Kang Zhang

Summary

Publications

  1. ncbi request reprint Plasma Mitochondrial DNA Levels as a Biomarker of Lipodystrophy Among HIV-infected Patients Treated with Highly Active Antiretroviral Therapy (HAART)
    Z Dai
    Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Curr Mol Med 15:975-9. 2015
  2. pmc Noninvasive prenatal diagnosis of common aneuploidies by semiconductor sequencing
    Can Liao
    Department of Prenatal Diagnostic Center, Guangzhou Women and Children s Medical Center, Guangzhou Medical University, Guangzhou 510623, China
    Proc Natl Acad Sci U S A 111:7415-20. 2014
  3. doi request reprint Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
    Kang Zhang
    Department of Ophthalmology and Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Nat Rev Drug Discov 11:541-59. 2012
  4. pmc Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration
    Kang Zhang
    Shiley Eye Center and Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:6241-5. 2011
  5. doi request reprint Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration
    Jeffrey R Sommer
    Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA
    Br J Ophthalmol 95:1749-54. 2011
  6. pmc Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids
    Peter X Shaw
    Molecular Medicine Research Center and Department of Ophthalmology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Proc Natl Acad Sci U S A 109:13757-62. 2012
  7. doi request reprint P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma
    Dorota Skowronska-Krawczyk
    Shiley Eye Institute, Department of Ophthalmology and Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 59:931-40. 2015
  8. pmc WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis
    Hong Ouyang
    1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China 2 Department of Ophthalmology, and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA
    Nature 511:358-61. 2014
  9. ncbi request reprint Unusual manifestations of x-linked retinoschisis: clinical profile and diagnostic evaluation
    Dhananjay Shukla
    Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India
    Am J Ophthalmol 144:419-423. 2007
  10. pmc An essential role of the cysteine-rich domain of FZD4 in Norrin/Wnt signaling and familial exudative vitreoretinopathy
    Kang Zhang
    Molecular Medicine Research Center and Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China 610041
    J Biol Chem 286:10210-5. 2011

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Plasma Mitochondrial DNA Levels as a Biomarker of Lipodystrophy Among HIV-infected Patients Treated with Highly Active Antiretroviral Therapy (HAART)
    Z Dai
    Institute for Genomic Medicine, University of California San Diego, La Jolla, CA 92093, USA
    Curr Mol Med 15:975-9. 2015
    ..2% and a specificity of 73.0%. Our data suggest that mitochondrial DNA levels may help to guide therapy selection with regards to HIV lipodystrophy risk. ..
  2. pmc Noninvasive prenatal diagnosis of common aneuploidies by semiconductor sequencing
    Can Liao
    Department of Prenatal Diagnostic Center, Guangzhou Women and Children s Medical Center, Guangzhou Medical University, Guangzhou 510623, China
    Proc Natl Acad Sci U S A 111:7415-20. 2014
    ....
  3. doi request reprint Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma
    Kang Zhang
    Department of Ophthalmology and Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China
    Nat Rev Drug Discov 11:541-59. 2012
    ..This Review discusses the current state of ocular drug therapy and highlights future therapeutic opportunities...
  4. pmc Ciliary neurotrophic factor delivered by encapsulated cell intraocular implants for treatment of geographic atrophy in age-related macular degeneration
    Kang Zhang
    Shiley Eye Center and Institute for Genomic Medicine, University of California at San Diego, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 108:6241-5. 2011
    ..These findings suggest that CNTF delivered by the encapsulated cell technology implant appears to slow the progression of vision loss in GA, especially in eyes with 20/63 or better vision at baseline...
  5. doi request reprint Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration
    Jeffrey R Sommer
    Department of Animal Science, North Carolina State University, Raleigh, North Carolina, USA
    Br J Ophthalmol 95:1749-54. 2011
    ..The authors generated transgenic pigs expressing human disease-causing ELOVL4 mutations to better model the pathobiology of this macular disease...
