Bernard Zinman

Summary

Publications

  1. doi request reprint Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, ON, Canada
    Lancet 377:924-31. 2011
  2. ncbi request reprint Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME™)
    Bernard Zinman
    Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada
    Cardiovasc Diabetol 13:102. 2014
  3. doi request reprint Glucagon response to oral glucose challenge in type 1 diabetes: lack of impact of euglycemia
    Caroline K Kramer
    Corresponding author Bernard Zinman
    Diabetes Care 37:1076-82. 2014
  4. doi request reprint Newer insulin analogs: advances in basal insulin replacement
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Diabetes Obes Metab 15:6-10. 2013
  5. pmc Cardiovascular disease risk profile and microvascular complications of diabetes: comparison of Indigenous cohorts with diabetes in Australia and Canada
    Louise J Maple-Brown
    Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Cardiovasc Diabetol 11:30. 2012
  6. doi request reprint Achieving a clinically relevant composite outcome of an HbA1c of <7% without weight gain or hypoglycaemia in type 2 diabetes: a meta-analysis of the liraglutide clinical trial programme
    B Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Diabetes Obes Metab 14:77-82. 2012
  7. doi request reprint Initial combination therapy for type 2 diabetes mellitus: is it ready for prime time?
    Bernard Zinman
    Leadership Sinai Centre for Diabetes, Samuel Lunenfeld Research Institute, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada
    Am J Med 124:S19-34. 2011
  8. pmc Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 32:1224-30. 2009
  9. doi request reprint Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study
    Bernard Zinman
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada
    Lancet 376:103-11. 2010
  10. pmc Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008

Detail Information

Publications88

  1. doi request reprint Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trial
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, ON, Canada
    Lancet 377:924-31. 2011
    ....
  2. ncbi request reprint Rationale, design, and baseline characteristics of a randomized, placebo-controlled cardiovascular outcome trial of empagliflozin (EMPA-REG OUTCOME™)
    Bernard Zinman
    Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada
    Cardiovasc Diabetol 13:102. 2014
    ..The aim of the ongoing EMPA-REG OUTCOME™ trial is to determine the long-term CV safety of empagliflozin, as well as investigating potential benefits on macro-/microvascular outcomes...
  3. doi request reprint Glucagon response to oral glucose challenge in type 1 diabetes: lack of impact of euglycemia
    Caroline K Kramer
    Corresponding author Bernard Zinman
    Diabetes Care 37:1076-82. 2014
    ..This abnormal glucagon response likely contributes to the postprandial hyperglycemia in T1D irrespective of ambient glycemia. ..
  4. doi request reprint Newer insulin analogs: advances in basal insulin replacement
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
    Diabetes Obes Metab 15:6-10. 2013
    ..While further study will be required, advances in basal insulin replacement may offer important advantages over existing options for starting insulin strategies...
  5. pmc Cardiovascular disease risk profile and microvascular complications of diabetes: comparison of Indigenous cohorts with diabetes in Australia and Canada
    Louise J Maple-Brown
    Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
    Cardiovasc Diabetol 11:30. 2012
    ..Our goal was to compare cardiovascular (CVD) risk profile and diabetes complications from three recent comprehensive studies of diabetes complications in different Indigenous populations in Australia and Canada...
  6. doi request reprint Achieving a clinically relevant composite outcome of an HbA1c of <7% without weight gain or hypoglycaemia in type 2 diabetes: a meta-analysis of the liraglutide clinical trial programme
    B Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Diabetes Obes Metab 14:77-82. 2012
    ....
  7. doi request reprint Initial combination therapy for type 2 diabetes mellitus: is it ready for prime time?
    Bernard Zinman
    Leadership Sinai Centre for Diabetes, Samuel Lunenfeld Research Institute, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada
    Am J Med 124:S19-34. 2011
    ....
  8. pmc Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 32:1224-30. 2009
    ..To determine the efficacy and safety of liraglutide (a glucagon-like peptide-1 receptor agonist) when added to metformin and rosiglitazone in type 2 diabetes...
