Yuan lin Zheng
Wu D, Wen X, Han X, Wang S, Wang Y, Shen M, et al
. Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-126-3p Inhibits Pancreatic Cancer Development by Targeting ADAM9. Mol Ther Nucleic Acids. 2019;16:229-245 pubmed publisher
Wu D, Wang S, Wen X, Han X, Wang Y, Shen M, et al
. LncRNA SNHG15 acts as a ceRNA to regulate YAP1-Hippo signaling pathway by sponging miR-200a-3p in papillary thyroid carcinoma. Cell Death Dis. 2018;9:947 pubmed publisher
..In summary, our findings demonstrated that SNHG15 serves as a competitively endogenous RNA (ceRNA) to regulate YAP1-Hippo signaling pathway by sponging miR-200a-3p in papillary thyroid carcinoma. ..
Han X, Wen X, Wang Y, Wang S, Shen M, Zhang Z, et al
. Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia. Mol Med. 2018;24:18 pubmed publisher
..The key findings of the present study demonstrated that CREB1 gene silencing results in aggravated VD that occurs as a result of inhibiting the PKA-CREB signaling pathway, thus exasperating cognitive dysfunction. ..
Fan S, Wang Y, Wang C, Jin H, Wu Z, Lu J, et al
. Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance. Free Radic Biol Med. 2018;120:330-341 pubmed publisher
..Our findings indicate that LASS2 plays an important role in the pathogenesis of diet-induced hepatic steatosis and is a potential novel target for prevention and intervention of liver diseases. ..
Zhang Z, Shan Q, Zhuang J, Zhang Y, Wang X, Fan S, et al
. Troxerutin inhibits 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-induced hepatocyte apoptosis by restoring proteasome function. Toxicol Lett. 2015;233:246-57 pubmed publisher
..This study provides novel mechanistic insights into the toxicity of BDE-47 and indicates that troxerutin might be a candidate for the prevention of and therapy for BDE-47-induced hepatotoxicity. ..
Wu D, Hong X, Wang L, Cui X, Lu J, Chen G, et al
. MicroRNA-17 inhibition overcomes chemoresistance and suppresses epithelial-mesenchymal transition through a DEDD-dependent mechanism in gastric cancer. Int J Biochem Cell Biol. 2018;102:59-70 pubmed publisher
..From the short review above, the key findings emerge that inhibition of miR-17 may have tumor suppressive effects on GC and enhance its chemosensitivity by promoting DEDD, highlighting a novel target for GC therapy. ..
Zhang Z, Zhang Y, Fan S, Zhuang J, Zheng Y, Lu J, et al
. Troxerutin protects against 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-induced liver inflammation by attenuating oxidative stress-mediated NADâº-depletion. J Hazard Mater. 2015;283:98-109 pubmed publisher
..This study provides novel mechanistic insights into the toxicity of BDE-47 and indicates that troxerutin might be used in the prevention and therapy of BDE-47-induced hepatotoxicity. ..
Sun C, Fan S, Wang X, Lu J, Zhang Z, Wu D, et al
. Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome. J Nutr Biochem. 2015;26:1029-40 pubmed publisher
Zhuang J, Wang S, Shan Q, Zhang Z, Li M, Zheng G, et al
. Adeno-associated virus vector-mediated expression of DJ-1 attenuates learning and memory deficits in 2, 2Â´, 4, 4Â´-tetrabromodiphenyl ether (BDE-47)-treated mice. J Hazard Mater. 2018;347:390-402 pubmed publisher
..Taken together, our results demonstrate that DJ-1 plays a pivotal role in BDE-47-induced neurotoxic effects and learning and memory deficits. ..