Daling Zhu

Summary

Publications

  1. doi request reprint Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension
    Daling Zhu
    College of Pharmacy, Harbin Medical University Daqing, Daqing 163319, Heilongjiang, People s Republic of China
    J Physiol Sci 62:163-72. 2012
  2. ncbi request reprint [Kv3.4 channel is involved in rat pulmonary vasoconstriction induced by 15-hydroxyeicosatetraenoic acid.]
    Qian Li
    College of Pharmacy The Pharmarceutical Department of the Second Affiliated Hospital, Harbin Medical University Biopharmacy Engineering Key Laboratory of Heilongjiang Province, Harbin 150086, China
    Sheng Li Xue Bao 58:77-82. 2006
  3. doi request reprint ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat
    Jun Ma
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Nangang District, Harbin, Heilongjiang, PR China
    J Cell Physiol 222:82-94. 2010
  4. doi request reprint Role of protein kinase C in 15-HETE-induced hypoxic pulmonary vasoconstriction
    Lei Guo
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, PR China
    Prostaglandins Leukot Essent Fatty Acids 80:115-23. 2009
  5. pmc Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells
    Jun Ma
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University Daqing, Daqing 163319, China
    J Lipid Res 53:1093-105. 2012
  6. doi request reprint Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition
    Lei Zhang
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Daqing, China
    Cell Signal 24:1931-9. 2012
  7. doi request reprint A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels
    Yun Liu
    Department of Biopharmaceutical Key Laboratory of Heilongjiang Province, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, PR China
    Pulm Pharmacol Ther 25:69-76. 2012
  8. doi request reprint 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells against apoptosis via HSP90
    Lei Zhang
    Institute of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang, Heilongjiang, PR China
    Life Sci 87:223-31. 2010
  9. doi request reprint Hypoxia suppresses Kv 2.1 channel expression through endogenous 15-hydroxyeicosatetraenoic acid in rat pulmonary artery
    Lei Guo
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150081, Heilongjiang, China
    J Physiol Sci 60:373-81. 2010
  10. doi request reprint Effect of Mitofusin 2 on smooth muscle cells proliferation in hypoxic pulmonary hypertension
    Dandan Zhang
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University Daqing, Daqing, Heilongjiang Province, PR China
    Microvasc Res 84:286-96. 2012

Collaborators

Detail Information

Publications53

  1. doi request reprint Role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in hypoxia-induced pulmonary hypertension
    Daling Zhu
    College of Pharmacy, Harbin Medical University Daqing, Daqing 163319, Heilongjiang, People s Republic of China
    J Physiol Sci 62:163-72. 2012
    ..Here, we focus on our important research into the role played by 15-LO/15-HETE, which promotes a proliferative, antiapoptotic, and vasoconstrictive physiological milieu leading to hypoxic pulmonary hypertension...
  2. ncbi request reprint [Kv3.4 channel is involved in rat pulmonary vasoconstriction induced by 15-hydroxyeicosatetraenoic acid.]
    Qian Li
    College of Pharmacy The Pharmarceutical Department of the Second Affiliated Hospital, Harbin Medical University Biopharmacy Engineering Key Laboratory of Heilongjiang Province, Harbin 150086, China
    Sheng Li Xue Bao 58:77-82. 2006
    ..4 mRNA and protein in rat PASMCs were significantly downregulated by 15-HETE (P<0.05). Based on all the information above, we conclude that Kv3.4 channel is involved in vasoconstriction induced by 15-HETE in rat PAs...
  3. doi request reprint ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat
    Jun Ma
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Nangang District, Harbin, Heilongjiang, PR China
    J Cell Physiol 222:82-94. 2010
    ..Thus, these findings indicate that 15-HETE protects PASMC from apoptosis, contributing to pulmonary vascular medial thickening, and the effect is, at least in part, mediated via the ROCK pathway...
  4. doi request reprint Role of protein kinase C in 15-HETE-induced hypoxic pulmonary vasoconstriction
    Lei Guo
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, PR China
    Prostaglandins Leukot Essent Fatty Acids 80:115-23. 2009
    ..15-HETE suppresses the expression of K(V) 1.5, K(V) 2.1 and K(V) 3.4 channels and inhibits I(K)(V) through the PKC signaling pathway in pulmonary arterial smooth muscle cells...
