Zhongheng Zhang

Summary

Publications

  1. doi request reprint Effectiveness of treatment based on PiCCO parameters in critically ill patients with septic shock and/or acute respiratory distress syndrome: a randomized controlled trial
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, 351, Mingyue Road, Jinhua, 321000, Zhejiang, People s Republic of China
    Intensive Care Med 41:444-51. 2015
  2. doi request reprint Do the observational studies using propensity score analysis agree with randomized controlled trials in the area of sepsis?
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University Electronic address
    J Crit Care 29:886.e9-15. 2014
  3. doi request reprint Platelet indices are novel predictors of hospital mortality in intensive care unit patients
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Zhejiang, PR China Electronic address
    J Crit Care 29:885.e1-6. 2014
  4. doi request reprint Observational studies using propensity score analysis underestimated the effect sizes in critical care medicine
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, No 351, Mingyue Street, Jinhua, Zhejiang, 321000, P R China Electronic address
    J Clin Epidemiol 67:932-9. 2014
  5. doi request reprint Ultrasonographic measurement of the respiratory variation in the inferior vena cava diameter is predictive of fluid responsiveness in critically ill patients: systematic review and meta-analysis
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Zhejiang, People s Republic of China Electronic address
    Ultrasound Med Biol 40:845-53. 2014
  6. doi request reprint Urine output on ICU entry is associated with hospital mortality in unselected critically ill patients
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, 351, Mingyue Road, Jinhua, 321000, Zhejiang, People s Republic of China
    J Nephrol 27:65-71. 2014
  7. pmc Higher serum chloride concentrations are associated with acute kidney injury in unselected critically ill patients
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, 351, Mingyue Road, 321000 Jinhua, Zhejiang Province, China
    BMC Nephrol 14:235. 2013
  8. doi request reprint Prediction of delirium in critically ill patients with elevated C-reactive protein
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang Province 321000, P R China Electronic address
    J Crit Care 29:88-92. 2014
  9. doi request reprint Microalbuminuria can predict the development of acute kidney injury in critically ill septic patients
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province, PR China
    J Nephrol 26:724-30. 2013
  10. doi request reprint Elevated serum cystatin C at continuous renal replacement therapy initiation predicts lack of renal recovery
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Zhejiang, China
    Clin Nephrol 79:356-61. 2013

