Jiapu Zhang

Summary

Publications

  1. request reprint
    Zhang J. The structural stability of wild-type horse prion protein. J Biomol Struct Dyn. 2011;29:369-77 pubmed
    ..Rich databases of salt bridges, hydrogen bonds and hydrophobic contacts for horse prion protein can be found in this paper. ..
  2. request reprint
    Zhang J. Studies on the structural stability of rabbit prion probed by molecular dynamics simulations. J Biomol Struct Dyn. 2009;27:159-62 pubmed
    ..This paper studies the inhibition mechanism of rabbit prion at molecular structural level by molecular dynamics simulations. ..
  3. Zhang J. Studies on the structural stability of rabbit prion probed by molecular dynamics simulations of its wild-type and mutants. J Theor Biol. 2010;264:119-22 pubmed publisher
    ..Simulation results confirm the structural stability of wild-type rabbit prion, and show that the salt bridge between D177 and R163 greatly contributes to the structural stability of rabbit prion protein...
  4. Zhang J. Optimal molecular structures of prion AGAAAAGA amyloid fibrils formatted by simulated annealing. J Mol Model. 2011;17:173-9 pubmed publisher
    ..The results presented here confirm standard simulated annealing as an effective tool in molecular modeling. The three constructed models for amyloid fibrils may be useful in furthering the goals of medicinal chemistry in this field. ..
  5. Zhang J. Comparison studies of the structural stability of rabbit prion protein with human and mouse prion proteins. J Theor Biol. 2011;269:88-95 pubmed publisher
    ....
  6. Zhang J, Sun J, Wu C. Optimal atomic-resolution structures of prion AGAAAAGA amyloid fibrils. J Theor Biol. 2011;279:17-28 pubmed publisher
    ..The optimal atomic-resolution structures of prion AGAAAAGA amyloid fibils reported in this paper have a value to the scientific community in its drive to find treatments for prion diseases. ..
  7. request reprint
    Zhang J, Liu D. Molecular dynamics studies on the structural stability of wild-type dog prion protein. J Biomol Struct Dyn. 2011;28:861-9 pubmed
    ..We also find that the salt bridges such as D177-R163 contribute to the structural stability of wild-type rabbit prion protein under neutral pH environment. ..
  8. Zhang J, Gao D, Yearwood J. A novel canonical dual computational approach for prion AGAAAAGA amyloid fibril molecular modeling. J Theor Biol. 2011;284:149-57 pubmed publisher
    ..Overall, this paper presents an important method and provides useful information for treatments of prion diseases. ..
  9. Zhang J, Zhang Y. Molecular dynamics studies on 3D structures of the hydrophobic region PrP(109-136). Acta Biochim Biophys Sin (Shanghai). 2013;45:509-19 pubmed publisher
    ..This article gives detailed reviews on the PrP(109-136) region and presents the studies of its three-dimensional structures and structural dynamics. ..

Detail Information

Publications9

  1. request reprint
    Zhang J. The structural stability of wild-type horse prion protein. J Biomol Struct Dyn. 2011;29:369-77 pubmed
    ..Rich databases of salt bridges, hydrogen bonds and hydrophobic contacts for horse prion protein can be found in this paper. ..
  2. request reprint
    Zhang J. Studies on the structural stability of rabbit prion probed by molecular dynamics simulations. J Biomol Struct Dyn. 2009;27:159-62 pubmed
    ..This paper studies the inhibition mechanism of rabbit prion at molecular structural level by molecular dynamics simulations. ..
  3. Zhang J. Studies on the structural stability of rabbit prion probed by molecular dynamics simulations of its wild-type and mutants. J Theor Biol. 2010;264:119-22 pubmed publisher
    ..Simulation results confirm the structural stability of wild-type rabbit prion, and show that the salt bridge between D177 and R163 greatly contributes to the structural stability of rabbit prion protein...
  4. Zhang J. Optimal molecular structures of prion AGAAAAGA amyloid fibrils formatted by simulated annealing. J Mol Model. 2011;17:173-9 pubmed publisher
    ..The results presented here confirm standard simulated annealing as an effective tool in molecular modeling. The three constructed models for amyloid fibrils may be useful in furthering the goals of medicinal chemistry in this field. ..
  5. Zhang J. Comparison studies of the structural stability of rabbit prion protein with human and mouse prion proteins. J Theor Biol. 2011;269:88-95 pubmed publisher
    ....
  6. Zhang J, Sun J, Wu C. Optimal atomic-resolution structures of prion AGAAAAGA amyloid fibrils. J Theor Biol. 2011;279:17-28 pubmed publisher
    ..The optimal atomic-resolution structures of prion AGAAAAGA amyloid fibils reported in this paper have a value to the scientific community in its drive to find treatments for prion diseases. ..
  7. request reprint
    Zhang J, Liu D. Molecular dynamics studies on the structural stability of wild-type dog prion protein. J Biomol Struct Dyn. 2011;28:861-9 pubmed
    ..We also find that the salt bridges such as D177-R163 contribute to the structural stability of wild-type rabbit prion protein under neutral pH environment. ..
  8. Zhang J, Gao D, Yearwood J. A novel canonical dual computational approach for prion AGAAAAGA amyloid fibril molecular modeling. J Theor Biol. 2011;284:149-57 pubmed publisher
    ..Overall, this paper presents an important method and provides useful information for treatments of prion diseases. ..
  9. Zhang J, Zhang Y. Molecular dynamics studies on 3D structures of the hydrophobic region PrP(109-136). Acta Biochim Biophys Sin (Shanghai). 2013;45:509-19 pubmed publisher
    ..This article gives detailed reviews on the PrP(109-136) region and presents the studies of its three-dimensional structures and structural dynamics. ..