Anti-phospholipid antibodies are associated with response to interferon-beta1a treatment in MS: results from a 3-year longitudinal studyRobert Zivadinov
Department of Neurology, School of Medicine and Biomedical Sciences, Buffalo Neuroimaging Analysis Center, 100 High St, Buffalo, NY 14203, USA
Neurol Res 34:761-9. 2012
..To prospectively investigate the associations of baseline serum anti-phospholipid antibody (APLA) status on evolution of clinical and MRI measures in a multiple sclerosis (MS) patient cohort treated with interferon-beta (IFN-beta)...
- Voxel-wise magnetization transfer imaging study of effects of natalizumab and IFNβ-1a in multiple sclerosis
R Zivadinov
Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA
Mult Scler 18:1125-34. 2012
....
Comparison of a 1.5T standard vs. 3T optimized protocols in multiple sclerosis patientsI Livshits
Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY, USA
Minerva Med 103:97-102. 2012
..This study investigated the superiority of the 3T optimized vs. the 1.5T standardized protocols in detecting gadolinium enhancing (GD-E) lesions in patients with MS...
Advances in understanding gray matter pathology in multiple sclerosis: Are we ready to redefine disease pathogenesis?Robert Zivadinov
Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
BMC Neurol 12:9. 2012
..Monitoring the evolution of GM damage is becoming an important marker in predicting future disease course and response to therapy in MS patients...
- Magnetization transfer imaging of acute black holes in patients on glatiramer acetate
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA
Front Biosci (Elite Ed) 4:1496-504. 2012
..4 %, p = 0.046); no significant MTR changes were found for pattern B. GA treatment significantly recovered MTR in ABHs and CBHs, possibly indicating a greater potential for remyelination...
- Serum lipid profiles are associated with disability and MRI outcomes in multiple sclerosis
Bianca Weinstock-Guttman
Department of Neurology, State University of New York, Buffalo, NY, USA
J Neuroinflammation 8:127. 2011
..Vascular co-morbidities are associated with increased risk of progression. Dyslipidemia, elevated LDL and reduced HDL may increase progression by activating inflammatory processes at the vascular endothelium...
- Role of platelets in neuroinflammation: a wide-angle perspective
Lawrence L Horstman
Wallace Coulter Platelet Laboratory, Division of Hematology and Oncology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, Florida, USA
J Neuroinflammation 7:10. 2010
..CONCLUSION: The final section summarizes evidence of platelet involvement in MS. The general conclusion is that platelets may be key players in MS and related disorders, and warrant more attention in neurological research...
- Antiphospholipid antibodies: paradigm in transition
Lawrence L Horstman
Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
J Neuroinflammation 6:3. 2009
..Finally, aPL in non-thrombotic disorders is reviewed. CONCLUSION: The current paradigm of aPL holds that they are important in thrombosis, but they may have much wider clinical significance, possibly of special interest in neurology...
- Hypoperfusion of brain parenchyma is associated with the severity of chronic cerebrospinal venous insufficiency in patients with multiple sclerosis: a cross-sectional preliminary report
Paolo Zamboni
Vascular Diseases Center, University of Ferrara Bellaria Neurosciences, Ferrara and Bologna, Italy
BMC Med 9:22. 2011
..We hypothesized a possible relationship between abnormal perfusion in MS and hampered venous outflow at the extracranial level, a condition possibly associated with MS and known as chronic cerebrospinal venous insufficiency (CCSVI)...
- Use of MR venography for characterization of the extracranial venous system in patients with multiple sclerosis and healthy control subjects
Robert Zivadinov
Department of Neurology, School of Medicine and Biomedical Sciences, Buffalo Neuroimaging Analysis Center, State University of New York, 100 High St, Buffalo, NY 14203, USA
Radiology 258:562-70. 2011
..To investigate the differences in the extracranial venous system in patients with multiple sclerosis (MS) and healthy control (HC) subjects by using magnetic resonance (MR) venography...
- Chronic cerebrospinal venous insufficiency and iron deposition on susceptibility-weighted imaging in patients with multiple sclerosis: a pilot case-control study
R Zivadinov
Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
Int Angiol 29:158-75. 2010
....
- Value of MR venography for detection of internal jugular vein anomalies in multiple sclerosis: a pilot longitudinal study
R Zivadinov
Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA
AJNR Am J Neuroradiol 32:938-46. 2011
..We assessed the role of conventional MRV for the detection of IJV anomalies in patients with MS diagnosed with CCSVI and in healthy controls who underwent MRV and Doppler sonography examinations during 6 months...