  5. pmc Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells
    Jun Ma
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University Daqing, Daqing 163319, China
    J Lipid Res 53:1093-105. 2012
    ....
  6. doi request reprint Platelet-derived growth factor (PDGF) induces pulmonary vascular remodeling through 15-LO/15-HETE pathway under hypoxic condition
    Lei Zhang
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Daqing, China
    Cell Signal 24:1931-9. 2012
    ..These results suggest that hypoxia promotes PASMCs proliferation and survival, contributing to pulmonary vascular medial hypertrophy, which is likely to be mediated via the PDGF-BB/15-LO-2/15-HETE pathway...
  7. doi request reprint A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels
    Yun Liu
    Department of Biopharmaceutical Key Laboratory of Heilongjiang Province, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, PR China
    Pulm Pharmacol Ther 25:69-76. 2012
    ..These observations suggest that 8-HUDE exerts acute effects on K(ATP) channel activity as well as subacute effects through decreased channel expression, and these effects are, at least in part, via the Kir6.1/SUR2B channel...
  8. doi request reprint 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells against apoptosis via HSP90
    Lei Zhang
    Institute of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang, Heilongjiang, PR China
    Life Sci 87:223-31. 2010
    ..As HSP90 is known to be involved in apoptosis in other tissues and cells, we aim to test whether anti-apoptotic effect of 15-HETE is regulated by the molecular chaperone in pulmonary artery smooth muscle cells...
  9. doi request reprint Hypoxia suppresses Kv 2.1 channel expression through endogenous 15-hydroxyeicosatetraenoic acid in rat pulmonary artery
    Lei Guo
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150081, Heilongjiang, China
    J Physiol Sci 60:373-81. 2010
    ..1 channel expression in comparison with 12-HETE and 5-HETE in cultured PASMCs and PA under normoxic conditions. These data indicate that hypoxia suppresses Kv2.1 channel expression through endogenous 15-HETE in PA...
  10. doi request reprint Effect of Mitofusin 2 on smooth muscle cells proliferation in hypoxic pulmonary hypertension
    Dandan Zhang
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University Daqing, Daqing, Heilongjiang Province, PR China
    Microvasc Res 84:286-96. 2012
    ..Thus, these results indicate that Mfn2 mediates PASMC proliferation in hypoxic pulmonary hypertension via the PI3K/Akt signaling pathway...
  11. doi request reprint Osthole relaxes pulmonary arteries through endothelial phosphatidylinositol 3-kinase/Akt-eNOS-NO signaling pathway in rats
    Li Yao
    Department of Pharmacognosy, College of Pharmacy, Harbin Medical University, Harbin 150081, China
    Eur J Pharmacol 699:23-32. 2013
    ..These may provide a new pulmonary vasodilator for the therapy of pulmonary arterial hypertension...
  12. ncbi request reprint Expression of 15-lipoxygenases in pulmonary arteries after hypoxia
    Ye Liu
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, China
    Pathology 41:476-83. 2009
    ....
  13. doi request reprint 15-HETE suppresses K(+) channel activity and inhibits apoptosis in pulmonary artery smooth muscle cells
    Yumei Li
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, 150081, Heilongjiang, People s Republic of China
    Apoptosis 14:42-51. 2009
    ..Our data indicated that 15-HETE inhibits the apoptosis in PASMCs through, at least in part, inactivating K(+) channels...
  14. pmc 8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway
    Jun Ma
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, PR China
    Exp Cell Res 316:2340-53. 2010
    ..Because 8,9-EET and not the 8,9-EET analog (214) protects pulmonary artery endothelial cells (PAECs), these observations suggest the potential to differentially promote apoptosis or survival with 8,9-EET or analogs in pulmonary arteries...
  15. doi request reprint 15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells from apoptosis via inducible nitric oxide synthase (iNOS) pathway
    Xiaowei Nie
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University Daqing, Daqing 163319, China
    Prostaglandins Other Lipid Mediat 97:50-9. 2012
    ....
