Jian Zhuge

Summary

Publications

  1. pmc Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 46:406-13. 2009
  2. doi request reprint A decrease in S-adenosyl-L-methionine potentiates arachidonic acid cytotoxicity in primary rat hepatocytes enriched in CYP2E1
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biochem 314:105-12. 2008
  3. pmc Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Biochem Biophys 466:177-85. 2007
  4. doi request reprint Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR)
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Biol Toxicol 25:253-63. 2009
  5. ncbi request reprint Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1
    Jian Zhuge
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Place, New York, NY 10029, USA
    Free Radic Biol Med 41:1100-12. 2006
  6. ncbi request reprint Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1
    Jian Zhuge
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Place, New York, NY 10029, USA
    Free Radic Biol Med 40:63-74. 2006
  7. doi request reprint Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008
  8. pmc Ethanol induction of CYP2A5: permissive role for CYP2E1
    Yongke Lu
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Drug Metab Dispos 39:330-6. 2011
  9. ncbi request reprint By-product formation by a novel glycerol-producing yeast, Candida glycerinogenes, with different O2 supplies
    Hairu Jin
    School of Biotechnology, Southern Yangtze University, Huihe Road No 170, Wuxi, Jiangsu Province 214036, PR China
    Biotechnol Lett 25:311-4. 2003
  10. ncbi request reprint Isolation and sequence analysis of the gene URA3 encoding the orotidine-5'-phosphate decarboxylase from Candida glycerinogenes WL2002-5, an industrial glycerol producer
    Yanli Li
    The Key Lab of Industrial Biotechnology of Ministry of Education, Research Centre of Industrial Microorganisms, Southern Yangtz University, Wuxi 214036, People s Republic of China
    Yeast 22:423-30. 2005