- Prevalence, sensitivity, and specificity of chronic cerebrospinal venous insufficiency in MS
R Zivadinov
Department of Neurology, School of Medicine and Biomedical Sciences Buffalo Neuroimaging Analysis Center, Buffalo, NY 14203, USA
Neurology 77:138-44. 2011
..Chronic cerebrospinal venous insufficiency (CCSVI) was recently described in patients with multiple sclerosis (MS). A subject is considered CCSVI positive if ≥ 2 venous hemodynamic (VH) criteria are fulfilled...
- Iron deposition and inflammation in multiple sclerosis. Which one comes first?
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
BMC Neurosci 12:60. 2011
..Creating a representative animal model that can study independently such relationship will be the key factor in this endeavor...
- Chronic cerebrospinal venous insufficiency in multiple sclerosis: diagnostic, pathogenetic, clinical and treatment perspectives
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY, USA
Expert Rev Neurother 11:1277-94. 2011
..The potential usefulness of endovascular treatment for CCSVI in multiple sclerosis patients is still unknown...
- Abnormal subcortical deep-gray matter susceptibility-weighted imaging filtered phase measurements in patients with multiple sclerosis: a case-control study
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY 14203, USA
Neuroimage 59:331-9. 2012
....
- Decreased brain venous vasculature visibility on susceptibility-weighted imaging venography in patients with multiple sclerosis is related to chronic cerebrospinal venous insufficiency
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY, USA
BMC Neurol 11:128. 2011
....
- Evidence for gray matter pathology in multiple sclerosis: a neuroimaging approach
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
J Neurol Sci 282:1-4. 2009
..GM pathology imaging correlates are related to disability progression, as measured both by motor and cognitive functional outcomes...
- Comparison of three different methods for measurement of cervical cord atrophy in multiple sclerosis
R Zivadinov
Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
AJNR Am J Neuroradiol 29:319-25. 2008
..We also wanted to evaluate the relationship between cervical cord atrophy and clinical disability in the presence of other conventional and nonconventional brain MR imaging metrics by using a unique additive variance regression model...
- Clinical efficacy, effects on MRI and tolerability of weekly intramuscular interferon-beta-1a in patients with MS and CIS
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, New York 14203, USA
Drugs Today (Barc) 44:601-13. 2008
..Early initiation of disease-modifying therapy after the diagnosis of relapsing-remitting MS or after a single demyelinating event (and evidence of lesions on MRI) allows patients the opportunity to obtain maximal long-term benefits...
- Use of perfusion- and diffusion-weighted imaging in differential diagnosis of acute and chronic ischemic stroke and multiple sclerosis
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, NY, USA
Neurol Res 30:816-26. 2008
....
- Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency: a pilot study in multiple sclerosis patients and healthy controls
D Hojnacki
The Jacobs Neurological Institute, State University of New York, Buffalo, NY, USA
Int Angiol 29:127-39. 2010
..The aim of this paper was to investigate the value of neck magnetic resonance venography (MRV) for the diagnosis of CCSVI compared to DS and SV in patients with MS and in healthy controls (HC)...
- Magnetic resonance imaging characteristics of children and adults with paediatric-onset multiple sclerosis
E A Yeh
Paediatric Multiple Sclerosis Centre, State University of New York at Buffalo, Buffalo, NY 14260 1200, USA
Brain 132:3392-400. 2009
..Despite this, disability is slower to accrue in paediatric onset multiple sclerosis than adult onset multiple sclerosis...
- Increased tissue damage and lesion volumes in African Americans with multiple sclerosis
B Weinstock-Guttman
The Jacobs Neurological Institute, Baird Multiple Sclerosis Center, Department of Neurology, State University of New York, E2 Buffalo General Hospital, Buffalo, NY 14203, USA
Neurology 74:538-44. 2010
..African American (AA) patients with multiple sclerosis (MS) have more rapid disease progression and poorer responses to disease-modifying therapies than white American (WA) patients with MS...
- Sensitivity and specificity for screening of chronic cerebrospinal venous insufficiency using a multimodal non-invasive imaging approach in patients with multiple sclerosis
K Dolic
Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA
Funct Neurol 26:205-14. 2011
..This study suggests that a multimodal non-invasive approach (DS and MRV) increases the specificity for a diagnosis of CCSVI in patients with MS...
