Zhi Guang Zhou

Summary

Publications

  1. ncbi request reprint Diagnostic value of carboxypeptidase-H autoantibodies in detecting latent autoimmune diabetes in adults
    Zhi Guang Zhou
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Hunan Yi Ke Da Xue Xue Bao 28:549-52. 2003
  2. ncbi request reprint [Quality control of radioligand assay for glutamic acid decarboxylase antibody]
    Gan Huang
    Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
    Hunan Yi Ke Da Xue Xue Bao 28:597-600. 2003
  3. ncbi request reprint [Replacement of insulin by fasting C-peptide in modified homeostasis model assessment to evaluate insulin resistance and islet beta cell function]
    Xia Li
    Department of Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 29:419-23. 2004
  4. ncbi request reprint [Islet beta cell function in latent autoimmune diabetes in adults with islet cell antibodies]
    Lin Yang
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 29:309-14. 2004
  5. ncbi request reprint [Characteristics of dysfunction of islet beta-cell in newly diagnosed type 2 diabetic patients]
    Yan Bing Li
    Department of Endocrinology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou 510080, China
    Zhonghua Yi Xue Za Zhi 86:2537-41. 2006
  6. pmc Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China
    Yufei Xiang
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital and the Diabetes Center, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, China
    Diabetes Care 34:1639-41. 2011
  7. pmc Exendin-4 protects mitochondria from reactive oxygen species induced apoptosis in pancreatic Beta cells
    Zhen Li
    Diabetes Center, Second Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, China
    PLoS ONE 8:e76172. 2013
  8. pmc Circulating lipocalin-2 and retinol-binding protein 4 are associated with intima-media thickness and subclinical atherosclerosis in patients with type 2 diabetes
    Yang Xiao
    Diabetes Center, The Second Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China
    PLoS ONE 8:e66607. 2013
  9. pmc Glycemic control among patients in China with type 2 diabetes mellitus receiving oral drugs or injectables
    Li nong Ji
    Department of Endocrinology and Metabolism, Peking University People s Hospital, No 11 Xizhimen Nandajie, Beijing 100044, China
    BMC Public Health 13:602. 2013
  10. pmc Comparative analysis of the alveolar macrophage proteome in ALI/ARDS patients between the exudative phase and recovery phase
    Haiyun Dong
    Intensive Care Unit, Diabetes Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    BMC Immunol 14:25. 2013

Collaborators

Detail Information

Publications67

  1. ncbi request reprint Diagnostic value of carboxypeptidase-H autoantibodies in detecting latent autoimmune diabetes in adults
    Zhi Guang Zhou
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Hunan Yi Ke Da Xue Xue Bao 28:549-52. 2003
    ..To investigate the diagnostic value of carboxypeptidase-H (CPH) autoantibodies in Chinese patients with the latent autoimmune diabetes in adults (LADA)...
  2. ncbi request reprint [Quality control of radioligand assay for glutamic acid decarboxylase antibody]
    Gan Huang
    Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
    Hunan Yi Ke Da Xue Xue Bao 28:597-600. 2003
    ..To supply the quality control for glutamic acid decarboxylase antibody (GAD-Ab) measurement using radioligand assay...
  3. ncbi request reprint [Replacement of insulin by fasting C-peptide in modified homeostasis model assessment to evaluate insulin resistance and islet beta cell function]
    Xia Li
    Department of Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 29:419-23. 2004
    ..To investigate the possibility of using C-peptide to replace insulin in homeostasis model assessment (Homa) to evaluate insulin resistance and islet beta cell function...
  4. ncbi request reprint [Islet beta cell function in latent autoimmune diabetes in adults with islet cell antibodies]
    Lin Yang
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 29:309-14. 2004
    ..To explore the predictive value and influence of islet cell antibody (ICA) and glutamic acid decarboxylase antibody (GAD-Ab) for beta cell function in latent autoimmune diabetes in adults (LADA) patients...
  5. ncbi request reprint [Characteristics of dysfunction of islet beta-cell in newly diagnosed type 2 diabetic patients]
    Yan Bing Li
    Department of Endocrinology, the First Affiliated Hospital of Sun Yat Sen University, Guangzhou 510080, China
    Zhonghua Yi Xue Za Zhi 86:2537-41. 2006
    ..To investigate the characteristics of the dysfunction of islet beta-cell in newly diagnosed type 2 diabetic patients...