  16. ncbi request reprint Role of ERK1/2 signaling pathways in 4-aminopyridine-induced rat pulmonary vasoconstriction
    Weina Han
    College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, P R of China
    Eur J Pharmacol 569:138-44. 2007
    ..These results indicate that ERK1/2 signaling pathway contributes to pulmonary vasoconstriction induced by 4-AP...
  17. doi request reprint Hypoxia suppresses KV1.5 channel expression through endogenous 15-HETE in rat pulmonary artery
    Xiaojie Chu
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin 150081, China
    Prostaglandins Other Lipid Mediat 88:42-50. 2009
    ..15-HETE contributes to the down-regulation of K(V)1.5 channel, inhibition of I(K(V)) and increase of native pulmonary artery tension after hypoxia. Hypoxia inhibits K(V)1.5 channel through 15-LOX/15-HETE pathway...
  18. doi request reprint Key role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in pulmonary vascular remodeling and vascular angiogenesis associated with hypoxic pulmonary hypertension
    Cui Ma
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Nangang District, Harbin, Heilongjiang, People s Republic of China
    Hypertension 58:679-88. 2011
    ..Together, these results show that 15-HETE mediates hypoxia-induced pulmonary vascular remodeling and stimulates angiogenesis via the Rho-kinase pathway...
  19. doi request reprint 15-HETE protects rat pulmonary arterial smooth muscle cells from apoptosis via the PI3K/Akt pathway
    Shuang Wang
    Institute of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, PR China
    Prostaglandins Other Lipid Mediat 91:51-60. 2010
    ..These changes depended on the PI3K/Akt signaling pathway in PASMCs. Thus a signal transduction pathway was demonstrated which is necessary for the effects of 15-HETE in protection PASMCs from apoptosis...
  20. doi request reprint Enhanced oral bioavailability of Wurenchun (Fructus Schisandrae Chinensis extracts) by self-emulsifying drug delivery systems
    Bing Shao
    Department of Pharmacy, Key Laboratory of Medications Research, College of Heilongjiang Province, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
    Drug Dev Ind Pharm 36:1356-63. 2010
    ..The main purpose of this work is to prepare self-emulsifying drug delivery systems (SEDDS) for enhancing the solubility, dissolution rate, and oral bioavailability of poorly water-soluble traditional Chinese medicines, Wurenchun...
  21. doi request reprint The key role of transforming growth factor-beta receptor I and 15-lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cells
    Yun Liu
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University Daqing, Daqing 163319, China
    Int J Biochem Cell Biol 44:1184-202. 2012
    ..Thus, new strategies aimed at combined blockade of TGFβRI as well as 15-LO may yield optimal therapeutic benefits...
  22. doi request reprint 15-Lipoxygenase promotes chronic hypoxia-induced pulmonary artery inflammation via positive interaction with nuclear factor-κB
    Jing Li
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University Daqing, Daqing, Heilongjiang, China
    Arterioscler Thromb Vasc Biol 33:971-9. 2013
    ..Here, we determined the contribution of 15-HETE in the hypoxia-induced pulmonary vascular inflammation...
  23. doi request reprint Role of the G-protein and tyrosine kinase--Rho/ROK pathways in 15-hydroxyeicosatetraenoic acid induced pulmonary vasoconstriction in hypoxic rats
    Yali Wang
    Department of Biopharmaceutical Sciences Department of Pharmacology, College of Pharmacy, Harbin Medical University and Biopharmaceutical Key Laboratory of Heilongjiang Province, Harbin 150081, People s Republic of China
    J Biochem 147:751-64. 2010
    ..These results suggest that 15-HETE may mediate the up-regulation of ROK expression through G-protein and tyrosine kinase pathways under hypoxic condition, leading to PA vasoconstriction...
  24. doi request reprint Cellular mechanisms and intracellular signaling pathways for the modulation of eNOS in pulmonary arteries by 15-HETE
    Lei Yu
    Department of Biopharmaceutical Sciences, College of Pharmacology, Harbin Medical University, Nangang District, Harbin, Heilongjiang, P R China
    J Recept Signal Transduct Res 32:87-95. 2012
    ..Therefore, 15-HETE initially inhibited the PAs constriction through the endothelial NO system, and both Ca²⁺ and the PI3K/Akt signaling systems are required for the effects of 15-HETE on PAs tone regulation...
