Lin Zhang

Summary

Publications

  1. ncbi request reprint Creation of a recombinant peptide substrate for fluorescence resonance energy transfer-based protease assays
    Lin Zhang
    Section on Hematology and Oncology, Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Anal Biochem 358:298-300. 2006
  2. ncbi request reprint Isolated antiplasmin deficiency presenting as a spontaneous bleeding disorder in a 63-year-old man
    Vallathucherry C Harish
    Section on Hematology and Oncology, Department of Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Blood Coagul Fibrinolysis 17:673-5. 2006
  3. ncbi request reprint Enhanced antitumor effect of the combination of tumstatin gene therapy and gemcitabine in murine models
    Bin Yao
    National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, People s Republic of China
    Hum Gene Ther 16:1075-86. 2005
  4. ncbi request reprint Construction and characterization of monoclonal antibodies specific for the R transactivator 185 of Epstein-Barr virus
    Yin Hua Zhu
    Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China
    J Virol Methods 144:12-6. 2007
  5. pmc MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration
    Lin Zhang
    Department of Environmental Health, University of Cincinnati, 123 E Shields St, Cincinnati, OH 45267 0056, USA
    Mol Cell Biol 25:60-5. 2005
  6. ncbi request reprint [The mechanism of transforming growth factor beta1 in myofibroblast differentiation]
    Hong Xu Liu
    Department of Thoracic Surgery, First Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Wai Ke Za Zhi 45:986-9. 2007
  7. ncbi request reprint [Further study on heterogeneic basis of complement C8 beta deficiency]
    Li Rao
    Department of Cardiology, West China College of Preclinical and Forensic Medicine, Key Lab of Biotherapy of Human Disease, Ministry of Education, West China Hospital, Sichuan University, Chengdu, PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:10-3. 2004
  8. ncbi request reprint MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis
    Lin Zhang
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Mol Vis 9:584-93. 2003
  9. ncbi request reprint [The role of Smad4 and MAPK proteins in signal transduction pathway in non-small cell lung cancer]
    Xiang dong Tong
    Department of Thoracic Surgery, First Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Zhong Liu Za Zhi 28:741-5. 2006
  10. doi request reprint A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy
    Lin Zhang
    Department of Medicine, Capital Medical University, Chao Yang Hospital, 8 Gong Ti South Road, Beijing 100020, China
    Circ Res 102:1426-32. 2008

Collaborators

Detail Information

Publications63

  1. ncbi request reprint Creation of a recombinant peptide substrate for fluorescence resonance energy transfer-based protease assays
    Lin Zhang
    Section on Hematology and Oncology, Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Anal Biochem 358:298-300. 2006
  2. ncbi request reprint Isolated antiplasmin deficiency presenting as a spontaneous bleeding disorder in a 63-year-old man
    Vallathucherry C Harish
    Section on Hematology and Oncology, Department of Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Blood Coagul Fibrinolysis 17:673-5. 2006
    ..Finally, since response to antifibrinolytics can be dramatic, deficiencies of antiplasmin must be considered in patients presenting at any age with a spontaneous bleeding disorder...
  3. ncbi request reprint Enhanced antitumor effect of the combination of tumstatin gene therapy and gemcitabine in murine models
    Bin Yao
    National Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, People s Republic of China
    Hum Gene Ther 16:1075-86. 2005
    ..A combination of these agents could be used in future studies and translated into the clinical setting...
  4. ncbi request reprint Construction and characterization of monoclonal antibodies specific for the R transactivator 185 of Epstein-Barr virus
    Yin Hua Zhu
    Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, China
    J Virol Methods 144:12-6. 2007
    ..The Mabs obtained in this study have a potential for the diagnosis of EBV associated diseases...
  5. pmc MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration
    Lin Zhang
    Department of Environmental Health, University of Cincinnati, 123 E Shields St, Cincinnati, OH 45267 0056, USA
    Mol Cell Biol 25:60-5. 2005
    ..Together, these pathways lead to the control of actin cytoskeleton reorganization and epithelial cell migration, contributing to the physiologic and pathological effects of activins on epithelial morphogenesis...
  6. ncbi request reprint [The mechanism of transforming growth factor beta1 in myofibroblast differentiation]
    Hong Xu Liu
    Department of Thoracic Surgery, First Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Wai Ke Za Zhi 45:986-9. 2007
    ..To investigate the mechanism underlying myofibroblast differentiation induced by transforming growth factor (TGF) beta1 in obliterative bronchiolitis following lung transplantation...