  6. pmc Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China
    Yufei Xiang
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital and the Diabetes Center, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, China
    Diabetes Care 34:1639-41. 2011
    ..To determine the relationship between selected cytokines and diabetes in Chinese subjects...
  7. pmc Exendin-4 protects mitochondria from reactive oxygen species induced apoptosis in pancreatic Beta cells
    Zhen Li
    Diabetes Center, Second Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, China
    PLoS ONE 8:e76172. 2013
    ..Based on these observations, we discuss the protective role of Exendin-4 against mitochondrial oxidative damage and its relationship with Ca(2+)-independent phospholipase A2...
  8. pmc Circulating lipocalin-2 and retinol-binding protein 4 are associated with intima-media thickness and subclinical atherosclerosis in patients with type 2 diabetes
    Yang Xiao
    Diabetes Center, The Second Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan, China
    PLoS ONE 8:e66607. 2013
    ..In this study, we evaluated the association of serum lipocalin-2 and RBP4 with intima-media thickness (IMT) and subclinical atherosclerosis in type 2 diabetic patients...
  9. pmc Glycemic control among patients in China with type 2 diabetes mellitus receiving oral drugs or injectables
    Li nong Ji
    Department of Endocrinology and Metabolism, Peking University People s Hospital, No 11 Xizhimen Nandajie, Beijing 100044, China
    BMC Public Health 13:602. 2013
    ..We assessed the efficacy of oral antidiabetes drugs (OADs), glucagon-like peptide-1 (GLP-1) receptor agonists, and insulin for treatment of T2DM across multiple regions in China...
  10. pmc Comparative analysis of the alveolar macrophage proteome in ALI/ARDS patients between the exudative phase and recovery phase
    Haiyun Dong
    Intensive Care Unit, Diabetes Center, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    BMC Immunol 14:25. 2013
    ..Despite decades of extensive studies, the morbidity and mortality for acute lung injury/acute respiratory distress syndrome (ALI/ARDS) remained high. Particularly, biomarkers essential for its early diagnosis and prognosis are lacking...
  11. pmc Variation of C peptide decay rate in diabetic patients with positive glutamic acid decarboxylase antibody: better discrimination with initial fasting C peptide
    Xia Li
    Key Laboratory of Diabetes Immunology, Ministry of Education Diabetes Center, Metabolic Syndrome Research Center, Institute of Metabolism and Endocrinology, 2nd Xiangya Hospital, Central South University, NO, 139 Middle Renmin Road, 410011, Changsha, Hunan, P, R, China
    BMC Endocr Disord 13:10. 2013
    ..We aimed to investigate whether initial C peptide levels could help differentiate variation of C peptide decay rate...
  12. pmc Frequency, immunogenetics, and clinical characteristics of latent autoimmune diabetes in China (LADA China study): a nationwide, multicenter, clinic-based cross-sectional study
    Zhiguang Zhou
    Diabetes Center, Institute of Metabolism and Endocrinology, The Second Xiangya Hospital and Key Laboratory of Diabetes Immunology Central South University, Ministry of Education, Changsha, China
    Diabetes 62:543-50. 2013
    ..Autoantibody positivity and titer could be important for LADA risk stratification and accurate therapeutic choice in clinical practice...
  13. pmc Prevalence of metabolic syndrome (MetS) in Chinese subjects gradually increased with impaired glucose homeostasis: a multicenter, clinical based, cross-sectional study
    Yufei Xiang
    Diabetes Center, 2nd Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, Hunan 410011, China
    BMC Public Health 12:675. 2012
    ..Metabolic Syndrome (MetS) is a high risk factor for Cardiovascular Diseases (CVD). We estimated to investigate how MetS prevalence by glucose homeostasis varies across different age and gender groups...
  14. ncbi request reprint [Latent autoimmune diabetes in adults: an update]
    Zhi Guang Zhou
    Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25:630-4. 2003
    ..The different pathological manifestations of LADA with different autoantibody titers can help throw light on the autoimmune process, laying foundation of prevention or even cure of type 1 diabetes...
