Xiang Yang Zhang

Summary

Publications

  1. doi request reprint Family support and employment as predictors of smoking cessation success: a randomized, double-blind, placebo-controlled trial of nicotine sublingual tablets in chinese smokers
    Hong Qiang Sun
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 35:183-8. 2009
  2. ncbi request reprint Cortisol and cytokines in chronic and treatment-resistant patients with schizophrenia: association with psychopathology and response to antipsychotics
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, PR China
    Neuropsychopharmacology 30:1532-8. 2005
  3. ncbi request reprint Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, PR China
    Schizophr Res 81:291-300. 2006
  4. ncbi request reprint Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, People s Republic of China
    J Clin Psychopharmacol 27:246-51. 2007
  5. ncbi request reprint Prolactin levels in male schizophrenic patients treated with risperidone and haloperidol: a double-blind and randomized study
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, People s Republic of China
    Psychopharmacology (Berl) 178:35-40. 2005
  6. doi request reprint Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics
    Mei Hong Xiu
    Center for Biological Psychiatry, Beijing Huilongguan Hospital, Beijing, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 33:1508-12. 2009
  7. ncbi request reprint Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, China
    J Clin Psychiatry 65:940-7. 2004
  8. doi request reprint Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, PR China
    Neuropharmacology 62:1928-34. 2012
  9. doi request reprint Increased serum S100B in never-medicated and medicated schizophrenic patients
    Xiang Yang Zhang
    Institute of Psychology, Chinese Academy of Sciences, Beijing, PR China
    J Psychiatr Res 44:1236-40. 2010
  10. pmc Cigarette smoking and cognitive function in Chinese male schizophrenia: a case-control study
    Xiang Yang Zhang
    Institute of Psychology, Chinese Academy of Sciences, Beijing, People s Republic of China
    PLoS ONE 7:e36563. 2012

Collaborators

Detail Information

Publications53

  1. doi request reprint Family support and employment as predictors of smoking cessation success: a randomized, double-blind, placebo-controlled trial of nicotine sublingual tablets in chinese smokers
    Hong Qiang Sun
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 35:183-8. 2009
    ..The purpose of this study is to assess social support and demographic factors that influence the success of smoking cessation aided with sublingual nicotine tablets in a Han Chinese population...
  2. ncbi request reprint Cortisol and cytokines in chronic and treatment-resistant patients with schizophrenia: association with psychopathology and response to antipsychotics
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, PR China
    Neuropsychopharmacology 30:1532-8. 2005
    ..Our results suggest that the imbalance in the HPA axis and cytokine system in patients with SCH is implicated in clinical symptoms, and is improved with atypical antipsychotic treatment...
  3. ncbi request reprint Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, PR China
    Schizophr Res 81:291-300. 2006
    ..Long-term treatments with typical and atypical antipsychotics may produce the similar effects on the antioxidant enzymes and lipid peroxidation...
  4. ncbi request reprint Association of clozapine-induced weight gain with a polymorphism in the leptin promoter region in patients with chronic schizophrenia in a Chinese population
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, People s Republic of China
    J Clin Psychopharmacol 27:246-51. 2007
    ..004, r(2) = 0.16), but not in female patients (P > 0.05). Thus, variation in the leptin gene may be a risk factor for weight gain in male patients with schizophrenia on long-term clozapine treatment...
  5. ncbi request reprint Prolactin levels in male schizophrenic patients treated with risperidone and haloperidol: a double-blind and randomized study
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, People s Republic of China
    Psychopharmacology (Berl) 178:35-40. 2005
    ..There are few data from systematic, double-blind clinical trials that have compared the effect of the typical and the atypical antipsychotics on serum prolactin (PRL) levels in patients with schizophrenia...
  6. doi request reprint Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics
    Mei Hong Xiu
    Center for Biological Psychiatry, Beijing Huilongguan Hospital, Beijing, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 33:1508-12. 2009
    ..Our findings indicated decreased BDNF serum levels in chronic patients with schizophrenia, which may be related to clinical phenotypes, including gender, antipsychotic treatment and the severity of psychotic symptoms...
  7. ncbi request reprint Changes in serum interleukin-2, -6, and -8 levels before and during treatment with risperidone and haloperidol: relationship to outcome in schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, China
    J Clin Psychiatry 65:940-7. 2004
    ....