  7. ncbi request reprint [Further study on heterogeneic basis of complement C8 beta deficiency]
    Li Rao
    Department of Cardiology, West China College of Preclinical and Forensic Medicine, Key Lab of Biotherapy of Human Disease, Ministry of Education, West China Hospital, Sichuan University, Chengdu, PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 21:10-3. 2004
    ..This study was conducted by the present authors in search of other possible causes for these two C8 beta deficient individuals...
  8. ncbi request reprint MEK kinase 1 regulates c-Jun phosphorylation in the control of corneal morphogenesis
    Lin Zhang
    Center for Environmental Genetics and Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267 0056, USA
    Mol Vis 9:584-93. 2003
    ..To study the in vivo role of MEK kinase 1 (MEKK1) in corneal development...
  9. ncbi request reprint [The role of Smad4 and MAPK proteins in signal transduction pathway in non-small cell lung cancer]
    Xiang dong Tong
    Department of Thoracic Surgery, First Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Zhong Liu Za Zhi 28:741-5. 2006
    ..To investigate the expression of Smad4 in non-small cell lung cancer (NSCLC), its correlation with MAPK (mitogen activated protein kinase) and their clinical significance in NSCLC...
  10. doi request reprint A missense mutation in the CHRM2 gene is associated with familial dilated cardiomyopathy
    Lin Zhang
    Department of Medicine, Capital Medical University, Chao Yang Hospital, 8 Gong Ti South Road, Beijing 100020, China
    Circ Res 102:1426-32. 2008
    ..We also show that this variant correlates with the presence of autoantibodies against CHRM2. Patients with C722G mutation have more progressive disease, characterized by sudden death, arrhythmia, and heart failure...
  11. ncbi request reprint A neutral protease from Bacillus nematocida, another potential virulence factor in the infection against nematodes
    Qiuhong Niu
    Laboratory for Conservation and Utilization of Bio Resources, Yunnan University, Kunming, 650091, People s Republic of China
    Arch Microbiol 185:439-48. 2006
    ..These data helped to understand the interaction between this bacterial pathogen and its host...
  12. ncbi request reprint Mutation screening of mismatch repair gene Mlh3 in familial esophageal cancer
    Hong Xu Liu
    Department of Thoracic Surgery, First Hospital, China Medical University, Shenyang 110001, Liaoning Province, China
    World J Gastroenterol 12:5281-6. 2006
    ..To shed light on the possible role of mismatch repair gene Mlh3 in familial esophageal cancer (FEC)...
  13. ncbi request reprint Up-regulation of PTEN (phosphatase and tensin homolog deleted on chromosome ten) mediates p38 MAPK stress signal-induced inhibition of insulin signaling. A cross-talk between stress signaling and insulin signaling in resistin-treated human endothelial cel
    Ying H Shen
    Section of Adult Cardiac Surgery, Texas Heart Institute at St Luke s Episcopal Hospital, Houston, Texas 77030, USA
    J Biol Chem 281:7727-36. 2006
    ..Our findings suggest that resistin-mediated inhibition of insulin signaling and eNOS activation may contribute to cardiovascular diseases...
  14. ncbi request reprint Genetic polymorphisms of the DNA repair gene and risk of nasopharyngeal carcinoma
    Zhi Hui Yang
    Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China
    DNA Cell Biol 26:491-6. 2007
    ..708, 95% CI: 1.338-5.478). Conclusion: The results indicated that XRCC1 codon 194 Trp allele and XPD codon 751 Lys allele may be contributing factors in the risk of NPC...
  15. ncbi request reprint Fragile X-associated tremor/ataxia syndrome: clinical features, genetics, and testing guidelines
    Elizabeth Berry-Kravis
    Department of Pediatrics, Rush University Medical Center, Chicago, Illinois 60612, USA
    Mov Disord 22:2018-30, quiz 2140. 2007
    ..We also provide guidelines for the practitioner to assist with identifying appropriate patients for DNA testing for FXTAS, as well as recommendations for genetic counseling once a diagnosis of FXTAS is made...
