Ferenc Zsila

Summary

Publications

  1. doi Apparent circular dichroism signature of stirring-oriented DNA and drug-DNA complexes
    Ferenc Zsila
    Chemical Biology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, POB 289, H 1519 Budapest, Hungary Electronic address
    Int J Biol Macromol 72:1034-40. 2015
  2. doi Role of the conformational flexibility of evodiamine in its binding to protein hosts: a comparative spectroscopic and molecular modeling evaluation with rutaecarpine
    Celesztina Domonkos
    Research Group of Chemical Biology, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, POB 289, H 1519, Budapest, Hungary
    Phys Chem Chem Phys 16:22632-42. 2014
  3. doi Subdomain IB is the third major drug binding region of human serum albumin: toward the three-sites model
    Ferenc Zsila
    Laboratory of Chemical Pharmacology, Institute of Molecular Pharmacology, Research Centre for Natural Sciences, H 1025 Budapest, Pusztaszeri ut 59 67, Hungary
    Mol Pharm 10:1668-82. 2013
  4. doi Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, PO Box 17, H 1525, Hungary
    Bioorg Med Chem 16:3759-72. 2008
  5. ncbi Selective binding of imatinib to the genetic variants of human alpha1-acid glycoprotein
    Ilona Fitos
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry Chemical Research Center, Hungarian Academy of Sciences, Budapest, POB 17, H 1525, Hungary
    Biochim Biophys Acta 1760:1704-12. 2006
  6. ncbi In vitro plasma protein binding and aqueous aggregation behavior of astaxanthin dilysinate tetrahydrochloride
    Ferenc Zsila
    Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, PO Box 17, H 1525, Hungary
    Bioorg Med Chem Lett 14:5357-66. 2004
  7. ncbi The drug binding site of human alpha1-acid glycoprotein: insight from induced circular dichroism and electronic absorption spectra
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, P O Box 17, H 1525, Hungary
    Biochim Biophys Acta 1770:797-809. 2007
  8. doi Organogold complexes probe a large beta-barrel cavity for human serum alpha1-acid glycoprotein
    Ferenc Zsila
    Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, P O Box 17, H 1525, Hungary
    Biochim Biophys Acta 1784:1106-14. 2008
  9. doi Fatty acid modulated human serum albumin binding of the β-carboline alkaloids norharmane and harmane
    Celesztina Domonkos
    Department of Biochemical Pharmacology, Institute of Molecular Pharmacology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, POB 17, H 1025, Budapest, Hungary
    Mol Pharm 10:4706-16. 2013
  10. ncbi Conformation selectivity in the binding of diazepam and analogues to alpha1-acid glycoprotein
    Ilona Fitos
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, H 1525 Budapest, Hungary
    Bioorg Med Chem 15:4857-62. 2007

