Jia Lang Zheng



  1. Wang C, Si L, Guo S, Zheng J. Negative effects of acute cadmium on stress defense, immunity, and metal homeostasis in liver of zebrafish: The protective role of environmental zinc dpre-exposure. Chemosphere. 2019;222:91-97 pubmed publisher
    ..Overall, long-term and environmental Zn pre-exposure mitigated Cd toxicity by the enhanced stress defense capacity and the down-regulated metal transport and inflammatory responses. ..
  2. Si L, Wang C, Guo S, Zheng J, Xia H. The lagged effects of environmentally relevant zinc on non-specific immunity in zebrafish. Chemosphere. 2019;214:85-93 pubmed publisher
    ..Overall, Zn acclimation persisted when fish recovered, which provides a new perspective about Zn toxicology. ..
  3. Zhu Q, Li W, Zheng J. Life-cycle exposure to cadmium induced compensatory responses towards oxidative stress in the liver of female zebrafish. Chemosphere. 2018;210:949-957 pubmed publisher
    ..Taken together, our data demonstrated that long-term and low-dose Cd induced adaptive responses with interlinked compensatory mechanism, which may protect fish against oxidative stress. ..
  4. Zheng J, Zhu Q, Wu C, Zhu A, Shen B, Zeng L. Zinc acclimation mitigated high zinc induced oxidative stress by enhancing antioxidant defenses in large yellow croaker Pseudosciaena crocea. Aquat Toxicol. 2016;172:21-9 pubmed publisher
    ..In conclusion, Zn acclimation mitigated high Zn-induced oxidative stress in large yellow croker, emphasizing a central role of transcription factor Nrf2 in the process. ..
  5. Zheng J, Yuan S, Wu C, Li W. Chronic waterborne zinc and cadmium exposures induced different responses towards oxidative stress in the liver of zebrafish. Aquat Toxicol. 2016;177:261-8 pubmed publisher
    ..The differences were not caused by the transcriptional level of related genes but depended on post-transcriptional modifications. ..
  6. Zheng J, Yuan S, Li W, Wu C. Positive and negative innate immune responses in zebrafish under light emitting diodes conditions. Fish Shellfish Immunol. 2016;56:382-387 pubmed publisher
  7. Zheng J, Yuan S, Wu C, Lv Z. Acute exposure to waterborne cadmium induced oxidative stress and immunotoxicity in the brain, ovary and liver of zebrafish (Danio rerio). Aquat Toxicol. 2016;180:36-44 pubmed publisher
  8. Yuan S, Xu H, Liu L, Zheng J. Different effects of blue and red light-emitting diodes on antioxidant responses in the liver and ovary of zebrafish Danio rerio. Fish Physiol Biochem. 2017;43:411-419 pubmed publisher
    ..In conclusion, our data demonstrated a positive effect of LDB and negative effect of LDR on fish antioxidant defenses, emphasizing the potentials of LDB as an effective light source in fish farming. ..
  9. Zheng J, Guo S, Yuan S, Xia H, Zhu Q, Lv Z. Preheating mitigates cadmium toxicity in zebrafish livers: Evidence from promoter demethylation, gene transcription to biochemical levels. Aquat Toxicol. 2017;190:104-111 pubmed publisher

More Information


  1. Zheng J, Yuan S, Wu C, Lv Z, Zhu A. Circadian time-dependent antioxidant and inflammatory responses to acute cadmium exposure in the brain of zebrafish. Aquat Toxicol. 2017;182:113-119 pubmed publisher
    ..Taken together, oxidative stress and immunotoxicity in the brain were more serious when fish were exposed to Cd in the evening than in the morning, highlighting the importance of circadian rhythm in Cd-induced neurotoxicity in fish. ..
  2. Yuan S, Lv Z, Zhu A, Zheng J, Wu C. Negative effect of chronic cadmium exposure on growth, histology, ultrastructure, antioxidant and innate immune responses in the liver of zebrafish: Preventive role of blue light emitting diodes. Ecotoxicol Environ Saf. 2017;139:18-26 pubmed publisher
    ..Finally, for the first time, our data demonstrated that LDB could protect fish against Cd toxicity. ..
  3. Guo S, Zheng J, Yuan S, Zhu Q, Wu C. Immunosuppressive effects and associated compensatory responses in zebrafish after full life-cycle exposure to environmentally relevant concentrations of cadmium. Aquat Toxicol. 2017;188:64-71 pubmed publisher
    ..Taken together, immunosuppressive effects and tissue-dependent compensatory responses were demonstrated in zebrafish after full life-cycle exposure to environmental levels of Cd, indicating a compromise between survival and immunity. ..
  4. Guo S, Zheng J, Yuan S, Zhu Q. Effects of heat and cadmium exposure on stress-related responses in the liver of female zebrafish: Heat increases cadmium toxicity. Sci Total Environ. 2018;618:1363-1370 pubmed publisher
    ..We found that heat indicators showed varied sensitivity between normal and Cd-exposed fish, emphasizing that the field metal pollution should be carefully considered when evaluating effects of climate change. ..