Detail Information

Publications32

  1. doi request reprint Effectiveness of treatment based on PiCCO parameters in critically ill patients with septic shock and/or acute respiratory distress syndrome: a randomized controlled trial
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, 351, Mingyue Road, Jinhua, 321000, Zhejiang, People s Republic of China
    Intensive Care Med 41:444-51. 2015
    ..To compare treatment based on either PiCCO-derived physiological values or central venous pressure (CVP) monitoring, we performed a prospective randomized controlled trial with group sequential analysis...
  2. doi request reprint Do the observational studies using propensity score analysis agree with randomized controlled trials in the area of sepsis?
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University Electronic address
    J Crit Care 29:886.e9-15. 2014
    ..However, the agreement between these two major methodological designs has never been investigated in this specific area. The present study aimed to compare the effect sizes between RCTs and PS-based studies...
  3. doi request reprint Platelet indices are novel predictors of hospital mortality in intensive care unit patients
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Zhejiang, PR China Electronic address
    J Crit Care 29:885.e1-6. 2014
    ..However, their association with mortality has never been investigated in a critical care setting. Our study aimed to investigate the association of PVI and mortality in unselected ICU patients...
  4. doi request reprint Observational studies using propensity score analysis underestimated the effect sizes in critical care medicine
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, No 351, Mingyue Street, Jinhua, Zhejiang, 321000, P R China Electronic address
    J Clin Epidemiol 67:932-9. 2014
    ..The present study aimed to compare effect sizes in PS-based observational studies vs. randomized controlled trials (RCTs) (or meta-analysis of RCTs)...
  5. doi request reprint Ultrasonographic measurement of the respiratory variation in the inferior vena cava diameter is predictive of fluid responsiveness in critically ill patients: systematic review and meta-analysis
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Zhejiang, People s Republic of China Electronic address
    Ultrasound Med Biol 40:845-53. 2014
    ..89). Our study indicates that ΔIVC measured with point-of-care ultrasonography is of great value in predicting fluid responsiveness, particularly in patients on controlled mechanical ventilation and those resuscitated with colloids. ..
  6. doi request reprint Urine output on ICU entry is associated with hospital mortality in unselected critically ill patients
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, 351, Mingyue Road, Jinhua, 321000, Zhejiang, People s Republic of China
    J Nephrol 27:65-71. 2014
    ..Urine output (UO) is routinely measured in the intensive care unit (ICU) but its prognostic value remains debated. The study aimed to investigate the association between day 1 UO and hospital mortality...
  7. pmc Higher serum chloride concentrations are associated with acute kidney injury in unselected critically ill patients
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, 351, Mingyue Road, 321000 Jinhua, Zhejiang Province, China
    BMC Nephrol 14:235. 2013
    ..Chloride administration has been found to be harmful to the kidney in critically ill patients. However the association between plasma chloride concentration and renal function has never been investigated...
  8. doi request reprint Prediction of delirium in critically ill patients with elevated C-reactive protein
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang Province 321000, P R China Electronic address
    J Crit Care 29:88-92. 2014
    ..We aimed to examine whether CRP on intensive care unit (ICU) entry was associated with subsequent development of delirium...
  9. doi request reprint Microalbuminuria can predict the development of acute kidney injury in critically ill septic patients
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province, PR China
    J Nephrol 26:724-30. 2013
    ..However, its value in predicting acute kidney injury (AKI) in an intensive care unit (ICU) setting has never been reported. This study aimed to investigate the link between MA and AKI...
  10. doi request reprint Elevated serum cystatin C at continuous renal replacement therapy initiation predicts lack of renal recovery
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Zhejiang, China
    Clin Nephrol 79:356-61. 2013
    ..The study aimed to investigate the association of CyC with renal recovery in critically ill patients requiring CRRT...
  11. doi request reprint Comparison of postpyloric tube feeding and gastric tube feeding in intensive care unit patients: a meta-analysis
    Zhongheng Zhang
    Department of Gastroenterology, Jinhua Municipal Central Hospital, Jinhua, China
    Nutr Clin Pract 28:371-80. 2013
    ..We aimed to systematically review the current evidence to see whether postpyloric feeding could provide additional benefits to intensive care unit (ICU) patients...
  12. doi request reprint Impact of delirium on clinical outcome in critically ill patients: a meta-analysis
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, 351, Mingyue Road, Jinhua, Zhejiang Province, 321000, PR China
    Gen Hosp Psychiatry 35:105-11. 2013
    ..Delirium is prevalent in the intensive care unit (ICU) and has been associated with negative clinical outcomes. However, a quantitative and systematic assessment of published studies has not been conducted...
  13. pmc Prognostic value of B-type natriuretic peptide (BNP) and its potential role in guiding fluid therapy in critically ill septic patients
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua, Zhejiang Province, People s Republic of China
    Scand J Trauma Resusc Emerg Med 20:86. 2012
    ..Furthermore, because BNP is primarily released from ventricles in response to myocardial stretch, the second aim of the study was to test whether the change in BNP was correlated to the amount of fluid balance...
  14. pmc Use of the PiCCO system in critically ill patients with septic shock and acute respiratory distress syndrome: a study protocol for a randomized controlled trial
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, 351 Mingyue Street, Jinhua City, Zhejiang, 3210002, PR China
    Trials 14:32. 2013
    ..The PiCCO (Pulse index Contour Continuous Cardiac Output, Pulsion Medical Systems, Germany) system has been developed and used in critical care settings for several years. However, its impact on clinical outcomes remains unknown...
  15. doi request reprint Prediction of pulmonary edema by plasma protein levels in patients with sepsis
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Zhejiang, People s Republic of China
    J Crit Care 27:623-9. 2012
    ..We evaluated the association of plasma protein levels with the increase in extravascular lung water index (ΔEVLWI) after fluid loading...