  16. ncbi request reprint XIAP is highly expressed in esophageal cancer and its downregulation by RNAi sensitizes esophageal carcinoma cell lines to chemotherapeutics
    Shuguang Zhang
    Department of Thoracic Surgery, The First Affiliated Hospital, China Medical University, Shenyang, China
    Cancer Biol Ther 6:973-80. 2007
    ....
  17. ncbi request reprint Development of bovine-ovine interspecies cloned embryos and mitochondria segregation in blastomeres during preimplantation
    Song Hua
    Institute of Bioengineering, Northwest A and F University, Shaanxi Province, Yangling, China
    Anim Reprod Sci 105:245-57. 2008
    ..Considerable unequal mitochondrial segregation occurred between blastomeres from the same iSCNT embryos...
  18. ncbi request reprint Sinomenine attenuates 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice
    Hong Cheng
    Department of Internal Medicine and Geriatrics, Zhongnan Hospital, Research Center of Digestive Diseases, Wuhan University School of Medicine, Wuhan 430071, PR China
    Int Immunopharmacol 7:604-11. 2007
    ..Our findings suggest that sinomenine attenuates TNBS-induced colitis in mice and the therapeutic mechanism might be related to the reduction of up-regulated colonic TNF-alpha and IFN-gamma production caused by TNBS...
  19. ncbi request reprint Purification and cloning of a novel serine protease from the nematode-trapping fungus Dactylellina varietas and its potential roles in infection against nematodes
    Jinkui Yang
    Laboratory for Conservation and Utilization of Bio Resources, Yunnan University, Kunming, Yunnan, 650091, People s Republic of China
    Appl Microbiol Biotechnol 75:557-65. 2007
    ..Our report identified a novel pathogenic protease from the nematode-trapping fungus D. varietas, and the three-dimensional structure of this protease was predicted using the Swiss-Prot method...
  20. doi request reprint Association of matrix metalloproteinases-9 gene polymorphisms with genetic susceptibility to esophageal squamous cell carcinoma
    Jin Wu
    Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, China
    DNA Cell Biol 27:553-7. 2008
    ..Our study shows for the first time that MMP-9 gene P574R polymorphism may contribute to a genetic risk factor for ESCC in a Chinese population...
  21. ncbi request reprint [Construction of a gastric cancer related gene GCRG213-specific siRNA expression vector and its effect on gastric cancer cells in vitro]
    Li li Gao
    Department of Gastroenterology, General Hospital of PLA, Beijing 100853, China
    Zhonghua Zhong Liu Za Zhi 29:84-8. 2007
    ..To investigate the effect of gene GCRG213 siRNA transfection into gastric cancer cell line MKN45 cells...
  22. ncbi request reprint Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation
    Wen Yue
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 13:4336-44. 2007
    ..The goal of this study is to identify novel genes frequently silenced by promoter hypermethylation in lung cancer...
  23. pmc R497K polymorphism in epidermal growth factor receptor gene is associated with the risk of acute coronary syndrome
    Lin Bo Gao
    Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, Sichuan, PR China
    BMC Med Genet 9:74. 2008
    ....
  24. doi request reprint Silencing alpha-fetoprotein expression induces growth arrest and apoptosis in human hepatocellular cancer cell
    Xiaojun Yang
    Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, 730030, Gansu, China
    Cancer Lett 271:281-93. 2008
    ..As such, the knockdown of AFP gene should be further investigated in vivo as a novel approach to HCC treatment...
  25. ncbi request reprint [Study on processing for Rhizoma Pinelliae Praeparatum by comprehensive evaluation of multiple mark]
    Lin Zhang
    Nanjing University of Chinese Medicine, Nanjing 210029, China
    Zhong Yao Cai 31:20-3. 2008
    ..To investigate the best processing technology of Rhizoma Pinelliae Praeparatum...
  26. pmc Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia
    Dawei Jiang
    Libin Cardiovascular Institutes of Alberta, Department of Physiology, University of Calgary, Calgary, Alberta, Canada
    J Biol Chem 283:20813-20. 2008
    ..Together, our data support a view in which altered luminal Ca(2+) regulation of RyR1 represents a primary causal mechanism of MH...
  27. doi request reprint Single-sperm typing
    Sigbjorn Lien
    Agricultural University of Norway, Aas, Norway
    Curr Protoc Hum Genet . 2002
    ..Newer methods for studying recombination over very short distances (a few kilobases) using total sperm DNA and allele-specific PCR are also discussed...