  9. doi request reprint Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study
    Bernard Zinman
    Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada
    Lancet 376:103-11. 2010
    ..The CANOE (CAnadian Normoglycemia Outcomes Evaluation) trial investigated whether low-dose combination therapy would affect development of type 2 diabetes...
  10. pmc Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
    Salam A Al-Attar
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 7:5. 2008
    ..The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples...
  11. ncbi request reprint Disparate associations of a functional promoter polymorphism in PCK1 with carotid wall ultrasound traits
    Robert A Hegele
    Robarts Research Institute, London, Ontario, Canada
    Stroke 36:2566-70. 2005
    ..We hypothesized that this polymorphism would be associated with carotid atherosclerosis in a sample of 150 aboriginal Canadians...
  12. pmc Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ont
    CMAJ 180:617-24. 2009
    ..We aimed to determine the incidence of type 2 diabetes in an Aboriginal community and to evaluate prospective associations with metabolic syndrome and its components...
  13. pmc Isolated hyperglycemia at 1 hour on oral glucose tolerance test in pregnancy resembles gestational diabetes mellitus in predicting postpartum metabolic dysfunction
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 31:1275-81. 2008
    ..Thus, we hypothesized that 1-h GIGT would be associated with the same adverse outcomes as GDM, i.e., increased infant birth weight and postpartum metabolic dysfunction...
  14. pmc Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes
    Philip W Connelly
    Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
    J Lipid Res 50:1216-22. 2009
    ..73 m(2). The lower mass of PON1, an anti-inflammatory HDL-associated enzyme, in T2DM with cystatin C-eGFR <60 ml/min per 1.73 m(2) may contribute to their increased risk for cardiovascular disease...
  15. pmc Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Cardiovasc Diabetol 9:39. 2010
    ..We aimed to investigate whether CRP was mediating the association between HNF1A G319S and type 2 diabetes in an Aboriginal Canadian population with a high prevalence of diabetes...
  16. pmc Prospective associations of vitamin D with β-cell function and glycemia: the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes 60:2947-53. 2011
    ..To examine the prospective associations of baseline vitamin D [25-hydroxyvitamin D; 25(OH)D] with insulin resistance (IR), β-cell function, and glucose homeostasis in subjects at risk for type 2 diabetes...
  17. pmc HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
    BMC Med Genet 12:1. 2011
    ..We aimed to investigate the association of the HNF1A G319S polymorphism with incident type 2 diabetes and to assess whether clinical risk variables for type 2 diabetes influence the association in an Aboriginal population...
  18. doi request reprint Systemic hemodynamic function in humans with type 1 diabetes treated with protein kinase Cβ inhibition and renin-angiotensin system blockade: a pilot study
    David Z I Cherney
    Division of Nephrology, Toronto General Hospital, University of Toronto, 585 University Ave, 8N 845, Toronto, ON M5G 2N2, Canada
    Can J Physiol Pharmacol 90:113-21. 2012
    ..The lack of effect on Ang II responses suggests that PKCβ inhibition may act through non-RAS pathways in humans with DM...
  19. pmc Hepatic insulin resistance is an early determinant of declining β-cell function in the first year postpartum after glucose intolerance in pregnancy
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 34:2431-4. 2011
    ..13 [95% CI 0.06-0.29]; P < 0.0001). CONCLUSIONS Hepatic insulin resistance is an early determinant of declining β-cell function after gestational dysglycemia...
  20. doi request reprint Maternal insulin sensitivity during pregnancy predicts infant weight gain and adiposity at 1 year of age
    Jill K Hamilton
    Hospital for Sick Children, Department of Pediatrics, Toronto, Ontario, Canada
    Obesity (Silver Spring) 18:340-6. 2010
    ..Further longitudinal study to evaluate obesity in this group of children will increase our understanding of the contribution of the intrauterine environment to their long-term health...
  21. ncbi request reprint Association of hematological parameters with insulin resistance and beta-cell dysfunction in nondiabetic subjects
    Anthony J G Hanley
    Department of Nutritional Sciences, University of Toronto, Fitzgerald Building, Toronto, Ontario, Canada M5S 3E2
    J Clin Endocrinol Metab 94:3824-32. 2009
    ....
