Hua Chuan Zheng

Summary

Publications

  1. ncbi request reprint Clinicopathological and prognostic significance of MUC-2, MUC-4 and MUC-5AC expression in japanese gastric carcinomas
    Li Jun Xiao
    Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang, China
    Asian Pac J Cancer Prev 13:6447-53. 2012
  2. pmc Downregulated parafibromin expression is a promising marker for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    Virchows Arch 452:147-55. 2008
  3. doi request reprint Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110001, China
    J Cancer Res Clin Oncol 137:585-96. 2011
  4. pmc Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomas
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    Virchows Arch 452:525-34. 2008
  5. doi request reprint Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110003, China
    Hum Pathol 39:1042-9. 2008
  6. pmc Expression profile of the REG gene family in colorectal carcinoma
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    J Histochem Cytochem 59:106-15. 2011
  7. doi request reprint Parafibromin expression is an independent prognostic factor for colorectal carcinomas
    Hua Chuan Zheng
    College of Basic Medicine, China Medical University, Shenyang 110001, China
    Hum Pathol 42:1089-102. 2011
  8. ncbi request reprint Arp2/3 overexpression contributed to pathogenesis, growth and invasion of gastric carcinoma
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    Anticancer Res 28:2225-32. 2008
  9. pmc Mapping the history and current situation of research on John Cunningham virus - a bibliometric analysis
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, PR China
    BMC Infect Dis 9:28. 2009
  10. doi request reprint SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    J Cancer Res Clin Oncol 135:1521-32. 2009

Collaborators

Detail Information

Publications55

  1. ncbi request reprint Clinicopathological and prognostic significance of MUC-2, MUC-4 and MUC-5AC expression in japanese gastric carcinomas
    Li Jun Xiao
    Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang, China
    Asian Pac J Cancer Prev 13:6447-53. 2012
    ..This study aimed to assess the clinicopathological and prognostic significance of MUC-2, MUC-4 and MUC-5AC in Japanese gastric cancer...
  2. pmc Downregulated parafibromin expression is a promising marker for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    Virchows Arch 452:147-55. 2008
    ..It was considered as a promising marker to indicate the aggressive behaviours and prognosis of gastric carcinomas...
  3. doi request reprint Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110001, China
    J Cancer Res Clin Oncol 137:585-96. 2011
    ..The study aimed to clarify the role of EMMPRIN expression in tumorigenesis and progression of colorectal carcinomas (CRC)...
  4. pmc Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomas
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    Virchows Arch 452:525-34. 2008
    ....
  5. doi request reprint Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomas
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110003, China
    Hum Pathol 39:1042-9. 2008
    ..They were considered objective and effective markers for the aggressive behavior and poor prognosis in gastric carcinomas...
  6. pmc Expression profile of the REG gene family in colorectal carcinoma
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    J Histochem Cytochem 59:106-15. 2011
    ..This study indicated that aberrant REG expression might be closely linked to the pathogenesis, invasion, or lymph node metastasis of CRCs. REG Iβ and HIP/PAP could be considered reliable markers of favorable prognosis of CRC patients...
  7. doi request reprint Parafibromin expression is an independent prognostic factor for colorectal carcinomas
    Hua Chuan Zheng
    College of Basic Medicine, China Medical University, Shenyang 110001, China
    Hum Pathol 42:1089-102. 2011
    ....
  8. ncbi request reprint Arp2/3 overexpression contributed to pathogenesis, growth and invasion of gastric carcinoma
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    Anticancer Res 28:2225-32. 2008
    ..The aim of this study was to clarify the roles of both molecules in tumorigenesis and progression of gastric carcinomas...
  9. pmc Mapping the history and current situation of research on John Cunningham virus - a bibliometric analysis
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, PR China
    BMC Infect Dis 9:28. 2009
    ..However, no bibliometric investigation has been reported to guide the researchers and potential readers...
  10. doi request reprint SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    J Cancer Res Clin Oncol 135:1521-32. 2009
    ..The purpose of this study was to identify the molecular changes during lens carcinogenesis and cancer progression induced by SV40 T antigen...
