Clinicopathological and Prognostic Significance of MUC-2, MUC-4 and MUC-5AC Expression in Japanese Gastric CarcinomasLi Jun Xiao
Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang, China E mail
Asian Pac J Cancer Prev 13:6447-53. 2012
..Their altered expression might therefore be employed as an indicator of pathobiological behavior...
- Role of PTEN and MMP-7 expression in growth, invasion, metastasis and angiogenesis of gastric carcinoma
Hua Chuan Zheng
The 4th Laboratory, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang, China
Pathol Int 53:659-66. 2003
..Close correlation between PTEN on MMP-7 expression provided a novel insight into the regulatory effects of PTEN on MMP-7 expression in gastric carcinoma...
Mixed-type gastric carcinomas exhibit more aggressive features and indicate the histogenesis of carcinomasHua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
Virchows Arch 452:525-34. 2008
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Overexpression of GRP78 and GRP94 are markers for aggressive behavior and poor prognosis in gastric carcinomasHua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110003, China
Hum Pathol 39:1042-9. 2008
..They were considered objective and effective markers for the aggressive behavior and poor prognosis in gastric carcinomas...
- Parafibromin expression is an independent prognostic factor for colorectal carcinomas
Hua Chuan Zheng
College of Basic Medicine, China Medical University, Shenyang 110001, China
Hum Pathol 42:1089-102. 2011
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- Arp2/3 overexpression contributed to pathogenesis, growth and invasion of gastric carcinoma
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
Anticancer Res 28:2225-32. 2008
..The aim of this study was to clarify the roles of both molecules in tumorigenesis and progression of gastric carcinomas...
- Mapping the history and current situation of research on John Cunningham virus - a bibliometric analysis
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, PR China
BMC Infect Dis 9:28. 2009
..However, no bibliometric investigation has been reported to guide the researchers and potential readers...
- SV40 T antigen disrupted the cell metabolism and the balance between proliferation and apoptosis in lens tumors of transgenic mice
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
J Cancer Res Clin Oncol 135:1521-32. 2009
..The purpose of this study was to identify the molecular changes during lens carcinogenesis and cancer progression induced by SV40 T antigen...
- The role of Reg IV gene and its encoding product in gastric carcinogenesis
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, 110001 China
Hum Pathol 41:59-69. 2010
..It was suggested that Reg IV expression should be considered as a good biomarker for gastric precancerous lesions and was especially related to the histogenic pathway of signet ring cell carcinoma...
- The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110001, China
Hum Pathol 42:424-33. 2011
..It was suggested that aberrant inhibitor of growth 5 expression may contribute to pathogenesis, growth, and invasion of colorectal carcinomas and could be considered as a promising marker to gauge aggressiveness of colorectal carcinomas...
- Nuclear or cytoplasmic localization of Bag-1 distinctly correlates with pathologic behavior and outcome of gastric carcinomas
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, 110001 China
Hum Pathol 41:724-36. 2010
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- The pathobiological behaviors and prognosis associated with Japanese gastric adenocarcinomas of pure WHO histological subtypes
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
Histol Histopathol 25:445-52. 2010
..Lower levels of proliferation and apoptosis, as well as alterations in tumor suppressor genes, mucin production and ER stress protein played important roles in the pathogenesis of poorly-differentiated and SRC carcinomas...
- Expression profile of the REG gene family in colorectal carcinoma
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
J Histochem Cytochem 59:106-15. 2011
..This study indicated that aberrant REG expression might be closely linked to the pathogenesis, invasion, or lymph node metastasis of CRCs. REG Iβ and HIP/PAP could be considered reliable markers of favorable prognosis of CRC patients...
- Downregulated parafibromin expression is a promising marker for pathogenesis, invasion, metastasis and prognosis of gastric carcinomas
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
Virchows Arch 452:147-55. 2008
..It was considered as a promising marker to indicate the aggressive behaviours and prognosis of gastric carcinomas...
