Jian Zhang

Summary

Publications

  1. ncbi request reprint Activation-induced cell death in T cells and autoimmunity
    Jian Zhang
    Departments of Orthopedic Surgery and Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Cell Mol Immunol 1:186-92. 2004
  2. pmc T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b
    Guilin Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Ave, MC 5100, Suite S 521, Chicago, IL 60637, USA
    Mol Cell Biol 28:2470-80. 2008
  3. ncbi request reprint Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation
    Dongdong Li
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 173:7135-9. 2004
  4. pmc T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells
    Guilin Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Immunol 191:632-9. 2013
  5. pmc CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis
    Tamas Bardos
    Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush Presbyterian St, Luke s Medical Center, Chicago, Illinois, USA
    Arthritis Res Ther 5:R106-13. 2003
  6. pmc E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity
    Hui Guo
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Cell Rep 1:472-82. 2012
  7. ncbi request reprint Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B
    Guilin Qiao
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 6063, USA
    J Immunol 179:4473-9. 2007
  8. pmc E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation
    Guilin Qiao
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA Committee on Immunology, University of Chicago, Chicago, IL 60637, USA Electronic address
    Cell Rep 6:709-23. 2014
  9. ncbi request reprint The effects of nimodipine on regional cerebral blood flow, brain water and electrolyte contents in rats with subarachnoid hemorrhage
    Bao Liang Sun
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Clin Hemorheol Microcirc 29:337-44. 2003
  10. ncbi request reprint [Distribution pattern of meso-micro soil fauna in Eucalyptus grandis plantation]
    Yumei Huang
    Dujiangyan Campus, Sichuan Agricultural University, Dujiangyan 611830, Sichuan, China
    Ying Yong Sheng Tai Xue Bao 17:2327-31. 2006

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Activation-induced cell death in T cells and autoimmunity
    Jian Zhang
    Departments of Orthopedic Surgery and Immunology Microbiology, Rush University Medical Center, Chicago, IL 60612, USA
    Cell Mol Immunol 1:186-92. 2004
    ..In this review, we summarize the most recent progress on the regulation of the susceptibility of T cells to AICD and its possible involvement in autoimmune diseases...
  2. pmc T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b
    Guilin Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Ave, MC 5100, Suite S 521, Chicago, IL 60637, USA
    Mol Cell Biol 28:2470-80. 2008
    ....
  3. ncbi request reprint Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation
    Dongdong Li
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    J Immunol 173:7135-9. 2004
    ..These observations indicate that CD28 and CTLA-4 tightly regulate Cbl-b expression which is critical for establishing the threshold for T cell activation...
  4. pmc T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells
    Guilin Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    J Immunol 191:632-9. 2013
    ..Furthermore, we show that Akt-2 but not Akt-1 regulates Foxp3 expression downstream of Cbl-b. Therefore, we demonstrate that Cbl-b regulates the fate of iTregs via controlling the threshold for T cell activation. ..
  5. pmc CD4+CD25+ immunoregulatory T cells may not be involved in controlling autoimmune arthritis
    Tamas Bardos
    Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush Presbyterian St, Luke s Medical Center, Chicago, Illinois, USA
    Arthritis Res Ther 5:R106-13. 2003
    ..Moreover, CD28-deficient mice, which have very few CD4+CD25+ T cells, were highly resistant to PGIA. These findings indicate that the CD4+CD25+ regulatory T cells may not play a critical role in controlling PGIA...
  6. pmc E3 ubiquitin ligase Cbl-b regulates Pten via Nedd4 in T cells independently of its ubiquitin ligase activity
    Hui Guo
    Section of Nephrology, Department of Medicine, The University of Chicago, 5841 S Maryland Avenue, Chicago, IL 60637, USA
    Cell Rep 1:472-82. 2012
    ..Hence, our data demonstrate that Cbl-b inhibits T cell activation by suppressing Pten inactivation independently of its ubiquitin ligase activity...
  7. ncbi request reprint Negative regulation of CD40-mediated B cell responses by E3 ubiquitin ligase Casitas-B-lineage lymphoma protein-B
    Guilin Qiao
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 6063, USA
    J Immunol 179:4473-9. 2007
    ..Together, our data suggest that Cbl-b attenuates CD40-mediated NF-kappaB and JNK activation, thereby suppressing B cell responses...
