Insulin degludec, an ultra-long-acting basal insulin, once a day or three times a week versus insulin glargine once a day in patients with type 2 diabetes: a 16-week, randomised, open-label, phase 2 trialBernard Zinman
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, ON, Canada
Lancet 377:924-31. 2011
....
- Newer insulin analogs: advances in basal insulin replacement
Bernard Zinman
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada
Diabetes Obes Metab 15:6-10. 2013
..While further study will be required, advances in basal insulin replacement may offer important advantages over existing options for starting insulin strategies...
Cardiovascular disease risk profile and microvascular complications of diabetes: comparison of Indigenous cohorts with diabetes in Australia and CanadaLouise J Maple-Brown
Menzies School of Health Research, Charles Darwin University, Darwin, NT, Australia
Cardiovasc Diabetol 11:30. 2012
..Our goal was to compare cardiovascular (CVD) risk profile and diabetes complications from three recent comprehensive studies of diabetes complications in different Indigenous populations in Australia and Canada...
- Low-dose combination therapy with rosiglitazone and metformin to prevent type 2 diabetes mellitus (CANOE trial): a double-blind randomised controlled study
Bernard Zinman
Department of Medicine, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada
Lancet 376:103-11. 2010
..The CANOE (CAnadian Normoglycemia Outcomes Evaluation) trial investigated whether low-dose combination therapy would affect development of type 2 diabetes...
- Initial combination therapy for type 2 diabetes mellitus: is it ready for prime time?
Bernard Zinman
Leadership Sinai Centre for Diabetes, Samuel Lunenfeld Research Institute, Mount Sinai Hospital and University of Toronto, Toronto, Ontario, Canada
Am J Med 124:S19-34. 2011
....
- Achieving a clinically relevant composite outcome of an HbA1c of <7% without weight gain or hypoglycaemia in type 2 diabetes: a meta-analysis of the liraglutide clinical trial programme
B Zinman
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
Diabetes Obes Metab 14:77-82. 2012
....
- Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
Bernard Zinman
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
Diabetes Care 32:1224-30. 2009
..To determine the efficacy and safety of liraglutide (a glucagon-like peptide-1 receptor agonist) when added to metformin and rosiglitazone in type 2 diabetes...
Disparate associations of a functional promoter polymorphism in PCK1 with carotid wall ultrasound traitsRobert A Hegele
Robarts Research Institute, London, Ontario, Canada
Stroke 36:2566-70. 2005
..We hypothesized that this polymorphism would be associated with carotid atherosclerosis in a sample of 150 aboriginal Canadians...
- Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample
Salam A Al-Attar
Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
Cardiovasc Diabetol 7:5. 2008
..The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples...
- Metabolic syndrome and its components as predictors of incident type 2 diabetes mellitus in an Aboriginal community
Sylvia H Ley
Department of Nutritional Sciences, University of Toronto, Toronto, Ont
CMAJ 180:617-24. 2009
..We aimed to determine the incidence of type 2 diabetes in an Aboriginal community and to evaluate prospective associations with metabolic syndrome and its components...
- Isolated hyperglycemia at 1 hour on oral glucose tolerance test in pregnancy resembles gestational diabetes mellitus in predicting postpartum metabolic dysfunction
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
Diabetes Care 31:1275-81. 2008
..Thus, we hypothesized that 1-h GIGT would be associated with the same adverse outcomes as GDM, i.e., increased infant birth weight and postpartum metabolic dysfunction...
- Assessing the association of the HNF1A G319S variant with C-reactive protein in Aboriginal Canadians: a population-based epidemiological study
Sylvia H Ley
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Cardiovasc Diabetol 9:39. 2010
..We aimed to investigate whether CRP was mediating the association between HNF1A G319S and type 2 diabetes in an Aboriginal Canadian population with a high prevalence of diabetes...
- HNF1A G319S variant, active cigarette smoking and incident type 2 diabetes in Aboriginal Canadians: a population-based epidemiological study
Sylvia H Ley
Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
BMC Med Genet 12:1. 2011
..We aimed to investigate the association of the HNF1A G319S polymorphism with incident type 2 diabetes and to assess whether clinical risk variables for type 2 diabetes influence the association in an Aboriginal population...