- Expression of Fas ligand and caspase-3 contributes to formation of immune escape in gastric cancer
Hua Chuan Zheng
The Fourth Lab Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
World J Gastroenterol 9:1415-20. 2003
..To study the role of Fas ligand (FasL) and Caspase-3 expression in carcinogenesis and progression of gastric cancer and molecular mechanisms of relevant immune escape...
- Expression of matrix metalloproteinase-7 involving in growth, invasion, metastasis and angiogenesis of gastric cancer
Zheng Huachuan
Lab 4, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang 110001
Chin Med Sci J 18:80-6. 2003
..To investigate the role of matrix metalloproteinase-7 (MMP-7) expression in caricinogenesis and progression of gastric cancer...
- Growth, invasion, metastasis, differentiation, angiogenesis and apoptosis of gastric cancer regulated by expression of PTEN encoding products
Hua Chuan Zheng
Lab 4, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China
World J Gastroenterol 9:1662-6. 2003
..To investigate expression of PTEN in gastric cancer and to explore its roles in tumorigenesis and progression of gastric cancer...
- Up-regulated EMMPRIN/CD147 protein expression might play a role in colorectal carcinogenesis and its subsequent progression without an alteration of its glycosylation and mRNA level
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110001, China
J Cancer Res Clin Oncol 137:585-96. 2011
..The study aimed to clarify the role of EMMPRIN expression in tumorigenesis and progression of colorectal carcinomas (CRC)...
- Expression of maspin and kai1 and their clinicopathological significance in carcinogenesis and progression of gastric cancer
Hua Chuan Zheng
The Fourth Laboratory, Cancer Institute, The First Affiliated Hospital of China Medical University, Shenyang 110001
Chin Med Sci J 19:193-8. 2004
..To investigate the roles of maspin and kai1 expression in tumorigenesis and progression of gastric cancer...
- Phosphorylated GSK3beta-ser9 and EGFR are good prognostic factors for lung carcinomas
Huachuan Zheng
Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Japan
Anticancer Res 27:3561-9. 2007
..Epithelial growth factor receptor (EGFR) might phosphorylate GSK3beta into inactive phosphorylated GSK3beta-ser9 (P-GSK3beta-ser9)...
- Involvement of inactive GSK3beta overexpression in tumorigenesis and progression of gastric carcinomas
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110001, China
Hum Pathol 41:1255-64. 2010
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- Beclin 1 expression is an independent prognostic factor for gastric carcinomas
Miao Yu
Department of Surgical Oncology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China
Tumour Biol 34:1071-83. 2013
..Beclin 1 expression might be employed to indicate the favorable prognosis of gastric carcinomas as an independent factor...
- Aberrant SERCA3 expression is closely linked to pathogenesis, invasion, metastasis, and prognosis of gastric carcinomas
Xiao Yan Xu
Department of Pathophysiology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang 110001, China
Tumour Biol 33:1845-54. 2012
..It might be employed to indicate the pathobiological behaviors and prognosis of gastric carcinomas...
- REG IV overexpression in an early stage of colorectal carcinogenesis: an immunohistochemical study
Xiao Han Li
Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama 930 0194, Japan
Histol Histopathol 25:473-84. 2010
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- The clinicopathological and prognostic significance of MUC-1 expression in Japanese gastric carcinomas: an immunohistochemical study of tissue microarrays
Xiao Han Li
Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Sugitani 2630, Toyama, Japan
Anticancer Res 28:1061-7. 2008
..In malignancies, MUC-1 may function as an anti-adhesion molecule, but can also promote adhesion and presumably metastasis...
- Role and clinicopathologic significance of CXC chemokine ligand 16 and chemokine (C-X-C motif) receptor 6 expression in gastric carcinomas
Ya Nan Xing
Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang 110001, China
Hum Pathol 43:2299-307. 2012
..The expression and serum concentration of CXC chemokine ligand 16 could indicate the aggressiveness and prognosis of gastric carcinomas...