  8. doi request reprint Effects of risperidone and haloperidol on superoxide dismutase and nitric oxide in schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, PR China
    Neuropharmacology 62:1928-34. 2012
    ....
  9. doi request reprint Increased serum S100B in never-medicated and medicated schizophrenic patients
    Xiang Yang Zhang
    Institute of Psychology, Chinese Academy of Sciences, Beijing, PR China
    J Psychiatr Res 44:1236-40. 2010
    ..The lower S100B levels in chronic than early-stage patients further suggest that antipsychotic treatment may reduce this neurodegeneration...
  10. pmc Cigarette smoking and cognitive function in Chinese male schizophrenia: a case-control study
    Xiang Yang Zhang
    Institute of Psychology, Chinese Academy of Sciences, Beijing, People s Republic of China
    PLoS ONE 7:e36563. 2012
    ....
  11. ncbi request reprint Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, People s Republic of China corrected
    Schizophr Res 57:247-58. 2002
    ..This immune disturbance is related to the subgroup of schizophrenic patients with characteristic clinical variables. The dysfunction of interaction or inter-adjustment between different cytokines may exist in schizophrenic patients...
  12. ncbi request reprint The effect of risperidone treatment on superoxide dismutase in schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, and dagger Beijing Huilongguan Hospital, Beijing, China
    J Clin Psychopharmacol 23:128-31. 2003
    ..The limitations of this study are the measurement of SOD levels by RIA rather than biochemical assay; the 2-week washout, which may not be adequate; and the measurement of only SOD enzyme and not the other antioxidant enzymes...
  13. doi request reprint Time-dependent neuroendocrine alterations and drug craving during the first month of abstinence in heroin addicts
    Jie Shi
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 35:267-72. 2009
    ..Heroin use and withdrawal cause abnormality in the endocrine system. However, the time course of neuroendocrine alterations in heroin addicts during pharmacologically unassisted withdrawal is still unclear...
  14. doi request reprint Association of functional dopamine-beta-hydroxylase (DBH) 19 bp insertion/deletion polymorphism with smoking severity in male schizophrenic smokers
    Xiang Yang Zhang
    Institute of Psychology, Chinese Academy of Sciences, Beijing, PR China
    Schizophr Res 141:48-53. 2012
    ..These results suggest that the DBH 5'-Ins/Del polymorphism may influence smoking severity among schizophrenic smokers...
  15. ncbi request reprint Elevated blood superoxide dismutase in neuroleptic-free schizophrenia: association with positive symptoms
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing 100083, PR China
    Psychiatry Res 117:85-8. 2003
    ..Blood SOD levels were significantly elevated in schizophrenia compared with control values. SOD levels showed a positive relationship with the BRPS and the SAPS total score in patients...
  16. ncbi request reprint The effects of Ginkgo biloba extract added to haloperidol on peripheral T cell subsets in drug-free schizophrenia: a double-blind, placebo-controlled trial
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, Beijing, 100083, People s Republic of China
    Psychopharmacology (Berl) 188:12-7. 2006
    ..To investigate the effects of Ginkgo biloba extract (EGb) administration on T lymphocyte subsets and superoxide dismutase (SOD) levels in schizophrenia...
  17. ncbi request reprint Decreased BDNF in serum of patients with chronic schizophrenia on long-term treatment with antipsychotics
    Yun Long Tan
    Institute of Mental Health, Peking University, Beijing 100083, PR China
    Neurosci Lett 382:27-32. 2005
    ..These findings suggest that serum BDNF levels in chronic schizophrenia under antipsychotic medication may be decreased. However, long-term effects of antipsychotics remain to be characterized...
  18. ncbi request reprint The effect of vitamin E treatment on tardive dyskinesia and blood superoxide dismutase: a double-blind placebo-controlled trial
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, 100083 Beijing, China dagger Beijing Hui Long Guan Hospital, 100096 Beijing, China
    J Clin Psychopharmacol 24:83-6. 2004
    ..05). These results support earlier findings of the efficacy of vitamin E in the treatment of TD. Moreover, the efficacy of vitamin E may be due to its ability to increase SOD level, which may reduce oxidative injure in tardive dyskinesia...