  15. ncbi request reprint Rosiglitazone combined with insulin preserves islet beta cell function in adult-onset latent autoimmune diabetes (LADA)
    Zhiguang Zhou
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China
    Diabetes Metab Res Rev 21:203-8. 2005
    ..Therefore, we hypothesized that LADA patients might benefit from thiazolidinediones treatment...
  16. ncbi request reprint Optimal cutoff point of glutamate decarboxylase antibody titers in differentiating two subtypes of adult-onset latent autoimmune diabetes
    X Li
    Diabetes Center, Second Xiangya Hospital, Central South University, 139 Renmin Zhong Road, Changsha, Hunan 410011, China
    Ann N Y Acad Sci 1037:122-6. 2004
    ..5% and 92.1%, respectively. These findings demonstrated that the two clinically distinct subtypes of LADA can be optimally discriminated by the GAD-Ab titers...
  17. ncbi request reprint [Relationship between autoantibodies and HLA-DQ genotypes in patients with type 1 diabetes mellitus]
    Jian Ping Wang
    Department of Endocrinology and Metabolism, Second Xiangya Hospital, Diabetes Center, Institute of Metabolism and Endocrinology, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 87:2380-4. 2007
    ..e., glutamic acid decarboxylase antibody (GADA), protein-tyrosine-phosphatase-2 autoantibody (IA-2A), and insulin autoantibody (IAA), and human leukocyte HLA-DQ genotypes in the patients with type 1 diabetes mellitus (T1DM)...
  18. doi request reprint Modulation of monocyte hyperresponsiveness to TLR ligands by 1,25-dihydroxy-vitamin D3 from LADA and T2DM
    Tao Du
    Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    Diabetes Res Clin Pract 83:208-14. 2009
    ..The modulation of 1,25(OH)(2)D3 on monocytes makes us to consider more potency of vitamin D3 as therapy in LADA and T2DM...
  19. ncbi request reprint [Etiological dissection in common anti-islet autoantibody-negative patients with type 1 diabetes]
    Dong Mei Zhang
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 84:1247-51. 2004
    ..To explore the immunological and genetic factors of common anti-islet autoantibody-negative patients with type 1 diabetes...
  20. ncbi request reprint [Immunological features of fulminant type 1 diabetes]
    Chao Zheng
    Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Hunan, China
    Zhonghua Yi Xue Za Zhi 89:2544-7. 2009
    ..To investigate the immunological features of fulminant type 1 diabetes...
  21. ncbi request reprint Change of glutamic acid decarboxylase antibody and protein tyrosine phosphatase antibody in Chinese patients with acute-onset type 1 diabetes mellitus
    Chen Chao
    Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Hunan Key Laboratory of Medical Epigenomics, Changsha, Hunan 410011, China
    Chin Med J (Engl) 126:4006-12. 2013
    ..Our study aimed to investigate the changes in positivity and titers of GADA and IA-2A during the course of Chinese acute-onset T1D patients and their relationships with clinical features...
  22. ncbi request reprint [Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes]
    Yu Yu Tan
    Institute of Metabolism and Endocrinology, Diabetic Center, Metabolic Syndrome Research Center, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 90:236-40. 2010
    ..To investigate the association of Killer cell immunoglobin-like receptor (KIR) gene and KIRs'ligand (HLA-C) gene polymorphisms with type 1 diabetes (T1DM)...
  23. ncbi request reprint [Mechanisms of human glutamic acid decarboxylase 65 DNA vaccine preventing diabetes in non-obese diabetic mice]
    Jian Hua Luo
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 84:1791-5. 2004
    ..To investigate the mechanisms of human GAD65 DNA vaccine preventing insulitis and diabetes in NOD mice...
  24. ncbi request reprint [The effect and mechanism of transient continuous subcutaneous insulin infusion therapy on beta cell function, insulin resistance and vascular endothelial injury in newly diagnosed type 2 diabetes]
    Shi Ping Liu
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Diabetes Center, Central South University, Changsha 410011, China
    Zhonghua Nei Ke Za Zhi 49:405-9. 2010
    ..To explore the effect of transient continuous subcutaneous insulin infusion (CSII) on ß cell function, insulin resistance and vascular endothelial injury in newly diagnosed type 2 diabetic patients and its potential mechanism...