- Association of the novel cardiovascular risk factors paraoxonase 1 and cystatin C in type 2 diabetes
Philip W Connelly
Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael s Hospital, University of Toronto, Toronto, Canada
J Lipid Res 50:1216-22. 2009
..73 m(2). The lower mass of PON1, an anti-inflammatory HDL-associated enzyme, in T2DM with cystatin C-eGFR <60 ml/min per 1.73 m(2) may contribute to their increased risk for cardiovascular disease...
- Prospective associations of vitamin D with β-cell function and glycemia: the PROspective Metabolism and ISlet cell Evaluation (PROMISE) cohort study
Sheena Kayaniyil
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Diabetes 60:2947-53. 2011
..To examine the prospective associations of baseline vitamin D [25-hydroxyvitamin D; 25(OH)D] with insulin resistance (IR), β-cell function, and glucose homeostasis in subjects at risk for type 2 diabetes...
- Systemic hemodynamic function in humans with type 1 diabetes treated with protein kinase Cβ inhibition and renin-angiotensin system blockade: a pilot study
David Z I Cherney
Division of Nephrology, Toronto General Hospital, University of Toronto, 585 University Ave, 8N 845, Toronto, ON M5G 2N2, Canada
Can J Physiol Pharmacol 90:113-21. 2012
..The lack of effect on Ang II responses suggests that PKCβ inhibition may act through non-RAS pathways in humans with DM...
- Hepatic insulin resistance is an early determinant of declining β-cell function in the first year postpartum after glucose intolerance in pregnancy
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
Diabetes Care 34:2431-4. 2011
..13 [95% CI 0.06-0.29]; P < 0.0001). CONCLUSIONS Hepatic insulin resistance is an early determinant of declining β-cell function after gestational dysglycemia...
- Maternal insulin sensitivity during pregnancy predicts infant weight gain and adiposity at 1 year of age
Jill K Hamilton
Hospital for Sick Children, Department of Pediatrics, Toronto, Ontario, Canada
Obesity (Silver Spring) 18:340-6. 2010
..Further longitudinal study to evaluate obesity in this group of children will increase our understanding of the contribution of the intrauterine environment to their long-term health...
- Complications of Type 2 Diabetes Among Aboriginal Canadians: prevalence and associated risk factors
Anthony J G Hanley
Leadership Sinai Centre for Diabetes, Lebovic Building, Room 5-210, Mt. Sinai Hospital, 600 University Ave, Toronto, Ontario, M5G 1X5, Canada
Diabetes Care 28:2054-7. 2005
- The graded relationship between glucose tolerance status in pregnancy and postpartum levels of low-density-lipoprotein cholesterol and apolipoprotein B in young women: implications for future cardiovascular risk
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Mailbox 21, Toronto, Ontario, Canada M5T 3L9
J Clin Endocrinol Metab 95:4345-53. 2010
..Because lipid factors can contribute to cardiovascular risk, we sought to characterize the relationship between gestational glucose tolerance status and lipid profile in pregnancy and the postpartum...
- Nontraditional cardiovascular risk factors in pediatric metabolic syndrome
Ravi Retnakaran
Division of Endocrinology, The Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Pediatr 148:176-82. 2006
..Furthermore, inclusion of these factors in factor analysis suggests that 5 core traits underlie the early development of an enhanced CV risk factor profile in Native children...
- Glucose intolerance in pregnancy and future risk of pre-diabetes or diabetes
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
Diabetes Care 31:2026-31. 2008
....
- Association of hematological parameters with insulin resistance and beta-cell dysfunction in nondiabetic subjects
Anthony J G Hanley
Department of Nutritional Sciences, University of Toronto, Fitzgerald Building, Toronto, Ontario, Canada M5S 3E2
J Clin Endocrinol Metab 94:3824-32. 2009
....
- Comparison of National Diabetes Data Group and American Diabetes Association diagnostic criteria for gestational diabetes in their identification of postpartum risk of glucose intolerance
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
Diabetes Res Clin Pract 85:40-6. 2009
....