  19. ncbi request reprint Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers
    Song Guo
    Institute of Mental Health, Peking University, Beijing, 100083, China
    Psychopharmacology (Berl) 190:449-56. 2007
    ..Recent evidence also suggests that a COMT polymorphism may be especially important in determining an individual's predisposition to developing nicotine dependence...
  20. pmc Stress enhances retrieval of drug-related memories in abstinent heroin addicts
    Li Yan Zhao
    National Institute on Drug Dependence, Peking University, Beijing, China
    Neuropsychopharmacology 35:720-6. 2010
    ..The potential of beta-adrenergic blockade to reduce or block stress-induced enhancement of drug-related memory retrieval may be relevant to preventing stress-induced relapse in abstinent heroin addicts...
  21. doi request reprint Circadian alteration in neurobiology during protracted opiate withdrawal in rats
    Su Xia Li
    National Institute on Drug Dependence, Peking University, Beijing, China
    J Neurochem 115:353-62. 2010
    ....
  22. doi request reprint Increased serum S100B levels in chronic schizophrenic patients on long-term clozapine or typical antipsychotics
    Ling Yan Qi
    Center for Biological Psychiatry, Beijing Huilongguan Hospital, Beijing, PR China
    Neurosci Lett 462:113-7. 2009
    ....
  23. ncbi request reprint Risperidone-induced increase in serum prolactin is correlated with positive symptom improvement in chronic schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, School of Medicine, Peking University, Beijing 100083, PR China
    Psychiatry Res 109:297-302. 2002
    ..The serum PRL levels at baseline could be used to predict the responses of schizophrenic patients to risperidone...
  24. doi request reprint Elevated interleukin-18 serum levels in chronic schizophrenia: Association with psychopathology
    Mei Hong Xiu
    Psychiatry Research Center, Beijing Huilongguan Hospital, Peking University, Beijing, China
    J Psychiatr Res 46:1093-8. 2012
    ..The aim of this study was to assess the clinical significance of serum IL-18 levels in various stages of schizophrenia...
  25. pmc BDNF Val66Met variant and smoking in a Chinese population
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS ONE 7:e53295. 2012
    ..However, the findings must be interpreted with caution because of the relatively small sample size for an association study. Results should be confirmed in a larger cohort...
  26. ncbi request reprint Decreased production of interleukin-2 (IL-2), IL-2 secreting cells and CD4+ cells in medication-free patients with schizophrenia
    Xiang Yang Zhang
    Institute of Mental Health, School of Medicine, Peking University, Beijing, China
    J Psychiatr Res 36:331-6. 2002
    ..The lower in vitro IL-2 production is probably related to the decreased number of T-cells that secret IL-2, as well as to the intrinsic disorder of the patients' T cells...
  27. ncbi request reprint Decreased plasma brain-derived neurotrophic factor levels in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements
    Yun Long Tan
    Institute of Mental Health, Peking University, Beijing 100083, China
    Schizophr Res 74:263-70. 2005
    ..Our results suggest that decreased BDNF may play an important role in the pathophysiology of TD. There may be a relationship between decreased BDNF levels and dyskinetic movements associated with TD...
  28. doi request reprint Socio-demographic and clinical characteristics of heavy and non-heavy smokers among schizophrenia inpatients in a Chinese Han population
    Xiang Yang Zhang
    Beijing Huilongguan Hospital, Beijing, 100096, People s Republic of China
    Psychopharmacology (Berl) 231:305-14. 2014
    ..Little is known about the association between smoking severity and clinical phenotypes in Chinese patients with schizophrenia...
  29. doi request reprint Clinical symptoms and cognitive impairment associated with male schizophrenia relate to plasma manganese superoxide dismutase activity: a case-control study
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Michael E DeBakey VA Medical Center, Houston, TX 77030, USA
    J Psychiatr Res 47:1049-53. 2013
    ..Our findings add to growing evidence that oxidative stress may be involved in the psychopathology of male schizophrenia, and its associated cognitive impairment...
  30. doi request reprint Thioredoxin, a novel oxidative stress marker and cognitive performance in chronic and medicated schizophrenia versus healthy controls
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    Schizophr Res 143:301-6. 2013
    ..The differential association of TRX and cognitive performance in schizophrenia and controls may be related to the impaired oxidative stress status of schizophrenia patients...