  8. pmc E3 ubiquitin ligase Cbl-b suppresses proallergic T cell development and allergic airway inflammation
    Guilin Qiao
    Section of Nephrology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA Committee on Immunology, University of Chicago, Chicago, IL 60637, USA Electronic address
    Cell Rep 6:709-23. 2014
    ..Therefore, our data reveal a function for Cbl-b in the regulation of Th2 and Th9 cell differentiation. ..
  9. ncbi request reprint The effects of nimodipine on regional cerebral blood flow, brain water and electrolyte contents in rats with subarachnoid hemorrhage
    Bao Liang Sun
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Clin Hemorheol Microcirc 29:337-44. 2003
    ..In conclusion, nimodipine partly prevents a decrease in cerebral blood supply and attenuates secondary cerebral ischemic injury after SAH...
  10. ncbi request reprint [Distribution pattern of meso-micro soil fauna in Eucalyptus grandis plantation]
    Yumei Huang
    Dujiangyan Campus, Sichuan Agricultural University, Dujiangyan 611830, Sichuan, China
    Ying Yong Sheng Tai Xue Bao 17:2327-31. 2006
    ..There were no significant differences in the density of meso-micro soil fauna and in the density-group index between E. grandis plantation and Quercus acutissima secondary forest...
  11. doi request reprint Recording and stimulating properties of chronically implanted longitudinal intrafascicular electrodes in peripheral fascicles in an animal model
    Xiujun Zheng
    Department of Orthopedic Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, People s Republic of China
    Microsurgery 28:203-9. 2008
    ..In conclusion, LIFEs have excellent recording and stimulating characters in addition to biocompatibility with peripheral fascicles. They can be implanted chronically into fascicles and record signals...
  12. ncbi request reprint Prediction of the interaction site on the surface of an isolated protein structure by analysis of side chain energy scores
    Shide Liang
    Department of Marine Biology, Ocean University of China, Qingdao, People s Republic of China
    Proteins 57:548-57. 2004
    ..We also found that the residue with the highest energy score on the surface of a small protomer is very possibly the key interaction residue...
  13. ncbi request reprint [NF-kappaB expression in lung tissue of acute lung injury rat model and the influence by antioxidant N-acetylcysteine]
    Jian Zhang
    Department of Respiratory Diseases, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 20:712-5. 2004
    ..To observe the NF-kappaB expression in the lung tissue of LPS-induced acute lung injury(ALI) rat model and the influence of N-acetylcysteine (NAC) on NF-kappaB expression...
  14. doi request reprint The language of medically unexplained dyspnea
    Jiangna Han
    Department of Pneumology, Peking Union Medical College Hospital, Beijing, China
    Chest 133:961-8. 2008
    ..The diagnosis is difficult. We investigated whether descriptors of dyspnea and associated symptoms of MUD are differentially diagnostic...
  15. ncbi request reprint [Clinical analysis of vascular reconstruction in 56 cases of lower extremity ischemia suffering from infrapopliteal arterial occlusion]
    Heng xi Yu
    Department of Vascular Surgery, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China
    Zhonghua Wai Ke Za Zhi 45:172-4. 2007
    ..To summarize therapeutic efficacy of vascular reconstruction in treating infrapopliteal arterial occlusion...
  16. ncbi request reprint [Expression of Endothelin-1 in laryngeal carcinoma]
    Jian Zhang
    Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China
    Lin Chuang Er Bi Yan Hou Ke Za Zhi 20:1124-5. 2006
    ..To study the expression and clinical significance of Endothelin-1 in laryngeal carcinoma...
  17. ncbi request reprint [Chemical constituents from roots Pseudostellaria heterophylla]
    Jian Zhang
    Jiangsu Provincial Academy of Traditional Chinese Medicine, Nanjing 210028, China
    Zhongguo Zhong Yao Za Zhi 32:1051-3. 2007
    ..To study the chemical constituents of Pseudostellaria heterophylla...
