tsst-1

Summary

Gene Symbol: tsst-1
Description: toxic shock syndrome toxin-1
Species:

Publications

  1. Nucleotide sequences and biologic properties of toxic shock syndrome toxin 1 from ovine- and bovine-associated Staphylococcus aureus
    P K Lee
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455 0312
    J Infect Dis 165:1056-63
  2. [Occurrence of selected enterotoxins and toxic shock syndrome toxin genes among sensitive and resistant to methicillin Staphylococcus aureus isolated from clinical samples]
    Katarzyna Garbacz
    Zakład Mikrobiologii Lekarskiej Akademii Medycznej w Gdańsku
    Med Dosw Mikrobiol 59:201-6
  3. Staphylococcus aureus of phage type 187 isolated from people occurred to be a genes carrier of eneterotoxin C and toxic shock syndrome toxin-1 (TSST-1)
    Lidia Piechowicz
    Department of Medical Microbiology, Medical University of Gdańsk, Do Studzienki 38, 80 227 Gdańsk, Poland
    Int J Hyg Environ Health 211:273-82
  4. [Presence of enterotoxin C and toxic shock syndrome toxin--1 (TSST-1) genes in population of Staphylococcus aureus phage type 187]
    Katarzyna Garbacz
    Zakład Mikrobiologii Lekarskiej AM w Gdańsku
    Med Dosw Mikrobiol 58:191-8
  5. Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1
    Beenu Moza
    Boston Biomedical Research Institute, Watertown, MA 02472, USA
    EMBO J 26:1187-97
  6. Successful treatment of staphylococcal toxic shock syndrome with linezolid: a case report and in vitro evaluation of the production of toxic shock syndrome toxin type 1 in the presence of antibiotics
    Dennis L Stevens
    Clin Infect Dis 42:729-30
  7. Characterization of a putative pathogenicity island from bovine Staphylococcus aureus encoding multiple superantigens
    J R Fitzgerald
    Department of Microbiology, Moyne Institute of Preventive Medicine, Republic of Ireland
    J Bacteriol 183:63-70
  8. Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity
    C A Earhart
    Department of Biochemistry, Medical School, University of Minnesota, Minneapolis 55455, USA
    Biochemistry 37:7194-202
  9. Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity
    G S Prasad
    Department of Biochemistry, Medical School, University of Minnesota, Minneapolis 55455, USA
    Protein Sci 6:1220-7
  10. The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 A resolution
    A C Papageorgiou
    School of Biology and Biochemistry, University of Bath, Claverton Down, UK
    J Mol Biol 260:553-69

Scientific Experts

  • J R Fitzgerald
  • Thibaut Van Zele
  • Katarzyna Garbacz
  • Lidia Piechowicz
  • Beenu Moza
  • Dennis L Stevens
  • C A Earhart
  • P M Schlievert
  • G S Prasad
  • D H Ohlendorf
  • Kai W Wucherpfennig
  • David M Kranz
  • Christine A Herfst
  • Melissa J Nicholson
  • Agata Dajnowska-Stanczewa
  • Anne Kathrin Wilbuer
  • Agata Dajnowska Stanczewa
  • Anne-Kathrin Wilbuer
  • Nilufer P Seth
  • Penny Zhu
  • John K McCormick
  • Rebecca A Buonpane
  • Eric J Sundberg
  • Ashok K Varma
  • Amy E Bryant
  • Randi J Wallace
  • Stephanie M Hamilton
  • D T Mitchell
  • K R Acharya
  • A C Papageorgiou
  • D L Murray
  • H S Tranter
  • R D Brehm
  • D M Pinheiro
  • M Matsumura
  • M M Dinges
  • R Radhakrishnan
  • W J Cook
  • R P Novick
  • D D Leonidas
  • K Harlos
  • P K Lee
  • E F Passalacqua
  • D I Stuart
  • E Y Jones
  • B N Kreiswirth
  • B L Smith
  • J R Deringer
  • W Eisner
  • E Carlson
  • D A Blomster-Hautamaa
  • S J Projan
  • J S Kornblum