- Relationship of the metabolic syndrome to carotid ultrasound traits
Rebecca L Pollex
Robarts Research Institute, London, Ontario, Canada
Cardiovasc Ultrasound 4:28. 2006
..We evaluated two carotid ultrasound measurements, namely intima media thickness and total plaque volume, in a Canadian Oji-Cree population with a high metabolic syndrome prevalence rate...
- Ethnicity modifies the effect of obesity on insulin resistance in pregnancy: a comparison of Asian, South Asian, and Caucasian women
Ravi Retnakaran
Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada M5G 1L5
J Clin Endocrinol Metab 91:93-7. 2006
..Prepregnancy BMI has a much greater effect on insulin resistance in pregnancy in Asian women than in Caucasians. Ethnicity thus emerges as a factor that modulates the effect of obesity on insulin resistance in pregnancy...
- Adipokines and incident type 2 diabetes in an Aboriginal Canadian [corrected] population: the Sandy Lake Health and Diabetes Project
Sylvia H Ley
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Diabetes Care 31:1410-5. 2008
....
- Effect of maternal weight, adipokines, glucose intolerance and lipids on infant birth weight among women without gestational diabetes mellitus
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ont
CMAJ 184:1353-60. 2012
..We sought to evaluate the independent effects of maternal glycemia, lipids, obesity, adipokines and inflammation on infant birth weight...
- Associations of prenatal metabolic abnormalities with insulin and adiponectin concentrations in human milk
Sylvia H Ley
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Am J Clin Nutr 95:867-74. 2012
....
- Association of parity with risk of type 2 diabetes and related metabolic disorders
Anthony J G Hanley
Department of Public Health Sciences, University of Toronto, Toronto, Canada
Diabetes Care 25:690-5. 2002
..The objective of this study was to investigate the association between parity and risk of glucose intolerance and related metabolic disorders using data from a population-based study in a Native Canadian community...
- Maternal obesity and familial history of diabetes have opposing effects on infant birth weight in women with mild glucose intolerance in pregnancy
Phillip Segal
Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Matern Fetal Neonatal Med 21:73-9. 2008
..We thus sought to evaluate the maternal constitutional and biochemical factors that determine infant birth weight in this patient population...
- Pre-gravid physical activity and reduced risk of glucose intolerance in pregnancy: the role of insulin sensitivity
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
Clin Endocrinol (Oxf) 70:615-22. 2009
..Thus, we sought to study the relationships between types of pre-gravid physical activity and metabolic parameters in pregnancy, including glucose tolerance, insulin sensitivity and beta-cell function...
- APOC1 T45S polymorphism is associated with reduced obesity indices and lower plasma concentrations of leptin and apolipoprotein C-I in aboriginal Canadians
Piya Lahiry
Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada
J Lipid Res 51:843-8. 2010
..0001), using a newly developed ELISA-based method. Taken together, these results suggest that at the whole human phenotype level, apo C-I is associated with the complex metabolic trait of obesity as well as with serum leptin levels...
- Lifestyle variables, non-traditional cardiovascular risk factors, and the metabolic syndrome in an Aboriginal Canadian population
Juan Liu
Department of Public Health Sciences, University of Toronto, Toronto, Ontario, Canada
Obesity (Silver Spring) 14:500-8. 2006
....
- Glucose intolerance in pregnancy and postpartum risk of metabolic syndrome in young women
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, 60 Murray Street, Suite L5 039, Toronto, Canada M5T3L9
J Clin Endocrinol Metab 95:670-7. 2010
....
- Age is a determinant of acute hemodynamic responses to hyperglycemia and angiotensin II in humans with uncomplicated type 1 diabetes mellitus
David Z I Cherney
Division of Nephrology, University Health Network, University of Toronto, Toronto, Canada
Am J Physiol Regul Integr Comp Physiol 299:R206-14. 2010
....
- Association of 25(OH)D and PTH with metabolic syndrome and its traditional and nontraditional components
Sheena Kayaniyil
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
J Clin Endocrinol Metab 96:168-75. 2011
..However, evidence to date is limited and inconsistent, and few studies have examined associations with nontraditional MetS components...