  25. doi request reprint Heme oxygenase-1 induces 15-lipoxygenase expression during hypoxia-induced pulmonary hypertension
    Xiaowei Nie
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University Daqing, Daqing 163319, China
    Int J Biochem Cell Biol 45:964-72. 2013
    ..Together, these data suggest that HO-1 is an important upstream mediator in the hypoxia-induced 15-LO up-regulation during HPH. Unveiling the relevance of HO-1 signaling in PHP provides attractive treatment targets for HPH...
  26. doi request reprint 15-HETE mediates sub-acute hypoxia-induced TRPC1 expression and enhanced capacitative calcium entry in rat distal pulmonary arterial myocytes
    Shanshan Li
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, PR China
    Prostaglandins Other Lipid Mediat 93:60-74. 2010
    ..These results suggest that 15-HETE mediated HPV through increased TRPC1 expression, leading to enhanced CCE, contributing to the maintenance of vascular tone...
  27. doi request reprint Increased expression and altered subcellular distribution of PKC-δ and PKC-ɛ in pulmonary arteries exposed to hypoxia and 15-HETE
    Xiaohong Li
    Department of Anaesthesiology, The First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang 150001, PR China
    Prostaglandins Other Lipid Mediat 93:84-92. 2010
    ..12) compared with siblings rats under normoxia. Thus, these findings indicate that PKC-δ and PKC-ɛ contributing to hypoxic pulmonary artery contraction elicited by 15-HETE...
  28. doi request reprint microRNA-138 plays a role in hypoxic pulmonary vascular remodelling by targeting Mst1
    Shanshan Li
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Daqing, Heilongjiang 163319, China
    Biochem J 452:281-91. 2013
    ..Therefore the results of the present study suggest that miR-138 appears to be a negative regulator of PASMC apoptosis, and plays an important role in HPVR (hypoxic pulmonary vascular remodelling)...
  29. doi request reprint The microRNA-328 regulates hypoxic pulmonary hypertension by targeting at insulin growth factor 1 receptor and L-type calcium channel-α1C
    Lei Guo
    Department of Biopharmaceutical Sciences, College of Pharmacy, Second Affiliated Hospital, Harbin Medical University, Nangang District, Harbin, People s Republic of China
    Hypertension 59:1006-13. 2012
    ..These results showed that miRNA-328, an important protecting factor, plays a significant role in PA constriction and remodeling by regulating multiple gene targets in hypoxic pulmonary hypertension...
  30. doi request reprint The key role of PGC-1α in mitochondrial biogenesis and the proliferation of pulmonary artery vascular smooth muscle cells at an early stage of hypoxic exposure
    Jingjing Rao
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University Daqing, Gaoxin District, Daqing, Heilongjiang, People s Republic of China
    Mol Cell Biochem 367:9-18. 2012
    ..This process might bring to light a potential adaptive mechanism for PASMCs to minimize hypoxic damage and our novel findings provide new insight into the development of hypoxic pulmonary hypertension...
  31. doi request reprint 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells
    Zhigang Wang
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin, Heilongjiang 150081, PR China
    Eur J Pharmacol 588:9-17. 2008
    ..Such effects were reversed in the presence of 17-ODYA. Thus, these findings indicate that 20-HETE protects PASMCs against apoptosis by acting on, at least in part, the intrinsic apoptotic pathway...
  32. doi request reprint Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs
    Yun Liu
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China
    Hypertens Res 34:630-9. 2011
    ....
  33. doi request reprint Staurosporine aglycone bilaterally regulates ERK1/2 phosphorylation in rat pulmonary arterial smooth muscle cells
    Jianing Zhang
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Heilongjiang, PR China
    Can J Physiol Pharmacol 86:424-30. 2008
    ..Together, these results suggest that SA has a strong dual regulating effect on ERK1/2 through the PKC and (or) PKA pathways in rat PASMCs...