  11. doi request reprint The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110001, China
    Hum Pathol 42:424-33. 2011
    ..It was suggested that aberrant inhibitor of growth 5 expression may contribute to pathogenesis, growth, and invasion of colorectal carcinomas and could be considered as a promising marker to gauge aggressiveness of colorectal carcinomas...
  12. doi request reprint Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, 110001 China
    Hum Pathol 41:724-36. 2010
    ....
  13. ncbi request reprint Phosphorylated GSK3beta-ser9 and EGFR are good prognostic factors for lung carcinomas
    Huachuan Zheng
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Japan
    Anticancer Res 27:3561-9. 2007
    ..Epithelial growth factor receptor (EGFR) might phosphorylate GSK3beta into inactive phosphorylated GSK3beta-ser9 (P-GSK3beta-ser9)...
  14. ncbi request reprint The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    Histol Histopathol 25:445-52. 2010
    ..Lower levels of proliferation and apoptosis, as well as alterations in tumor suppressor genes, mucin production and ER stress protein played important roles in the pathogenesis of poorly-differentiated and SRC carcinomas...
  15. ncbi request reprint Expression of Fas ligand and caspase-3 contributes to formation of immune escape in gastric cancer
    Hua Chuan Zheng
    The Fourth Lab Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
    World J Gastroenterol 9:1415-20. 2003
    ..To study the role of Fas ligand (FasL) and Caspase-3 expression in carcinogenesis and progression of gastric cancer and molecular mechanisms of relevant immune escape...
  16. ncbi request reprint Expression of matrix metalloproteinase-7 involving in growth, invasion, metastasis and angiogenesis of gastric cancer
    Zheng Huachuan
    Lab 4, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang 110001
    Chin Med Sci J 18:80-6. 2003
    ..To investigate the role of matrix metalloproteinase-7 (MMP-7) expression in caricinogenesis and progression of gastric cancer...
  17. ncbi request reprint Growth, invasion, metastasis, differentiation, angiogenesis and apoptosis of gastric cancer regulated by expression of PTEN encoding products
    Hua Chuan Zheng
    Lab 4, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
    World J Gastroenterol 9:1662-6. 2003
    ..To investigate expression of PTEN in gastric cancer and to explore its roles in tumorigenesis and progression of gastric cancer...
  18. ncbi request reprint Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma
    Hua Chuan Zheng
    The 4th Laboratory, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, China
    Pathol Int 53:659-66. 2003
    ..Close correlation between PTEN on MMP-7 expression provided a novel insight into the regulatory effects of PTEN on MMP-7 expression in gastric carcinoma...
  19. doi request reprint Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110001, China
    Hum Pathol 41:1255-64. 2010
    ....
  20. ncbi request reprint Expression of maspin and kai1 and their clinicopathological significance in carcinogenesis and progression of gastric cancer
    Hua Chuan Zheng
    The Fourth Laboratory, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang 110001
    Chin Med Sci J 19:193-8. 2004
    ..To investigate the roles of maspin and kai1 expression in tumorigenesis and progression of gastric cancer...
  21. doi request reprint The role of Reg IV gene and its encoding product in gastric carcinogenesis
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, 110001 China
    Hum Pathol 41:59-69. 2010
    ..It was suggested that Reg IV expression should be considered as a good biomarker for gastric precancerous lesions and was especially related to the histogenic pathway of signet ring cell carcinoma...
  22. doi request reprint Beclin 1 expression is an independent prognostic factor for gastric carcinomas
    Miao Yu
    Department of Surgical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China
    Tumour Biol 34:1071-83. 2013
    ..Beclin 1 expression might be employed to indicate the favorable prognosis of gastric carcinomas as an independent factor...
  23. doi request reprint Aberrant SERCA3 expression is closely linked to pathogenesis, invasion, metastasis, and prognosis of gastric carcinomas
    Xiao Yan Xu
    Department of Pathophysiology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang 110001, China
    Tumour Biol 33:1845-54. 2012
    ..It might be employed to indicate the pathobiological behaviors and prognosis of gastric carcinomas...
