Yunzeng Zou



  1. Zhang X, Wang X, Wu J, Peng J, Deng X, Shen Y, et al. The diagnostic values of circulating miRNAs for hypertension and bioinformatics analysis. Biosci Rep. 2018;38: pubmed publisher
  2. Lu H, Huang D, Yao K, Li C, Chang S, Dai Y, et al. Insulin enhances dendritic cell maturation and scavenger receptor-mediated uptake of oxidised low-density lipoprotein. J Diabetes Complications. 2015;29:465-71 pubmed publisher
    ..The results of the present study indicate that one of the mechanisms by which insulin promotes atherogenesis is mediated by its effects on DCs. ..
  3. Gong H, Chen Z, Zhang X, Li Y, Zhang J, Chen Y, et al. Urotensin II Protects Cardiomyocytes from Apoptosis Induced by Oxidative Stress through the CSE/H2S Pathway. Int J Mol Sci. 2015;16:12482-98 pubmed publisher
    ..These results suggest that increased plasma UII level may protect cardiomyocytes at the early-phase of acute myocardial infarction in patients. ..
  4. Li Y, Sun S, Ding Z, Yang C, Zhang G, Jiang Q, et al. Temporal and spatial expression of fgfbp genes in zebrafish. Gene. 2018;659:128-136 pubmed publisher
    ..Our work offers a starting point to uncover roles of FGFBP family genes and the possible mechanisms of FGF-dependent and -independent actions of FGFBP in vertebrates. ..
  5. Liu H, Gao W, Yuan J, Wu C, Yao K, Zhang L, et al. Exosomes derived from dendritic cells improve cardiac function via activation of CD4(+) T lymphocytes after myocardial infarction. J Mol Cell Cardiol. 2016;91:123-33 pubmed publisher
    ..Our findings provide the basis for a novel strategy for the treatment of MI through the systemic delivery of DEXs. ..
  6. Wang S, Wu J, You J, Shi H, Xue X, Huang J, et al. HSF1 deficiency accelerates the transition from pressure overload-induced cardiac hypertrophy to heart failure through endothelial miR-195a-3p-mediated impairment of cardiac angiogenesis. J Mol Cell Cardiol. 2018;118:193-207 pubmed publisher
  7. Li Y, Jiang Q, Ding Z, Liu G, Yu P, Jiang G, et al. Identification of a Common Different Gene Expression Signature in Ischemic Cardiomyopathy. Genes (Basel). 2018;9: pubmed publisher
    ..Further, the top DEGs were validated by RT-PCR in human samples. Our study explored the possible molecular mechanisms of heart failure caused by ischemic heart disease. ..
  8. Wang X, Ye Y, Gong H, Wu J, Yuan J, Wang S, et al. The effects of different angiotensin II type 1 receptor blockers on the regulation of the ACE-AngII-AT1 and ACE2-Ang(1-7)-Mas axes in pressure overload-induced cardiac remodeling in male mice. J Mol Cell Cardiol. 2016;97:180-90 pubmed publisher
    ..In contrast, Telmisartan, Valsartan and Irbesartan only played a role in the presence of AngII, and Losartan had no effect in the presence of AngII in vitro. ..
  9. Yu P, Zhao J, Jiang H, Liu M, Yang X, Zhang B, et al. Neural cell adhesion molecule-1 may be a new biomarker of coronary artery disease. Int J Cardiol. 2018;257:238-242 pubmed publisher
    ..599-0.884, p=0.001), adjusting for age, gender, current smoking status, cholesterol, triglyceride, glucose, creatine, homocysteine, cTnT, and NT-proBNP. These findings suggested that NCAM-1 may be a potential biomarker of CAD. ..