- Adiponectin in a native Canadian population experiencing rapid epidemiological transition
Anthony J G Hanley
Leadership Sinai Centre for Diabetes, Mt Sinai Hospital, Toronto, Ontario, Canada
Diabetes Care 26:3219-25. 2003
....
- Gestational diabetes and postpartum physical activity: evidence of lifestyle change 1 year after delivery
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
Obesity (Silver Spring) 18:1323-9. 2010
..83, P = 0.005). In conclusion, women with GDM successfully increased their leisure-time activity in the first year postpartum, reflecting an element of lifestyle change following this diagnosis...
- The impact of family history of diabetes on risk factors for gestational diabetes
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
Clin Endocrinol (Oxf) 67:754-60. 2007
..We thus hypothesized that the risk factors for gestational hyperglycaemia in women with FHD may differ from those in women without FHD...
- Risk of early progression to prediabetes or diabetes in women with recent gestational dysglycaemia but normal glucose tolerance at 3-month postpartum
Ravi Retnakaran
Division of Endocrinology, University of Toronto, Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada
Clin Endocrinol (Oxf) 73:476-83. 2010
..In this context, we sought to evaluate the risk of early progression to dysglycaemia in women with NGT at 3-month postpartum and identify predictors thereof...
- The impact of insulin resistance on proinsulin secretion in pregnancy: hyperproinsulinemia is not a feature of gestational diabetes
Ravi Retnakaran
Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
Diabetes Care 28:2710-5. 2005
..These data suggest that relative proinsulin secretion in late pregnancy is primarily related to insulin resistance and does not necessarily reflect beta-cell function...
- Association of apolipoprotein B with incident type 2 diabetes in an aboriginal Canadian population
Sylvia H Ley
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Clin Chem 56:666-70. 2010
..We assessed the association of apo B with incident type 2 diabetes and compared it with traditional lipid variables as a risk predictor in aboriginal Canadians...
- Postpartum metabolic function in women delivering a macrosomic infant in the absence of gestational diabetes mellitus
Simone Kew
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
Diabetes Care 34:2608-13. 2011
..Thus, to test this hypothesis, we assessed metabolic function during and after pregnancy in a cohort of women stratified according to the presence/absence of GDM and LGA delivery, respectively...
- The antepartum glucose values that predict neonatal macrosomia differ from those that predict postpartum prediabetes or diabetes: implications for the diagnostic criteria for gestational diabetes
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada M5T3L9
J Clin Endocrinol Metab 94:840-5. 2009
..Thus, to test this assumption, we sought to evaluate the predictive capacity of each glucose value on antepartum OGTT in relation to LGA and postpartum prediabetes/diabetes...
- Effect of Rosiglitazone and Ramipril on {beta}-cell function in people with impaired glucose tolerance or impaired fasting glucose: the DREAM trial
Anthony J Hanley
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Diabetes Care 33:608-13. 2010
....
- Hyperbolic relationship between insulin secretion and sensitivity on oral glucose tolerance test
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
Obesity (Silver Spring) 16:1901-7. 2008
..Based on these findings, the product of these two indices emerges as a potential OGTT-based measure of beta-cell function...
- A comparison of ultrasound measurements to assess carotid atherosclerosis development in subjects with and without type 2 diabetes
Rebecca L Pollex
Robarts Research Institute, London, Ontario, Canada
Cardiovasc Ultrasound 3:15. 2005
..Thus, the objective of this study was to compare the traditional intima-media thickness measurement against the novel total plaque volume measurement in analyzing carotid atherosclerosis development in individuals with type 2 diabetes...
- Association between the -455T>C promoter polymorphism of the APOC3 gene and the metabolic syndrome in a multi-ethnic sample
Rebecca L Pollex
Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada
BMC Med Genet 8:80. 2007
..The objective of this study is to examine the APOC3 -455T>C and the INSIG2 rs7566605 polymorphisms as potential genetic determinants for MetS in a multi-ethnic sample...