  31. doi request reprint Association between TNF-α promoter -308A/G polymorphism and tardive dyskinesian Chinese Han patients with schizophrenia
    Fan Wang
    National Institute on Drug Dependence, Peking University, Beijing, 100191, China
    Prog Neuropsychopharmacol Biol Psychiatry 37:106-10. 2012
    ..The present study investigated whether this variation is associated with clinical phenotypes and TD in schizophrenia in a genetically homogeneous northern Chinese Han population...
  32. doi request reprint Decreased levels of serum brain-derived neurotrophic factor in drug-naïve first-episode schizophrenia: relationship to clinical phenotypes
    Da Chun Chen
    Beijing Huilongguan Hospital, Beijing, People s Republic of China
    Psychopharmacology (Berl) 207:375-80. 2009
    ..However, there have been few systematic studies to examine the relationship between BDNF levels and psychopathology in first-episode and drug-naïve patients with schizophrenia...
  33. doi request reprint Sex difference in QTc prolongation in chronic institutionalized patients with schizophrenia on long-term treatment with typical and atypical antipsychotics
    Fu De Yang
    Beijing Huilongguan Hospital, Beijing, 100096, People s Republic of China
    Psychopharmacology (Berl) 216:9-16. 2011
    ....
  34. doi request reprint Extract of Ginkgo biloba treatment for tardive dyskinesia in schizophrenia: a randomized, double-blind, placebo-controlled trial
    Wu Fang Zhang
    Key laboratory for Mental Health, Ministry of Health, Institute of Mental Health, Peking University, China
    J Clin Psychiatry 72:615-21. 2011
    ..The aim of the study was to evaluate the efficacy of EGb-761, a standardized extract given in capsule form, in treating TD in schizophrenia patients...
  35. ncbi request reprint Blood superoxide dismutase level in schizophrenic patients with tardive dyskinesia: association with dyskinetic movements
    Xiang Yang Zhang
    Institute of Mental Health, Peking University, 100083 Beijing, China
    Schizophr Res 62:245-50. 2003
    ..Our data support the view that free radicals may be involved in the pathophysiology of TD. There may exist a relationship between the free radical metabolism and the severity of dyskinesia of TD patients...
  36. doi request reprint Cognition impairment in schizophrenia patients with tardive dyskinesia: Association with plasma superoxide dismutase activity
    Jing Qin Wu
    School of Biomedical Sciences and Pharmacy, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia Schizophrenia Research Institute, Sydney, Australia Biological Psychiatry Center, Beijing Huilongguan Hospital, Peking University, Beijing, China
    Schizophr Res 152:210-6. 2014
    ..Oxidative stress might serve as a functionally linking node between TD development and cognition dysfunction in schizophrenia. ..
  37. doi request reprint Tardive dyskinesia is associated with greater cognitive impairment in schizophrenia
    Jing Qin Wu
    School of Biomedical Sciences and Pharmacy, Faculty of Health, The University of Newcastle, University Drive, Callaghan, NSW 2308, Australia Schizophrenia Research Institute, Sydney, Australia Psychiatry Research Center, Beijing Huilongguan Hospital, Peking University, Beijing, China
    Prog Neuropsychopharmacol Biol Psychiatry 46:71-7. 2013
    ..This study examined the relationship between TD and cognitive deficits in Chinese patients with schizophrenia...
  38. doi request reprint Prevalence, demographic and clinical correlates of suicide attempts in Chinese medicated chronic inpatients with schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA
    J Psychiatr Res 47:1370-5. 2013
    ..These results suggest that Chinese inpatients with schizophrenia attempt suicide more often than the general population. Further, some demographic and clinical variables are risk factors for suicide attempts in schizophrenia. ..
  39. pmc Serum cortisol secretion during heroin abstinence is elevated only nocturnally
    Su Xia Li
    National Institute on Drug Dependence, Peking University, Beijing, China
    Am J Drug Alcohol Abuse 34:321-8. 2008
    ..The abstinent heroin-dependent participants had significantly higher plasma cortisol levels nocturnally suggesting a loss of diurnal variation in these heroin subjects...