  22. ncbi request reprint Nontraditional cardiovascular risk factors in pediatric metabolic syndrome
    Ravi Retnakaran
    Division of Endocrinology, The Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 148:176-82. 2006
    ..To study the relationships between nontraditional cardiovascular (CV) risk factors and components of the metabolic syndrome in Native Canadian children, a population at risk of future CV disease...
  23. pmc Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 31:2026-31. 2008
    ....
  24. doi request reprint The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: implications for future cardiovascular risk
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, Ontario, Canada M5T 3L9
    J Clin Endocrinol Metab 95:4345-53. 2010
    ..Because lipid factors can contribute to cardiovascular risk, we sought to characterize the relationship between gestational glucose tolerance status and lipid profile in pregnancy and the postpartum...
  25. ncbi request reprint Complications of Type 2 Diabetes Among Aboriginal Canadians: prevalence and associated risk factors
    Anthony J G Hanley
    Leadership Sinai Centre for Diabetes, Lebovic Building, Room 5 210, Mt Sinai Hospital, 600 University Ave, Toronto, Ontario, M5G 1X5, Canada
    Diabetes Care 28:2054-7. 2005
  26. doi request reprint Comparison of National Diabetes Data Group and American Diabetes Association diagnostic criteria for gestational diabetes in their identification of postpartum risk of glucose intolerance
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Res Clin Pract 85:40-6. 2009
    ....
  27. pmc Relationship of the metabolic syndrome to carotid ultrasound traits
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 4:28. 2006
    ..We evaluated two carotid ultrasound measurements, namely intima media thickness and total plaque volume, in a Canadian Oji-Cree population with a high metabolic syndrome prevalence rate...
  28. ncbi request reprint Ethnicity modifies the effect of obesity on insulin resistance in pregnancy: a comparison of Asian, South Asian, and Caucasian women
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada M5G 1L5
    J Clin Endocrinol Metab 91:93-7. 2006
    ..Nevertheless, there has been limited study of insulin action during pregnancy in these ethnic groups...
  29. pmc Adipokines and incident type 2 diabetes in an Aboriginal Canadian [corrected] population: the Sandy Lake Health and Diabetes Project
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 31:1410-5. 2008
    ....
  30. doi request reprint Vitamin D status and cardiometabolic assessment in infancy
    Simone Kew
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Pediatr Res 74:217-22. 2013
    ..Therefore, we sought to determine whether vitamin D status was associated with cardiometabolic measures in infants...
  31. pmc Effect of maternal weight, adipokines, glucose intolerance and lipids on infant birth weight among women without gestational diabetes mellitus
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ont
    CMAJ 184:1353-60. 2012
    ..We sought to evaluate the independent effects of maternal glycemia, lipids, obesity, adipokines and inflammation on infant birth weight...
  32. doi request reprint Associations of prenatal metabolic abnormalities with insulin and adiponectin concentrations in human milk
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Am J Clin Nutr 95:867-74. 2012
    ....
  33. ncbi request reprint Lifestyle variables, non-traditional cardiovascular risk factors, and the metabolic syndrome in an Aboriginal Canadian population
    Juan Liu
    Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
    Obesity (Silver Spring) 14:500-8. 2006
    ....
  34. pmc Pre-gravid physical activity and reduced risk of glucose intolerance in pregnancy: the role of insulin sensitivity
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Clin Endocrinol (Oxf) 70:615-22. 2009
    ..Thus, we sought to study the relationships between types of pre-gravid physical activity and metabolic parameters in pregnancy, including glucose tolerance, insulin sensitivity and beta-cell function...
  35. ncbi request reprint Association of parity with risk of type 2 diabetes and related metabolic disorders
    Anthony J G Hanley
    Department of Public Health Sciences, University of Toronto, Toronto, Canada
    Diabetes Care 25:690-5. 2002
    ..The objective of this study was to investigate the association between parity and risk of glucose intolerance and related metabolic disorders using data from a population-based study in a Native Canadian community...