- Impact of maternal metabolic abnormalities in pregnancy on human milk and subsequent infant metabolic development: methodology and design
Sylvia H Ley
Department of Nutritional Sciences, University of Toronto, Toronto, Canada
BMC Public Health 10:590. 2010
..The objective of this report is to present the methodology and design of this study...
- Low serum levels of high-molecular weight adiponectin in Indo-Asian women during pregnancy: evidence of ethnic variation in adiponectin isoform distribution
Ravi Retnakaran
Division of Endocrinology, University of Toronto, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G1X5
Diabetes Care 29:1377-9. 2006
- Reduced adiponectin concentration in women with gestational diabetes: a potential factor in progression to type 2 diabetes
Ravi Retnakaran
Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
Diabetes Care 27:799-800. 2004
- Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes
Rebecca L Pollex
Robarts Research Institute, London, Ontario, Canada
Cardiovasc Diabetol 4:17. 2005
..The objective of this study was to investigate a possible role for the MTHFR 677C>T gene polymorphism with PAD in subjects with type 2 diabetes from an isolated aboriginal Canadian population...
- Impaired glucose tolerance of pregnancy is a heterogeneous metabolic disorder as defined by the glycemic response to the oral glucose tolerance test
Ravi Retnakaran
Division of Endocrinology, University of Toronto, Ontario, Canada
Diabetes Care 29:57-62. 2006
..The metabolic phenotype associated with 1-h IGT resembles that of GDM, whereas the phenotype associated with 2-h/3-h IGT exhibits similarity to that of NGT...
- Cigarette smoking and cardiovascular risk factors among Aboriginal Canadian youths
Ravi Retnakaran
Division of Endocrinology, Department of Medicine, University of Toronto, Toronto, Ont
CMAJ 173:885-9. 2005
..The association of cigarette smoking with an enhanced cardiovascular risk profile at an early age may be a factor contributing to the high prevalence of cardiovascular disease in this Aboriginal population...
- Changes over time in glycemic control, insulin sensitivity, and beta-cell function in response to low-dose metformin and thiazolidinedione combination therapy in patients with impaired glucose tolerance
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, and Department of Nutritional Sciences, University of Toronto, Toronto, Canada
Diabetes Care 34:1601-4. 2011
..9 years. We evaluate the temporal changes in glycemic control, insulin sensitivity, and β-cell function during this trial...
- Maternal serum adiponectin and infant birthweight: the role of adiponectin isoform distribution
Gabie K B Ong
Faculty of Arts and Sciences, University of Toronto, Toronto, ON, Canada
Clin Endocrinol (Oxf) 67:108-14. 2007
....
- Determinants of insulin resistance in infants at age 1 year: impact of gestational diabetes mellitus
Carla A Borgono
Division of General Internal Medicine, University of Toronto, Toronto, Ontario, Canada
Diabetes Care 35:1795-7. 2012
..Thus, we sought to identify early life determinants of insulin resistance in infants of women with and without GDM...
- Circadian variation in the response to the glucose challenge test in pregnancy: implications for screening for gestational diabetes mellitus
Robert J Goldberg
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Ontario, Canada
Diabetes Care 35:1578-84. 2012
..Thus, using their subsequent OGTT (performed in the morning), we sought to characterize the metabolic function of women with positive GCTs in relation to the timing of their test...
- The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial
Bernard Zinman
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, and University of Toronto, Toronto, Ontario, Canada
Ann Intern Med 146:477-85. 2007
..Exenatide therapy is effective in combination with metformin or sulfonylureas for treating type 2 diabetes. Thiazolidinediones (TZDs) also are commonly used, but the efficacy of exenatide with a TZD has not been reported...
- An abnormal screening glucose challenge test in pregnancy predicts postpartum metabolic dysfunction, even when the antepartum oral glucose tolerance test is normal
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Division of Endocrinology, University of Toronto, Toronto, Canada
Clin Endocrinol (Oxf) 71:208-14. 2009
..Thus, we sought to characterize the obstetrical and postpartum metabolic significance of an abnormal GCT in women with normal glucose tolerance (NGT) on antepartum OGTT...