  24. ncbi request reprint REG IV overexpression in an early stage of colorectal carcinogenesis: an immunohistochemical study
    Xiao Han Li
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama 930 0194, Japan
    Histol Histopathol 25:473-84. 2010
    ....
  25. ncbi request reprint [Expression of PTEN-encoding product in different stages of carcinogenesis and progression of gastric carcinoma]
    Hua Chuan Zheng
    Fourth Laboratory, Cancer Institute, First Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Zhong Liu Za Zhi 25:13-6. 2003
    ....
  26. doi request reprint Role and clinicopathologic significance of CXC chemokine ligand 16 and chemokine (C-X-C motif) receptor 6 expression in gastric carcinomas
    Ya Nan Xing
    Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang 110001, China
    Hum Pathol 43:2299-307. 2012
    ..The expression and serum concentration of CXC chemokine ligand 16 could indicate the aggressiveness and prognosis of gastric carcinomas...
  27. doi request reprint The roles of REIC gene and its encoding product in gastric carcinoma
    Xiao Yan Xu
    Department of Pathophysiology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang, China
    Cell Cycle 11:1414-31. 2012
    ..Downregulated REIC expression was closely linked to aggressive behaviors and poor prognosis of gastric carcinoma...
  28. ncbi request reprint Bag-3 expression is involved in pathogenesis and progression of colorectal carcinomas
    Xue Yang
    Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang, China
    Histol Histopathol 28:1147-56. 2013
    ..05). Our study indicated that aberrant Bag-3 expression might be involved in colorectal adenoma-adenocarcinoma sequence and subsequent progression...
  29. ncbi request reprint PTEN expression and mutation in colorectal carcinomas
    Xiao Han Li
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Sugitani 2630, Toyama, Japan
    Oncol Rep 22:757-64. 2009
    ..PTEN expression may be a good marker for the prognosis of colorectal carcinoma...
  30. ncbi request reprint PTEN encoding product: a marker for tumorigenesis and progression of gastric carcinoma
    Lin Yang
    No 4 Lab, Cancer Institute, The First Affiliated Hospital, China Medical University, Shenyang 110001, China
    World J Gastroenterol 9:35-9. 2003
    ..To detect the expression of PTEN encoding product in normal mucosa, intestinal metaplasia (IM), dysplasia and carcinoma of the stomach, and to investigate its clinical implication in tumorigenesis and progression of gastric carcinoma...
  31. doi request reprint Cytoplasmic and nuclear maspin expression in lung carcinomas: an immunohistochemical study using tissue microarrays
    Hua Chuan Zheng
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    Appl Immunohistochem Mol Morphol 16:459-65. 2008
    ..The cytoplasmic maspin may play an important role in lung carcinomas by regulating apoptosis and thus is a favorable prognostic marker for AD patients, whereas the nuclear location may be linked to promotion of angiogenesis...
  32. ncbi request reprint The clinicopathological and prognostic significance of MUC-1 expression in Japanese gastric carcinomas: an immunohistochemical study of tissue microarrays
    Xiao Han Li
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Sugitani 2630, Toyama, Japan
    Anticancer Res 28:1061-7. 2008
    ..In malignancies, MUC-1 may function as an anti-adhesion molecule, but can also promote adhesion and presumably metastasis...
  33. doi request reprint COL4A3 expression correlates with pathogenesis, pathologic behaviors, and prognosis of gastric carcinomas
    Xiao Cui Nie
    Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang 110001, China
    Hum Pathol 44:77-86. 2013
    ..COL4A3 overexpression might be used as a marker of gastric intestinal metaplasia and mucinous and signet ring cell carcinoma...
  34. ncbi request reprint Parafibromin expression in lung normal tissue and carcinoma: its comparison with clinicopathological parameters of carcinoma
    Pu Xia
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    Histol Histopathol 26:1039-47. 2011
    ..Parafibromin expression could be employed to indicate the favorable prognosis of patients with adenocarcinoma...