  16. doi request reprint Prognostic value of extravascular lung water index in critically ill patients: a systematic review of the literature
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Central Hospital, Zhejiang 321000, PR China
    J Crit Care 27:420.e1-8. 2012
    ..The prognostic value of extravascular lung water (EVLW) has been widely investigated; however, a wide range of its predictive accuracy has been reported...
  17. doi request reprint Variables associated with circuit life span in critically ill patients undergoing continuous renal replacement therapy: a prospective observational study
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Zhejiang, PR China
    ASAIO J 58:46-50. 2012
    ..Other variables of hematocrit, albumin levels, platelet count, aPTT, PT, or dose of heparin were not significantly associated with circuit life...
  18. ncbi request reprint C-reactive protein as a predictor of mortality in critically ill patients: a meta-analysis and systematic review
    Z Zhang
    Department of Critical Care Medicine, Jinhua Central Hospital, Zhejiang Province, China
    Anaesth Intensive Care 39:854-61. 2011
    ....
  19. doi request reprint Intensive- vs less-intensive-dose continuous renal replacement therapy for the intensive care unit-related acute kidney injury: a meta-analysis and systematic review
    Zhongheng Zhang
    Intensive Care Unit of Jinhua Central Hospital, Zhejiang 321000, China
    J Crit Care 25:595-600. 2010
    ..The aim of the study is to summarize the effect of intensive-dose continuous renal replacement therapy (CRRT) on the mortality and other clinical outcomes...
  20. doi request reprint Cystatin C in prediction of acute kidney injury: a systemic review and meta-analysis
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Zhejiang, People s Republic of China
    Am J Kidney Dis 58:356-65. 2011
    ..Cystatin C (CysC) has been proposed as a filtration marker for the early detection of acute kidney injury (AKI); however, a wide range of its predictive accuracy has been reported...
  21. doi request reprint Accuracy of stroke volume variation in predicting fluid responsiveness: a systematic review and meta-analysis
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Central Hospital, 351 Mingyue Road, Jinhua, 321000, Zhejiang, People s Republic of China
    J Anesth 25:904-16. 2011
    ..We therefore undertook a systematic review and meta-analysis of clinical trials that investigated the diagnostic value of SVV in predicting fluid responsiveness...
  22. doi request reprint Efficacy and safety of regional citrate anticoagulation in critically ill patients undergoing continuous renal replacement therapy
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Central Hospital, 351 Mingyue Road, Jinhua 321000, Zhejiang, China
    Intensive Care Med 38:20-8. 2012
    ..In recent years, several randomized controlled trials have been conducted to investigate its superiority over other anticoagulation modes. Thus, we performed a systematic review of available evidence on the efficacy and safety of RCA...
  23. doi request reprint Actually delivered dose of continuous renal replacement therapy is underestimated in hemofiltration
    Zhongheng Zhang
    From the Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Zhejiang, P R China
    ASAIO J 59:622-6. 2013
    ..44 (p < 0.001). K significantly overestimates Kx during CRRT, and the difference increases progressively over time. Filters are recommended to be changed at 48-72 hours on a routine basis. ..
  24. pmc Predictive value of ionized calcium in critically ill patients: an analysis of a large clinical database MIMIC II
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Zhejiang, P R China
    PLoS ONE 9:e95204. 2014
    ..However, these studies are small in sample size and the results are conflicting. The present study aimed to establish the association of iCa with mortality by using a large clinical database...
  25. doi request reprint Antipyretic therapy in critically ill patients with sepsis: an interaction with body temperature
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Zhejiang, P R China
    PLoS ONE 10:e0121919. 2015
    ..The effect of antipyretic therapy on mortality in patients with sepsis remains undetermined. The present study aimed to investigate the role of antipyretic therapy in ICU patients with sepsis by using a large clinical database...
  26. pmc The prognostic value of cardiac dysfunction assessed by bedside echocardiography in critically ill patients with COPD requiring mechanical ventilation: a study protocol
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Jinhua, Zhejiang, People s Republic of China
    BMJ Open 4:e005359. 2014
    ..Cardiac function is often impaired in this disease, but its association with clinical outcome has not been fully established...
  27. pmc Changes in brain natriuretic peptide are correlated with changes in global end-diastolic volume index
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua 321000, P R China
    J Thorac Dis 5:156-60. 2013
    ..The study aimed to investigate the correlation between the changes in BNP and the changes in GEDVI measured with transpulmonary thermodilution technique...
  28. doi request reprint Normalized lactate load is associated with development of acute kidney injury in patients who underwent cardiopulmonary bypass surgery
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Zhejiang, P R China
    PLoS ONE 10:e0120466. 2015
    ..However, the association of lactate and AKI has not been well established. The study aimed to explore the association of normalized lactate load with AKI in patients undergoing cardiac surgery...
  29. doi request reprint Prediction model for critically ill patients with acute respiratory distress syndrome
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Zhejiang, P R China
    PLoS ONE 10:e0120641. 2015
    ..Early recognition of patients at high risk of death is of vital importance in managing them. The aim of the study was to establish a prediction model by using variables that were readily available in routine clinical practice...
  30. pmc Lactate clearance as a useful biomarker for the prediction of all-cause mortality in critically ill patients: a systematic review study protocol
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Zhejiang, People s Republic of China
    BMJ Open 4:e004752. 2014
    ..However, conflicting results exist, which mandates a systematic review to clarify the association between lactate clearance and clinical outcome...
  31. doi request reprint Lactate clearance is a useful biomarker for the prediction of all-cause mortality in critically ill patients: a systematic review and meta-analysis*
    Zhongheng Zhang
    Department of Critical Care Medicine, Jinhua Municipal Central Hospital, Jinhua Hospital of Zhejiang University, Zhejiang, People s Republic of China
    Crit Care Med 42:2118-25. 2014
    ..However, the results are conflicting. The present study aimed to explore the diagnostic accuracy of lactate clearance in predicting mortality in critically or acutely ill patients...