  18. ncbi request reprint [Targeting glycyrrhetinic acid to hepatic stellate cells in treating rat liver fibrosis]
    Qi Sheng Zhang
    Department of Gastroenterology, Branch of Shanghai No 1 People s Hospital, Shanghai 200081, China
    Zhonghua Gan Zang Bing Za Zhi 13:664-7. 2005
    ..Its organ distribution, specific combination with HSC and anti-fibrotic effect on livers were studied...
  19. ncbi request reprint [Pinus koraiensis seed consumption by rodents and birds]
    Xiao Lin Yao
    Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, China
    Ying Yong Sheng Tai Xue Bao 19:1759-63. 2008
    ..01). In addition, rodents consumed more embedded seeds in broad-leaved P. koraiensis mixed forest than in birch forest, and the consumption amount in the two forests decreased with increasing embedded depth...
  20. doi request reprint Lack of association between methylenetetrahydrofolate reductase gene A1298C polymorphism and breast cancer susceptibility
    Li Xin Qiu
    Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China
    Mol Biol Rep 38:2295-9. 2011
    ..However, large sample and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted to confirm this finding...
  21. doi request reprint The p21 Ser31Arg polymorphism and breast cancer risk: a meta-analysis involving 51,236 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 124:475-9. 2010
    ..However, large sample and representative population-based studies with homogeneous breast cancer patients and well-matched controls are warranted to confirm this finding...
  22. ncbi request reprint [Experimental study of biocompatibility of LIFEs in peripheral fascicles]
    Xiu jun Zheng
    Orthopedic Department, Zhong Shan Hospital Affiliated to FuDan University, Shanghai 200032, China
    Zhonghua Yi Xue Za Zhi 83:2152-7. 2003
    ..And to discuss the possibility of peripheral fascicular signals as a new signal source to control an electronic prosthetic hand...
  23. ncbi request reprint Effects of extract of Ginkgo biloba on spasms of the basilar artery and cerebral microcirculatory perfusion in rats with subarachnoid hemorrhage
    Bao Liang Sun
    Institute of Microcirculation, Affiliated Hospital of Taishan Medical College, Taian, Shandong 271000, China
    Clin Hemorheol Microcirc 29:231-8. 2003
    ..In conclusion, EGb, by antagonizing the overproduction of endo- thelin-1, partly reverses cerebral vasospasm and improves microcirculation, and thus relieves secondary ischemic brain injury after experimental SAH...
  24. ncbi request reprint Short-term outcome of olfactory ensheathing cells transplantation for treatment of amyotrophic lateral sclerosis
    Lin Chen
    Beijing Xishan Institute for Neuroregeneration and Functional Recovery in Shijingshan District, Beijing 100041, PR China
    Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 21:961-6. 2007
    ..To determine whether transplanting olfactory ensheathing cells (OECs) is effective in controlling or reversing the deterioration caused by amyotrophic lateral sclerosis (ALS)...
  25. doi request reprint XPD Lys751Gln polymorphism and breast cancer susceptibility: a meta-analysis involving 28,709 subjects
    Li Xin Qiu
    Department of Medical Oncology, Cancer Hospital, Fudan University, Shanghai, China
    Breast Cancer Res Treat 124:229-35. 2010
    ..20; Gln/Gln vs. Lys/Lys: OR = 1.15, 95% CI = 1.01-1.31; dominant model: OR = 1.12, 95% CI = 1.03-1.23). In conclusion, this meta-analysis suggests that the XPD 751Gln allele is a low-penetrant risk factor for developing breast cancer...
  26. ncbi request reprint [Associations between the plasma inflammatory markers and plaque morphologies of coronary artery lesions]
    Xian Wang
    Heart Centre of Beijing Army General Hospital, Beijing 100700, China
    Zhonghua Nei Ke Za Zhi 47:27-30. 2008
    ..To evaluate the vulnerability of coronary artery plaque with coronary angiography (CAG), intravascular ultrasound (IVUS) and the levels of plasma inflammatory markers...
  27. pmc Program death-1 regulates peripheral T cell tolerance via an anergy-independent mechanism
    Guilin Qiao
    Section of Nephrology, Department of Medicine, The University of Chicago, Chicago, IL 60637, USA
    Clin Immunol 143:128-33. 2012
    ..Therefore, we first demonstrate that PD-1 controls peripheral T cell tolerance via an anergy-independent but iTreg-dependent mechanism...