- Iron deposition on SWI-filtered phase in the subcortical deep gray matter of patients with clinically isolated syndrome may precede structure-specific atrophy
J Hagemeier
Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, NY 14203, USA
AJNR Am J Neuroradiol 33:1596-601. 2012
..We also examined the association of abnormal phase with conventional MR imaging outcomes at first clinical onset...
- Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis
R Zivadinov
Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY 14203, USA
Neurology 73:504-10. 2009
..Cigarette smoking has been linked to higher susceptibility and increased risk of progressive multiple sclerosis (MS). The effects of smoking on MRI characteristics of patients with MS have not been evaluated...
- Neuromyelitis optica immunoglobulins as a marker of disease activity and response to therapy in patients with neuromyelitis optica
B Weinstock-Guttman
Baird Multiple Sclerosis Center, State University of New York at Buffalo, Buffalo, NY Department of Neurology, State University of New York at Buffalo, Buffalo, NY 14203, USA
Mult Scler 14:1061-7. 2008
..To determine whether neuromyelitis optica (NMO) immunoglobulin (IgG) antibody status in NMO/Devic's disease patients followed prospectively is persistent or can change relative to the clinical status and/or response to therapy...
- Epstein-Barr virus is associated with grey matter atrophy in multiple sclerosis
R Zivadinov
Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, New York 14260, USA
J Neurol Neurosurg Psychiatry 80:620-5. 2009
..The aim of the study was to determine whether the presence of anti-Epstein-Barr virus (EBV) antibodies is associated with MRI measures of brain injury and neurodegeneration in patients with multiple sclerosis (MS)...
- Gender-related differences in MS: a study of conventional and nonconventional MRI measures
R Antulov
Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York at Buffalo, Buffalo, New York 14203, USA
Mult Scler 15:345-54. 2009
..Studies showed gender-associated differences in multiple sclerosis (MS) disease evolution and in the evolution of conventional magnetic resonance imaging (MRI) findings...
- Intra- and extraluminal structural and functional venous anomalies in multiple sclerosis, as evidenced by 2 noninvasive imaging techniques
K Dolic
Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, USA
AJNR Am J Neuroradiol 33:16-23. 2012
..Our aim was to investigate the prevalence and number of intra- and extraluminal structural and functional extracranial venous abnormalities by using DS and MRV, in patients with MS and HCs...
- Soluble receptor for advanced glycation end products in multiple sclerosis: a potential marker of disease severity
Z Sternberg
Department of Neurology, Baird MS Center, Jacobs Neurological Institute, Buffalo, NY 14203, USA
Mult Scler 14:759-63. 2008
....
- Memory impairment in multiple sclerosis: correlation with deep grey matter and mesial temporal atrophy
R H B Benedict
Jacobs Neurological Institute, Buffalo Neuroimaging Analysis Center, and Department of Neurology, State University of New York at Buffalo, New York 14203, USA
J Neurol Neurosurg Psychiatry 80:201-6. 2009
..However, the importance of mesial temporal lobe (MTL) atrophy in MS is largely untested and poorly understood. New structural imaging techniques permit volumetric measures of multiple regions within the MTL lobe and DGM...
- Rapid disease course in African Americans with multiple sclerosis
I Kister
Department of Neurology, NYU School of Medicine, Multiple Sclerosis Care Center, New York, NY 10003 3804, USA
Neurology 75:217-23. 2010
..MSSS is a frequency-rank algorithm relating MS disability to disease duration in a large, untreated reference population. Design/..
- Mechanisms of action of disease-modifying agents and brain volume changes in multiple sclerosis
R Zivadinov
Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
Neurology 71:136-44. 2008
..The effects of corticosteroid therapy on changes in BV in patients with MS help clarify the mechanisms through which potent anti-inflammatory treatments may prevent, stabilize, or induce BV loss...
- Glatiramer acetate recovers microscopic tissue damage in patients with multiple sclerosis. A case-control diffusion imaging study
R Zivadinov
Buffalo Neuroimaging Analysis Center, Department of Neurology, University of Buffalo, Buffalo, NY, United States The Jacobs Neurological Institute, Department of Neurology, University of Buffalo, Buffalo, NY, United States
Pathophysiology 18:61-8. 2011
..Patients on GA and HC did not develop significant global or regional atrophy over 2 years. GA significantly improved microscopic tissue damage in the brain, as measured by DWI over the 1- and 2-year follow-up...
