A tract-specific framework for white matter morphometry combining macroscopic and microscopic tract featuresHui Zhang
Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Med Image Anal 14:666-73. 2010
..We show that, compared to using microscopic features alone, combining the macroscopic and microscopic features gives a more complete characterization of the disease...
Evaluation of shape-based normalization in the corpus callosum for white matter connectivity analysisHui Sun
Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, USA
Med Image Comput Comput Assist Interv 10:777-84. 2007
..These results suggest that cm-rep is an appropriate tool for normalizing the MSCC in white matter studies...
- Shape-based normalization of the corpus callosum for DTI connectivity analysis
Hui Sun
Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
IEEE Trans Med Imaging 26:1166-78. 2007
..These results suggest that cm-rep is an appropriate tool for normalizing the corpus callosum in white matter studies...
- Unbiased white matter atlas construction using diffusion tensor images
Hui Zhang
Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, USA
Med Image Comput Comput Assist Interv 10:211-8. 2007
..Our results suggest that using full tensor information can better align the orientations of WM fiber bundles...
- High-dimensional spatial normalization of diffusion tensor images improves the detection of white matter differences: an example study using amyotrophic lateral sclerosis
Hui Zhang
Penn Image Computing and Science Laboratory, University of Pennsylvania, Philadelphia, PA 19104, USA
IEEE Trans Med Imaging 26:1585-97. 2007
..We also found that high-dimensional approaches, by leveraging full tensor features instead of tensor-derived indices, can further improve the alignment of WM tracts...
- A tract-specific framework for white matter morphometry combining macroscopic and microscopic tract features
Hui Zhang
Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, USA
Med Image Comput Comput Assist Interv 12:141-9. 2009
..We show that, compared to using microscopic features alone, combining the macroscopic and microscopic features gives a more holistic characterization of the disease...
- Hippocampus-specific fMRI group activation analysis using the continuous medial representation
Paul A Yushkevich
Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, 3600 Market St, Ste 370, Philadelphia, PA 19104, USA
Neuroimage 35:1516-30. 2007
..Human Brain Mapping, 2(4): 189-210) at low levels of smoothing, suggesting that greater specificity can be achieved by the new method without a severe tradeoff in sensitivity...
- Fuzzy nonparametric DTI segmentation for robust cingulum-tract extraction
Suyash P Awate
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Med Image Comput Comput Assist Interv 10:294-301. 2007
..The results on real DT images demonstrate that the proposed method extracts the cingulum bundle significantly more accurately as compared to tractography...
- Deformable registration of diffusion tensor MR images with explicit orientation optimization
Hui Zhang
Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, 3600 Market Street, Suite 370, Philadelphia, PA 19104, USA
Med Image Anal 10:764-85. 2006
..The alignment of white matter structures is assessed using a novel scheme of computing distances between the corresponding fiber bundles derived from tractography...
- Continuous medial representation for anatomical structures
Paul A Yushkevich
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
IEEE Trans Med Imaging 25:1547-64. 2006
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- Tensor-based morphometry of fibrous structures with application to human brain white matter
Hui Zhang
Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, USA
Med Image Comput Comput Assist Interv 12:466-73. 2009
..In this paper, we describe the theoretical framework of our approach in detail and illustrate its application to study brain white matter. Our results show that additional insights can be gained with the proposed analysis...
- A fuzzy, nonparametric segmentation framework for DTI and MRI analysis: with applications to DTI-tract extraction
Suyash P Awate
Penn Image Computing and Science Laboratory PICSL, Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104 USA
IEEE Trans Med Imaging 26:1525-36. 2007
..The results demonstrate that the proposed method extracts this structure significantly more accurately as compared to tractography...
- Deformable registration of diffusion tensor MR images with explicit orientation optimization
Hui Zhang
Department of Computer and Information Science, University of Pennsylvania, USA
Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 8:172-9. 2005
..A comparison with affine registration for inter-subject normalization of 8 subjects shows that our algorithm improves the alignment of manually segmented white matter structures (corpus callosum and cortio-spinal tracts)...
- Parametric medial shape representation in 3-D via the Poisson partial differential equation with non-linear boundary conditions
Paul A Yushkevich
Department of Radiology, University of Pennsylvania, USA
Inf Process Med Imaging 19:162-73. 2005
..In this paper, the representation is carefully defined and the results of fitting the hippocampus in a deformable templates framework are presented...