  28. pmc Transcriptional regulation of PIK3CA oncogene by NF-kappaB in ovarian cancer microenvironment
    Nuo Yang
    Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 3:e1758. 2008
    ..These results offer a new mechanism through which the tumor microenvironment directly activates oncogenic pathways in tumor cells...
  29. doi request reprint Critical role for c-FLIP(L) on Fas resistance in colon carcinoma cell line HT-29
    Fenglin Zang
    Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute and Hospital, Tianjin Medical University, Tianjin 300060, PR China
    Cell Biol Int 32:329-36. 2008
    ..In conclusion, our study indicated that c-FLIP(L) might be a suppressor of Fas-mediated apoptosis in Fas antigen expressing colon carcinoma and therefore a potential target for novel anticancer therapies...
  30. doi request reprint Determination of vitexin and isovitexin in pigeonpea using ultrasonic extraction followed by LC-MS
    Yujie Fu
    Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, PR China
    J Sep Sci 31:268-75. 2008
    ..From all these results, we may conclude that the developed method is appropriate for the quality control of pigeonpea and other plant extract products developed from pigeonpea...
  31. ncbi request reprint MicroRNA epigenetic alterations in human cancer: one step forward in diagnosis and treatment
    Nuo Yang
    Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Int J Cancer 122:963-8. 2008
    ....
  32. ncbi request reprint PINCH-1 regulates the ERK-Bim pathway and contributes to apoptosis resistance in cancer cells
    Ka Chen
    Departments of Pathology and Pharmacology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    J Biol Chem 283:2508-17. 2008
    ..Our results demonstrate a strong dependence of multiple types of apoptosis-resistant cancer cells on PINCH-1 and provide new insights into the molecular mechanism by which cancer cells are protected from apoptosis...
  33. pmc Loss of luminal Ca2+ activation in the cardiac ryanodine receptor is associated with ventricular fibrillation and sudden death
    Dawei Jiang
    Department of Physiology and Biophysics, University of Calgary, Calgary, AB, Canada
    Proc Natl Acad Sci U S A 104:18309-14. 2007
    ..These findings also indicate that although suppressing enhanced SOICR is a promising antiarrhythmic strategy, its oversuppression can also lead to arrhythmias...
  34. ncbi request reprint miRNA genetic alterations in human cancers
    Antonis Giannakakis
    University of Pennsylvania School of Medicine, Center for Research on Early Detection and Cure of Ovarian Cancer, Rm1209 BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Expert Opin Biol Ther 7:1375-86. 2007
    ..The aim of this review is to describe miRNA expression and how its deregulation is involved in the pathophysiology of human cancers...
  35. ncbi request reprint A rapid and sensitive LC-MS/MS method for determination of coenzyme Q10 in tobacco (Nicotiana tabacum L.) leaves
    Yuangang Zu
    Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin, PR China
    J Sep Sci 29:1607-12. 2006
    ..4%. Analysis took 5 min, making the method suitable for rapid determination of CoQ10 in tobacco leaves. The proposed method has been successfully applied to the analysis of CoQ10 in the leaves from eight varieties of tobacco...
  36. ncbi request reprint Distribution of GATA86C08, GATA158G03, D11S2001 alleles in Chinese population sample
    Bing Long
    Institute of Forensic Medicine, Sichuan University West China University of Medical Sciences, Chengdu 610041, Sichuan, China
    J Forensic Sci 51:950. 2006
  37. ncbi request reprint [Expression and clinical significance of MAPK in non-small cell lung cancer]
    Zhen fa Zhang
    Department of Chest Surgery, The First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Zhonghua Yi Xue Za Zhi 85:339-42. 2005
    ....
  38. ncbi request reprint Transcriptional coactivator Drosophila eyes absent homologue 2 is up-regulated in epithelial ovarian cancer and promotes tumor growth
    Lin Zhang
    Abramson Family Cancer Research Institute, Center for Research on Reproduction and Women s Health, University of Pennsylvania School of Medicine, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Cancer Res 65:925-32. 2005
    ..Therefore, this study suggests an important role of EYA2 in ovarian cancer and its potential application as a therapeutic target...
  39. ncbi request reprint [A multiplex for simultaneous amplification of three Y-STR loci using modified primers]
    Yi Jia
    Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 36:17-9. 2005
    ..To develop a multiplex method for simultaneous detection of Y-STR loci...