- Semi-automatic brain region extraction (SABRE) reveals superior cortical and deep gray matter atrophy in MS
D A Carone
Buffalo Neuroimaging Analysis Center, Buffalo, NY 14203, USA
Neuroimage 29:505-14. 2006
..5%), and superior parietal (-6.1%) regions, with SP patients having lower volumes. Overall, atrophy in MS is diffuse and mostly related to GM loss particularly in deep GM and superior frontal-parietal regions...
- Subcortical and cortical gray matter atrophy in a large sample of patients with clinically isolated syndrome and early relapsing-remitting multiple sclerosis
N Bergsland
Buffalo Neuroimaging Analysis Center, University at Buffalo, Buffalo, NY 14203, USA
AJNR Am J Neuroradiol 33:1573-8. 2012
....
- Interferon beta-1a slows progression of brain atrophy in relapsing-remitting multiple sclerosis predominantly by reducing gray matter atrophy
R Zivadinov
Department of Neurology, Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, University at Buffalo, State University of New York, Buffalo, NY, USA
Mult Scler 13:490-501. 2007
..Although neurological deficiencies in MS are primarily due to loss of WM, the clinical significance of GM atrophy has not been fully explored in MS...
- Retinal architecture predicts pupillary reflex metrics in MS
A R Salter
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Texas, USA
Mult Scler 15:479-86. 2009
..To study the relation of retinal nerve fiber layer thinning to clinical and physiologic measures of visual function in patients with MS or neuromyelitis optica and unilateral optic neuropathy...
- Extent of cerebellum, subcortical and cortical atrophy in patients with MS: a case-control study
Deepa Preeti Ramasamy
Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York at Buffalo, Buffalo, NY, USA
J Neurol Sci 282:47-54. 2009
..This study confirmed selective deep gray matter atrophy (mostly thalamic), revealed cerebellum WM atrophy from the earliest clinical stages, and showed that cortical thinning advances with disease progression...
- A sensitive, noise-resistant method for identifying focal demyelination and remyelination in patients with multiple sclerosis via voxel-wise changes in magnetization transfer ratio
Michael Dwyer
Buffalo Neuroimaging Analysis Center, State University of New York, Buffalo, NY, USA
J Neurol Sci 282:86-95. 2009
..It improves on the sensitivity of other approaches, and may increase the statistical power of studies investigating the effects of therapy on MRI outcomes in MS...
- MRI characteristics of patients with antiphospholipid syndrome and multiple sclerosis
Milena Stosic
Department of Neurology, School of Medicine and Biomedical Sciences, State University of New York, Buffalo, NY 14203, USA
J Neurol 257:63-71. 2010
..MRI reveals more profound injury in patients with MS versus PAPLS. APLA mediates heterogeneous cerebral pathology that remains to be further investigated...
- Independent contributions of cortical gray matter atrophy and ventricle enlargement for predicting neuropsychological impairment in multiple sclerosis
Ayda Tekok Kilic
Department of Neurology, University at Buffalo, State University of New York, USA
Neuroimage 36:1294-300. 2007
..For the first time, we show an independent relationship between cortical atrophy and cognitive impairment after accounting for the effects of central atrophy...
- Application of hidden Markov random field approach for quantification of perfusion/diffusion mismatch in acute ischemic stroke
Michael G Dwyer
Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, NY, USA
Neurol Res 30:827-34. 2008
..For the in vivo dataset, the mean absolute error decreased from 564.6% for thresholding to 34.2% for the delay-weighted HMRF approach. The described method represents a significant improvement over thresholding techniques...
- Longitudinal correlates of fatigue in multiple sclerosis
E Patrick
Department of Neurology, State University of New York at Stony Brook, New York 11794 8121, USA
Mult Scler 15:258-61. 2009
..To determine the predictors of longitudinal changes in fatigue based on pain, mood, and neurological impairment across multiple sclerosis (MS) subtypes...
- Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: a pilot study
Elliot M Frohman
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75235, USA
J Neurol Sci 282:96-105. 2009
..Measurement of retinal nerve fiber layer (RNFL) thickness in multiple sclerosis (MS) is gaining increasing attention...
- Thalamic involvement in multiple sclerosis: a diffusion-weighted magnetic resonance imaging study
Andrew J Fabiano
Buffalo Neuroimaging Analysis Center, Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
J Neuroimaging 13:307-14. 2003
..Both indirect and direct mechanisms of gray matter injury may play a role in the pathophysiology of MS...
