Ji-Qiang Zhang



  1. Sun T, Liu Z, Liu M, Guo Y, Sun H, Zhao J, et al. Hippocampus-specific Rictor knockdown inhibited 17β-estradiol induced neuronal plasticity and spatial memory improvement in ovariectomized mice. Behav Brain Res. 2019;364:50-61 pubmed publisher
  2. Chen W, Deng Y, Zhang J, Tang K. Uniaxial repetitive mechanical overloading induces influx of extracellular calcium and cytoskeleton disruption in human tenocytes. Cell Tissue Res. 2015;359:577-587 pubmed publisher
    ..These findings provide novel experimental evidence for the pathology of tendon calcification and indicate that the blockade of calcium influx is a potential target for the prevention and treatment of calcific tendinopathy. ..
  3. Bian C, Huang Y, Zhu H, Zhao Y, Zhao J, Zhang J. Steroid Receptor Coactivator-1 Knockdown Decreases Synaptic Plasticity and Impairs Spatial Memory in the Hippocampus of Mice. Neuroscience. 2018;377:114-125 pubmed publisher
  4. Liu M, Huangfu X, Zhao Y, Zhang D, Zhang J. Steroid receptor coactivator-1 mediates letrozole induced downregulation of postsynaptic protein PSD-95 in the hippocampus of adult female rats. J Steroid Biochem Mol Biol. 2015;154:168-75 pubmed publisher
    ..Additionally, since letrozole is frequently used to treat estrogen-sensitive breast cancer, the above results also indicate its potential side effects in clinical administration. ..
  5. Chen W, Tang H, Zhou M, Hu C, Zhang J, Tang K. Dexamethasone inhibits the differentiation of rat tendon stem cells into tenocytes by targeting the scleraxis gene. J Steroid Biochem Mol Biol. 2015;152:16-24 pubmed publisher
    ..In conclusion, dexamethasone inhibits the differentiation of TSCs to tenocytes by inhibiting the scleraxis gene. ..
  6. Zhao Y, Zhu M, Yu Y, Qiu L, Zhang Y, He L, et al. Brain REST/NRSF Is Not Only a Silent Repressor but Also an Active Protector. Mol Neurobiol. 2017;54:541-550 pubmed publisher
  7. Zhao M, Yu Z, Zhang Y, Huang X, Hou J, Zhao Y, et al. Iron-induced neuronal damage in a rat model of post-traumatic stress disorder. Neuroscience. 2016;330:90-9 pubmed publisher
    ..We concluded that SPS stress increased iron in some cognition-related brain regions and subsequently cause neuronal injury, indicating that the iron may function in the pathology of PTSD. ..
  8. Zhao J, Bian C, Liu M, Zhao Y, Sun T, Xing F, et al. Orchiectomy and letrozole differentially regulate synaptic plasticity and spatial memory in a manner that is mediated by SRC-1 in the hippocampus of male mice. J Steroid Biochem Mol Biol. 2018;178:354-368 pubmed publisher
    ..These results also suggest a pivotal role of SRC-1 in the action of steroids; thus, SRC-1 may serve as a novel therapeutic target for cognitive disorders. ..
  9. request reprint
    Zhang J, Su B, Cai W. Immunolocalization of estrogen receptor beta in the hypothalamic paraventricular nucleus of female mice during pregnancy, lactation and postnatal development. Brain Res. 2004;997:89-96 pubmed

More Information


  1. Bian C, Zhao Y, Guo Q, Xiong Y, Cai W, Zhang J. Aromatase inhibitor letrozole downregulates steroid receptor coactivator-1 in specific brain regions that primarily related to memory, neuroendocrine and integration. J Steroid Biochem Mol Biol. 2014;141:37-43 pubmed publisher
    ..Furthermore, these potential central adverse effects of letrozole should be taken into serious considerations. ..
  2. Qiu L, Zhao Y, Guo Q, Zhang Y, He L, Li W, et al. Dose-dependent regulation of steroid receptor coactivator-1 and steroid receptors by testosterone propionate in the hippocampus of adult male mice. J Steroid Biochem Mol Biol. 2016;156:23-31 pubmed publisher
  3. Zhao Y, Yu Y, Zhang Y, He L, Qiu L, Zhao J, et al. Letrozole regulates actin cytoskeleton polymerization dynamics in a SRC-1 dependent manner in the hippocampus of mice. J Steroid Biochem Mol Biol. 2017;167:86-97 pubmed publisher
  4. Zhao Y, He L, Zhang Y, Zhao J, Liu Z, Xing F, et al. Estrogen receptor alpha and beta regulate actin polymerization and spatial memory through an SRC-1/mTORC2-dependent pathway in the hippocampus of female mice. J Steroid Biochem Mol Biol. 2017;174:96-113 pubmed publisher