  40. pmc SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells
    Manu Kohli
    Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 101:16897-902. 2004
    ..These results establish that SMAC/Diablo is essential for the apoptosis induced by NSAIDs in colon cancer cells...
  41. ncbi request reprint [Clinicopathological significance of homeobox gene BP1 mRNA expression in human breast cancer]
    Man Yu
    Oncology Central Laboratory, Tianjin Cancer Institute and Hospital, Tianjin, 300060, P R China
    Ai Zheng 23:855-9. 2004
    ..However, the reports on the function of BP1 in solid tumors are rare. The study was designed to determine the expression of BP1 gene in breast cancer and to analyze its relationship with various clinicopathological factors...
  42. ncbi request reprint [A study on the construction of allelic ladders for 4 short tandem repeat loci (D7S817, D10S1432, D10S1213 and D18S865) and their genetic polymorphism in two Chinese populations]
    Yi Jia
    Key Laboratory of Biotheraphy of Human Diseases, Ministry of Education, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 34:610-3. 2003
    ..To produce standard allelic ladders for four STR loci(D7S817, D10S1432, D10S1213 and D18S865) by recombined plasmids and use them in the research of genetic polymorphism...
  43. pmc A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure
    Lin Zhang
    Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    EMBO J 22:4443-54. 2003
    ..This study also suggests that the signaling mechanisms that control eyelid closure in mammals and dorsal closure in Drosophila are evolutionarily conserved...
  44. ncbi request reprint Sequence polymorphisms of the mitochondrial DNA control region in 105 Chinese Han population
    Li Rao
    Department of Cardiology, The First Affiliated Hospital, 610041 Sichuan University, Chengdu, PR China
    J Forensic Sci 48:891-5. 2003
  45. ncbi request reprint The oncogene phosphatidylinositol 3'-kinase catalytic subunit alpha promotes angiogenesis via vascular endothelial growth factor in ovarian carcinoma
    Lin Zhang
    Abramson Family Cancer Research Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Cancer Res 63:4225-31. 2003
    ....
  46. ncbi request reprint Screening poly [dA/dT(-)] cDNA for gene identification
    San Ming Wang
    Section of Hematology and Oncology, University of Chicago Medical Center, IL, USA
    Methods Mol Biol 221:197-205. 2003
  47. ncbi request reprint Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer
    Lin Zhang
    Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia 19104, USA
    N Engl J Med 348:203-13. 2003
    ..Although tumor-infiltrating T cells have been documented in ovarian carcinoma, a clear association with clinical outcome has not been established...
  48. pmc Role of the proposed pore-forming segment of the Ca2+ release channel (ryanodine receptor) in ryanodine interaction
    S R Wayne Chen
    Cardiovascular Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Biophys J 82:2436-47. 2002
    ..These results are consistent with the view that the proposed pore-forming segment is a critical determinant of ryanodine interaction. A putative model of ryanodine-ryanodine receptor interaction is proposed...
  49. ncbi request reprint Improved therapeutic effectiveness by combining recombinant CXC chemokine ligand 10 with Cisplatin in solid tumors
    Gang Li
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, The People s Republic of China
    Clin Cancer Res 11:4217-24. 2005
    ..CXC chemokine ligand 10 (CXCL10) is a potent inhibitor of angiogenesis. We wonder whether the combination of CXCL10 with cisplatin would improve the therapeutic antitumor efficacy...
  50. ncbi request reprint [Forensic applications of the sequencing of mitochondrial DNA cytochrome oxidase subunit I and II gene for idenfication of Sarcosaphagous flies (diptera)]
    Ji Feng Cai
    Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 36:393-6. 2005
    ....
  51. ncbi request reprint Protective effects of minocycline on behavioral changes and neurotoxicity in mice after administration of methamphetamine
    Lin Zhang
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1 8 1 Inohana, Chiba 260 8670, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1381-93. 2006
    ..Therefore, minocycline could be considered as a useful drug for the treatment of several symptoms associated with METH abuse in humans...
  52. ncbi request reprint Signature patterns revealed by microarray analyses of mice infected with influenza virus A and Streptococcus pneumoniae
    Hong Zhang
    Z BioMed Inc, 15725 Crabbs Branch Way, Rockville, MD 20855, USA
    Microbes Infect 8:2172-85. 2006
    ..The advantage of this novel approach is that the detection of pathogens is based on the differences in host gene expression profiles in response to different pathogens instead of detecting pathogens directly...
