Yuan lin Zheng

Summary

Publications

  1. Wu D, Wen X, Han X, Wang S, Wang Y, Shen M, et al. Bone Marrow Mesenchymal Stem Cell-Derived Exosomal MicroRNA-126-3p Inhibits Pancreatic Cancer Development by Targeting ADAM9. Mol Ther Nucleic Acids. 2019;16:229-245 pubmed publisher
  2. Wu D, Wang S, Wen X, Han X, Wang Y, Shen M, et al. LncRNA SNHG15 acts as a ceRNA to regulate YAP1-Hippo signaling pathway by sponging miR-200a-3p in papillary thyroid carcinoma. Cell Death Dis. 2018;9:947 pubmed publisher
    ..In summary, our findings demonstrated that SNHG15 serves as a competitively endogenous RNA (ceRNA) to regulate YAP1-Hippo signaling pathway by sponging miR-200a-3p in papillary thyroid carcinoma. ..
  3. Han X, Wen X, Wang Y, Wang S, Shen M, Zhang Z, et al. Effects of CREB1 gene silencing on cognitive dysfunction by mediating PKA-CREB signaling pathway in mice with vascular dementia. Mol Med. 2018;24:18 pubmed publisher
    ..The key findings of the present study demonstrated that CREB1 gene silencing results in aggravated VD that occurs as a result of inhibiting the PKA-CREB signaling pathway, thus exasperating cognitive dysfunction. ..
  4. Fan S, Wang Y, Wang C, Jin H, Wu Z, Lu J, et al. Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance. Free Radic Biol Med. 2018;120:330-341 pubmed publisher
    ..Our findings indicate that LASS2 plays an important role in the pathogenesis of diet-induced hepatic steatosis and is a potential novel target for prevention and intervention of liver diseases. ..
  5. Zhang Z, Shan Q, Zhuang J, Zhang Y, Wang X, Fan S, et al. Troxerutin inhibits 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-induced hepatocyte apoptosis by restoring proteasome function. Toxicol Lett. 2015;233:246-57 pubmed publisher
    ..This study provides novel mechanistic insights into the toxicity of BDE-47 and indicates that troxerutin might be a candidate for the prevention of and therapy for BDE-47-induced hepatotoxicity. ..
  6. Wu D, Hong X, Wang L, Cui X, Lu J, Chen G, et al. MicroRNA-17 inhibition overcomes chemoresistance and suppresses epithelial-mesenchymal transition through a DEDD-dependent mechanism in gastric cancer. Int J Biochem Cell Biol. 2018;102:59-70 pubmed publisher
    ..From the short review above, the key findings emerge that inhibition of miR-17 may have tumor suppressive effects on GC and enhance its chemosensitivity by promoting DEDD, highlighting a novel target for GC therapy. ..
  7. Zhang Z, Zhang Y, Fan S, Zhuang J, Zheng Y, Lu J, et al. Troxerutin protects against 2,2',4,4'-tetrabromodiphenyl ether (BDE-47)-induced liver inflammation by attenuating oxidative stress-mediated NAD⁺-depletion. J Hazard Mater. 2015;283:98-109 pubmed publisher
    ..This study provides novel mechanistic insights into the toxicity of BDE-47 and indicates that troxerutin might be used in the prevention and therapy of BDE-47-induced hepatotoxicity. ..
  8. Sun C, Fan S, Wang X, Lu J, Zhang Z, Wu D, et al. Purple sweet potato color inhibits endothelial premature senescence by blocking the NLRP3 inflammasome. J Nutr Biochem. 2015;26:1029-40 pubmed publisher
  9. Zhuang J, Wang S, Shan Q, Zhang Z, Li M, Zheng G, et al. Adeno-associated virus vector-mediated expression of DJ-1 attenuates learning and memory deficits in 2, 2´, 4, 4´-tetrabromodiphenyl ether (BDE-47)-treated mice. J Hazard Mater. 2018;347:390-402 pubmed publisher
    ..Taken together, our results demonstrate that DJ-1 plays a pivotal role in BDE-47-induced neurotoxic effects and learning and memory deficits. ..