- Diabetes mellitus and breast cancer: a retrospective population-based cohort study
Lorraine L Lipscombe
Institute for Clinical Evaluative Sciences, M4N 3M5, Toronto, Ontario, Canada
Breast Cancer Res Treat 98:349-56. 2006
..The purpose of this study was to compare the incidence of breast cancer in postmenopausal women with and without diabetes...
- Beta-cell function declines within the first year postpartum in women with recent glucose intolerance in pregnancy
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
Diabetes Care 33:1798-804. 2010
..In this context, we queried whether metabolic changes that occur in the 1st year postpartum vary in relation to gestational glucose tolerance status...
- Free fatty acid-mediated impairment of glucose-stimulated insulin secretion in nondiabetic Oji-Cree individuals from the Sandy Lake community of Ontario, Canada: a population at very high risk for developing type 2 diabetes
Andre Carpentier
Department of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
Diabetes 52:1485-95. 2003
..Whether this reflects an inherent resistance to lipotoxicity or an already-present lipotoxic effect in this population will require further study...
- Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes
Sheena Kayaniyil
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
Diabetes Care 33:1379-81. 2010
..To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes...
- Cystatin C is associated with cardiovascular risk factors and metabolic syndrome in Aboriginal youth
Ravi Retnakaran
Division of Endocrinology, University of Toronto, Toronto, Canada
Pediatr Nephrol 22:1007-13. 2007
..0072). In summary, increased cystatin C is associated with an enhanced CV risk factor profile in Aboriginal youth and may be an early event in the natural history of vascular disease...
- Effect of macronutrient intake during the second trimester on glucose metabolism later in pregnancy
Sylvia H Ley
Department of Nutritional Sciences, Mount Sinai Hospital, Toronto, Canada
Am J Clin Nutr 94:1232-40. 2011
..Dietary intake is known to influence glucose metabolism, but there is little consensus on the optimal distribution of macronutrient intakes during pregnancy to prevent gestational diabetes (GDM)...
- Clinical inertia in response to inadequate glycemic control: do specialists differ from primary care physicians?
Baiju R Shah
Institute for Clinical Evaluative Sciences, G106 2075 Bayview Ave, Toronto, ON, Canada M4N 3M5
Diabetes Care 28:600-6. 2005
..quot; Because data suggest that specialist care results in better control than primary care, we evaluated whether specialists demonstrated less clinical inertia than primary care physicians...
- The impact of diabetes on survival following breast cancer
Lorraine L Lipscombe
Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
Breast Cancer Res Treat 109:389-95. 2008
..The purpose of this study was to examine the impact of diabetes on survival following breast cancer...
- Continuous subcutaneous insulin infusion versus multiple daily injections: the impact of baseline A1c
Ravi Retnakaran
Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
Diabetes Care 27:2590-6. 2004
..Thus, CSII emerges as an important modality for implementing intensive therapy and may be uniquely advantageous in patients with poor glycemic control...
- Effect of rosiglitazone, metformin, and glyburide on bone biomarkers in patients with type 2 diabetes
Bernard Zinman
Samuel Lunenfeld Research Institute, Mount Sinai Hospital and University of Toronto, Ontario, Canada
J Clin Endocrinol Metab 95:134-42. 2010
..An increase in bone fractures has been observed in women taking thiazolidinediones...
- Deficiencies in the quality of diabetes care: comparing specialist with generalist care misses the point
Baiju R Shah
Institute for Clinical Evaluative Sciences, Toronto, ON, Canada
J Gen Intern Med 22:275-9. 2007
..The development of such interventions to help all physicians implement better quality care could greatly benefit people with diabetes...
- Risk of development of diabetes mellitus after diagnosis of gestational diabetes
Denice S Feig
Department of Medicine, University of Toronto, Toronto, Ont
CMAJ 179:229-34. 2008
..However, the precise relation between these 2 conditions remains unknown. We sought to determine the incidence of diabetes mellitus after diagnosis of gestational diabetes...
- Increased prevalence of prior breast cancer in women with newly diagnosed diabetes
Lorraine L Lipscombe
Institute for Clinical Evaluative Sciences, Toronto, Ontario, Canada
Breast Cancer Res Treat 98:303-9. 2006
..Because insulin levels are at their highest prior to the development of diabetes, breast cancer risk may be even greater during the pre-diabetes period...