  34. doi request reprint 15-lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation
    Jun Ma
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University Daqing, Daqing 163319, China
    Int J Biochem Cell Biol 45:1031-41. 2013
    ....
  35. doi request reprint Differential sensitivities of the vascular KATP channel to various PPAR activators
    Yingji Wang
    Department of Biology, Georgia State University, Atlanta, GA 30302 4010, United States Harbin Medical University School of Pharmacy, Harbin, Heilongjiang, China
    Biochem Pharmacol 85:1495-503. 2013
    ..The structural information of the PPAR agonists may be useful for the development of new therapeutical modalities with less cardiovascular side-effects...
  36. doi request reprint Biliverdin reductase/bilirubin mediates the anti-apoptotic effect of hypoxia in pulmonary arterial smooth muscle cells through ERK1/2 pathway
    Shasha Song
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical, University Daqing, Daqing 163319, China
    Exp Cell Res 319:1973-87. 2013
    ..Taken together, our data indicate that BVR contributes to the inhibitory process of hypoxia on PASMC apoptosis, which is mediated by bilirubin through ERK1/2 pathway. ..
  37. doi request reprint Vasoactive intestinal polypeptide relaxes isolated rat pulmonary artery rings through two distinct mechanisms
    Shuang Zhang
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, 157 Baojian Road, Nangang District, Harbin 150081, Heilongjiang, People s Republic of China
    J Physiol Sci 60:389-97. 2010
    ..The results suggested that the vasodilatation effect of VIP on rat PAs is mediated by both vascular endothelium and smooth muscle, involving respectively the PI3K/Akt-eNOS pathway and the PKA-K(ATP) channel pathway...
  38. doi request reprint Pharmacokinetics and biodistribution of itraconazole in rats and mice following intravenous administration in a novel liposome formulation
    Jingling Tang
    Department of Pharmaceutics, School of Pharmacy, Harbin Medical University, Harbin, 150086, China
    Drug Deliv 17:223-30. 2010
    ..Meanwhile, the low distribution of ITZ-LPs in heart and kidney was of great advantage to reduce the toxicity for heart and kidney. These results indicated that the ITZ-LPs can be a potential intravenous formulation of itraconazole...
  39. doi request reprint Local expression of insulin-like growth factor-I, insulin-like growth factor-I receptor, and estrogen receptor alpha in ovarian cancer
    Yuan An
    Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, China
    Onkologie 32:638-44. 2009
    ..Estrogen receptor alpha (ERalpha), which plays a role in the etiology of ovarian cancer, both regulates and is influenced by the IGF family...
  40. doi request reprint The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells
    Jing Jiang
    Institute of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, Heilongjiang, PR China
    J Recept Signal Transduct Res 31:45-52. 2011
    ....
  41. doi request reprint Preeclampsia activates 15-lipoxygenase and its metabolite 15-hydroxyeicosatetraenoic acid enhances constriction in umbilical arteries
    Yuguang Wang
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Harbin Medical University, Nangang District, Harbin, Heilongjiang, China
    Prostaglandins Leukot Essent Fatty Acids 86:79-84. 2012
    ....
  42. ncbi request reprint Effect of sodium ozagrel on the activity of rat CYP2D6
    Hong Wu
    College of Pharmacy, Harbin Medical University, Harbin 150081, PR China Mudanjiang Medical College, Mudanjiang 157011, PR China
    Eur J Pharmacol 573:55-9. 2007
    ..In conclusion, sodium ozagrel metabolism in rats is mediated primarily through CYP2D6, and sodium ozagrel can induce CYP2D6 activity...
  43. doi request reprint Growth inhibition of human ovarian cancer cells by blocking STAT3 activation with small interfering RNA
    Liying Cai
    Department of Obstetrics and Gynecology, First Affiliated Hospital of Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin, Heilongjiang 150001, PR China
    Eur J Obstet Gynecol Reprod Biol 148:73-80. 2010
    ....
  44. doi request reprint HPLC determination of 4-hydroxy-anethole trithione in plasma via enzymatic hydrolysis and its application to bioequivalence study
    Weiyong Li
    Institute of Clinic Pharmacy, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, PR China
    J Pharm Biomed Anal 47:612-7. 2008
    ....
