Jia L Zhuo

Summary

Publications

  1. pmc Proximal nephron
    Jia L Zhuo
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Compr Physiol 3:1079-123. 2013
  2. pmc Novel signaling mechanisms of intracellular angiotensin II-induced NHE3 expression and activation in mouse proximal tubule cells
    X C Li
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Renal Physiol 303:F1617-28. 2012
  3. pmc New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II
    Jia L Zhuo
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Peptides 32:1551-65. 2011
  4. pmc Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Henry Ford Hospital, Detroit, MI 48202, USA
    Am J Physiol Renal Physiol 293:F586-93. 2007
  5. pmc Proximal tubule-dominant transfer of AT(1a) receptors induces blood pressure responses to intracellular angiotensin II in AT(1a) receptor-deficient mice
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Am J Physiol Regul Integr Comp Physiol 304:R588-98. 2013
  6. pmc Phosphoproteomic analysis of AT1 receptor-mediated signaling responses in proximal tubules of angiotensin II-induced hypertensive rats
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, 1500 North State Street, Jackson, MS 39216, USA
    Kidney Int 80:620-32. 2011
  7. pmc AT1 receptor-mediated uptake of angiotensin II and NHE-3 expression in proximal tubule cells through a microtubule-dependent endocytic pathway
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol Renal Physiol 297:F1342-52. 2009
  8. pmc Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Henry Ford Hospital, Detroit, MI 48202, USA
    Clin Sci (Lond) 114:591-601. 2008
  9. pmc AT1a receptor signaling is required for basal and water deprivation-induced urine concentration in AT1a receptor-deficient mice
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of MississippiMedical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 303:F746-56. 2012
  10. pmc AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Kidney Int 76:169-77. 2009