  35. doi request reprint The role of RhoC in ovarian epithelial carcinoma: a marker for carcinogenesis, progression, prognosis, and target therapy
    Yang Zhao
    Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Gynecol Oncol 130:570-8. 2013
    ..Ras homolog gene family member C (RhoC) is a small G protein/guanosine triphosphatase involved in tumor mobility, invasion, and metastasis...
  36. doi request reprint MTA1 expression correlates significantly with ER-alpha methylation in breast cancer
    Xiao Yun Mao
    Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People s Republic of China
    Tumour Biol 33:1565-72. 2012
    ..These data strongly support the hypothesis that methylation is involved in the relation between MTA1 and ERα in breast cancer...
  37. doi request reprint The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression
    Ya Nan Xing
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110001, China
    Hum Pathol 42:25-35. 2011
    ..It was suggested that aberrant ING5 expression may contribute to pathogenesis, growth, and invasion of gastric carcinomas and could be considered as a promising marker to gauge aggressiveness and prognosis of gastric carcinoma...
  38. ncbi request reprint Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression
    Hua Chuan Zheng
    Department of Diagnostic Pathology, Graduate School of Medical and Pharmaceutical Sciences, University of Toyama, Toyama, 930 0194, Japan
    J Cancer Res Clin Oncol 134:481-8. 2008
    ..The aim of this study was to clarify the role of Pim-3 expression in the tumorigenesis and the development of gastric carcinomas...
  39. ncbi request reprint High JC virus load in gastric cancer and adjacent non-cancerous mucosa
    Yoshihiro Murai
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama 430 0194, Japan
    Cancer Sci 98:25-31. 2007
    ....
  40. doi request reprint Increased N-myc downstream-regulated gene 1 expression is associated with breast atypia-to-carcinoma progression
    Xiao Yun Mao
    Department of Breast Surgery, Department of Surgical Oncology, Research Unit of General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, People s Republic of China
    Tumour Biol 32:1271-6. 2011
    ..NDRG1 expression might participate in the carcinogenesis and progression of invasive breast cancer. These findings provide further evidence that NDRG1 may serve as an important biomarker for invasive breast cancer...
  41. ncbi request reprint [The secreted level of REIC protein in gastric carcinoma and its role of proliferation inhibition]
    Xiao Yan Xu
    Department of Pathophysiology, College of Basic Medicine, China Medical University, and Department of Surgical Oncology, The First Affiliated Hospital, Shenyang, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 27:568-70. 2011
    ..To detect secretory REIC content in serum from the patients with gastric carcinoma and cell culture medium of gastric carcinoma cell lines, and determine the effects of recombinant REIC on proliferation of gastric carcinoma cells...
  42. ncbi request reprint The screening of viral risk factors in tongue and pharyngolaryngeal squamous carcinoma
    Yang Zheng
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan
    Anticancer Res 30:1233-8. 2010
    ..The aim of this study is to clarify the viral risk factors for tongue and pharyngolaryngeal squamous carcinomas and the oncogenic role of DNA viruses...
  43. doi request reprint MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer
    Lei Xu
    Department of Respiratory Medicine, The 4th Affiliated Hospital of China Medical University, No 4, Shangdong Road, Yuhong District, Shenyang, Liaoning, 110032, China
    Virchows Arch 459:415-22. 2011
    ..MTA1 expression correlated with cigarette smoke in NSCLC and suggested that it may play an important role in the smoked-related progress of NSCLC...
  44. ncbi request reprint Comparison in pathological behaviours & prognosis of gastric cancers from general hospitals between China & Japan
    Miao Yu
    Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
    Indian J Med Res 132:295-302. 2010
    ..The aim of this study was to understand the difference in clinicopathological behaviours and prognosis of gastric cancer in patients from China and Japan...
  45. doi request reprint Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study
    Hekmat Osman Abdel-Aziz
    Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan
    J Cancer Res Clin Oncol 134:777-88. 2008
    ..The aim of this study was to clarify the role or related mechanisms of galectin-3 in lung carcinogenesis...
  46. doi request reprint Aberrant Beclin 1 expression is closely linked to carcinogenesis, differentiation, progression, and prognosis of ovarian epithelial carcinoma
    Yang Zhao
    Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China
    Tumour Biol 35:1955-64. 2014
    ..Beclin 1 expression might be employed to indicate the worse prognosis of ovarian carcinomas, albeit not an independent factor. ..