More Information

Publications20

  1. Lu H, Jin P, Tang Y, Fan S, Zhang Z, Wang F, et al. microRNA-136 inhibits proliferation and promotes apoptosis and radiosensitivity of cervical carcinoma through the NF-κB pathway by targeting E2F1. Life Sci. 2018;199:167-178 pubmed publisher
    ..Based on our results, miR-136 inhibits proliferation, while acting to promote apoptosis and radiosensitivity in cervical carcinoma by targeting E2F1 through the NF-κB signaling pathway, resulting in improved prognoses. ..
  2. Zhuang J, Wen X, Zhang Y, Shan Q, Zhang Z, Zheng G, et al. TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice. Brain Behav Immun. 2017;65:99-110 pubmed publisher
  3. Wang X, Zhang Z, Zheng G, Wang A, Sun C, Qin S, et al. The Inhibitory Effects of Purple Sweet Potato Color on Hepatic Inflammation Is Associated with Restoration of NAD⁺ Levels and Attenuation of NLRP3 Inflammasome Activation in High-Fat-Diet-Treated Mice. Molecules. 2017;22: pubmed publisher
    ..In summary, PSPC protected against HFD-induced hepatic inflammation by boosting NAD⁺ level to inhibit NLRP3 inflammasome activation. ..
  4. Jin X, Wang S, Shen M, Wen X, Han X, Wu J, et al. Effects of rehabilitation training on apoptosis of nerve cells and the recovery of neural and motor functions in rats with ischemic stroke through the PI3K/Akt and Nrf2/ARE signaling pathways. Brain Res Bull. 2017;134:236-245 pubmed publisher
    ..Our results indicated that the rehabilitation training can inhibit the apoptosis of nerve cells as well as promote the recovery of both neural Rehabilitation training in rats with IS. ..
  5. Shen M, Wang S, Wen X, Han X, Wang Y, Zhou X, et al. Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K/Akt/mTOR signaling pathway in rats with traumatic brain injury. Biomed Pharmacother. 2017;95:885-893 pubmed publisher
    ..The data shows that Dex exerts a neuroprotective effect via the activation of the PI3K/Akt/mTOR signaling pathway in rats with TBI. ..
  6. Wang Y, Shen M, Wang S, Wen X, Han X, Zhang Z, et al. Inhibition of the TGF-?1/Smad signaling pathway protects against cartilage injury and osteoarthritis in a rat model. Life Sci. 2017;189:106-113 pubmed publisher
    ..Our findings suggested that up-regulation of TGF-?1 inhibited the TGF-?1/Smad signaling pathway acting to alleviate OA, thus highlighting the potential of the TGF-?1/Smad signaling pathway as a therapeutic target for treatment of OA. ..
  7. Cai Q, Tang Y, Fan S, Zhang Z, Li H, Huang S, et al. In vivo effects of dexmedetomidine on immune function and tumor growth in rats with ovarian cancer through inhibiting the p38MAPK/NF-?B signaling pathway. Biomed Pharmacother. 2017;95:1830-1837 pubmed publisher
    ..The findings of the study suggest that a particular dosage of DEX may act to enhance the immune function of rats with OC by inhibiting the p38MAPK/NF-?B signaling pathway. ..
  8. Jin P, Lu H, Tang Y, Fan S, Zhang Z, Wang Y, et al. The effect of DNA-PKcs gene silencing on proliferation, migration, invasion and apoptosis, and in vivo tumorigenicity of human osteosarcoma MG-63 cells. Biomed Pharmacother. 2017;96:1324-1334 pubmed publisher
    ..The observations and findings of the study suggested that the silencing of DNA-PKcs inhibits the proliferation, migration and invasion, while acting to promote cell apoptosis in MG-63 cells and osteosarcoma growth in nude mice. ..
  9. Zhang Z, Wang X, Zheng G, Shan Q, Lu J, Fan S, et al. Troxerutin Attenuates Enhancement of Hepatic Gluconeogenesis by Inhibiting NOD Activation-Mediated Inflammation in High-Fat Diet-Treated Mice. Int J Mol Sci. 2016;18: pubmed publisher
  10. Hong X, Wu D, Lu J, Zheng Y, Tu W, Yan J. Lipoprotein (a) as a Predictor of Early Stroke Recurrence in Acute Ischemic Stroke. Mol Neurobiol. 2018;55:718-726 pubmed publisher
    ..704-0.859; P < 0.01). Our findings suggest that elevated serum Lp(a) levels can predict the risk of early stroke recurrence in patients with first-ever ischemic stroke. Further research is needed to replicate these findings. ..
  11. Shan Q, Zheng G, Zhu A, Cao L, Lu J, Wu D, et al. Epigenetic modification of miR-10a regulates renal damage by targeting CREB1 in type 2 diabetes mellitus. Toxicol Appl Pharmacol. 2016;306:134-43 pubmed publisher
    ..Collectively, these results elucidate that HDAC3/miR-10a/CREB1 serves as a new mechanism underlying kidney injury, providing potential therapeutic targets in type 2 diabetes. ..