- Reproducibility and accuracy of quantitative magnetic resonance imaging techniques of whole-brain atrophy measurement in multiple sclerosis
Robert Zivadinov
Department of Neurology, School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, Buffalo, New York 14203, USA
J Neuroimaging 15:27-36. 2005
..Whole-brain atrophy is of growing interest as an outcome measure in multiple sclerosis (MS) clinical trials. The authors compared the reproducibility and accuracy of 3 quantitative techniques of measurement in patients with MS...
- Regional specificity of magnetization transfer imaging in multiple sclerosis
Christopher W Tjoa
Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, New York, USA
J Neuroimaging 18:130-6. 2008
..We also studied the topography of MTR changes in multiple sclerosis (MS) and in normal controls (NC), and preliminarily examined the clinical usefulness of this method...
- Validity of the Wisconsin Card Sorting and Delis-Kaplan Executive Function System (DKEFS) Sorting Tests in multiple sclerosis
Brett A Parmenter
Department of Neurology, State University of New York at Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY 14203, USA
J Clin Exp Neuropsychol 29:215-23. 2007
..While both tests appear to have good validity in the MS population, the availability of alternative forms makes the DKEFS an attractive alternative to the WCST, as was suggested by a consensus panel...
- Neuropsychological impairment in systemic lupus erythematosus: a comparison with multiple sclerosis
R H B Benedict
Division of Cognitive and Behavioral Neurosciences, State University of New York at Buffalo, School of Medicine, Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
Neuropsychol Rev 18:149-66. 2008
..There is less evidence for neurodegenerative changes in SLE, but patients are increasingly at risk for cerebrovascular disease. We conclude by offering some suggestions for future clinical and imaging research...
- Effect of MRI coregistration on serial short-term brain volume changes in multiple sclerosis
David A Fritz
Buffalo Neuroimaging Analysis Center, Department of Neurology, The Jacobs Neurological Institute, University at Buffalo, State University of New York, 14203, USA
Neurol Res 28:275-9. 2006
..A longer observation period is needed to assess whether coregistration can affect the measurement of long-term brain volume changes...
- Neocortical atrophy, third ventricular width, and cognitive dysfunction in multiple sclerosis
Ralph H B Benedict
Department of Neurology, School of Medicine, State University of New York at Buffalo, 100 High Street, Buffalo, NY 14203, USA
Arch Neurol 63:1301-6. 2006
..Cognitive dysfunction is common in multiple sclerosis (MS). Correlations are reported between atrophy and neuropsychological test results...
- Interferon inhibitory activity in patients with multiple sclerosis
Kailash Chadha
Department of Cell and Molecular Biology, Roswell Park Cancer Institute, Jacobs Neurological Institute, Buffalo, New York 14263, USA
Arch Neurol 63:1579-84. 2006
..Interferon inhibitory activity (IIA) is a logical candidate for explaining neutralizing antibody-negative partial responsiveness to interferon beta in multiple sclerosis (MS), but its role has not been evaluated...
- Cortical atrophy and personality in multiple sclerosis
Ralph H B Benedict
Department of Neurology, State University of New York at Buffalo, School of Medicine, New York, USA
Neuropsychology 22:432-41. 2008
..These findings suggest that cortical atrophy in MS is associated with adverse impact on personality, although longitudinal research is needed to test this hypothesis...
- Quantitative diffusion weighted imaging measures in patients with multiple sclerosis
Eleonora Tavazzi
Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
Neuroimage 36:746-54. 2007
..ENT is a sensitive marker of overall brain damage that is strongly related to clinical impairment in patients with SP MS...
- Detection of cortical lesions is dependent on choice of slice thickness in patients with multiple sclerosis
Ondrej Dolezal
Department of Neurology, State University of New York at Buffalo, Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Buffalo, New York 14203, USA
Int Rev Neurobiol 79:475-89. 2007
..Cortical and juxtacortical lesions contribute more to disability development than total T2-LV alone...
- Positivity of cytomegalovirus antibodies predicts a better clinical and radiological outcome in multiple sclerosis patients
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, Department of Neurology, The Jacobs Neurological Institute, University at Buffalo, State University of New York, 14203, USA
Neurol Res 28:262-9. 2006
....