Collaborators

Detail Information

Publications34

  1. doi Apparent circular dichroism signature of stirring-oriented DNA and drug-DNA complexes
    Ferenc Zsila
    Chemical Biology Research Group, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, POB 289, H 1519 Budapest, Hungary Electronic address
    Int J Biol Macromol 72:1034-40. 2015
    ..Stirring-induced changes of the CD profile also enable to clarify the DNA binding mode of various compounds (e.g., imatinib, thioflavin T) which would remain ambiguous considering isotropic spectral data only. ..
  2. doi Role of the conformational flexibility of evodiamine in its binding to protein hosts: a comparative spectroscopic and molecular modeling evaluation with rutaecarpine
    Celesztina Domonkos
    Research Group of Chemical Biology, Institute of Organic Chemistry, Research Centre for Natural Sciences, Hungarian Academy of Sciences, POB 289, H 1519, Budapest, Hungary
    Phys Chem Chem Phys 16:22632-42. 2014
    ..In contrast to EVD, the nearly planar geometry of the indoloquinazoline ring system of RTC allows its stacked dimeric binding to the HSA. ..
  3. doi Subdomain IB is the third major drug binding region of human serum albumin: toward the three-sites model
    Ferenc Zsila
    Laboratory of Chemical Pharmacology, Institute of Molecular Pharmacology, Research Centre for Natural Sciences, H 1025 Budapest, Pusztaszeri ut 59 67, Hungary
    Mol Pharm 10:1668-82. 2013
    ..Brief case studies are presented to illustrate how the evaluation of spectral changes of tetrapyrrole CD probes gains new insight into the HSA binding properties of endogenous as well as pharmaceutical compounds...
  4. doi Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, PO Box 17, H 1525, Hungary
    Bioorg Med Chem 16:3759-72. 2008
    ..In case of chloroquine, no significant binding interaction was found either with AAG or HSA. Pharmacological aspects of the results are discussed...
  5. ncbi Selective binding of imatinib to the genetic variants of human alpha1-acid glycoprotein
    Ilona Fitos
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry Chemical Research Center, Hungarian Academy of Sciences, Budapest, POB 17, H 1525, Hungary
    Biochim Biophys Acta 1760:1704-12. 2006
    ..The binding affinity of imatinib to human serum albumin (nKa approximately 3 x 10(4)M(-1)) is low. Pharmacologically relevant binding interactions with other drugs can be expected on the F1-S variant of AGP...
  6. ncbi In vitro plasma protein binding and aqueous aggregation behavior of astaxanthin dilysinate tetrahydrochloride
    Ferenc Zsila
    Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, PO Box 17, H 1525, Hungary
    Bioorg Med Chem Lett 14:5357-66. 2004
    ....
  7. ncbi The drug binding site of human alpha1-acid glycoprotein: insight from induced circular dichroism and electronic absorption spectra
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, P O Box 17, H 1525, Hungary
    Biochim Biophys Acta 1770:797-809. 2007
    ....
  8. doi Organogold complexes probe a large beta-barrel cavity for human serum alpha1-acid glycoprotein
    Ferenc Zsila
    Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, P O Box 17, H 1525, Hungary
    Biochim Biophys Acta 1784:1106-14. 2008
    ..The organogold complexes were successfully docked into the central cavity of this model...
  9. doi Fatty acid modulated human serum albumin binding of the β-carboline alkaloids norharmane and harmane
    Celesztina Domonkos
    Department of Biochemical Pharmacology, Institute of Molecular Pharmacology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, POB 17, H 1025, Budapest, Hungary
    Mol Pharm 10:4706-16. 2013
    ....
  10. ncbi Conformation selectivity in the binding of diazepam and analogues to alpha1-acid glycoprotein
    Ilona Fitos
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry Chemical Research Center, Hungarian Academy of Sciences, PO Box 17, H 1525 Budapest, Hungary
    Bioorg Med Chem 15:4857-62. 2007
    ..Studies with the separated genetic variants of AGP proved similar binding affinities, but markedly different conformation selectivities. For diazepam bound by the F1-S variant, a P/M selectivity of about 2 could be estimated...
  11. doi Selective binding interactions of deramciclane to the genetic variants of human alpha(1)-acid glycoprotein
    Ilona Fitos
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Hungarian Academy of Sciences, Budapest, POB 17, H 1525, Hungary
    Biochim Biophys Acta 1800:367-72. 2010
    ..Genetic variants of AGP have different ligand binding properties. The binding of deramciclane (DER), a chiral anxiolytic agent, has been studied on A and F1/S genetic variants of AGP...
  12. ncbi Unique, pH-dependent biphasic band shape of the visible circular dichroism of curcumin-serum albumin complex
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Chemistry, Chemical Research Center, Budapest, Hungary
