B164]. Bioorg Khim. 1993;19:133-8 pubmed