Research Grants

Collaborators

Detail Information

Publications19

  1. pmc Proximal nephron
    Jia L Zhuo
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi, USA
    Compr Physiol 3:1079-123. 2013
    ....
  2. pmc Novel signaling mechanisms of intracellular angiotensin II-induced NHE3 expression and activation in mouse proximal tubule cells
    X C Li
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, Mississippi 39216 4505, USA
    Am J Physiol Renal Physiol 303:F1617-28. 2012
    ..We conclude that intracellular ANG II may induce NHE3 expression and activation in mPCTs via AT(1a)- and AT(2) receptor-mediated activation of MAP kinases ERK 1/2 and NF-κB signaling pathways...
  3. pmc New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II
    Jia L Zhuo
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Peptides 32:1551-65. 2011
    ....
  4. pmc Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Henry Ford Hospital, Detroit, MI 48202, USA
    Am J Physiol Renal Physiol 293:F586-93. 2007
    ....
  5. pmc Proximal tubule-dominant transfer of AT(1a) receptors induces blood pressure responses to intracellular angiotensin II in AT(1a) receptor-deficient mice
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216, USA
    Am J Physiol Regul Integr Comp Physiol 304:R588-98. 2013
    ..These results suggest that AT(1a) receptors and intracellular ANG II in proximal tubules of the kidney play an important physiological role in blood pressure regulation...
  6. pmc Phosphoproteomic analysis of AT1 receptor-mediated signaling responses in proximal tubules of angiotensin II-induced hypertensive rats
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, The University of Mississippi Medical Center, 1500 North State Street, Jackson, MS 39216, USA
    Kidney Int 80:620-32. 2011
    ..Thus, PKCα and PKCβII, GSK3α and GSK3β, and cAMP-dependent signaling pathways may have important roles in regulating proximal tubular sodium and fluid transport in Ang II-induced hypertensive rats...
  7. pmc AT1 receptor-mediated uptake of angiotensin II and NHE-3 expression in proximal tubule cells through a microtubule-dependent endocytic pathway
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Am J Physiol Renal Physiol 297:F1342-52. 2009
    ....
  8. pmc Long-term hyperglucagonaemia induces early metabolic and renal phenotypes of Type 2 diabetes in mice
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Henry Ford Hospital, Detroit, MI 48202, USA
    Clin Sci (Lond) 114:591-601. 2008
    ..This supports the idea that glucagon receptor blockade may be beneficial in treating insulin resistance and Type 2 diabetic renal complications...
  9. pmc AT1a receptor signaling is required for basal and water deprivation-induced urine concentration in AT1a receptor-deficient mice
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of MississippiMedical Center, 2500 N State St, Jackson, MS 39216 4505, USA
    Am J Physiol Renal Physiol 303:F746-56. 2012
    ..These results demonstrate that AT(1a) receptor-mediated ANG II signaling is required to maintain tonic AVP release and regulate V(2) receptor-mediated responses to water deprivation in the inner medulla...
  10. pmc AT1a receptor knockout in mice impairs urine concentration by reducing basal vasopressin levels and its receptor signaling proteins in the inner medulla
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Kidney Int 76:169-77. 2009
    ..We suggest that AT(1a) receptor deletion causes polyuria and urine concentration defects by decreasing basal AVP release and impairing AVP-induced receptor signaling in the inner medulla...
  11. pmc Intrarenal transfer of an intracellular fluorescent fusion of angiotensin II selectively in proximal tubules increases blood pressure in rats and mice
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, 39216 4505, USA
    Am J Physiol Renal Physiol 300:F1076-88. 2011
    ..These results provide evidence that proximal tubule-selective transfer of an intracellular ANG II fusion protein increases blood pressure by activating AT(1a) receptors and increasing sodium reabsorption in proximal tubules...
  12. pmc Evidence for a functional intracellular angiotensin system in the proximal tubule of the kidney
    Brianne Ellis
    Laboratoory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 302:R494-509. 2012
    ....
  13. pmc Nuclear factor-kappaB as a hormonal intracellular signaling molecule: focus on angiotensin II-induced cardiovascular and renal injury
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Hospital, and Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48202, USA
    Curr Opin Nephrol Hypertens 17:37-43. 2008
    ..The purpose of this article is to highlight the role of NF-kappaB as an intracellular signaling for angiotensin II and clinical perspectives of targeting NF-kappaB signaling in treating hypertensive and renal diseases...
  14. pmc Novel roles of intracrine angiotensin II and signalling mechanisms in kidney cells
    Jia L Zhuo
    Laboratory of Receptor and Signal Transduction, Henry Ford Hospital, and Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48202, USA
    J Renin Angiotensin Aldosterone Syst 8:23-33. 2007
    ..This information may aid future development of drugs to prevent and treat Ang II-induced target organ injury in cardiovascular and renal diseases by blocking intracellular and/or nuclear actions of Ang II...
  15. pmc Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Henry Ford Hospital, Detroit, MI 48202, USA
    Clin Sci (Lond) 113:183-93. 2007
    ....
  16. pmc AT1 receptor-mediated accumulation of extracellular angiotensin II in proximal tubule cells: role of cytoskeleton microtubules and tyrosine phosphatases
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Henry Ford Hospital, Detroit 48202, USA
    Am J Physiol Renal Physiol 291:F375-83. 2006
    ..We conclude that extracellular ANG II is internalized in PTCs through AT(1) receptor-mediated endocytosis and that internalized ANG II may play a functional role in proximal tubule cells by inhibiting intracellular cAMP signaling...
  17. pmc Cross-talk between angiotensin II and glucagon receptor signaling mediates phosphorylation of mitogen-activated protein kinases ERK 1/2 in rat glomerular mesangial cells
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Henry Ford Hospital, Detroit, MI 48202, USA
    Biochem Pharmacol 71:1711-9. 2006
    ..The inhibitory effect of PD 123319 on glucagon-induced ERK 1/2 phosphorylation further suggests that AT2 receptors also play a similar role in this response...
  18. pmc Current insights and new perspectives on the roles of hyperglucagonemia in non-insulin-dependent type 2 diabetes
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS, 39216, USA
    Curr Hypertens Rep 15:522-30. 2013
    ....
  19. pmc AT1 receptor-activated signaling mediates angiotensin IV-induced renal cortical vasoconstriction in rats
    Xiao C Li
    Laboratory of Receptor and Signal Transduction, Division of Hypertension and Vascular Research, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI 48202, USA
    Am J Physiol Renal Physiol 290:F1024-33. 2006
    ..These results suggest that, at nanomolar concentrations, ANG IV can increase MAP and induce renal cortical effects by interacting with AT(1) receptor-activated signaling...

Research Grants1

  1. Novel Roles of Intracrine Angiotensin II in Proximal Tubule Cells
    Jia L Zhuo; Fiscal Year: 2010
    ..The new information generated by this project will help us better understand renal mechanisms of hypertension and develop new drugs to treat hypertension. ..