- Statistical modeling of shape and appearance using the continuous medial representation
Paul A Yushkevich
Department of Radiology, University of Pennsylvania, USA
Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 8:725-32. 2005
..The approach is illustrated by the principal components analysis of the shape and appearance of the hippocampus in T1-weighted MRI from a schizophrenia study...
- Hippocampus-specific fMRI group activation analysis with continuous M-Reps
Paul A Yushkevich
Penn Image Computing and Science Laboratory, University of Pennsylvania, USA
Med Image Comput Comput Assist Interv Int Conf Med Image Comput Comput Assist Interv 9:284-91. 2006
..When applied to real fMRI data, the method detects more significant hippocampal activation than the established whole-brain method...
- Structure-specific statistical mapping of white matter tracts
Paul A Yushkevich
Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA
Neuroimage 41:448-61. 2008
..The framework is demonstrated in a study of white matter differences in pediatric chromosome 22q11.2 deletion syndrome...
Multivariate analysis of structural and diffusion imaging in traumatic brain injuryBrian Avants
Department of Radiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Acad Radiol 15:1360-75. 2008
..We use this technique to study MV effects of traumatic brain injury (TBI)...
- Electromagnetic tracking for abdominal interventions in computer aided surgery
Hui Zhang
Department of Radiology, Imaging Science and Information Systems (ISIS) Center, Georgetown University, and Georgetown University Hospital, Washington, DC 20007, USA
Comput Aided Surg 11:127-36. 2006
..Based on these tests, we conclude that our system can provide quick and accurate localization of tracked instruments in abdominal interventions, and that it offers a user-friendly display for the physician...
- Pentazocine-induced antinociception is mediated mainly by μ-opioid receptors and compromised by κ-opioid receptors in mice
Haihua Shu
Department of Anesthesiology, First Affiliated Hospital of Sun Yat sen University, 58 Zhongshan 2nd Road, Guangzhou, Guangdong, 510080, China
J Pharmacol Exp Ther 338:579-87. 2011
..This provides the first reasonable hypothesis to explain the ceiling effects of pentazocine analgesia characterized by a biphasic dose response...
- Ad.mda-7 (IL-24) selectively induces apoptosis in hepatocellular carcinoma cell lines, suppresses metastasis, and enhances the effect of doxorubicin on xenograft tumors
Cong Jun Wang
Department of General Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China
Oncol Res 18:561-74. 2010
..MDA-7/IL-24 represents a new class of cancer suppressor genes that may be useful in the targeted therapy of HCC...
- [Effect of different treatment methods on quality of American ginseng roots]
Yuan Li
College of Food Science and Nutritional Engineering, China Agricultural University Key Laboratory of Fruits Vegetables Processing, Beijing 100193, China
Zhongguo Zhong Yao Za Zhi 35:145-8. 2010
..In general, the treatment A is more benefit to keep the quality of fresh roots of American Ginseng during 180 days of storage...
- The Bragg gap vanishing phenomena in one-dimensional photonic crystals
Hui Zhang
College of Electronic Science and Engineering, National University of Defense Technology, Changsha, Hunan, PR China
Opt Express 17:7800-6. 2009
..The experimental results and the simulations agree extremely well with the theoretical expectation...
- Computational investigation of the enzymatic mechanisms of phosphothreonine lyase
Qiang Pei
Niu Huang Lab, National Institute of Biological Sciences, Beijing, PR China
Biophys Chem 157:16-23. 2011
..The reaction mechanism used by phosphothreonine lyases might serve as a method of programmed regulation to fine tune their enzymatic activity...
- Two-stage registration for real-time deformable compensation using an electromagnetic tracking device
Hui Zhang
Imaging Science and Information System ISIS Center, Department of Radiology, Georgetown University, Washington, DC, USA
Med Image Comput Comput Assist Interv 8:992-9. 2005
..Phantom and swine studies have demonstrated the utility of this technique...
- Expression and regulation of antiviral protein APOBEC3G in human neuronal cells
Yan Jian Wang
Division of Allergy and Immunology, Joseph Stokes, Jr Research Institute at The Children s Hospital of Philadelphia, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Neuroimmunol 206:14-21. 2009
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