  36. doi request reprint Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy
    Phillip Segal
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Matern Fetal Neonatal Med 21:73-9. 2008
    ..We thus sought to evaluate the maternal constitutional and biochemical factors that determine infant birth weight in this patient population...
  37. pmc Glucose intolerance in pregnancy and postpartum risk of metabolic syndrome in young women
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Toronto, Canada M5T3L9
    J Clin Endocrinol Metab 95:670-7. 2010
    ....
  38. pmc APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians
    Piya Lahiry
    Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
    J Lipid Res 51:843-8. 2010
    ..0001), using a newly developed ELISA-based method. Taken together, these results suggest that at the whole human phenotype level, apo C-I is associated with the complex metabolic trait of obesity as well as with serum leptin levels...
  39. doi request reprint Age is a determinant of acute hemodynamic responses to hyperglycemia and angiotensin II in humans with uncomplicated type 1 diabetes mellitus
    David Z I Cherney
    Division of Nephrology, University Health Network, University of Toronto, Toronto, Canada
    Am J Physiol Regul Integr Comp Physiol 299:R206-14. 2010
    ....
  40. doi request reprint Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    J Clin Endocrinol Metab 96:168-75. 2011
    ..However, evidence to date is limited and inconsistent, and few studies have examined associations with nontraditional MetS components...
  41. doi request reprint Risk of early progression to prediabetes or diabetes in women with recent gestational dysglycaemia but normal glucose tolerance at 3-month postpartum
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 73:476-83. 2010
    ..In this context, we sought to evaluate the risk of early progression to dysglycaemia in women with NGT at 3-month postpartum and identify predictors thereof...
  42. ncbi request reprint Adiponectin in a native Canadian population experiencing rapid epidemiological transition
    Anthony J G Hanley
    Leadership Sinai Centre for Diabetes, Mt Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 26:3219-25. 2003
    ....
  43. doi request reprint Association of apolipoprotein B with incident type 2 diabetes in an aboriginal Canadian population
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Clin Chem 56:666-70. 2010
    ..We assessed the association of apo B with incident type 2 diabetes and compared it with traditional lipid variables as a risk predictor in aboriginal Canadians...
  44. pmc Gestational diabetes and postpartum physical activity: evidence of lifestyle change 1 year after delivery
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Obesity (Silver Spring) 18:1323-9. 2010
    ..83, P = 0.005). In conclusion, women with GDM successfully increased their leisure-time activity in the first year postpartum, reflecting an element of lifestyle change following this diagnosis...
  45. ncbi request reprint The impact of family history of diabetes on risk factors for gestational diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Clin Endocrinol (Oxf) 67:754-60. 2007
    ..We thus hypothesized that the risk factors for gestational hyperglycaemia in women with FHD may differ from those in women without FHD...
  46. ncbi request reprint The impact of insulin resistance on proinsulin secretion in pregnancy: hyperproinsulinemia is not a feature of gestational diabetes
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 28:2710-5. 2005
    ..Thus, we sought to determine whether GDM is characterized by relative hyperproinsulinemia as measured by the proinsulin-to-C-peptide ratio, an alternate measure of proinsulin secretion that is not affected by hepatic insulin extraction...
  47. pmc Postpartum metabolic function in women delivering a macrosomic infant in the absence of gestational diabetes mellitus
    Simone Kew
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 34:2608-13. 2011
    ..Thus, to test this hypothesis, we assessed metabolic function during and after pregnancy in a cohort of women stratified according to the presence/absence of GDM and LGA delivery, respectively...
  48. pmc Effect of Rosiglitazone and Ramipril on {beta}-cell function in people with impaired glucose tolerance or impaired fasting glucose: the DREAM trial
    Anthony J Hanley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Diabetes Care 33:608-13. 2010
    ....
  49. pmc A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Ultrasound 3:15. 2005
    ..Thus, the objective of this study was to compare the traditional intima-media thickness measurement against the novel total plaque volume measurement in analyzing carotid atherosclerosis development in individuals with type 2 diabetes...