  25. ncbi request reprint [Metabolic syndrome and latent autoimmune diabetes in adults]
    Xia Li
    Department of Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 25:676-9. 2003
    ..To investigate the prevalence of metabolic syndrome (MS) in latent autoimmune diabetes in adults (LADA) and to study the positivity of glutamic acid decarboxylase autoantibody (GADA) in diabetic patients with MS...
  26. ncbi request reprint [Subclassification of seronegative type 1 diabetic subjects with HLA-DQ genotypes]
    Dong Mei Zhang
    Institute of Metabolism and Endocrinology, The Second Xiang Ya Hospital, Central South University, Changsha 410011, China
    Zhonghua Nei Ke Za Zhi 43:174-8. 2004
    ..To reveal the relationship between disease phenotype and HLA-DQ genotype in autoantibody-negative type 1 diabetics and to explore whether HLA-DQ genotypes can reclassify seronegative type 1 diabetic patients...
  27. ncbi request reprint [Decrease of FOXP3 mRNA in CD4+ T cells in latent autoimmune diabetes in adult]
    Zhi fang Yang
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Diabetes Center of Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 86:2533-6. 2006
    ..To study the percentage of peripheral blood CD4(+)CD25(+) T cells and the expression of FOXP3 mRNA in the patients with latent autoimmune diabetes in adult (LADA)...
  28. ncbi request reprint [Detection of GAD65 reactive T cells in some Chinese subjects initially diagnosed as with idiopathic type 1 diabetes]
    Yi Zhang
    Diabetes Center, Institute of Metabolism and Endocrinology, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 87:1102-5. 2007
    ..To demonstrate the existence of islet-associated antigen-specific T cells in some of type 1B patients...
  29. ncbi request reprint [Preventive effects of pioglitazone on diabetes and relevant mechanisms, experimental study on non-obese diabetic mice]
    Jian hao Pei
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 84:411-5. 2004
    ..To explore the effects of pioglitazone on insulitis and diabetes and relevant mechanism...
  30. ncbi request reprint [Clinical and immunological characteristics in rapid-onset type 1 diabetes with hyperamylasemia]
    Chi Zhang
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 85:967-71. 2005
    ..To investigate the clinical characteristics and different status of islet autoantibodies of rapid-onset type 1 diabetes in China with elevated serum pancreatic enzymes...
  31. ncbi request reprint [Adult-onset latent autoimmune diabetes and autoimmune thyroid disease]
    Ping Jin
    Institute of Endocrinology and Metabolism, The Second Xiangya Hospital of Central South University, Changsha 410011, China
    Zhonghua Nei Ke Za Zhi 43:363-7. 2004
    ..To investigate the relationship between latent autoimmune diabetes in adults (LADA) and thyroid autoimmunity...
  32. ncbi request reprint [Immunological characteristics and islet function in first-degree relatives of latent autoimmune diabetes in adults]
    Can Hou
    Department of Endocrinology, Diabetes Center, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 89:1820-4. 2009
    ..To investigate the immunological features and pancreatic beta cell function of first-degree relatives of latent autoimmune diabetes in adults (LADA)...
  33. ncbi request reprint [Use of ABC typing to redefine subtypes of acute-onset type 1 diabetes mellitus: study of 308 patients]
    Chi Zhang
    Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 88:797-801. 2008
    ..To investigate the feasibility of ABC typing to redefine the subtypes of acute-onset type 1 diabetes mellitus (DM)...
  34. ncbi request reprint [Improved radioligand assay of insulin autoantibody]
    Jian Ping Wang
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 29:414-8. 2004
    ..To establish an improved radioligand assay of insulin autoantibody (IAA) and to investigate the diagnostic role of IAA in type 1 diabetes (T1DM)...
  35. ncbi request reprint [Identification of the two subtypes of latent autoimmune diabetes in adults by glutamic acid decarboxylase 65 antibody titers]
    Xia Li
    Department of Endocrinology, Xiang Ya Second Hospital, Central South University, Changsha 410011, China
    Zhonghua Nei Ke Za Zhi 42:7-10. 2003
    ..To compare the clinical characteristics between type 2 diabetes and latent autoimmune diabetes in adults (LADA) and to define the two distinct types of LADA with different glutamic acid decarboxylase antibody (GADA) titers...