- Brain atrophy and white matter hyperintensities in early Parkinson's disease(a)
Turi O Dalaker
Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York 14203, USA
Mov Disord 24:2233-41. 2009
..We conclude that global structural brain changes are not a major feature in patients with incident PD...
- Central nervous system atrophy and clinical status in multiple sclerosis
Robert Zivadinov
Department of Neurology, University at Buffalo, SUNY School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, 100 High Street, Buffalo, NY 14203, USA
J Neuroimaging 14:27S-35S. 2004
..The authors conclude that measurement of atrophy of the CNS is emerging as a clinically relevant biomarker of the MS disease process...
- Clinical-magnetic resonance imaging correlations in multiple sclerosis
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, NY 14203, USA
J Neuroimaging 15:10S-21S. 2005
..Therefore, the short and long-term studies that aim to measure the degree and severity of the neurodegenerative MS disease process should incorporate these MRI metrics as part of their standard routine MRI protocols...
- Regional lobar atrophy predicts memory impairment in multiple sclerosis
Ralph H B Benedict
Department of Neurology, SUNY Buffalo School of Medicine, Buffalo, NY 14203, USA
AJNR Am J Neuroradiol 26:1824-31. 2005
..42-0.64). CONCLUSION: Regional atrophy accounts for more variance than lesion burden, whole brain atrophy, or lateral ventricle volume in predicting multiple sclerosis-associated memory dysfunction...
- Correction for intracranial volume in analysis of whole brain atrophy in multiple sclerosis: the proportion vs. residual method
Michael P Sanfilipo
Department of Neurology, SUNY-University at Buffalo School of Medicine and Biomedical Sciences, NY 14203, USA
Neuroimage 22:1732-43. 2004
..Our findings suggest that head size correction of brain regions with the residual method generally may provide advantages over the proportion method...
- Role of MRI in multiple sclerosis II: brain and spinal cord atrophy
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
Front Biosci 9:647-64. 2004
..This should in turn lead to better long term neurologic functioning and a better quality of life for patients with MS...
- Steroids and brain atrophy in multiple sclerosis
Robert Zivadinov
Department of Neurology, SUNY University at Buffalo School of Medicine and Biomedical, Sciences, Buffalo, NY, USA
J Neurol Sci 233:73-81. 2005
..Further longitudinal studies are needed to elucidate pathogenetic mechanisms contributing to brain volume fluctuations in autoimmune diseases and multiple sclerosis...
- Pharmacogenetics of MXA SNPs in interferon-beta treated multiple sclerosis patients
Bianca Weinstock-Guttman
Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
J Neuroimmunol 182:236-9. 2007
..No significant association was found between the MXA genotype at these two SNPs and clinical, MRI and MXA gene expression in MS patients treated with IFN-beta therapy...
- Progressive cerebral disease in lymphomatoid granulomatosis causes anterograde amnesia and neuropsychiatric disorder
Dominic A Carone
Department of Neurology, State University of New York (SUNY) at Buffalo School of Medicine, and Jacobs Neurological Institute, USA
J Neuroimaging 16:163-6. 2006
..We speculate that temporal lobe atrophy was influenced by the established susceptibility of this region in various neurological diseases...
- Interferon-beta treatment for relapsing multiple sclerosis
Bianca Weinstock-Guttman
The Jacobs Neurological Institute, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
Expert Opin Biol Ther 8:1435-47. 2008
..Recombinant forms of IFN-beta were the first therapeutic intervention found to be effective at interfering with the course of multiple sclerosis (MS), a chronic and debilitating disease affecting the CNS in young adults...
- Neuroimaging in multiple sclerosis
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, Buffalo, New York 14203, USA
Int Rev Neurobiol 79:449-74. 2007
..However, evidence is increasing that these nonconventional MRI measures correlate better with both existing and developing neurological impairment and disability when compared to conventional metrics...
- The place of conventional MRI and newly emerging MRI techniques in monitoring different aspects of treatment outcome
Robert Zivadinov
Dept of Neurology, School of Medicine and Biomedical Sciences, State University of New York, NY, USA
J Neurol 255:61-74. 2008
..Although detecting the status of neuronal integrity using MRI techniques continues to improve, a "gold standard" model remains to be established...
- Acute demyelinating optic neuritis: a review
Steven David Brass
Department of Neurology, Brigham and Women s Hospital, Harvard Medical School, Partners Multiple Sclerosis Center, Boston, MA, USA
Front Biosci 13:2376-90. 2008
....
