Lei Zhang

Summary

Publications

  1. Lin C, Xu J, Yang W, Wang C, Li Y, Cheng L, et al. Smurf Downregulates Echinoid in the Amnioserosa To Regulate Drosophila Dorsal Closure. Genetics. 2017;206:985-992 pubmed publisher
    ..Together, our results demonstrate that transcriptional repression of Ed followed by Smurf-mediated downregulation of pretranslated Ed in amnioserosa regulates the establishment of a taut leading edge during dorsal closure. ..
  2. Zhang W, Xu J, Li J, Guo T, Jiang D, Feng X, et al. The TEA domain family transcription factor TEAD4 represses murine adipogenesis by recruiting the cofactors VGLL4 and CtBP2 into a transcriptional complex. J Biol Chem. 2018;293:17119-17134 pubmed publisher
    ..These findings reveal critical insights into the role of the TEAD4-VGLL4-CtBP2 transcriptional repressor complex in suppression of adipogenesis in murine preadipocytes. ..
  3. Yin M, Zhang L. Hippo signaling in epithelial stem cells. Acta Biochim Biophys Sin (Shanghai). 2015;47:39-45 pubmed publisher
    ..Here we provide an overview of its roles in regulating stem cells in epithelial tissues and its potential implications in related cancers. ..
  4. Huang H, Li J, Hu L, Ge L, Ji H, Zhao Y, et al. Bantam is essential for Drosophila intestinal stem cell proliferation in response to Hippo signaling. Dev Biol. 2014;385:211-9 pubmed publisher
  5. Jiao S, Wang H, Shi Z, Dong A, Zhang W, Song X, et al. A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer. Cancer Cell. 2014;25:166-80 pubmed publisher
    ..These findings suggest that disruption of YAP-TEADs interaction by a VGLL4-mimicking peptide may be a promising therapeutic strategy against YAP-driven human cancers. ..
  6. Hu L, Huang H, Li J, Yin M, Lu Y, Wu W, et al. Drosophila casein kinase 2 (CK2) promotes warts protein to suppress Yorkie protein activity for growth control. J Biol Chem. 2014;289:33598-607 pubmed publisher
    ..Taken together, our results uncover a dual role of CK2; although its major role is promoting cell survive, it may potentially be a growth inhibitor as well. ..
  7. Dong L, Li J, Huang H, Yin M, Xu J, Li P, et al. Growth suppressor lingerer regulates bantam microRNA to restrict organ size. J Mol Cell Biol. 2015;7:415-28 pubmed publisher
    ..Moreover, we find that Lig physically interacts with and requires Salvador to restrict cell growth. Taken together, we demonstrate that Lig functions as a critical growth suppressor to control organ size via ban and Hippo signaling. ..
  8. Wang S, Lu Y, Yin M, Wang C, Wu W, Li J, et al. Importin α1 Mediates Yorkie Nuclear Import via an N-terminal Non-canonical Nuclear Localization Signal. J Biol Chem. 2016;291:7926-37 pubmed publisher
    ..Taken together, we identified a potential nuclear localization signal at the N-terminal end of Yorkie as well as a critical role for Importin α1 in Yorkie nuclear import. ..
  9. Xu J, Hao X, Yin M, Lu Y, Jin Y, Xu J, et al. Prevention of medulla neuron dedifferentiation by Nerfin-1 requires inhibition of Notch activity. Development. 2017;144:1510-1517 pubmed publisher
    ..Repressing Notch signaling largely rescues dedifferentiation in nerfin-1 mutant clones. Thus, we conclude that Nerfin-1 represses Notch activity in medulla neurons and prevents them from dedifferentiation. ..