Collaborators

Detail Information

Publications18

  1. pmc Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 46:406-13. 2009
    ..These results indicate that mitochondria are the critical targets of pyrazole plus LPS in mediating liver injury...
  2. doi request reprint A decrease in S-adenosyl-L-methionine potentiates arachidonic acid cytotoxicity in primary rat hepatocytes enriched in CYP2E1
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Mol Cell Biochem 314:105-12. 2008
    ..Such interactions, e.g. induction of CYP2E1, decline in SAM and polyunsaturated fatty acid-induced lipid peroxidation, may contribute to alcohol-induced liver injury...
  3. pmc Depletion of S-adenosyl-l-methionine with cycloleucine potentiates cytochrome P450 2E1 toxicity in primary rat hepatocytes
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Arch Biochem Biophys 466:177-85. 2007
    ..This is due to elevated ROS production by CYP2E1 coupled to lower levels of hepatoprotective SAM and GSH. We speculate that such interactions e.g. induction of CYP2E1, decline in SAM and GSH may contribute to alcohol liver toxicity...
  4. doi request reprint Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR)
    Jian Zhuge
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Cell Biol Toxicol 25:253-63. 2009
    ..The cytotoxicity mechanism of AICAR in E47 cells is suggested to include AMPK activation, p53 phosphorylation, p21 expression, overexpression of CYP2E1, and intracellular ROS accumulation...
  5. ncbi request reprint Increased toxicity by transforming growth factor-beta 1 in liver cells overexpressing CYP2E1
    Jian Zhuge
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Place, New York, NY 10029, USA
    Free Radic Biol Med 41:1100-12. 2006
    ..Potentiation of TGF-beta1-induced cell death by CYP2E1 may contribute to mechanisms of alcohol-induced liver disease...
  6. ncbi request reprint Serum deprivation-induced HepG2 cell death is potentiated by CYP2E1
    Jian Zhuge
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Place, New York, NY 10029, USA
    Free Radic Biol Med 40:63-74. 2006
    ..Potentiation of serum deprivation-induced cell death by CYP2E1 may contribute to the sensitivity of the liver to alcohol-induced ischemia and growth factor deprivation...
  7. doi request reprint Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice
    Yongke Lu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 47:1483-94. 2008
    ....
  8. pmc Ethanol induction of CYP2A5: permissive role for CYP2E1
    Yongke Lu
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA
    Drug Metab Dispos 39:330-6. 2011
    ..The possibility that induction of CYP2E1 is permissive for the induction of CYP2A5 may reflect a new contribution by CYP2E1 to the actions of ethanol...
  9. ncbi request reprint By-product formation by a novel glycerol-producing yeast, Candida glycerinogenes, with different O2 supplies
    Hairu Jin
    School of Biotechnology, Southern Yangtze University, Huihe Road No 170, Wuxi, Jiangsu Province 214036, PR China
    Biotechnol Lett 25:311-4. 2003
    ..6 g l(-1)) was produced. In addition, ethanol decreased to 0.4 g l(-1) and the glycerol yield improved from 34 to 50% (w/w) by adding 50 g sulphite l(-1), nevertheless, acetic acid increased to 7.8 g l(-1)...
  10. ncbi request reprint Isolation and sequence analysis of the gene URA3 encoding the orotidine-5'-phosphate decarboxylase from Candida glycerinogenes WL2002-5, an industrial glycerol producer
    Yanli Li
    The Key Lab of Industrial Biotechnology of Ministry of Education, Research Centre of Industrial Microorganisms, Southern Yangtz University, Wuxi 214036, People s Republic of China
    Yeast 22:423-30. 2005
    ..65% amino acid sequence similarity to the S. cerevisiae URA3 protein. Furthermore, the cloned ORF fully complemented the ura3 mutation of S. cerevisiae, confirming that it encodes for the C. glycerinogenes Ura3 (CgUra3) protein...
  11. doi request reprint An efficient genetic transformation method for glycerol producer Candida glycerinogenes
    Xianzhong Chen
    The Key Lab of Industrial Biotechnology, The Ministry of Education and Research Center of Industrial Microorganisms, School of Biotechnology, Jiangnan University, Wuxi 214122, China
    Microbiol Res 163:531-7. 2008
    ..With this method, a maximal transformation frequency of 394+/-50transformants/mug plasmid DNA was obtained. The transformation method will foster genetic manipulation of this industrial strain...
  12. ncbi request reprint Heterologous expression of human cytochrome P450 2E1 in HepG2 cell line
    Jian Zhuge
    Department of Pathophysiology, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China
    World J Gastroenterol 9:2732-6. 2003
    ..To assess the metabolic and toxicological characteristics of CYP2E1, we cloned CYP2E1 cDNA and established a HepG2 cell line stably expressing recombinant CYP 2E1...
  13. doi request reprint Cloning and characterization of a NAD+-dependent glycerol-3-phosphate dehydrogenase gene from Candida glycerinogenes, an industrial glycerol producer
    Xianzhong Chen
    Key Laboratory of Industrial Biotechnology of Ministry of Education and School of Biotechnology, Jiangnan University, Wuxi, China
    FEMS Yeast Res 8:725-34. 2008
    ..cerevisiae mutants transformed with the empty plasmid showed only slight increases. The full-length CgGPD gene sequence including upstream and downstream regions has been deposited in GenBank under accession no. EU186536...
  14. ncbi request reprint Cloning and over-expression of an alkaline protease from Bacillus licheniformis
    Xue Ming Tang
    The Key Laboratory of Industrial Biotechnology, Ministry of Education, Research Center of Industrial Microbiology, Southern Yangtze University, Wuxi 214036, P R China
    Biotechnol Lett 26:975-9. 2004
    ..SDS-PAGE analysis indicated a Mr of 30.5 kDa. The amino acid sequence deduced from the DNA sequence analysis revealed a 98% identity to that of Bacillus licheniformis 6816...
  15. ncbi request reprint Three new alternative splicing variants of human cytochrome P450 2D6 mRNA in human extratumoral liver tissue
    Jian Zhuge
    Department of Pathophysiology, Environmental Genomics Center, School of Medicine, Zhejiang University, Hangzhou 310031, Zhejiang Province, China
    World J Gastroenterol 10:3356-60. 2004
    ..To identify the new alternative splicing variants of human CYP2D6 in human extratumoral liver tissue with RT-PCR and sequencing...
  16. ncbi request reprint Construction of a flocculating yeast for fuel ethanol production
    Fu Zhuan Wang
    Research Center of Industrial Microorganisms, School of Biotechnology, Jiangnan University, Wuxi 214122, PR China
    Biotechnol Lett 30:97-102. 2008
    ..5 to 6.0. Furthermore, the ethanol concentration and other properties of the transformant strain ZWA46-F2 were similar to those of the wild-type strain ZWA46...
  17. ncbi request reprint Purification and characterisation of an alkaline protease used in tannery industry from Bacillus licheniformis
    Xue Ming Tang
    The Key Laboratory of Industrial Biotechnology, Ministry of Education, Research Center of Industrial Microbiology, Southern Yangtze University, Wuxi 214036, PR China
    Biotechnol Lett 26:1421-4. 2004
    ..It was optimally active at pH 11 and at 60 degrees C (assayed over 10 min). The protease was completely inhibited by phenylmethylsulfonyl fluoride and diodopropyl fluorophosphate, with little increase upon Ca2+ and Mg2+ addition...
  18. ncbi request reprint [Research progress on the glycerol kinase]
    Xuena Guo
    Key Laboratory of Industrial Biotechnology, Ministry of Education Southern Yangtes University, Wuxi 214036, China
    Wei Sheng Wu Xue Bao 42:510-3. 2002