  53. ncbi request reprint [Detecting the DNA polymorphism of human complement component C8A by PCR-SSCP analysis]
    Zhi Hui Yang
    Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 37:471-3. 2006
    ..The aim of this study is to establish a new method for detecting the DNA polymorphism of human complement component C8A...
  54. ncbi request reprint [Correlation between desmin gene, platelet-activating factor acetylhydrolase gene and dilated cardiomyopathy]
    Bin Wang
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 37:391-4. 2006
    ....
  55. ncbi request reprint PUMA Dissociates Bax and Bcl-X(L) to induce apoptosis in colon cancer cells
    Lihua Ming
    Department of Pathology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 281:16034-42. 2006
    ..Together, these results indicate that PUMA initiates apoptosis in part by dissociating Bax and Bcl-X(L), thereby promoting Bax multimerization and mitochondrial translocation...
  56. ncbi request reprint Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients
    Jian Chen
    State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, PR China
    Biochem Biophys Res Commun 341:1059-65. 2006
    ..We further studied Pin1 and Nek6 mRNA level in 40 pairs of hepatocellular carcinoma cases, finding significant correlations between Nek6 and Pin1 mRNA expression levels in these samples...
  57. pmc Functional coupling of p38-induced up-regulation of BiP and activation of RNA-dependent protein kinase-like endoplasmic reticulum kinase to drug resistance of dormant carcinoma cells
    Aparna C Ranganathan
    Department of Biomedical Sciences, School of Public Health and Center for Excellence in Cancer Genomics, University at Albany, State University of New York, Rensselaer, NY 12144, USA
    Cancer Res 66:1702-11. 2006
    ..We propose that stress-dependent activation of p38 via BiP up-regulation and PERK activation protects dormant tumor cells from stress insults, such as chemotherapy...
  58. ncbi request reprint Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice
    Hong Cheng
    Department of Internal Medicine and Geriatrics, Zhongnan Hospital, Research Center of Digestive Diseases, Wuhan University School of Medicine, Wuhan 430071, PR China
    Pharmacol Res 53:202-8. 2006
    ..Our findings suggest that matrine improves TNBS-induced colitis in mice and the therapeutic mechanism might be related to the reduction of up-regulated colonic TNF-alpha production caused by TNBS...
  59. pmc Phosphatidylinositol-3-kinase signaling mediates vascular smooth muscle cell expression of periostin in vivo and in vitro
    Guohong Li
    Cardiovascular Division of Internal Medicine and Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA, USA
    Atherosclerosis 188:292-300. 2006
    ..The objective of the present study was to understand mechanisms underlying periostin upregulation in balloon-injured rat carotid arteries and in cultured vascular smooth muscle cells (VSMCs)...
  60. ncbi request reprint Human cytomegalovirus inhibits Akt-mediated eNOS activation through upregulating PTEN (phosphatase and tensin homolog deleted on chromosome 10)
    Ying H Shen
    Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Adult Cardiac Services, Texas Heart Institute, St Luke s Episcopal Hospital, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Cardiovasc Res 69:502-11. 2006
    ..In the current study, we investigated the effects of HCMV infection on eNOS activation in human aortic endothelial cells (HAECs)...
  61. ncbi request reprint [Association between phospholamban gene mutation and dilated cardiomyopathy in the Chengdu area]
    Xin Yun Chen
    Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 36:683-5. 2005
    ..To find out whether phospholamban (PLN) is the virulence gene of dilated cardiomyopathy (DCM) in the Chinese of Chengdu...
  62. ncbi request reprint Allele frequency of two STRs D8S1115 [corrected] and D8S1122 in two populations
    Gengqian Zhang
    College of Forensic Medicine, Sichuan University, Chengdu 610041, PR China
    J Forensic Sci 50:965. 2005
  63. ncbi request reprint Different effects of glucose starvation on expression and stability of VEGF mRNA isoforms in murine ovarian cancer cells
    Lin Zhang
    Center for Research on Reproduction and Women s Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Biochem Biophys Res Commun 292:860-8. 2002
    ..Our results indicate that under metabolic stress conditions VEGF144 is the most dramatically up-regulated VEGF isoform, probably through mechanism(s) different from the three abundant VEGF isoforms...