  28. ncbi request reprint Ubiquitin ligases in T cell activation and autoimmunity
    Jian Zhang
    Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL 60612, USA
    Clin Immunol 111:234-40. 2004
    ..This review summarizes the recent advances defining the roles of several ubiquitin ligases in T cell activation and autoimmunity...
  29. pmc Collagen-induced arthritis is exacerbated in IL-10-deficient mice
    Alison Finnegan
    Department of Medicine, Section of Rheumatology, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois, USA
    Arthritis Res Ther 5:R18-24. 2003
    ..Since IL-10 levels are elevated in rheumatoid arthritis synovial fluid, these findings may have relevance to rheumatoid arthritis...
  30. ncbi request reprint IL-4 potentiates activated T cell apoptosis via an IL-2-dependent mechanism
    Jian Zhang
    Section of Biochemistry and Molecular Biology, Department of Orthopedic Surgery, Rush University at Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Immunol 170:3495-503. 2003
    ..Furthermore, IL-4 regulates the T cell thresholds for IL-2 signaling during AICD. These data suggest that IL-4 promotes AICD via an IL-2-dependent mechanism...
  31. ncbi request reprint IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms
    Alison Finnegan
    Section of Rheumatology, Department of Medicine, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Immunol 169:3345-52. 2002
    ..Taken together, these results suggest that IL-4 regulates the severity of disease in PGIA by controlling IL-12 production, which in turn regulates the magnitude of IFN-gamma expression through a Stat4-dependent pathway...
  32. ncbi request reprint Shedding of the interleukin-6 (IL-6) receptor (gp80) determines the ability of IL-6 to induce gp130 phosphorylation in human osteoblasts
    Csaba Vermes
    Department of Orthopedic Surgery, Rush University, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Biol Chem 277:16879-87. 2002
    ..This unique mechanism provides the flexibility for osteoblasts to control their own responsiveness to IL-6 via the activation of an IL-6R sheddase, resulting in an immediate production of functionally active osteoblast-derived sIL-6R...
  33. ncbi request reprint Cutting edge: regulation of T cell activation threshold by CD28 costimulation through targeting Cbl-b for ubiquitination
    Jian Zhang
    Section of Molecular Medicine, Department of Orthopedic Surgery, Rush Medical College at Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    J Immunol 169:2236-40. 2002
    ..Our results demonstrate that CD28 costimulation regulates the threshold for T cell activation, at least in part, by promoting Cbl-b ubiquitination and degradation...
  34. pmc Prediction of geometrically feasible three-dimensional structures of pseudoknotted RNA through free energy estimation
    Jian Zhang
    Department of Bioengineering, University of Illinois at Chicago, Chicago, Illinois 60607, USA
    RNA 15:2248-63. 2009
    ..These close-to-native structures can be used as starting points for further refinement to derive accurate three-dimensional structures of RNA molecules, including those with pseudoknots...
  35. ncbi request reprint Foxp3 controls autoreactive T cell activation through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection
    Xing Chang
    Department of Pathology, Ohio State University Medical Center, 129 Hamilton Hall, 1645 Neil Avenue, Columbus, OH 43210, USA
    Clin Immunol 121:274-85. 2006
    ..The results suggest that autoreactive T cell activation is controlled by Foxp3 through transcriptional regulation of early growth response genes and E3 ubiquitin ligase genes, independently of thymic selection...
  36. ncbi request reprint Involvement of prostaglandin E2 released from leptomeningeal cells in increased expression of transforming growth factor-beta in glial cells and cortical neurons during systemic inflammation
    Zhou Wu
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    J Neurosci Res 85:184-92. 2007
    ..Furthermore, TGF-beta1 may also exert a protective effect directly on the cortical neurons...
  37. ncbi request reprint Longitudinally implanted intrafascicular electrodes for stimulating and recording fascicular physioelectrical signals in the sciatic nerve of rabbits
    Xiujun Zheng
    Department of Orthopedic Surgery, Zhong Shan Hospital, Fudan University, Shanghai, People s Republic of China
    Microsurgery 23:268-73. 2003
    ..They can provide a new way to study fascicular physioelectrical signals and their function in the activity of peripheral nerves...
