Kang Zhang

Summary

Publications

  1. Liao C, Yin A, Peng C, Fu F, Yang J, Li R, et al. Noninvasive prenatal diagnosis of common aneuploidies by semiconductor sequencing. Proc Natl Acad Sci U S A. 2014;111:7415-20 pubmed publisher
  2. Chi W, Li F, Chen H, Wang Y, Zhu Y, Yang X, et al. Caspase-8 promotes NLRP1/NLRP3 inflammasome activation and IL-1? production in acute glaucoma. Proc Natl Acad Sci U S A. 2014;111:11181-6 pubmed publisher
    ..These results provide new insight into the pathogenesis of glaucoma and point to a treatment strategy. ..
  3. Liang H, Tsui B, Ni H, Valentim C, Baxter S, Liu G, et al. Evaluation and accurate diagnoses of pediatric diseases using artificial intelligence. Nat Med. 2019;25:433-438 pubmed publisher
    ..Although this impact may be most evident in areas where healthcare providers are in relative shortage, the benefits of such an AI system are likely to be universal. ..
  4. He J, Baxter S, Xu J, Xu J, Zhou X, Zhang K. The practical implementation of artificial intelligence technologies in medicine. Nat Med. 2019;25:30-36 pubmed publisher
    ..We summarize the current regulatory environment in the United States and highlight comparisons with other regions in the world, notably Europe and China. ..
  5. Li G, Xu F, Zhu J, Krawczyk M, Zhang Y, Yuan J, et al. Transcription Factor PAX6 (Paired Box 6) Controls Limbal Stem Cell Lineage in Development and Disease. J Biol Chem. 2015;290:20448-54 pubmed publisher
    ..Thus, loss of PAX6 converts LSCs to epidermal stem cells, as demonstrated by a switch in the keratin gene expression profile and by the appearance of congenital dermoid tissue. ..
  6. Dai Z, Cai W, Hu F, Lan Y, Li L, Chung C, et al. Plasma Mitochondrial DNA Levels as a Biomarker of Lipodystrophy Among HIV-infected Patients Treated with Highly Active Antiretroviral Therapy (HAART). Curr Mol Med. 2015;15:975-9 pubmed
    ..2% and a specificity of 73.0%. Our data suggest that mitochondrial DNA levels may help to guide therapy selection with regards to HIV lipodystrophy risk. ..
  7. request reprint
    Hu H, Liu H, Peng C, Deng T, Fu X, Chung C, et al. Clinical Experience of Non-Invasive Prenatal Chromosomal Aneuploidy Testing in 190,277 Patient Samples. Curr Mol Med. 2016;16:759-766 pubmed
    ..Our findings indicate that NIPT has the potential to replace serum biochemistry screening and could be performed at the early gestational age of 9~12 weeks. ..
  8. Kermany D, Goldbaum M, Cai W, Valentim C, Liang H, Baxter S, et al. Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning. Cell. 2018;172:1122-1131.e9 pubmed publisher
    ..This tool may ultimately aid in expediting the diagnosis and referralĀ of these treatable conditions, thereby facilitating earlier treatment, resulting in improved clinical outcomes. VIDEO ABSTRACT. ..
  9. Liu L, Li K, Fu X, Chung C, Zhang K. A Forward Look At Noninvasive Prenatal Testing. Trends Mol Med. 2016;22:958-968 pubmed publisher
    ..We discuss here the most current advances in diagnostic NIPT, its applications and limitations, as well as the development of future technology and possible clinical applications. ..

More Information

Publications12

  1. Yu F, Luo J, Mo J, Liu G, Kim Y, Meng Z, et al. Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP. Cancer Cell. 2014;25:822-30 pubmed publisher
    ..This study reveals an essential role of the Hippo-YAP pathway in Gq/11-induced tumorigenesis and suggests YAP as a potential drug target for UM patients carrying mutations in GNAQ or GNA11. ..
  2. Skowronska Krawczyk D, Zhao L, Zhu J, Weinreb R, Cao G, Luo J, et al. P16INK4a Upregulation Mediated by SIX6 Defines Retinal Ganglion Cell Pathogenesis in Glaucoma. Mol Cell. 2015;59:931-40 pubmed publisher
    ..Our study provides important insights linking genetic susceptibility to the underlying mechanism of RGC death and provides a unified theory of glaucoma pathogenesis. ..
  3. Zhang K, Zhang L, Weinreb R. Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma. Nat Rev Drug Discov. 2012;11:541-59 pubmed publisher
    ..This Review discusses the current state of ocular drug therapy and highlights future therapeutic opportunities...