  45. doi request reprint Effects of ephedra water decoction and cough tablets containing ephedra and liquorice on CYP1A2 and the pharmacokinetics of theophylline in rats
    Jingling Tang
    Department of Pharmaceutics, School of Pharmacy, Harbin Medical University, Harbin 150086, China
    Phytother Res 26:470-4. 2012
    ..These results demonstrated that EWD or MXCT pretreatment obviously induced CYP1A2 activity, therefore, speeding up the metabolism of theophylline. The concomitant use of EWD or MXCT may decrease the effect of theophylline in rats...
  46. doi request reprint A novel combination therapy with arsenic trioxide and parthenolide against pancreatic cancer cells
    Wei Wang
    Department of Hematology, The First Clinical College of Harbin Medical University, Harbin, China
    Pancreas 38:e114-23. 2009
    ..To investigate the anticancer effect and potential mechanism of combination treatment with arsenic trioxide (ATO) and parthenolide (PTL) in human pancreatic cancer cells...
  47. doi request reprint Carboxylesterase 2 is downregulated in colorectal cancer following progression of the disease
    Xiaobo Tang
    College of Pharmacy, Harbin Medical University, Harbin, China
    Cancer Invest 26:178-81. 2008
    ....
  48. pmc Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: injury and recovery
    Rong Zhang
    Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China
    Int J Radiat Biol 84:487-97. 2008
    ..To characterize structural and functional injuries following a single dose of whole-thorax irradiation that might be survivable after a nuclear attack/accident...
  49. pmc Rosiglitazone selectively inhibits K(ATP) channels by acting on the K(IR) 6 subunit
    Lei Yu
    Department of Biology, Georgia State University, Atlanta, Georgia 30302 4010, USA
    Br J Pharmacol 167:26-36. 2012
    ..Therefore, we performed experiments to determine whether other isoforms of K(ATP) channels are also sensitive to rosiglitazone and what their sensitivities are...
  50. doi request reprint Subacute hypoxia suppresses Kv3.4 channel expression and whole-cell K+ currents through endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells
    Lei Guo
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin 150081, China
    Eur J Pharmacol 587:187-95. 2008
    ..4 channel expression. These data indicate that the 15-LOX pathway via its metabolite, 15-HETE, seems to play a role in the down-regulation of Kv3.4 expression and I(K) inhibition after subacute hypoxia...
  51. ncbi request reprint Role of 15-hydroxyeicosatetraenoic acid in phosphorylation of ERK1/2 and caldesmon in pulmonary arterial smooth muscle cells
    Changlian Lu
    College of Pharmacy, Harbin Medical University, Daling Zhu Key Laboratory of Biopharmaceutical Engineering of Heilongjiang Province, Harbin, Heilongjiang 150081, P R China
    Can J Physiol Pharmacol 84:1061-9. 2006
    ....
  52. doi request reprint Tanshinone IIA improves miR-133 expression through MAPK ERK1/2 pathway in hypoxic cardiac myocytes
    Li Zhang
    Department of Pharmacology State Province Key Laboratories of Biomedicine Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education, Daqing, Heilongjiang, PR China
    Cell Physiol Biochem 30:843-52. 2012
    ..The present study demonstrated that tanshinone IIA enhanced cell resistance to hypoxic insult by upregulating miR-133 expression through activating MAPK ERK1/2 in neonatal cardiomyocytes...
  53. doi request reprint Highly sensitive determination of Schisandrin and Schisandrin B in plasma of rats after administration of Wurenchun (Fructus Schisandrae Chinensis Extracts) preparations by LC-ESI-MS/MS
    Jingling Tang
    Department of Pharmaceutics, School of Pharmacy, Harbin Medical University, Harbin, 150086, China
    Biomed Chromatogr 24:675-81. 2010
    ..5 and 107.2%. Finally, the LC-ESI-MS/MS method was successfully applied to study the pharmacokinetics of Schisandrin and Schisandrin B in rats after administration of Wurenchun commercial formulations to rats...