  38. ncbi request reprint Impaired Fas-induced apoptosis of T lymphocytes in patients with abdominal aortic aneurysms
    Jian Zhang
    Third General Surgery Department, First Affiliated Hospital, China Medical University, Shenyang, China
    J Vasc Surg 45:1039-46. 2007
    ..The aim of this work was to assess apoptosis mediated by the cell death receptor Fas in peripheral T lymphocytes from patients with abdominal aortic aneurysms (AAA)...
  39. doi request reprint All-atom replica exchange molecular simulation of protein BBL
    Jian Zhang
    Department of Physics, National Laboratory of Solid State Microstructure, Institute of Biophysics, Nanjing University, Nanjing, China
    Proteins 72:1038-47. 2008
    ..Compared with the experimental data (Sadqi et al., Nature 2006; 442:317), our results indicate that the Naf-BBL (pH5.3) may have an even lower barrier height and cooperativity...
  40. ncbi request reprint [Chemical constituents from the flower of Paulownia fortunei( seem. ) Hemsl]
    Wen da Duan
    School of Pharmaceutical Sciences, Lanzhou University, Lanzhou 730000, China
    Zhong Yao Cai 30:168-70. 2007
    ..To study the chemical constituents of the flower of Paulownia fortunei (Seem.) Hemsl...
  41. pmc Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia
    Piotr Walczak
    Division of MR Research, Russell H Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 217 Traylor, 720 Rutland Ave, Baltimore, MD 21205 2195, USA
    Stroke 39:1569-74. 2008
    ..We assessed the suitability of laser Doppler flow (LDF) signal measurements and magnetic resonance (MR) imaging for noninvasive dual monitoring of targeted IA cell delivery...
  42. doi request reprint Improved long-term recording of nerve signal by modified intrafascicular electrodes in rabbits
    Xiaofeng Jia
    Department of Orthopedic Surgery, Zhong Shan Hospital, Fudan University, Shanghai, People s Republic of China
    Microsurgery 28:173-8. 2008
    ..05) and a greater total functioning electrode time (P = 0.006). Intrafascicular electrodes with a spring-like structure demonstrated superior potential for long-term electrophysiological monitoring over straight electrodes...
  43. pmc Conformational transition pathway in the allosteric process of human glucokinase
    Jian Zhang
    Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, and Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China
    Proc Natl Acad Sci U S A 103:13368-73. 2006
    ..These predictions also have been verified by mutagenesis and kinetic analyses in this study. These observations are beneficial to understanding the mechanism of GK regulation and designing the compounds for treating metabolic diseases...
  44. ncbi request reprint Neuroma-in-continuity model in rabbits
    Chunhui Song
    Department of Orthopedic Surgery, Fudan University, Zhong Shan Hospital, Shanghai, China
    Ann Plast Surg 57:317-22. 2006
    ..These electrophysiologic and molecular markers' expression data can be used as reliable parameters for evaluation of management of the neuroma-in-continuity...
  45. pmc Effects of disulfide bonds on folding behavior and mechanism of the beta-sheet protein tendamistat
    Meng Qin
    National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing 210093, China
    Biophys J 90:272-86. 2006
    ..The implementation of this work indicates that the modified Gō-like model really describes the folding behavior of protein tendamistat and could be used to study the folding of other disulfide-bonded proteins...
  46. ncbi request reprint Thermodynamic stability and kinetic foldability of a lattice protein model
    Jie Li
    National Lab of Solid State Microstructure and Physics Department, Nanjing University, Nanjing 210093, China
    J Chem Phys 120:6274-87. 2004
    ..The folding of model proteins with the MMJ potentials is fast. However, the relationship between the foldability and the thermodynamic stability of the mutated sequences is complex...
  47. ncbi request reprint Twists and turns of the cation-dependent mannose 6-phosphate receptor. Ligand-bound versus ligand-free receptor
    Linda J Olson
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 277:10156-61. 2002
    ..4...