  36. ncbi request reprint [Inhibition of islet beta cell apoptosis and prevention diabetes by subcutaneous administration of insulin in NOD mice]
    Tie Jian Jiang
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:499-504. 2006
    ..To investigate the effects of subcutaneous administration of insulin on insulitis,beta cell apoptosis and diabetes in non-obese diabetic (NOD) mice, and to explore the mechanism of immune tolerance induced by insulin...
  37. ncbi request reprint [Relation between insulin resistance and glutamic acid decarboxylase antibody titers in latent autoimmune diabetes in adults]
    Xia Li
    Second Xiangya Hospital, Diabetes Center, Institute of Metabolism and Endocrinology, Central South University, Changsha 410011, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:1247-9. 2010
    ..To investigate the relation between insulin resistance and glutamic acid decarboxylase antibody (GAD-Ab) titers in latent autoimmune diabetes in adults (LADA)...
  38. ncbi request reprint [Clinical characteristics and classification of 2128 outpatients with diabetes]
    Hai Ying Qi
    Department of Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 29:184-6. 2004
    ..To determine the clinical characteristics of diabetic outpatients and their classification,and to provide some suggestions for diagnostics, education and follow-up of outpatients...
  39. ncbi request reprint [Diagnostic role of SOX13 antibody in latent autoimmune diabetes of adults]
    Li Rong Li
    Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 85:235-9. 2005
    ..To explore the diagnostic role of SOX13 antibody in latent autoimmune diabetes of adults (LADA)...
  40. ncbi request reprint Six-year follow-up of pancreatic beta cell function in adults with latent autoimmune diabetes
    Lin Yang
    Institute of Metabolism and Endocrinology, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
    World J Gastroenterol 11:2900-5. 2005
    ....
  41. ncbi request reprint [Glitazones protects beta cell function from cytotoxic cytokines through PPAR gamma-dependent mechanisms]
    Xia Li
    Second Xiangya Hospital, Diabetes Center, Institute of Metabolism and Endocrinology, Central South University, Changsha 410011, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:1530-3. 2010
    ..To investigate the protective effects of glitazones on islet beta cells and PPAR gamma dependence of such effects...
  42. ncbi request reprint [1α, 25(OH)(2) D(3) protects pancreatic β-cell line from cytokine-induced apoptosis and impaired insulin secretion]
    An ping Wang
    Diabetes Center, Second Xiangya Hospital and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 92:695-9. 2012
    ..To explore the protective effects and potential mechanisms of 1α, 25(OH)(2) D(3) (VitD(3)) on pancreatic β-cells...
  43. ncbi request reprint Gene expression changes in patients with fulminant type 1 diabetes
    Zhen Wang
    Diabetes Center, Second Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, Hunan 410011, China
    Chin Med J (Engl) 124:3613-7. 2011
    ..Fulminant type 1 diabetes (F1D) is a complex disease. Microarray analysis was used to identify gene expression changes and obtain understanding of the underlying mechanisms...
  44. ncbi request reprint [Effects of pravastatin in prevention of diabetes and mechanism thereof: experiment with non-obese diabetic mice]
    Song Zhang
    Diabetes Center, Metabolic Syndrome Research Center, Institute of Metabolism and Endocrinology, Xiangya Second Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 88:568-72. 2008
    ..To explore the effects of pravastatin in prevention of diabetes and mechanisms thereof...
  45. ncbi request reprint IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population
    Qiong Huang
    Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha, China
    Acta Pharmacol Sin 31:709-17. 2010
    ....
  46. ncbi request reprint [Inhibitory effects of thiazolidinedione upon cytokine-induced apoptosis in pancreatic beta-cell line]
    An ping Wang
    Diabetes Center and Metabolic Syndrome Research Center, Institute of Metabolism and Endocrinology, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 89:1989-93. 2009
    ..To investigate the protective effects and potential mechanisms of TZD upon pancreatic beta-cells...