    Biochem Biophys Res Commun 301:776-82. 2003
    ..Deprotonation of phenolic OH group(s) of curcumin seems to be the reason leading to the conformational alteration of HSA-bound curcumin...
  13. ncbi Probing protein binding sites by circular dichroism spectroscopy
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Chemistry, Chemical Research Centre, Budapest, POB 17, 1525, Hungary
    Curr Drug Discov Technol 1:133-53. 2004
    ..It can provide valuable data on the stereochemistry, number, location and nature of the binding sites. This paper is aimed to survey briefly the literature and the results of recent investigations undertaken in this field...
  14. ncbi Circular dichroism and absorption spectroscopic data reveal binding of the natural cis-carotenoid bixin to human alpha1-acid glycoprotein
    Ferenc Zsila
    Department of Bioorganic Chemistry, Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, P O Box 17, H 1525, Hungary
    Bioorg Chem 33:298-309. 2005
    ..To the authors' knowledge, the current study represents the first human lipocalin protein for which carotenoid binding affinity has been explored in vitro with these techniques...
  15. doi Chaperone-like activity of the acute-phase component human serum alpha 1-acid glycoprotein: inhibition of thermal- and chemical-induced aggregation of various proteins
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, H 1025 Budapest, Pusztaszeri ut 59 67, Hungary
    Bioorg Med Chem Lett 20:1205-9. 2010
    ....
  16. ncbi Specific ligand binding on genetic variants of human alpha1-acid glycoprotein studied by circular dichroism spectroscopy
    Ilona Fitos
    Department of Molecular Pharmacology, Institute of Chemistry, Chemical Research Center, Hungarian Academy of Sciences, P O Box 17, H 1525, Budapest, Hungary
    Biochem Pharmacol 67:679-88. 2004
    ..The induced CD spectrum of dicumarol was found to change sign in the presence of imipramine, as a manifestation of high-affinity ternary complex formation on the F1-S variant...
  17. doi Aromatic side-chain cluster of biotin binding site of avidin allows circular dichroism spectroscopic investigation of its ligand binding properties
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, H 1025, Budapest, Pusztaszeri ut 59 67, Hungary
    J Mol Recognit 24:995-1006. 2011
    ..The important role in the ligand binding of a polar side-chain cluster at the bottom of the biotin-binding cavity as well as the analogous avidin-binding mode of HABA and fenamic acid type NSAIDs have been proposed...
  18. doi Biliverdin is the endogenous ligand of human serum alpha1-acid glycoprotein
    Ferenc Zsila
    Chemical Research Center, Hungarian Academy of Sciences, Institute of Biomolecular Chemistry, H 1025 Budapest, Pusztaszeri ut 59 67, Hungary
    Biochem Biophys Res Commun 372:503-7. 2008
    ..Possible biological implications of the BV binding ability of AAG with special emphasis on the heme oxygenase-1 pathway are discussed...
  19. ncbi Circular dichroism spectroscopic studies reveal pH dependent binding of curcumin in the minor groove of natural and synthetic nucleic acids
    Ferenc Zsila
    Institute of Biomolecular Chemistry, Chemical Research Center, H 1525, Budapest, P O Box 17, Hungary
    Org Biomol Chem 2:2902-10. 2004
    ..As well as being an essentially new phenolic minor groove binder agent curcumin is also a promising molecular probe to study biologically important, pH and cation induced conformational polymorphisms of nucleic acids...
  20. doi Combination of chiroptical, absorption and fluorescence spectroscopic methods reveals multiple, hydrophobicity-driven human serum albumin binding of the antimalarial atovaquone and related hydroxynaphthoquinone compounds
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, H 1025 Budapest, Pusztaszeri ut 59 67, Hungary
    Org Biomol Chem 8:4905-14. 2010
    ....
  21. ncbi Multiple ligand-binding properties of the lipocalin member chicken alpha1-acid glycoprotein studied by circular dichroism and electronic absorption spectroscopy: the essential role of the conserved tryptophan residue
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, P O Box 17, H 1525, Hungary
    Biochim Biophys Acta 1760:1248-73. 2006
    ..Overall, cAGP serves as a simple, ultimate model to extend our knowledge on ligand-binding properties of lipocalins and to study the role of tryptophan residues in molecular recognition processes...
  22. doi Evaluation of drug-human serum albumin binding interactions with support vector machine aided online automated docking
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, H 1025 Budapest, Pusztaszeri ut 59 67, Hungary
    Bioinformatics 27:1806-13. 2011
    ..Our SVM model and the potential offered by the combined use of in silico calculation methods and experimental binding data is illustrated...
  23. ncbi Molecular modeling of non-covalent binding of homochiral (3S,3'S)-astaxanthin to matrix metalloproteinase-13 (MMP-13)