Detail Information

Publications14

  1. Nucleotide sequences and biologic properties of toxic shock syndrome toxin 1 from ovine- and bovine-associated Staphylococcus aureus
    P K Lee
    Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455 0312
    J Infect Dis 165:1056-63
    ..Also, TSST-ovine was less reactive to certain monoclonal antibodies raised against TSST-1...
  2. [Occurrence of selected enterotoxins and toxic shock syndrome toxin genes among sensitive and resistant to methicillin Staphylococcus aureus isolated from clinical samples]
    Katarzyna Garbacz
    Zakład Mikrobiologii Lekarskiej Akademii Medycznej w Gdańsku
    Med Dosw Mikrobiol 59:201-6
    ..No correlation between presence of the particular genes and clinical samples was observed...
  3. Staphylococcus aureus of phage type 187 isolated from people occurred to be a genes carrier of eneterotoxin C and toxic shock syndrome toxin-1 (TSST-1)
    Lidia Piechowicz
    Department of Medical Microbiology, Medical University of Gdańsk, Do Studzienki 38, 80 227 Gdańsk, Poland
    Int J Hyg Environ Health 211:273-82
    ..Additionally, the fact that almost all of them have the enterotoxin genes and tst gene allows to consider them the strains of potentially high virulence...
  4. [Presence of enterotoxin C and toxic shock syndrome toxin--1 (TSST-1) genes in population of Staphylococcus aureus phage type 187]
    Katarzyna Garbacz
    Zakład Mikrobiologii Lekarskiej AM w Gdańsku
    Med Dosw Mikrobiol 58:191-8
    ..Almost all of them (93.8%) had the enterotoxin C gene and TSST-1 gene. This fact allows to consider them the strains of potentially high virulence...
  5. Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1
    Beenu Moza
    Boston Biomedical Research Institute, Watertown, MA 02472, USA
    EMBO J 26:1187-97
    ..Our data also suggest that protein plasticity plays an exceptionally significant role in this affinity maturation process that results in more than a 3000-fold increase in affinity...
  6. Successful treatment of staphylococcal toxic shock syndrome with linezolid: a case report and in vitro evaluation of the production of toxic shock syndrome toxin type 1 in the presence of antibiotics
    Dennis L Stevens
    Clin Infect Dis 42:729-30
  7. Characterization of a putative pathogenicity island from bovine Staphylococcus aureus encoding multiple superantigens
    J R Fitzgerald
    Department of Microbiology, Moyne Institute of Preventive Medicine, Republic of Ireland
    J Bacteriol 183:63-70
    ..This suggests that the presence of SaPIbov may contribute to modulation of the bovine immune response...
  8. Structures of five mutants of toxic shock syndrome toxin-1 with reduced biological activity
    C A Earhart
    Department of Biochemistry, Medical School, University of Minnesota, Minneapolis 55455, USA
    Biochemistry 37:7194-202
    ....
  9. Refined structures of three crystal forms of toxic shock syndrome toxin-1 and of a tetramutant with reduced activity
    G S Prasad
    Department of Biochemistry, Medical School, University of Minnesota, Minneapolis 55455, USA
    Protein Sci 6:1220-7
    ..173 to 1.9 A resolution)...
  10. The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 A resolution
    A C Papageorgiou
    School of Biology and Biochemistry, University of Bath, Claverton Down, UK
    J Mol Biol 260:553-69
    ....
  11. Structure of toxic shock syndrome toxin 1
    G S Prasad
    Department of Biochemistry, University of Minnesota Medical School, Minneapolis 55455
    Biochemistry 32:13761-6
    ..An adjacent region along this helix is proposed to be critical in the ability of TSST-1 to induce toxic shock syndrome...
  12. Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1
    K R Acharya
    School of Biology and Biochemistry, University of Bath, UK
    Nature 367:94-7
    ..But TSST-1 lacks several of the structural features highlighted as central to superantigen activity in the staphylococcal enterotoxin B and we therefore reappraise the structural basis of superantigen action...
  13. The nucleotide and partial amino acid sequence of toxic shock syndrome toxin-1
    D A Blomster-Hautamaa
    J Biol Chem 261:15783-6
    ..Computer analyses of the amino acid sequence showed that TSST-1 has little or no sequence homology with biologically related toxins, streptococcal pyrogenic exotoxin A, and staphylococcal enterotoxins B and C...
  14. Detection of enterotoxin DNA in Staphylococcus aureus strains obtained from the middle meatus in controls and nasal polyp patients
    Thibaut Van Zele
    Ear, Nose, and Throat Department, Upper Airways Research Laboratory, Ghent University Hospital, Ghent, Belgium
    Am J Rhinol 22:223-7
    ..However, in NPs, a higher number of strains belonged to agr I or II, which are associated with strains causing enterotoxin-mediated disease...