  47. doi request reprint Crizotinib may be used in Lewis lung carcinoma: a novel use for crizotinib
    Pu Xia
    Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, School of Basic Medical Science, China Medical University, Shenyang, Liaoning 110001, P R China
    Oncol Rep 30:139-48. 2013
    ..In these assays, crizotinib was found to dock into Smad3 and activate the Smad signaling pathway. Overall, these studies demonstrate the antitumor activity of crizotinib in LLC cell line, and provide a novel use for crizotinib...
  48. pmc The anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) on the aggressive phenotypes of ovarian carcinoma cells
    Shuo Chen
    Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang, China
    PLoS ONE 8:e79781. 2013
    ..As such, aberrant acetylation of histone H3 and H4 may play an important role in the carcinogenesis and differentiation of ovarian carcinoma. ..
  49. pmc The involvement of RhoA and Wnt-5a in the tumorigenesis and progression of ovarian epithelial carcinoma
    Shuo Chen
    Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Int J Mol Sci 14:24187-99. 2013
    ..Ras homolog gene family member A (RhoA) is involved in Wnt-5a-induced migration of gastric and breast cancer cells. We investigated the roles of RhoA and Wnt-5a in ovarian carcinoma...
  50. pmc BTG1 expression correlates with the pathogenesis and progression of ovarian carcinomas
    Yang Zhao
    Department of Gynecology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Int J Mol Sci 14:19670-80. 2013
    ..038). Altered BTG1 expression might play a role in the pathogenesis and progression of ovarian carcinoma by modulating proliferation, migration, invasion, the cell cycle, and apoptosis. ..
  51. pmc p53 nuclear accumulation and ERalpha expression in ductal hyperplasia of breast in a cohort of 215 Chinese women
    Xiao Yun Mao
    Department of Breast Surgery, Research Unit of General Surgery, The First Affiliated Hospital of China Medical University, and Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences of China Medical University, Shenyang, Liaoning Province, 110001, China
    J Exp Clin Cancer Res 29:112. 2010
    ..However, p53 nuclear accumulation and ERalpha expression have not been assessed in ductal hyperplasia co-existing with ductal carcinoma in situ (DCIS) or IDC versus pure ductal hyperplasia without DCIS or IDC...
  52. doi request reprint Distinct radiosensitivity of lung carcinoma stem-like side population and main population cells
    Pu Xia
    Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, School of Basic Medical Science, China Medical University, Shenyang, People s Republic of China
    Cancer Biother Radiopharm 28:471-8. 2013
    ..Among these, both cancer stem-like side population (SP) and main population (MP) cells may contribute to tumorigenesis and resistance to radiation therapy. However, the detailed mechanism responsible for this effect remains unknown...
  53. doi request reprint Mild hyperthermia prior to electroporation increases transfection efficiency in HCT 116, HeLa S3 and SGC 7901 cells
    Zheng Li Wei
    Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama, 930 0194, Japan
    Biotechnol Lett 32:367-71. 2010
    ..These results demonstrate that the transfection efficiency was enhanced by mild preheating. The mechanism partially involves increased macromolecular particle accumulation...
  54. ncbi request reprint Oxidative stress-induced apoptosis of bile duct cells in primary biliary cirrhosis
    Thucydides L Salunga
    Department of Pathology I, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    J Autoimmun 29:78-86. 2007
    ..We conclude that intracellular GSH reduction leads directly to BEC apoptosis. Modulation of these events will be critical to reduce immune-mediated destruction...
  55. ncbi request reprint [Altered expression of PTEN gene and LOH of its epigenetic microsatellite in gastric carcinoma]
    Jin Yi Li
    Armed Police General Hospital, Beijing 100039, China
    Zhonghua Zhong Liu Za Zhi 26:389-92. 2004
    ..To investigate the expression of PTEN and loss of heterozygosity (LOH) of its epigenetic microsatellite in gastric carcinoma and explore their roles in progression of gastric carcinoma...