  48. ncbi request reprint Discovering novel chemical inhibitors of human cyclophilin A: virtual screening, synthesis, and bioassay
    Jian Li
    Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School of the Chinese Academy of Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Bioorg Med Chem 14:2209-24. 2006
    ..5-6.2 microM. Pharmacological assay indicated that these four compounds demonstrated somewhat inhibition activities against the proliferation of spleen cells...
  49. ncbi request reprint Dynamic mechanism for the autophosphorylation of CheA histidine kinase: molecular dynamics simulations
    Jian Zhang
    Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China
    J Am Chem Soc 127:11709-19. 2005
    ..Accordingly, a mechanism of the autophosphorylation of CheA is proposed as that the ATP conformational switch triggers the opening of the ATP lid of P4, leading to P1 binding tightly, and subsequently autophosphorylation from ATP to P1...
  50. ncbi request reprint Ciliary neurotrophic factor for acceleration of peripheral nerve regeneration: an experimental study
    Jian Zhang
    Division of Plastic Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    J Reconstr Microsurg 20:323-7. 2004
    ..These results indicate that topical application of CNTF to the injury site potentiates motor nerve axonal regrowth and axon maturation during peripheral nerve regeneration...
  51. ncbi request reprint L-arginine improves cerebral blood perfusion and vasomotion of microvessels following subarachnoid hemorrhage in rats
    Bao Liang Sun
    Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Clin Hemorheol Microcirc 29:391-400. 2003
    ....
  52. ncbi request reprint [Hepatic injury induced by acute lung injury in aging rats]
    Yewei Du
    Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005, China
    Zhonghua Jie He He Hu Xi Za Zhi 25:744-7. 2002
    ..To investigate the induction of hepatic function damage by acute lung injury (ALI) in aging rats and the effect of Ginkgo Biloba extract (GBE) on this process...
  53. ncbi request reprint Synthesis of a targeting drug for antifibrosis of liver; a conjugate for delivering glycyrrhetin to hepatic stellate cells
    Jian Zhang
    State Key Laboratory of Bio organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, People s Republic of China
    Glycoconj J 19:423-9. 2002
    ..The result suggests there were 6 approximately 7 glycyrrhetin molecules having been conjugated to the carrier. Targeting glycyrrhetin to HSC might reduce its adverse affects and increase the efficacy...
  54. ncbi request reprint Longitudinal intrafascicular electrodes in collection and analysis of sensory signals of the peripheral nerve in a feline model
    Li jun Li
    Department of Orthopedic Surgery, Zhong Shan Hospital, Fudan University, Shanghai, China
    Microsurgery 25:561-5. 2005
    ..These data provide useful information for further study of control of electronic prostheses...
  55. ncbi request reprint Differential roles of constitutively activated ERK1/2 and NF-kappa B in cytotoxicity and proliferation by human NK cell lines
    Shujuan Liang
    Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua Western Road, Jinan 250012, China
    Int Immunopharmacol 5:839-48. 2005
    ....
  56. pmc An immunocompromised BALB/c mouse model for respiratory syncytial virus infection
    Xiaoyuan Kong
    Department of Internal Medicine, Division of Allergy and Immunology, Joy McCann Culverhouse Airway Disease Research Center, University of South Florida College of Medicine, USA
    Virol J 2:3. 2005
    ..BALB/c mice were treated with cyclophosphamide (CYP) and five days later, they were infected with RSV intranasally. Pulmonary RSV titers, inflammation and airway hyperresponsiveness were measured five days after infection...
  57. ncbi request reprint The binding of synthetic analogs of the upstream, terminal residue of the O-polysaccharides (O-PS) of Vibrio cholerae O:1 serotypes Ogawa and Inaba to two murine monoclonal antibodies (MAbs) specific for the Ogawa lipopolysaccharide (LPS)
    Ximan Liao
    Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health, Bethesda, MD 20892 0815, USA
    Carbohydr Res 337:2437-42. 2002
    ..The results obtained allow further rationalization of the structural basis for the binding of V. cholerae O:1 antigens to their homologous antibodies...