- Corticosteroids for multiple sclerosis: II. Application for disease-modifying effects
Anjali Shah
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
Neurotherapeutics 4:627-32. 2007
..Nevertheless, we will focus on the rationale and practical schemes that can be considered for using corticosteroids (CS) (and perhaps even ACTH) in an attempt to modify various domains of ongoing disease activity...
- Immune cell BDNF secretion is associated with white matter volume in multiple sclerosis
Bianca Weinstock Guttman
Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, United States
J Neuroimmunol 188:167-74. 2007
..To investigate the relationship between immune cell secretion of brain-derived neurotrophic factor (BDNF) with clinical and MRI variables in multiple sclerosis (MS) patients...
- Gene-environment interactions between HLA B7/A2, EBV antibodies are associated with MRI injury in multiple sclerosis
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, Department of Neurology, University at Buffalo, State University of New York, Buffalo, NY, USA
J Neuroimmunol 209:123-30. 2009
....
- Advanced magnetic resonance imaging metrics: implications for multiple sclerosis clinical trials
Robert Zivadinov
University of Buffalo Department of Neurology, School of Medicine and Biomedical Sciences, The Jacobs Neurological Institute, Buffalo, New York 14203, USA
Methods Find Exp Clin Pharmacol 31:29-40. 2009
..The objective of this review is to provide a brief description of these advanced MRI measures and to discuss preliminary clinical studies that employ these techniques in order to evaluate the efficacy of DMTs...
- Signal abnormalities on 1.5 and 3 Tesla brain MRI in multiple sclerosis patients and healthy controls. A morphological and spatial quantitative comparison study
Carol Di Perri
Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Department of Neurology, State University of New York, Buffalo, NY 14203, USA
Neuroimage 47:1352-62. 2009
..This study provides important information regarding morphological and spatial differences between data acquired using 1.5 T and 3 T protocols at the two scanner field strengths...
- HLA-DRB1*1501, -DQB1*0301, -DQB1*0302, -DQB1*0602, and -DQB1*0603 alleles are associated with more severe disease outcome on MRI in patients with multiple sclerosis
Robert Zivadinov
Department of Neurology, State University of New York at Buffalo, Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, State University at Buffalo, New York 14203, USA
Int Rev Neurobiol 79:521-35. 2007
..High-resolution HLA genotyping analysis revealed a robust relationship between alleles HLA-DRB1*1501, -DQB1*0301, -DQB1*0302, -DQB1*0602, and -DQB1*0603, and more severe damage on inflammatory and neurodegenerative MRI measures...
- The role of quantitative neuroimaging indices in the differentiation of ischemia from demyelination: an analytical study with case presentation
Romy Hoque
Department of Neurology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71103, USA
Int Rev Neurobiol 79:491-519. 2007
..Chronic ischemic and demyelinating lesions were evaluated for comparison as well...
- Reliability and validity of neuropsychological screening and assessment strategies in MS
Ralph H B Benedict
SUNY Buffalo School of Medicine, Jacobs Neurological Institute, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203, USA
J Neurol 254:II22-II25. 2007
..Work with new non-conventional brain imaging techniques and finer analysis of reliability during serial testing protocols is underway...
- Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis
Erica Grazioli
Jacobs Neurological Institute, Buffalo General Hospital, Buffalo, NY 14203, USA
J Neurol Sci 268:12-7. 2008
..067). There was negative correlation between average RNFL thickness (average of both eyes) and disability as assessed by EDSS (p=0.02). The results support potential usefulness of OCT for MS patient monitoring and research applications...
- White matter hyperintensities do not impact cognitive function in patients with newly diagnosed Parkinson's disease
Turi O Dalaker
Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York at Buffalo, Buffalo, NY 14203, USA
Neuroimage 47:2083-9. 2009
..We conclude that in this PD cohort, cognitive impairment seems to be independent of WMH damage...
- Role of MRI in multiple sclerosis I: inflammation and lesions
Robert Zivadinov
Neuroimaging Analysis Center, School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14203, USA
Front Biosci 9:665-83. 2004
..In particular, the use of these techniques is promising in elucidating mechanisms underlying the accumulation of tissue damage, repair and functional reorganization of neural pathways in patients with MS...
- [Cognitive impairment in multiple sclerosis patients]
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, Department of Neurology, School of Medicine and Biomedical Sciences, Buffalo, NY, USA
Lijec Vjesn 126:204-10. 2004
..Cognitive dysfunctions affect relationships and working ability of patients...
