Gene Symbol: BA_3514
Description: N-acyl homoserine lactonase
Species: Bacillus anthracis str. Ames
Kim M, Choi W, Kang H, Lee J, Kang B, Kim K, et al
. The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase. Proc Natl Acad Sci U S A. 2005;102:17606-11 pubmed publisher
..We present experimental evidence that AHL-lactonase is a metalloenzyme containing two zinc ions involved in catalysis, and we propose a catalytic mechanism for bacterial metallo-AHL-lactonases...
Dong Y, Gusti A, Zhang Q, Xu J, Zhang L. Identification of quorum-quenching N-acyl homoserine lactonases from Bacillus species. Appl Environ Microbiol. 2002;68:1754-9 pubmed
..Sequence comparison of the gene products and motif analysis showed that the gene products belong to the same family of AHL lactonases...
Reimmann C, Ginet N, Michel L, Keel C, Michaux P, Krishnapillai V, et al
. Genetically programmed autoinducer destruction reduces virulence gene expression and swarming motility in Pseudomonas aeruginosa PAO1. Microbiology. 2002;148:923-32 pubmed publisher
..In conclusion, introduction of an AHL degradation gene into P. aeruginosa could block cell-cell communication and exoproduct formation, but failed to interfere with surface colonization...
Carlier A, Uroz S, Smadja B, Fray R, Latour X, Dessaux Y, et al
. The Ti plasmid of Agrobacterium tumefaciens harbors an attM-paralogous gene, aiiB, also encoding N-Acyl homoserine lactonase activity. Appl Environ Microbiol. 2003;69:4989-93 pubmed
..In Erwinia strain 6276, the lactonases reduced the endogenous acyl-HSL level and the bacterial virulence in planta...
Liu D, Lepore B, Petsko G, Thomas P, Stone E, Fast W, et al
. Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis. Proc Natl Acad Sci U S A. 2005;102:11882-7 pubmed publisher