  58. ncbi request reprint [Targeted glycyrrhetinic acid to receptors of hepatic stellate cells for the treatment of rat liver fibrosis: a pilot study]
    Qi Sheng Zhang
    Department of Gastroenterology, The Branch of Shanghai First People s Hospital, Shanghai 200081, China
    Zhonghua Gan Zang Bing Za Zhi 12:512. 2004
  59. ncbi request reprint [The protection of seed oil of Hippophae rharmnoides on ischemic cerebral infarction in rats]
    Ti juan Cheng
    Lanzhou Medical College, Lanzhou 730000, Ganshu, China
    Zhongguo Zhong Yao Za Zhi 28:548-50. 2003
    ..To study the protection of seed oil of Hippophae rhamnoides on ischemic cerebral infarction in rats and the mechanism of the action...
  60. ncbi request reprint Chemical constituents from Alpinia tonkinensis
    Jian Zhang
    Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210038, China
    J Asian Nat Prod Res 6:199-204. 2004
    ..Their structures have been elucidated by spectral analysis...
  61. ncbi request reprint Enhancement of rat sciatic nerve regeneration by fibronectin and laminin through a silicone chamber
    Jian Zhang
    Department of Orthopedic Surgery, Zhongshan Hospital, Shanghai University, China
    J Reconstr Microsurg 19:467-72. 2003
    ..The authors conclude that local applications of fibronectin and laminin into the nerve chambers can significantly improve axonal regeneration and maturation of injured rat sciatic nerves...
  62. pmc PIRSF: family classification system at the Protein Information Resource
    Cathy H Wu
    Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, 3900 Reservoir Road, NW, Box 571414, Washington, DC 20057 1414, USA
    Nucleic Acids Res 32:D112-4. 2004
    ..PIRSF can be utilized to analyze phylogenetic profiles, to reveal functional convergence and divergence, and to identify interesting relationships between homeomorphic families, domains and structural classes...
  63. pmc Design, synthesis, and evaluation of potent and selective ligands for the dopamine 3 (D3) receptor with a novel in vivo behavioral profile
    Jianyong Chen
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Med Chem 51:5905-8. 2008
    ..Our in vivo functional assays showed that this compound is a partial agonist at the D3 receptor with no detectable activity at the D2 receptor...
  64. doi request reprint Residues on the dimer interface of SARS coronavirus 3C-like protease: dimer stability characterization and enzyme catalytic activity analysis
    Shuai Chen
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai, China
    J Biochem 143:525-36. 2008
    ..The present study would help us better understand the dimerization-activity relationship of SARS-CoV 3CL pro and afford potential information for designing anti-viral compounds targeting the dimer interface of the protease...
  65. ncbi request reprint The carboxy terminus of EmbC from Mycobacterium smegmatis mediates chain length extension of the arabinan in lipoarabinomannan
    Libin Shi
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Biol Chem 281:19512-26. 2006
    ....
  66. ncbi request reprint SPAN-XB core promoter sequence is regulated in myeloma cells by specific CpG dinucleotides associated with the MeCP2 protein
    Zhiqing Wang
    Division of Hematology and Oncology, Texas Tech University Health Sciences Center, Amarillo, TX, USA
    Int J Cancer 119:2878-84. 2006
    ..We, therefore, conclude that SPAN-XB core promoter function in myeloma cells is associated with MeCP2 protein binding and regulated by specific CpG dinucleotide sequences...
  67. pmc Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections
    Zhiqiang Qin
    Key Laboratory of Medical Molecular Virology, Ministry of Education and Ministry of Public Health, Institute of Medical Microbiology, Shanghai Medical School of Fudan University, Shanghai, PR China
    BMC Microbiol 6:96. 2006
    ..It has an urgent need to design novel antibiotics against staphylococci infections, especially those can kill cells embedded in biofilm...
  68. ncbi request reprint Acquired tolerance in cadmium-adapted lung epithelial cells: roles of the c-Jun N-terminal kinase signaling pathway and basal level of metallothionein
    Andy T Y Lau
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, People s Republic of China
    Toxicol Appl Pharmacol 215:1-8. 2006
    ....
  69. ncbi request reprint Involvement of COX-1 and up-regulated prostaglandin E synthases in phosphatidylserine liposome-induced prostaglandin E2 production by microglia
    Jian Zhang
    Laboratory of Oral Aging Science, Faculty of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 172:112-20. 2006
    ....