More Information


  1. Zhou N, Ye Y, Wang X, Ma B, Wu J, Li L, et al. Heat shock transcription factor 1 protects against pressure overload-induced cardiac fibrosis via Smad3. J Mol Med (Berl). 2017;95:445-460 pubmed publisher
    ..Deficiency of HSF1 deteriorates fibrotic response and cardiac dysfunction upon TAC. HSF1 inhibits phosphorylation and nuclear distribution of Smad3 via direct binding to Smad3. Active Smad3 blocks the anti-fibrotic effect of HSF1. ..
  2. You J, Wu J, Zhang Q, Ye Y, Wang S, Huang J, et al. Differential cardiac hypertrophy and signaling pathways in pressure versus volume overload. Am J Physiol Heart Circ Physiol. 2017;:ajpheart.00212.2017 pubmed publisher
    ..Here, we aimed to differentiate the load-mediated signaling pathways involved in pressure versus volume overload cardiac hypertrophy...
  3. Huang J, Wu J, Wang S, You J, Ye Y, Ding Z, et al. Ultrasound biomicroscopy validation of a murine model of cardiac hypertrophic preconditioning: comparison with a hemodynamic assessment. Am J Physiol Heart Circ Physiol. 2017;313:H138-H148 pubmed publisher
    ..The protocol may be of great importance in the successful establishment of the hypertrophic preconditioning model for further mechanistic and pharmacological studies. ..
  4. Liu M, Yu P, Jiang H, Yang X, Zhao J, Zou Y, et al. The Essential Role of Pin1 via NF-?B Signaling in Vascular Inflammation and Atherosclerosis in ApoE-/- Mice. Int J Mol Sci. 2017;18: pubmed publisher
    ..hy926 cells and decreased THP-1 cell adhesion to oxLDL-stimulated endothelial cells through the NF-?B signal pathway. Our findings indicate that Pin1 plays a vital role on the development of vascular inflammation and atherosclerosis. ..
  5. Zou Y, Li J, Ma H, Jiang H, Yuan J, Gong H, et al. Heat shock transcription factor 1 protects heart after pressure overload through promoting myocardial angiogenesis in male mice. J Mol Cell Cardiol. 2011;51:821-9 pubmed publisher
    ..We conclude that HSF1 promotes cardiac angiogenesis through suppression of p53 and subsequent upregulation of HIF-1 in endothelial cells during chronic pressure overload, leading to the maintenance of cardiac adaptation. ..
  6. Guo J, Ma L, Shi H, Zhu J, Wu J, Ding Z, et al. Alginate Oligosaccharide Prevents Acute Doxorubicin Cardiotoxicity by Suppressing Oxidative Stress and Endoplasmic Reticulum-Mediated Apoptosis. Mar Drugs. 2016;14: pubmed publisher
    ..Taken together, these findings identify AOS as a potent compound that prevents acute DOX cardiotoxicity, at least in part, by suppression of oxidative stress and endoplasmic reticulum-mediated apoptosis. ..
  7. Sun Y, Kang L, Li J, Liu H, Wang Y, Wang C, et al. Advanced glycation end products impair the functions of saphenous vein but not thoracic artery smooth muscle cells through RAGE/MAPK signalling pathway in diabetes. J Cell Mol Med. 2016;20:1945-55 pubmed publisher
    ..It is the intrinsic 'inactive' tendency of SMCA that contributes to the different rates of graft disease between SV and ITA after CABG. ..
  8. Pei Y, Jiang R, Zou Y, Wang Y, Zhang S, Wang G, et al. Effects of Fine Particulate Matter (PM2.5) on Systemic Oxidative Stress and Cardiac Function in ApoE(-/-) Mice. Int J Environ Res Public Health. 2016;13: pubmed publisher
    ..In conclusion, PM2.5 exposure could cause oxidative and ANS injuries, and ApoE(-/-) mice displayed more severe oxidative effects induced by PM2.5. ..
  9. Zou Y, Liang Y, Gong H, Zhou N, Ma H, Guan A, et al. Ryanodine receptor type 2 is required for the development of pressure overload-induced cardiac hypertrophy. Hypertension. 2011;58:1099-110 pubmed publisher