  47. ncbi request reprint [Protective effect of adipocytes fatty acid binding protein inhibitor on pancreas islet cell against macrophage-mediated cytotoxicity of mice in vitro]
    Shi Ping Liu
    Institute of Metabolism and Endocrinology, the Second Xiangya Hospital Diabetes Center, Central South University, Key Laboratory of Diabetes Immunology, Ministry of Education, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 92:3300-4. 2012
    ..To investigate the potential role of adipocytes fatty acid binding protein (A-FABP)inhibitor to prevent pancreatic islet cells from cytotoxic injury by inflammatory cytokines released from macrophage...
  48. ncbi request reprint [Value of zinc transporter 8 autoantibody in the diagnostic classification of acute-onset diabetics]
    Lin Yang
    Diabetes Center, Institute of Metabolism and Endocrinology, Department of Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 90:2536-40. 2010
    ..to explore the application significance of zinc transporter 8 autoantibody (ZnT8A) in the diagnostic classification of acute-onset diabetics...
  49. ncbi request reprint [Serum of obesity induce the activation of TLR4/NF-κB signaling pathway on THP-1 cell line]
    Lan Yao
    Insititute of Metabolism and Endocrinology, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 90:3119-23. 2010
    ..To investigate the activation of TLR4/NF-κB signaling pathway and the level of inflammation in volunteers with varying degrees of metabolic disorders and the effect of intervention by TLR4 monoclonal antibody...
  50. ncbi request reprint Hypoadiponectinemia predicts impaired endothelium-independent vasodilation in newly diagnosed type 2 diabetic patients: an 8-year prospective study
    Hui Li
    Diabetes Center, Second Xiangya Hospital, and Institute of Metabolism and Endocrinology, Key Laboratory of Diabetes Immunology, Ministry of Education, Central South University, Changsha, Hunan 410011, China
    Chin Med J (Engl) 124:3607-12. 2011
    ..The aim of this study was to investigate whether low adiponectin levels predict the impairment of endothelial function in newly diagnosed type 2 diabetic patients in an 8-year prospective study...
  51. ncbi request reprint Regulation by 1, 25-dihydroxy-vitamin D3 on altered TLRs expression and response to ligands of monocyte from autoimmune diabetes
    Tao Du
    Diabetes Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    Clin Chim Acta 402:133-8. 2009
    ..Altered Toll-like receptors (TLRs) expression and response of monocyte may be associated with insulin sensitivity, obesity and diabetes...
  52. ncbi request reprint [Relationship of adipocyte fatty acid-binding protein to adiponectin ratio with femoral intima-media thickness and endothelium-dependent vasodilation in patients with newly-diagnosed type 2 diabetes mellitus]
    Yang Xiao
    Department of Endocrinology, Second Xiangya Hospital, Diabetes Center, Institute of Metabolism and Endocrinology, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 90:231-5. 2010
    ....
  53. ncbi request reprint [Isolation and purification of islets in non-obese diabetic mice]
    Tie Jian Jiang
    Department of Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Hunan Yi Ke Da Xue Xue Bao 27:85-7. 2002
    ..To investigate the method of isolating and purifying islets in non-obese diabetic (NOD) mice...
  54. ncbi request reprint [Diagnostic value of protein tyrosine phosphatase-2beta antibody (IA-2betaA) in type 1 diabetes]
    Hui Li
    Diabetic Center, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 88:939-42. 2008
    ..To explore the prevalence and clinical features of protein tyrosine phosphatase-2beta antibody (IA-2betaA) in type 1 diabetes (T1DM)...
  55. ncbi request reprint [Effects of glimepiride and metformin on free fatty acid in patients with Type 2 diabetes mellitus]
    Jia zhen Tang
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 29:631-4. 2004
    ....
  56. ncbi request reprint [Association of CTLA-4 + 49A/G and CT60 gene polymorphism with type 1 diabetes and thyroid autoimmunity]
    Ping Jin
    Diabetes Center, Metabolic Syndrome Research Center, Institute of Metabolism and Endocrinology, 2nd Xiangya Hospital, Central South University, Changsha, Hunan 410011, China
    Zhonghua Yi Xue Za Zhi 89:1246-9. 2009
    ..To investigate the association of CTLA-4 + 49A/G and CT60 gene polymorphisms with type 1 diabetes (T1DM) and thyroid autoimmunity. Subjects Three hundred thirty-two T1DM patients and 476 controls were recruited in the study...