- Alemtuzumab and multiple sclerosis: therapeutic application
Alireza Minagar
Louisiana State University Health Sciences Center, Department of Neurology, 1501 Kings Highway, Shreveport, LA 71130, USA
Expert Opin Biol Ther 10:421-9. 2010
..An emerging group of biologic agents with great potential for treatment of immune-mediated disorders such as MS are monoclonal antibodies. A review of alemtuzumab in MS is presented...
- Neuroimaging of cognitive impairments in vascular disease
Carol Di Perri
Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York 14203, USA
Int Rev Neurobiol 84:49-80. 2009
....
- Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, Department of Neurology, State University of New York, Buffalo, NY 14260, USA
Hum Mol Genet 16:2659-68. 2007
..There were no significant associations between Met66 allele status and other neurocognitive measures. The BDNF Met66 allele is associated with lower damage as evidenced by measurement of NGMV and T2-LV in MS patients...
- Diffusion-weighted imaging predicts cognitive impairment in multiple sclerosis
Ralph H B Benedict
Department of Neurology, State University of New York SUNY at Buffalo, School of Medicine, Buffalo, NY 14203, USA
Mult Scler 13:722-30. 2007
..Given its overall simplicity and moderate correlation with cognition, DWI may offer several logistic advantages over more traditional MRI measures when predicting the presence of NP impairment...
- Predicting neuropsychological abnormalities in multiple sclerosis
Ralph H B Benedict
Department of Neurology, School of Medicine, State University of New York, SUNY at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, 14203, USA
J Neurol Sci 245:67-72. 2006
..We conclude that the MSNQ is reliable and valid for detecting neuropsychological and neuropsychiatric complications of MS...
- Update on the relationships between neuropsychological dysfunction and structural MRI in multiple sclerosis
Ayda Tekok-Kilic
Department of Neurology, State University of New York, Buffalo School of Medicine and Biomedical Sciences, Buffalo, NY, USA
Expert Rev Neurother 6:323-31. 2006
..In this article, recent contributions to the literature regarding the correlation between MRI and neuropsychological function in MS are reviewed...
- Can imaging techniques measure neuroprotection and remyelination in multiple sclerosis?
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute, Department of Neurology, SUNY Buffalo, Buffalo, NY 14203, USA
Neurology 68:S72-82; discussion S91-6. 2007
..Although detecting the status of neuronal integrity using MRI techniques continues to improve, a "gold standard" model remains to be established...
- Corticosteroids for multiple sclerosis: I. Application for treating exacerbations
Elliot M Frohman
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235, USA
Neurotherapeutics 4:618-26. 2007
..This review discusses the pharmacology of these agents, to better understand how they may act to mitigate attacks and to provide some practical formulations for how to use them in the clinic for the benefit of patients...
- [Use of magnetic resonance imaging in the diagnosis and prognosis of multiple sclerosis]
Robert Zivadinov
Buffalo Neuroimaging Analysis Center, The Jacobs Neurological Institute and Baird MS Research Center, Department of Neurology, School of Medicine and Biomedical Sciences University Buffalo, State University of New York, Buffalo, NY, USA
Lijec Vjesn 128:295-308. 2006
..Additional short- and long-term prospective studies are requested to establish their value in the diagnosis and prognosis of multiple sclerosis...
- Optical coherence tomography in multiple sclerosis
Elliot Frohman
Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 75235, USA
Lancet Neurol 5:853-63. 2006
..In this review, we consider the usefulness of optical imaging of the retina as a biomarker for neurodegeneration in multiple-sclerosis...
- A magnetization transfer MRI study of deep gray matter involvement in multiple sclerosis
Jitendra Sharma
Center for Neurological Imaging, Partners MS Center, Department of Neurology, Brigham/Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neuroimaging 16:302-10. 2006
..It remains to be determined if other MRI techniques are more sensitive than MTI for detecting pathology in these areas...
- Predicting quality of life in multiple sclerosis: accounting for physical disability, fatigue, cognition, mood disorder, personality, and behavior change
Ralph H B Benedict
Department of Neurology, School of Medicine, State University of New York at Buffalo, Buffalo General Hospital, Neurology, Suite D 6, 100 High Street, Buffalo, NY 14203, USA
J Neurol Sci 231:29-34. 2005
..The findings highlight core clinical problems that merit early identification and further research regarding the development of effective treatment...