- The roles of REIC gene and its encoding product in gastric carcinoma
Xiao Yan Xu
Department of Pathophysiology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang, China
Cell Cycle 11:1414-31. 2012
..Downregulated REIC expression was closely linked to aggressive behaviors and poor prognosis of gastric carcinoma...
- PTEN expression and mutation in colorectal carcinomas
Xiao Han Li
Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Sugitani 2630, Toyama, Japan
Oncol Rep 22:757-64. 2009
..PTEN expression may be a good marker for the prognosis of colorectal carcinoma...
- PTEN encoding product: a marker for tumorigenesis and progression of gastric carcinoma
Lin Yang
No 4 Lab, Cancer Institute, The First Affiliated Hospital, China Medical University, Shenyang 110001, China
World J Gastroenterol 9:35-9. 2003
..To detect the expression of PTEN encoding product in normal mucosa, intestinal metaplasia (IM), dysplasia and carcinoma of the stomach, and to investigate its clinical implication in tumorigenesis and progression of gastric carcinoma...
- Cytoplasmic and nuclear maspin expression in lung carcinomas: an immunohistochemical study using tissue microarrays
Hua Chuan Zheng
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
Appl Immunohistochem Mol Morphol 16:459-65. 2008
..The cytoplasmic maspin may play an important role in lung carcinomas by regulating apoptosis and thus is a favorable prognostic marker for AD patients, whereas the nuclear location may be linked to promotion of angiogenesis...
- COL4A3 expression correlates with pathogenesis, pathologic behaviors, and prognosis of gastric carcinomas
Xiao Cui Nie
Department of Biochemistry and Molecular Biology, Institute of Pathology and Pathophysiology, College of Basic Medicine, China Medical University, Shenyang 110001, China
Hum Pathol 44:77-86. 2013
..COL4A3 overexpression might be used as a marker of gastric intestinal metaplasia and mucinous and signet ring cell carcinoma...
- Parafibromin expression in lung normal tissue and carcinoma: its comparison with clinicopathological parameters of carcinoma
Pu Xia
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
Histol Histopathol 26:1039-47. 2011
..Parafibromin expression could be employed to indicate the favorable prognosis of patients with adenocarcinoma...
- MTA1 expression correlates significantly with ER-alpha methylation in breast cancer
Xiao Yun Mao
Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, 110001, People s Republic of China
Tumour Biol 33:1565-72. 2012
..These data strongly support the hypothesis that methylation is involved in the relation between MTA1 and ERα in breast cancer...
- High JC virus load in gastric cancer and adjacent non-cancerous mucosa
Yoshihiro Murai
Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama 430 0194, Japan
Cancer Sci 98:25-31. 2007
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- The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression
Ya Nan Xing
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang 110001, China
Hum Pathol 42:25-35. 2011
..It was suggested that aberrant ING5 expression may contribute to pathogenesis, growth, and invasion of gastric carcinomas and could be considered as a promising marker to gauge aggressiveness and prognosis of gastric carcinoma...
- Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression
Hua Chuan Zheng
Department of Diagnostic Pathology, Graduate School of Medical and Pharmaceutical Sciences, University of Toyama, Toyama, 930 0194, Japan
J Cancer Res Clin Oncol 134:481-8. 2008
..The aim of this study was to clarify the role of Pim-3 expression in the tumorigenesis and the development of gastric carcinomas...
- Increased N-myc downstream-regulated gene 1 expression is associated with breast atypia-to-carcinoma progression
Xiao Yun Mao
Department of Breast Surgery, Department of Surgical Oncology, Research Unit of General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, People s Republic of China
Tumour Biol 32:1271-6. 2011
..NDRG1 expression might participate in the carcinogenesis and progression of invasive breast cancer. These findings provide further evidence that NDRG1 may serve as an important biomarker for invasive breast cancer...