  40. pmc The interaction of polymorphisms of IL10 and DBH was associated with general symptoms of PANSS with TD in Chinese Han schizophrenic patients
    Hongqiang Sun
    Beijing Hui Long Guan Hospital, Peking University, Beijing, China
    PLoS ONE 8:e70963. 2013
    ..The present study investigated whether these variations and their interaction were associated with clinical phenotypes of TD with schizophrenia in a genetically homogeneous northern Chinese Han population...
  41. doi request reprint Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats
    Yan qin Li
    National Institute on Drug Dependence, Peking University, 38 Xue Yuan Road, Haidian District, Beijing, China
    Psychopharmacology (Berl) 199:245-53. 2008
    ..While many manipulations used to study these consequences alter mother-infant interactions, the effects of sibling interactions are less well characterized...
  42. ncbi request reprint Effect of the BDNF Val66Met genotype on episodic memory in schizophrenia
    Yun Long Tan
    Schizophr Res 77:355-6. 2005
  43. ncbi request reprint BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, TX 77030, USA
    Neuropsychopharmacology 33:2200-5. 2008
    ..Our results suggest that variation in the BDNF gene may be a risk factor for weight gain in male patients with schizophrenia on long-term antipsychotic treatment, and decreased BDNF levels may be associated with weight gain in females...
  44. ncbi request reprint Lack of association between the BDNF C270T polymorphism and schizophrenia in a Chinese Han population
    Wenjun Li
    Schizophr Res 97:297-8. 2007
  45. doi request reprint Association between interleukin-6 receptor polymorphism and patients with schizophrenia
    Shilong Sun
    Schizophr Res 102:346-7. 2008
  46. doi request reprint Association between interleukin-3 receptor alpha polymorphism and schizophrenia in the Chinese population
    Shilong Sun
    Research Center for Neuroscience and MH Radiobiology Research Unit, Jilin University, Changchun, PR China
    Neurosci Lett 440:35-7. 2008
    ..07-1.71; Genotype, chi2=6.85, d.f.=2, p=0.033). Our results indicate a small but significant contribution of the IL3RA polymorphism to susceptibility to schizophrenia, suggesting that the IL3 pathway may be involved in schizophrenia...
  47. ncbi request reprint Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenic patients with tardive dyskinesia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Tex, USA
    J Clin Psychiatry 68:754-60. 2007
    ..However, the relationship between antioxidant enzymes, lipid peroxidation products, and the severity of TD symptoms has not been determined within a single patient group...
  48. ncbi request reprint Nicotine dependence, symptoms and oxidative stress in male patients with schizophrenia
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, 2002 Holcombe Boulevard, Houston, TX 77030, USA
    Neuropsychopharmacology 32:2020-4. 2007
    ....
  49. ncbi request reprint Serum BDNF levels and weight gain in schizophrenic patients on long-term treatment with antipsychotics
    Xiang Yang Zhang
    Menninger Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, VA Medical Center, Houston, TX 77030, USA
    J Psychiatr Res 41:997-1004. 2007
    ..Antipsychotic class exerted differential effects over BDNF levels and BMI gain. Our findings suggest that decreased BDNF levels may be associated with weight gain in female schizophrenic patients on long-term antipsychotic treatment...
  50. ncbi request reprint The interaction between superoxide dismutase and prolactin is involved in response to haloperidol and risperidone treatment in schizophrenia: a double-blind and randomized study
    Xiang Yang Zhang
    J Clin Psychopharmacol 26:103-5. 2006
  51. ncbi request reprint Brain-derived neurotrophic factor polymorphisms and smoking in schizophrenia
    Zhi Ren Wang
    Schizophr Res 97:299-301. 2007
  52. ncbi request reprint Chronic neonatal isolation stress enhances cocaine-induced increases in ventral striatal dopamine levels in rat pups
    Therese A Kosten
    Department of Psychiatry, Yale University School of Medicine, Room S 305 CMHC, 34 Park Street, New Haven, CT 06508, USA
    Brain Res Dev Brain Res 141:109-16. 2003
    ....
  53. doi request reprint The CCR5 32-bp deletion allele is rare in a Chinese population
    Fan Wang
    Schizophr Res 101:341-3. 2008