Zhou Zhou



  1. Xu F, Xiang Q, Huang J, Chen Q, Yu N, Long X, et al. Exosomal miR-423-5p mediates the proangiogenic activity of human adipose-derived stem cells by targeting Sufu. Stem Cell Res Ther. 2019;10:106 pubmed publisher
    ..Exosomal miR-423-5p mediated the proangiogenic activity of hADSCs by targeting Sufu, which may contribute to the exploitation of exosomes from hADSCs as a therapeutic tool for regenerative medicine. ..
  2. Jun C, Huan H, Wei F, Duozhi S, Chen L, Yang S, et al. Detection of pathogens from resected heart valves of patients with infective endocarditis by next-generation sequencing. Int J Infect Dis. 2019;: pubmed publisher
    ..The NGS technology should be considered an essential supplement to culture-based methods, particularly for unculturable or difficult-to-culture microorganisms. ..
  3. Cheng J, Hu H, Kang Y, Chen W, Fang W, Wang K, et al. Identification of pathogens in culture-negative infective endocarditis cases by metagenomic analysis. Ann Clin Microbiol Antimicrob. 2018;17:43 pubmed publisher
    ..However, more efforts should be made to optimize protocols for sample processing, sequencing and bioinformatics analysis. ..
  4. Yang H, Ma Y, Luo M, Zhao K, Zhang Y, Zhu G, et al. Identification of gross deletions in FBN1 gene by MLPA. Hum Genomics. 2018;12:46 pubmed publisher
    ..Our finding expands the mutation spectrum of large FBN1 deletions and emphasizes the importance of screening for large FBN1 deletions in clinical genetic testing, especially for those with classic Marfan phenotype. ..
  5. Chen W, Li W, Ma Y, Zhang Y, Han B, Liu X, et al. Secondary findings in 421 whole exome-sequenced Chinese children. Hum Genomics. 2018;12:42 pubmed publisher
    ..In conclusion, secondary findings are not so rare in Chinese children, which means that we should pay more attention to the clinical interpretation of sequencing results. ..
  6. Zhang Y, Peng R, Li X, Yu J, Chen X, Zhou Z. Serum chloride as a novel marker for adding prognostic information of mortality in chronic heart failure. Clin Chim Acta. 2018;483:112-118 pubmed publisher
    ..639-0.739, p?<?0.001). In a Chinese Han population, admission serum chloride concentrations are inversely associated with all-cause mortality of CHF patients and provide incremental prognostic information of serum sodium. ..
  7. Yang H, Zeng Q, Ma Y, Liu B, Chen Q, Li W, et al. Genetic analyses in a cohort of 191 pulmonary arterial hypertension patients. Respir Res. 2018;19:87 pubmed publisher
    ..Analyses of PAH causal genes have a great help to clinical diagnosis and deep implications in disease treatment. ..
  8. Wang Z, Liu Z, Wang W, Fu Y, Chen W, Li W, et al. Two common mutations within CYP2C19 affected platelet aggregation in Chinese patients undergoing PCI: a one-year follow-up study. Pharmacogenomics J. 2019;19:157-163 pubmed publisher
    ..This research suggested that LOF alleles and risk haplotypes in CYP2C19 could significantly attenuate the response to clopidogrel, which resulted in platelet aggregation. ..
  9. Yang H, Luo M, Chen Q, Fu Y, Zhang J, Qian X, et al. Genetic testing of the FBN1 gene in Chinese patients with Marfan/Marfan-like syndrome. Clin Chim Acta. 2016;459:30-35 pubmed publisher
    ..These results expand the FBN1 mutation spectrum and enrich our knowledge of genotype-phenotype correlations. Genetic testing for MFS and its related aortic diseases is increasingly important for early intervention and treatment. ..

More Information


  1. Zhang Y, Yang H, Chen Q, Yu J, Chen X, Liu S, et al. A novel PROS1 mutation, c.74dupA, was identified in a protein S deficiency family. Thromb Res. 2016;148:125-127 pubmed publisher
    ..Therefore, genetic testing of PROS1 appeared important for the early diagnosis of hereditary protein S deficiency, and it allowed the application of prophylactic interventions to prevent the incidence of severe thrombosis. ..
  2. Li J, Tan M, Xiang Q, Zhou Z, Yan H. Thrombin-activated platelet-derived exosomes regulate endothelial cell expression of ICAM-1 via microRNA-223 during the thrombosis-inflammation response. Thromb Res. 2017;154:96-105 pubmed publisher
    ..Our results suggest that thrombin-activated platelet-derived exosomes inhibit ICAM-1 expression during inflammation. MiR-223 may mediate this process via regulation of the NF-κB and MAPK pathways. ..