  6. pmc Complement factor H genotypes impact risk of age-related macular degeneration by interaction with oxidized phospholipids
    Peter X Shaw
    Molecular Medicine Research Center and Department of Ophthalmology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China
    Proc Natl Acad Sci U S A 109:13757-62. 2012
    ..Together, these findings suggest that CFH influences AMD risk by modulating oxidative stress, inflammation, and abnormal angiogenesis...
  7. doi request reprint P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma
    Dorota Skowronska-Krawczyk
    Shiley Eye Institute, Department of Ophthalmology and Institute of Engineering in Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 59:931-40. 2015
    ..Our study provides important insights linking genetic susceptibility to the underlying mechanism of RGC death and provides a unified theory of glaucoma pathogenesis. ..
  8. pmc WNT7A and PAX6 define corneal epithelium homeostasis and pathogenesis
    Hong Ouyang
    1 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China 2 Department of Ophthalmology, and Biomaterial and Tissue Engineering Center of Institute of Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA
    Nature 511:358-61. 2014
    ..These findings suggest a central role of the WNT7A-PAX6 axis in corneal epithelial cell fate determination, and point to a new strategy for treating corneal surface diseases...
  9. ncbi request reprint Unusual manifestations of x-linked retinoschisis: clinical profile and diagnostic evaluation
    Dhananjay Shukla
    Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Madurai, Tamil Nadu, India
    Am J Ophthalmol 144:419-423. 2007
    ..To describe the unusual clinical manifestations and diagnostic evaluation of X-linked retinoschisis (XLR)...
  10. pmc An essential role of the cysteine-rich domain of FZD4 in Norrin/Wnt signaling and familial exudative vitreoretinopathy
    Kang Zhang
    Molecular Medicine Research Center and Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China 610041
    J Biol Chem 286:10210-5. 2011
    ..This study identified a new class of FZD4 gene mutations in human disease and demonstrates a critical role of the CRD in Norrin binding and activation of the β-catenin pathway...
  11. doi request reprint Slit-Robo signaling in ocular angiogenesis
    Haoyu Chen
    Chinese University of Hong Kong, Shantou, China
    Adv Exp Med Biol 664:457-63. 2010
    ..Further investigation is required to better understand Slit-Robo signaling and develop novel therapy for angiogenesis...
  12. pmc Common-path low-coherence interferometry fiber-optic sensor guided microincision
    Kang Zhang
    Johns Hopkins University, Department of Electrical and Computer Engineering, Baltimore, Maryland 21218, USA
    J Biomed Opt 16:095003. 2011
    ....
  13. doi request reprint Salidroside protects retinal endothelial cells against hydrogen peroxide-induced injury via modulating oxidative status and apoptosis
    Kai Shi
    A Department of Ophthalmology, West China Hospital, Sichuan University, Chendu, China
    Biosci Biotechnol Biochem 79:1406-13. 2015
    ..This finding presents salidroside as an attractive agent with potential to attenuate retinopathic diseases. ..
  14. pmc Genome-wide methylation profiles reveal quantitative views of human aging rates
    Gregory Hannum
    Department of Bioengineering, University of California, San Diego, San Diego, CA 92093, USA
    Mol Cell 49:359-67. 2013
    ..Our model highlights specific components of the aging process and provides a quantitative readout for studying the role of methylation in age-related disease...
  15. doi request reprint Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and Disease
    Gen Li
    From the Molecular Medicine Research Center, West China Hospital, Sichuan University, Sichuan 610041, China
    J Biol Chem 290:20448-54. 2015
    ..Thus, loss of PAX6 converts LSCs to epidermal stem cells, as demonstrated by a switch in the keratin gene expression profile and by the appearance of congenital dermoid tissue. ..