  50. doi request reprint Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Obesity (Silver Spring) 16:1901-7. 2008
    ..Based on these findings, the product of these two indices emerges as a potential OGTT-based measure of beta-cell function...
  51. pmc Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample
    Rebecca L Pollex
    Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
    BMC Med Genet 8:80. 2007
    ..The objective of this study is to examine the APOC3 -455T>C and the INSIG2 rs7566605 polymorphisms as potential genetic determinants for MetS in a multi-ethnic sample...
  52. pmc The antepartum glucose values that predict neonatal macrosomia differ from those that predict postpartum prediabetes or diabetes: implications for the diagnostic criteria for gestational diabetes
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada M5T3L9
    J Clin Endocrinol Metab 94:840-5. 2009
    ..Thus, to test this assumption, we sought to evaluate the predictive capacity of each glucose value on antepartum OGTT in relation to LGA and postpartum prediabetes/diabetes...
  53. ncbi request reprint The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada
    Ann Intern Med 146:477-85. 2007
    ..Exenatide therapy is effective in combination with metformin or sulfonylureas for treating type 2 diabetes. Thiazolidinediones (TZDs) also are commonly used, but the efficacy of exenatide with a TZD has not been reported...
  54. pmc Impact of maternal metabolic abnormalities in pregnancy on human milk and subsequent infant metabolic development: methodology and design
    Sylvia H Ley
    Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    BMC Public Health 10:590. 2010
    ..The objective of this report is to present the methodology and design of this study...
  55. ncbi request reprint Impaired glucose tolerance of pregnancy is a heterogeneous metabolic disorder as defined by the glycemic response to the oral glucose tolerance test
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Ontario, Canada
    Diabetes Care 29:57-62. 2006
    ..e., a single abnormal value on an OGTT), however, are not well established. We sought to evaluate the metabolic phenotype of pregnant women with IGT in relation to the timing of their isolated hyperglycemia...
  56. ncbi request reprint Reduced adiponectin concentration in women with gestational diabetes: a potential factor in progression to type 2 diabetes
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 27:799-800. 2004
  57. ncbi request reprint Low serum levels of high-molecular weight adiponectin in Indo-Asian women during pregnancy: evidence of ethnic variation in adiponectin isoform distribution
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G1X5
    Diabetes Care 29:1377-9. 2006
  58. pmc Cigarette smoking and cardiovascular risk factors among Aboriginal Canadian youths
    Ravi Retnakaran
    Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ont
    CMAJ 173:885-9. 2005
    ....
  59. ncbi request reprint Maternal serum adiponectin and infant birthweight: the role of adiponectin isoform distribution
    Gabie K B Ong
    Faculty of Arts and Sciences, University of Toronto, Toronto, ON, Canada
    Clin Endocrinol (Oxf) 67:108-14. 2007
    ....
  60. pmc Changes over time in glycemic control, insulin sensitivity, and beta-cell function in response to low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, and Department of Nutritional Sciences, University of Toronto, Toronto, Canada
    Diabetes Care 34:1601-4. 2011
    ..9 years. We evaluate the temporal changes in glycemic control, insulin sensitivity, and β-cell function during this trial...
  61. pmc Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes
    Rebecca L Pollex
    Robarts Research Institute, London, Ontario, Canada
    Cardiovasc Diabetol 4:17. 2005
    ..The objective of this study was to investigate a possible role for the MTHFR 677C>T gene polymorphism with PAD in subjects with type 2 diabetes from an isolated aboriginal Canadian population...
  62. pmc Determinants of insulin resistance in infants at age 1 year: impact of gestational diabetes mellitus
    Carla A Borgono
    Division of General Internal Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:1795-7. 2012
    ..Thus, we sought to identify early life determinants of insulin resistance in infants of women with and without GDM...
  63. pmc Circadian variation in the response to the glucose challenge test in pregnancy: implications for screening for gestational diabetes mellitus
    Robert J Goldberg
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
    Diabetes Care 35:1578-84. 2012
    ..Thus, using their subsequent OGTT (performed in the morning), we sought to characterize the metabolic function of women with positive GCTs in relation to the timing of their test...