  70. ncbi request reprint Expression analysis of the NDRG2 gene in mouse embryonic and adult tissues
    Xiao Lan Hu
    Department of Biochemistry and Molecular Biology State Key Laboratory of Cancer Biology of China, Fourth Military Medical University, 17 Changle West Road, Xi an 710032, People s Republic of China
    Cell Tissue Res 325:67-76. 2006
    ..This is the first demonstration of Ndrg2 protein expression in both embryonic and adult mouse tissues. Our results suggest that NDRG2 plays important roles in histogenesis and organogenesis...
  71. pmc Predicting protein-protein interactions based only on sequences information
    Juwen Shen
    Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, and Graduate School of Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China
    Proc Natl Acad Sci U S A 104:4337-41. 2007
    ..In addition, such supplementary experimental information can enhance the prediction ability of the method...
  72. ncbi request reprint [The role of estrogen in the formation and development of abdominal aortic aneurysm: experiment with rats]
    Xiao Fei Wu
    Third Department of General Surgery, First Affiliated Hospital, China Medical University, Shenyang 110001, China
    Zhonghua Yi Xue Za Zhi 87:471-4. 2007
    ..To investigate the role of estrogen in the formation and development of abdominal aortic aneurysm (AAA)...
  73. ncbi request reprint Folding mechanism of beta-hairpins studied by replica exchange molecular simulations
    Jian Zhang
    National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, China
    Proteins 62:672-85. 2006
    ..It is found that the hydrogen bonds with higher stabilities need not play more important roles in the folding process, and vice versa...
  74. ncbi request reprint Adsorption of malachite green from aqueous solution onto carbon prepared from Arundo donax root
    Jian Zhang
    School of Environmental Science and Engineering, Shandong University, Jinan 250100, China
    J Hazard Mater 150:774-82. 2008
    ..Adsorption kinetics was determined using pseudo-first-order model, pseudo-second-order model and intraparticle diffusion model. The results showed that the adsorption of MG onto ADRC followed pseudo-second-order model...
  75. ncbi request reprint Synthesis and structural properties of lanthanide complexes formed with tropolonate ligands
    Jian Zhang
    Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Inorg Chem 46:6473-82. 2007
    ..This analysis will aid us in optimizing ligand design for improved photophysical properties of the complex...
  76. ncbi request reprint BioThesaurus: a web-based thesaurus of protein and gene names
    Hongfang Liu
    Department of Information Systems, University of Maryland at Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, USA
    Bioinformatics 22:103-5. 2006
    ..The BioThesaurus web site allows the retrieval of synonymous names of given protein entries and the identification of protein entries sharing the same names...
  77. ncbi request reprint Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor
    Nan Sang
    Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Neurosci 25:9858-70. 2005
    ..Our results suggest that PGE2 synthesized by postsynaptically localized COX-2 functions as a retrograde messenger in hippocampal synaptic signaling via a presynaptic EP2 receptor...
  78. ncbi request reprint Effects of zinc binding on the conformational distribution of the amyloid-beta peptide based on molecular dynamics simulations
    Wenfei Li
    National Laboratory of Solid State Microstructure and Department of Physics, Nanjing University, Nanjing 210093, China
    J Phys Chem B 111:13814-21. 2007
    ....
  79. pmc General transcription factor IIA-gamma increases osteoblast-specific osteocalcin gene expression via activating transcription factor 4 and runt-related transcription factor 2
    Shibing Yu
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15240, USA
    J Biol Chem 283:5542-53. 2008
    ..This study shows that a general transcription factor, TFIIA gamma, facilitates osteoblast-specific gene expression through interactions with two important bone transcription factors ATF4 and Runx2...
  80. ncbi request reprint Autogenous venous graft with one-stage prepared Schwann cells as a conduit for repair of long segmental nerve defects
    Feng Zhang
    Department of Orthopedic Surgery, Zhong Shan Hospital, Shanghai Medical University, Shanghai, China
    J Reconstr Microsurg 18:295-300. 2002
    ..These results suggested that isolated Schwann cells are able to survive in a vein graft, and that the vein graft with intraluminal seeded Schwann cells could be an alternative for repairing injured nerves with long gaps...