- Administrative data algorithms can describe ambulatory physician utilization
Baiju R Shah
Institute for Clinical Evaluative Sciences, G106 2075 Bayview Avenue, Toronto, ON, Canada M4N 3M5
Health Serv Res 42:1783-96. 2007
..To validate algorithms using administrative data that characterize ambulatory physician care for patients with a chronic disease...
- Does hypoadiponectinemia explain the increased risk of diabetes and cardiovascular disease in South Asians?
Ravi Retnakaran
Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, Canada
Diabetes Care 29:1950-4. 2006
- Type 2 diabetes and impaired glucose tolerance in aboriginal populations: a global perspective
Catherine H Y Yu
Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Ontario, Canada
Diabetes Res Clin Pract 78:159-70. 2007
..To perform a systematic review of the prevalence of type 2 diabetes and impaired glucose tolerance (IGT) in aboriginal populations worldwide...
- Cross-sectional and prospective associations between abdominal adiposity and proinsulin concentration
Anthony J G Hanley
Department of Public Health Sciences, University of Toronto, Ontario M5S 1A8, Canada
J Clin Endocrinol Metab 87:77-83. 2002
..24, P = 0.03, respectively). These data highlight the detrimental effects of abdominal obesity on beta-cell function, and support the hypothesis that beta-cell dysfunction occurs early in the natural history of glucose intolerance...
- Changes in diabetes self-care behaviors make a difference in glycemic control: the Diabetes Stages of Change (DiSC) study
Helen Jones
Leadership Sinai Center for Diabetes, Mount Sinai Hospital and University of Toronto, Toronto, Canada
Diabetes Care 26:732-7. 2003
..01). CONCLUSIONS: This study demonstrates that this intervention has the potential of positively impacting the health of broad populations of individuals with diabetes, not just the minority who are ready for change...
- Effects of vitamin E on cardiovascular and microvascular outcomes in high-risk patients with diabetes: results of the HOPE study and MICRO-HOPE substudy
Eva Lonn
Department of Medicine and Population Health Institute, McMaster University, Hamilton, Ontario, Canada
Diabetes Care 25:1919-27. 2002
..However, data from randomized clinical trials are limited. Therefore, we evaluated the effects of vitamin E supplementation on major CV outcomes and on the development of nephropathy in people with diabetes...
- Diabetes care in the U.S. and Canada
Gillian L Booth
Department of Medicine, Division of Endocrinology and Metabolism, St Michael s Hospital, Toronto, Ontario, Canada
Diabetes Care 25:1149-53. 2002
..To compare the glycemic control of patients with type 1 diabetes treated in the U.S. and Canada...
- Phenotypic characteristics of GAD antibody-positive recently diagnosed patients with type 2 diabetes in North America and Europe
Bernard Zinman
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
Diabetes 53:3193-200. 2004
..1 vs. 83.7%, P = 0.0009). These phenotypic differences may underlie a potential difference in the natural history of hyperglycemia and its clinical outcomes...
- C-reactive protein and gestational diabetes: the central role of maternal obesity
Ravi Retnakaran
Division of Endocrinology, University of Toronto, Toronto M5G 1X5, Ontario, Canada
J Clin Endocrinol Metab 88:3507-12. 2003
..These data suggest a model in which obesity mediates a systemic inflammatory response, with possible downstream metabolic sequelae, including insulin resistance and glucose dysregulation...
- Type 2 diabetes mellitus: magnitude of the problem and failure to achieve glycemic control
Bernard Zinman
Leadership Sinai Centre for Diabetes, University of Toronto, Toronto, Ontario, Canada
Endocrinol Metab Clin North Am 35:3-5; discussion 17-19. 2006
- Genes, environment and Oji-Cree type 2 diabetes
Robert A Hegele
Robarts Research Institute RAH, HC, London, ON, Canada
Clin Biochem 36:163-70. 2003
..There is also evidence for genetic determination of related metabolic traits in the Oji-Cree...
