William J Zinnanti

Summary

Publications

  1. pmc Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease
    William J Zinnanti
    Penn State College of Medicine, Box 149, 500 University Drive, Hershey, PA 17033, USA
    Brain 132:903-18. 2009
  2. doi request reprint Mouse model of encephalopathy and novel treatment strategies with substrate competition in glutaric aciduria type I
    William J Zinnanti
    Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Mol Genet Metab 100:S88-91. 2010
  3. pmc Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I
    William J Zinnanti
    Jake Gittlen Cancer Research Foundation, Department of Pathology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Invest 117:3258-70. 2007
  4. ncbi request reprint A diet-induced mouse model for glutaric aciduria type I
    William J Zinnanti
    Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033, USA
    Brain 129:899-910. 2006
  5. pmc Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD)
    Kristen J Skvorak
    Department of Pediatrics, University of Pittsburgh School of Medicine, USA Children s Hospital of Pittsburgh of UPMC, USA
    Biochim Biophys Acta 1792:1004-10. 2009
  6. doi request reprint The influence of diabetes on glutamate metabolism in retinas
    Kavitha Gowda
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurochem 117:309-20. 2011

Detail Information

Publications6

  1. pmc Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease
    William J Zinnanti
    Penn State College of Medicine, Box 149, 500 University Drive, Hershey, PA 17033, USA
    Brain 132:903-18. 2009
    ..Norleucine should be further tested as a potential treatment to prevent encephalopathy in children with maple syrup urine disease during catabolic stress...
  2. doi request reprint Mouse model of encephalopathy and novel treatment strategies with substrate competition in glutaric aciduria type I
    William J Zinnanti
    Department of Pediatrics, SUNY Downstate Medical Center, Brooklyn, NY, USA
    Mol Genet Metab 100:S88-91. 2010
    ....
  3. pmc Mechanism of age-dependent susceptibility and novel treatment strategy in glutaric acidemia type I
    William J Zinnanti
    Jake Gittlen Cancer Research Foundation, Department of Pathology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Invest 117:3258-70. 2007
    ..Blocking brain lysine uptake reduced glutaric acid levels and brain injury. These findings provide what we believe are new monitoring and treatment strategies that may translate for use in human GA-I...
  4. ncbi request reprint A diet-induced mouse model for glutaric aciduria type I
    William J Zinnanti
    Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033, USA
    Brain 129:899-910. 2006
    ..Thus, the Gcdh-/- mouse exposed to high protein or lysine may be a useful model of human GA-1 including developmentally dependent striatal vulnerability...
  5. pmc Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD)
    Kristen J Skvorak
    Department of Pediatrics, University of Pittsburgh School of Medicine, USA Children s Hospital of Pittsburgh of UPMC, USA
    Biochim Biophys Acta 1792:1004-10. 2009
    ....
  6. doi request reprint The influence of diabetes on glutamate metabolism in retinas
    Kavitha Gowda
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurochem 117:309-20. 2011
    ..The data suggest the hypothesis that glutamate levels in retinal Müller cells from diabetic rats are elevated because of the presence of excess BCAAs, and that elevated glutamate in Müller cells causes glutamate excitotoxicity...