  64. pmc Beta-cell function declines within the first year postpartum in women with recent glucose intolerance in pregnancy
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 33:1798-804. 2010
    ..In this context, we queried whether metabolic changes that occur in the 1st year postpartum vary in relation to gestational glucose tolerance status...
  65. ncbi request reprint Diabetes mellitus and breast cancer: a retrospective population-based cohort study
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, M4N 3M5, Toronto, Ontario, Canada
    Breast Cancer Res Treat 98:349-56. 2006
    ..The purpose of this study was to compare the incidence of breast cancer in postmenopausal women with and without diabetes...
  66. pmc An abnormal screening glucose challenge test in pregnancy predicts postpartum metabolic dysfunction, even when the antepartum oral glucose tolerance test is normal
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Division of Endocrinology, University of Toronto, Toronto, Canada
    Clin Endocrinol (Oxf) 71:208-14. 2009
    ..Thus, we sought to characterize the obstetrical and postpartum metabolic significance of an abnormal GCT in women with normal glucose tolerance (NGT) on antepartum OGTT...
  67. pmc Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:1379-81. 2010
    ..To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes...
  68. ncbi request reprint Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes
    Andre Carpentier
    Department of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Diabetes 52:1485-95. 2003
    ..Whether this reflects an inherent resistance to lipotoxicity or an already-present lipotoxic effect in this population will require further study...
  69. ncbi request reprint Cystatin C is associated with cardiovascular risk factors and metabolic syndrome in Aboriginal youth
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Canada
    Pediatr Nephrol 22:1007-13. 2007
    ..0072). In summary, increased cystatin C is associated with an enhanced CV risk factor profile in Aboriginal youth and may be an early event in the natural history of vascular disease...
  70. doi request reprint Effect of macronutrient intake during the second trimester on glucose metabolism later in pregnancy
    Sylvia H Ley
    Department of Nutritional Sciences, Mount Sinai Hospital, Toronto, Canada
    Am J Clin Nutr 94:1232-40. 2011
    ..Dietary intake is known to influence glucose metabolism, but there is little consensus on the optimal distribution of macronutrient intakes during pregnancy to prevent gestational diabetes (GDM)...
  71. ncbi request reprint Continuous subcutaneous insulin infusion versus multiple daily injections: the impact of baseline A1c
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 27:2590-6. 2004
    ..Thus, a comparison of efficacy between CSII and MDII should be undertaken only in studies that used rapid-acting analogs for both intensive regimens...
  72. ncbi request reprint Clinical inertia in response to inadequate glycemic control: do specialists differ from primary care physicians?
    Baiju R Shah
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5
    Diabetes Care 28:600-6. 2005
    ..Failure to do so can be termed "clinical inertia." Because data suggest that specialist care results in better control than primary care, we evaluated whether specialists demonstrated less clinical inertia than primary care physicians...
  73. ncbi request reprint The impact of diabetes on survival following breast cancer
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    Breast Cancer Res Treat 109:389-95. 2008
    ..The purpose of this study was to examine the impact of diabetes on survival following breast cancer...
  74. doi request reprint Effect of rosiglitazone, metformin, and glyburide on bone biomarkers in patients with type 2 diabetes
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital and University of Toronto, Ontario, Canada
    J Clin Endocrinol Metab 95:134-42. 2010
    ..An increase in bone fractures has been observed in women taking thiazolidinediones...
  75. pmc Deficiencies in the quality of diabetes care: comparing specialist with generalist care misses the point
    Baiju R Shah
    Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
    J Gen Intern Med 22:275-9. 2007
    ..The development of such interventions to help all physicians implement better quality care could greatly benefit people with diabetes...
  76. pmc Risk of development of diabetes mellitus after diagnosis of gestational diabetes
    Denice S Feig
    Department of Medicine, University of Toronto, Toronto, Ont
    CMAJ 179:229-34. 2008
    ..However, the precise relation between these 2 conditions remains unknown. We sought to determine the incidence of diabetes mellitus after diagnosis of gestational diabetes...