    Zsolt Bikadi
    Virtua Drug, Ltd, Budapest, Hungary
    Bioorg Med Chem 14:5451-8. 2006
    ..Therefore, the modeling study predicts potential direct enzyme-inhibitory activity of AST against MMP-13, a behavior that may be exploited in mammalian systems in which pathological upregulation of MMP activity is paramount...
  24. ncbi Determination of human serum alpha1-acid glycoprotein and albumin binding of various marketed and preclinical kinase inhibitors
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, H 1525, Budapest, P O Box 17, Hungary
    Curr Med Chem 16:1964-77. 2009
    ..Structural, biological and drug binding properties of AAG as well as the applicability of the CD method in studying drug-protein binding interactions are also briefly reviewed...
  25. doi Novel circular dichroism spectroscopic approach for detection of ligand binding of proteins: avidin as example
    Ferenc Zsila
    Chemical Research Center, Hungarian Academy of Sciences, Institute of Biomolecular Chemistry, H 1025 Budapest, 59 67 Pusztaszeri út, Hungary
    Anal Biochem 391:154-6. 2009
    ..This novel, fast, microgram (microg) scale approach can be applied for detection of ligand binding of additional proteins displaying avidin-like far-UV CD spectra...
  26. ncbi Supramolecular exciton chirality of carotenoid aggregates
    Miklos Simonyi
    Department of Molecular Pharmacology Institute of Chemistry, CRC, Budapest, Hungary
    Chirality 15:680-98. 2003
    ....
  27. doi Binding of alkaloids into the S1 specificity pocket of α-chymotrypsin: evidence from induced circular dichroism spectra
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, H 1025, Budapest, Pusztaszeri u 59 67, Hungary
    Org Biomol Chem 9:4127-37. 2011
    ..Furthermore, the results provide a novel, CD spectroscopic based approach for probing the ligand binding of αCHT and related proteases...
  28. ncbi Binding of the pepper alkaloid piperine to bovine beta-lactoglobulin: circular dichroism spectroscopy and molecular modeling study
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, P O Box 17, H 1525, Hungary
    J Agric Food Chem 53:10179-85. 2005
    ..Additional molecular modeling calculations indicated that the beta-barrel of human tear lipocalin, human serum retinol binding protein, and human neutrophil gelatinase associated lipocalin might also accommodate a piperine molecule...
  29. ncbi Overlapping ligand specificity of P-glycoprotein and serum alpha(1)-acid glycoprotein: evidences and potential implications
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, Hungary
    Curr Drug Metab 8:563-93. 2007
    ....
  30. ncbi Probing the binding of the flavonoid, quercetin to human serum albumin by circular dichroism, electronic absorption spectroscopy and molecular modelling methods
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Chemistry, Chemical Research Center, P O Box 17, H 1525, Budapest, Hungary
    Biochem Pharmacol 65:447-56. 2003
    ..Additionally, the position of quercetin within the binding pocket allows simultaneous binding of other ligands such as warfarin, or sodium salycilate...
  31. doi Circular dichroism spectroscopy is a sensitive tool for investigation of bilirubin-enzyme interactions
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, H 1025 Budapest, Pusztaszeri út 59 67, Hungary
    Biomacromolecules 12:221-7. 2011
    ....
  32. doi Inhibition of heat- and chemical-induced aggregation of various proteins reveals chaperone-like activity of the acute-phase component and serine protease inhibitor human alpha(1)-antitrypsin
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, Budapest, Pusztaszeri út, Hungary
    Biochem Biophys Res Commun 393:242-7. 2010
    ....
  33. ncbi Binding of anti-prion agents to glycosaminoglycans: evidence from electronic absorption and circular dichroism spectroscopy
    Ferenc Zsila
    Department of Molecular Pharmacology, Institute of Biomolecular Chemistry, Chemical Research Center, POB 17, Budapest, H 1525, Hungary
    Biochem Biophys Res Commun 346:1267-74. 2006
    ..These results call the attention to the alteration of GAG-prion/GAG-amyloid interactions by which these compounds might exert their anti-prion/anti-amyloidogenic activities...
  34. doi Influence of acid-induced conformational variability on protein separation in reversed phase high performance liquid chromatography
    Balázs Bobály
    Research Centre for Natural Sciences, Hungarian Academy of Sciences, Pusztaszeri ut 59 67, Budapest 1025, Hungary Budapest University of Technology and Economics, Department of Inorganic and Analytical Chemistry, Szt Gellert ter 4, Budapest 1111, Hungary
    J Chromatogr A 1325:155-62. 2014
    ..Conformation change was monitored by circular dichroism spectroscopy and mass spectrometry; and it was shown that not only TFA but FA can also induce molten globule formation. ..