- [The secreted level of REIC protein in gastric carcinoma and its role of proliferation inhibition]
Xiao Yan Xu
Department of Pathophysiology, College of Basic Medicine, China Medical University, and Department of Surgical Oncology, The First Affiliated Hospital, Shenyang, China
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 27:568-70. 2011
..To detect secretory REIC content in serum from the patients with gastric carcinoma and cell culture medium of gastric carcinoma cell lines, and determine the effects of recombinant REIC on proliferation of gastric carcinoma cells...
- The screening of viral risk factors in tongue and pharyngolaryngeal squamous carcinoma
Yang Zheng
Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan
Anticancer Res 30:1233-8. 2010
..The aim of this study is to clarify the viral risk factors for tongue and pharyngolaryngeal squamous carcinomas and the oncogenic role of DNA viruses...
- MTA1 expression correlates significantly with cigarette smoke in non-small cell lung cancer
Lei Xu
Department of Respiratory Medicine, The 4th Affiliated Hospital of China Medical University, No 4, Shangdong Road, Yuhong District, Shenyang, Liaoning, 110032, China
Virchows Arch 459:415-22. 2011
..MTA1 expression correlated with cigarette smoke in NSCLC and suggested that it may play an important role in the smoked-related progress of NSCLC...
- Comparison in pathological behaviours & prognosis of gastric cancers from general hospitals between China & Japan
Miao Yu
Department of Biochemistry and Molecular Biology, College of Basic Medicine, China Medical University, Shenyang, China
Indian J Med Res 132:295-302. 2010
..The aim of this study was to understand the difference in clinicopathological behaviours and prognosis of gastric cancer in patients from China and Japan...
- Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study
Hekmat Osman Abdel-Aziz
Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan
J Cancer Res Clin Oncol 134:777-88. 2008
..The aim of this study was to clarify the role or related mechanisms of galectin-3 in lung carcinogenesis...
- [Expression of PTEN-encoding product in different stages of carcinogenesis and progression of gastric carcinoma]
Hua-chuan Zheng
Fourth Laboratory, Cancer Institute, First Hospital, China Medical University, Shenyang 110001, China
Zhonghua Zhong Liu Za Zhi 25:13-6. 2003
..PTEN may be an objective marker for pathologically biological behavior of gastric carcinoma...
- p53 nuclear accumulation and ERalpha expression in ductal hyperplasia of breast in a cohort of 215 Chinese women
Xiao Yun Mao
Department of Breast Surgery, Research Unit of General Surgery, The First Affiliated Hospital of China Medical University, and Department of Biochemistry and Molecular Biology, College of Basic Medical Sciences of China Medical University, Shenyang, Liaoning Province, 110001, China
J Exp Clin Cancer Res 29:112. 2010
..However, p53 nuclear accumulation and ERalpha expression have not been assessed in ductal hyperplasia co-existing with ductal carcinoma in situ (DCIS) or IDC versus pure ductal hyperplasia without DCIS or IDC...
- Oxidative stress-induced apoptosis of bile duct cells in primary biliary cirrhosis
Thucydides L Salunga
Department of Pathology I, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
J Autoimmun 29:78-86. 2007
..We conclude that intracellular GSH reduction leads directly to BEC apoptosis. Modulation of these events will be critical to reduce immune-mediated destruction...
- Mild hyperthermia prior to electroporation increases transfection efficiency in HCT 116, HeLa S3 and SGC 7901 cells
Zheng Li Wei
Department of Radiological Sciences, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama, 930 0194, Japan
Biotechnol Lett 32:367-71. 2010
..These results demonstrate that the transfection efficiency was enhanced by mild preheating. The mechanism partially involves increased macromolecular particle accumulation...
- [Altered expression of PTEN gene and LOH of its epigenetic microsatellite in gastric carcinoma]
Jin-Yi Li
Armed Police General Hospital, Beijing 100039, China
Zhonghua Zhong Liu Za Zhi 26:389-92. 2004
..It suggests that altered PTEN gene contributes to tumorigenesis and progression of gastric carcinomas...