  77. ncbi request reprint Type 2 diabetes and impaired glucose tolerance in aboriginal populations: a global perspective
    Catherine H Y Yu
    Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Ontario, Canada
    Diabetes Res Clin Pract 78:159-70. 2007
    ..To perform a systematic review of the prevalence of type 2 diabetes and impaired glucose tolerance (IGT) in aboriginal populations worldwide...
  78. ncbi request reprint Increased prevalence of prior breast cancer in women with newly diagnosed diabetes
    Lorraine L Lipscombe
    Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
    Breast Cancer Res Treat 98:303-9. 2006
    ..Because insulin levels are at their highest prior to the development of diabetes, breast cancer risk may be even greater during the pre-diabetes period...
  79. ncbi request reprint Does hypoadiponectinemia explain the increased risk of diabetes and cardiovascular disease in South Asians?
    Ravi Retnakaran
    Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
    Diabetes Care 29:1950-4. 2006
  80. pmc Administrative data algorithms can describe ambulatory physician utilization
    Baiju R Shah
    Institute for Clinical Evaluative Sciences, G106 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
    Health Serv Res 42:1783-96. 2007
    ..To validate algorithms using administrative data that characterize ambulatory physician care for patients with a chronic disease...
  81. ncbi request reprint Cross-sectional and prospective associations between abdominal adiposity and proinsulin concentration
    Anthony J G Hanley
    Department of Public Health Sciences, University of Toronto, Ontario M5S 1A8, Canada
    J Clin Endocrinol Metab 87:77-83. 2002
    ..24, P = 0.03, respectively). These data highlight the detrimental effects of abdominal obesity on beta-cell function, and support the hypothesis that beta-cell dysfunction occurs early in the natural history of glucose intolerance...
  82. ncbi request reprint Changes in diabetes self-care behaviors make a difference in glycemic control: the Diabetes Stages of Change (DiSC) study
    Helen Jones
    Leadership Sinai Center for Diabetes, Mount Sinai Hospital and University of Toronto, Toronto, Canada
    Diabetes Care 26:732-7. 2003
    ....
  83. ncbi request reprint Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy
    Eva Lonn
    Department of Medicine and Population Health Institute, McMaster University, Hamilton, Ontario, Canada
    Diabetes Care 25:1919-27. 2002
    ..However, data from randomized clinical trials are limited. Therefore, we evaluated the effects of vitamin E supplementation on major CV outcomes and on the development of nephropathy in people with diabetes...
  84. ncbi request reprint C-reactive protein and gestational diabetes: the central role of maternal obesity
    Ravi Retnakaran
    Division of Endocrinology, University of Toronto, Toronto M5G 1X5, Ontario, Canada
    J Clin Endocrinol Metab 88:3507-12. 2003
    ..These data suggest a model in which obesity mediates a systemic inflammatory response, with possible downstream metabolic sequelae, including insulin resistance and glucose dysregulation...
  85. ncbi request reprint Diabetes care in the U.S. and Canada
    Gillian L Booth
    Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, Toronto, Ontario, Canada
    Diabetes Care 25:1149-53. 2002
    ..To compare the glycemic control of patients with type 1 diabetes treated in the U.S. and Canada...
  86. ncbi request reprint Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe
    Bernard Zinman
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Diabetes 53:3193-200. 2004
    ..1 vs. 83.7%, P = 0.0009). These phenotypic differences may underlie a potential difference in the natural history of hyperglycemia and its clinical outcomes...
  87. ncbi request reprint Type 2 diabetes mellitus: magnitude of the problem and failure to achieve glycemic control
    Bernard Zinman
    Leadership Sinai Centre for Diabetes, University of Toronto, Toronto, Ontario, Canada
    Endocrinol Metab Clin North Am 35:3-5; discussion 17-19. 2006
  88. ncbi request reprint Genes, environment and Oji-Cree type 2 diabetes
    Robert A Hegele
    Robarts Research Institute RAH, HC, London, ON, Canada
    Clin Biochem 36:163-70. 2003
    ..There is also evidence for genetic determination of related metabolic traits in the Oji-Cree...