  16. doi request reprint Malattia leventinese/Doyne honeycomb retinal dystrophy in a chinese family with mutation of the EFEMP1 gene
    Ting Zhang
    Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China Molecular Medicine Research Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China Department of Ophthalmology, University of California San Diego, La Jolla, California and Institute for Genomic Medicine, University of California San Diego, La Jolla, California
    Retina 34:2462-71. 2014
    ..To characterize the clinical features and molecular genetic findings in a Chinese pedigree with Malattia leventinese/Doyne honeycomb retinal dystrophy...
  17. pmc Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP
    Fa Xing Yu
    Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA
    Cancer Cell 25:822-30. 2014
    ..This study reveals an essential role of the Hippo-YAP pathway in Gq/11-induced tumorigenesis and suggests YAP as a potential drug target for UM patients carrying mutations in GNAQ or GNA11. ..
  18. doi request reprint RAD51 gene is associated with advanced age-related macular degeneration in Chinese population
    Jie Zhou
    Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China
    Clin Biochem 46:1689-93. 2013
    ..This study aims to investigate whether variations in RAD51, B3GALTL, TNFRSF10A and REST-C4ORF14-POLR2B-IGFBP7 are associated with advanced forms of age-related macular degeneration (AMD) in Chinese population...
  19. pmc Essential role of ELOVL4 protein in very long chain fatty acid synthesis and retinal function
    Richard Harkewicz
    Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 287:11469-80. 2012
    ..Altogether, this study demonstrates the essential role of ELOVL4 in VLC-PUFA synthesis and retinal function...
  20. doi request reprint Pharmacogenomics of response to anti-VEGF therapy in exudative age-related macular degeneration
    Vaidehi S Dedania
    Department of Ophthalmology, Albany Medical Center, Lions Eye Institute, Albany, New York Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts Department of Ophthalmology, University of California, Shiley Eye Center, Institute for Genomic Medicine, La Jolla, California and Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota
    Retina 35:381-91. 2015
    ..To determine whether there is an association between response to intravitreal anti-vascular endothelial growth factor agents and genotype in patients with neovascular age-related macular degeneration...
  21. doi request reprint Lanosterol reverses protein aggregation in cataracts
    Ling Zhao
    1 Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China 2 State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou 510060, China 3 Department of Ophthalmology and Biomaterials and Tissue Engineering Center, Institute for Engineering in Medicine, University of California San Diego, La Jolla, California 92093, USA
    Nature 523:607-11. 2015
    ..Our study identifies lanosterol as a key molecule in the prevention of lens protein aggregation and points to a novel strategy for cataract prevention and treatment. ..
  22. ncbi request reprint Current therapeutic approaches in neovascular age-related macular degeneration
    Duy H Nguyen
    Department of Ophthalmology, University of California San Diego, La Jolla, California 92093, USA
    Discov Med 15:343-8. 2013
    ..Continued investigation into inhibiting VEGF as well as targeting other crucial factors that contribute to neovascular AMD is an active field of research that is expected to accelerate the progress of neovascular AMD therapy...
  23. pmc High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6
    Li Zhang
    Molecular Medicine Research Center and Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China
    J Biol Chem 287:1520-6. 2012
    ..Furthermore, we showed enhanced SMAD signaling in htra1(-/-) mice. Our data suggests a critical role of HTRA1 in the regulation of angiogenesis via TGF-β signaling and identified GDF6 as a novel disease gene for AMD...
  24. pmc Induced pluripotent stem cell therapies for geographic atrophy of age-related macular degeneration
    Hongjun Du
    Institute for Genomic Medicine and Shiley Eye Center, University of California at San Diego, La Jolla, CA 92093, USA
    Semin Ophthalmol 26:216-24. 2011
    ..For now, RPE cells and photoreceptors derived from patient-specific iPS cells can serve as a valuable tool in elucidating the mechanism of pathogenesis and drug discovery for GA...
  25. pmc Assessing susceptibility to age-related macular degeneration with genetic markers and environmental factors
    Yuhong Chen
    Institute for Genomic Medicine and Shiley Eye Center, University of California, San Diego, USA
    Arch Ophthalmol 129:344-51. 2011
    ....