  57. ncbi request reprint [Construction and identification of 2 secreted human GAD65 fragment DNA vaccines]
    Song Zhang
    Institute of Metabolism and Endocrinology, Diabetes Center, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:997-1001. 2007
    ..To construct and identify 2 secreted human GAD65 fragment DNA vaccines...
  58. ncbi request reprint [Complete Freund's adjuvant-induced splenic T cell apoptosis in the prevention of diabetes in non-obese diabetic mice]
    Xiao Xi Wang
    Department of Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Hunan Yi Ke Da Xue Xue Bao 27:105-7. 2002
    ..To study the apoptosis of T lymphocytes in the spleen and its role in complete Freund's adjuvant (CFA) preventing diabetes in non-obese diabetic (NOD) mice...
  59. ncbi request reprint [Paget disease of single bone--a case report]
    Yi Zhang
    Institute of Metabolism and Endocrine, Xiangya Second Hospital, Zhong Nan University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 85:647-8. 2005
  60. ncbi request reprint [Relationship between body fat distribution and insulin resistance, islet β cell function and metabolic disorders in adults]
    Xiao Jie Yang
    Diabetes Center, Department of Endocrinology, Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhonghua Yi Xue Za Zhi 93:2867-70. 2013
    ..To explore the relationship between body fat distribution, insulin resistance, islet β cell function and metabolic disorders in adult population...
  61. ncbi request reprint [Development and evaluation of quality of life scale for patients with type 2 diabetes mellitus]
    Le san Wang
    Department of Epidemiology and Statistics, School of Public Health, Central South University, Changsha 410078, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:21-7. 2005
    ..To develop a specific quality of life scale for Chinese Type 2 diabetes mellitus (DM) patients...
  62. ncbi request reprint [Liposome and complete Freund's adjuvant for the prevention of insulitis in non-obese diabetic mice]
    Heng Su
    Department of Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Hunan Yi Ke Da Xue Xue Bao 27:32-4. 2002
    ..To explore the effects of complete Freund's adjuvant (CFA), incomplete Freund's adjuvant(IFA), large multilamellar liposome (LML) and small cationic liposome (DOTAP) on insulitis and diabetes...
  63. ncbi request reprint [Histone H3 acetylation of tumor necrosis factor-alpha and cyclooxygenase-2 in patients with type 2 diabetes]
    Can Hou
    Department of Endocrinology, Central South University, Changsha, Hunan, China
    Zhonghua Yi Xue Za Zhi 91:1805-8. 2011
    ....
  64. doi request reprint Diabetes self-management, depressive symptoms, quality of life and metabolic control in youth with type 1 diabetes in China
    Jia Guo
    School of Nursing, Central South University, Changsha, Hunan Province, China
    J Clin Nurs 22:69-79. 2013
    ..To assess diabetes self-management, depressive symptoms, quality of life and metabolic control in a cohort of youth with type 1 diabetes in mainland China. Predictors of self-management and depressive symptoms were also explored...
  65. ncbi request reprint [Comparison of 3 working definitions of metabolic syndrome in male medical examinees]
    Qiong Feng
    Institute of Endocrinology and Metabolism, Second Xiangya Hospital, Central South University, Changsha 410011, China
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 30:130-4. 2005
    ....
  66. ncbi request reprint Multicenter clinical study on the efficacy and safety of inhalable insulin aerosol in the treatment of type 2 diabetes
    Zhi hong Liao
    Department of Endocrinology, First Affiliated Hospital of Sun Yat sen University, Guangzhou, Guangdong, China
    Chin Med J (Engl) 121:1159-64. 2008
    ..The aim of this multicenter clinical study was to evaluate the efficacy and safety of this new Inh-Ins as a treatment of type 2 diabetes. Regular porcine insulin (RI) was used as a control...
  67. doi request reprint Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    Xinmei Zhang
    Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, China
    Diabetes 57:1246-53. 2008
    ..This study aimed to investigate the relationship between its serum levels and various cardiometabolic parameters in humans...