Chunyu Zeng

Summary

Publications

  1. request reprint
    Zeng C, Liu Y, Wang Z, He D, Huang L, Yu P, et al. Activation of D3 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Circ Res. 2006;99:494-500 pubmed
    ..One mechanism of hypertension may be related to increased renal expression of AT(1) receptors due decreased D(3) receptor regulation. ..
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    Zeng C, Felder R, Jose P. A new approach for treatment of hypertension: modifying D1 dopamine receptor function. Cardiovasc Hematol Agents Med Chem. 2006;4:369-77 pubmed
    ..We also discuss possible new approaches developing anti-hypertensive medicine by increasing renal dopamine production, enhancing D(1) receptor function, or modifying its interactions with other blood pressure-regulating systems. ..
  3. Yang D, Fu W, Li L, Xia X, Liao Q, Yue R, et al. Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction. Clin Sci (Lond). 2017;131:2919-2932 pubmed publisher
    ..In conclusion, porcupine inhibitor CGX1321 reduces MI injury by limiting fibrosis and promoting regeneration. It promotes cardiomyocyte proliferation by stimulating cell cycle regulating genes with a Hippo/YAP-independent pathway. ..
  4. Han Y, Liao X, Gao Z, Yang S, Chen C, Liu Y, et al. Cardiac troponin I exacerbates myocardial ischaemia/reperfusion injury by inducing the adhesion of monocytes to vascular endothelial cells via a TLR4/NF-κB-dependent pathway. Clin Sci (Lond). 2016;130:2279-2293 pubmed publisher
    ..Inhibition of TLR4 may be an alternative strategy to reduce cTnI-induced myocardial I/R injury. ..
  5. request reprint
    Zeng C, Wang Z, Li H, Yu P, Zheng S, Wu L, et al. D3 dopamine receptor directly interacts with D1 dopamine receptor in immortalized renal proximal tubule cells. Hypertension. 2006;47:573-9 pubmed
  6. Guan W, Wang Z, Liu Y, Han Y, Ren H, Eric Wang W, et al. Protective effects of tirofiban on ischemia/reperfusion-induced renal injury in vivo and in vitro. Eur J Pharmacol. 2015;761:144-52 pubmed publisher
    ..The present in vivo and in vitro study indicated that tirofiban pretreatment exerts a protective effect on I/R injury in kidney through regulation of eNOS/iNOS balance. ..
  7. Zeng C, Villar V, Yu P, Zhou L, Jose P. Reactive oxygen species and dopamine receptor function in essential hypertension. Clin Exp Hypertens. 2009;31:156-78 pubmed publisher
    ..Decreased dopamine receptor function and increased ROS production, working in concert or independent of each other, contribute to the pathogenesis of essential hypertension. ..
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    Zeng C, Zhang M, Asico L, Eisner G, Jose P. The dopaminergic system in hypertension. Clin Sci (Lond). 2007;112:583-97 pubmed
    ..This review summarizes the physiology of the different dopamine receptors in the regulation of blood pressure, and the relationship between dopamine receptor subtypes and hypertension. ..
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    Zeng C, Luo Y, Asico L, Hopfer U, Eisner G, Felder R, et al. Perturbation of D1 dopamine and AT1 receptor interaction in spontaneously hypertensive rats. Hypertension. 2003;42:787-92 pubmed
    ..This regulation and D1/AT1 receptor interaction are different in RPT cells of WKY and SHR. An altered interaction of D1 and AT1 receptors may play a role in the impaired sodium excretion and enhanced vasoconstriction in hypertension. ..

More Information

Publications17

  1. Chen K, Deng K, Wang X, Wang Z, Zheng S, Ren H, et al. Activation of D4 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Hypertension. 2015;65:153-60 pubmed publisher
    ..We suggest that an aberrant interaction between D4 and AT1 receptors may play a role in the abnormal regulation of sodium excretion in hypertension. ..
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    Zeng C, Wang X, Liu G, Yang C. Effects of ACE inhibitor and beta-adrenergic blocker on plasma NPY and NPY receptors in aortic vascular smooth muscle cells from SHR and WKY rats. Neuropeptides. 2002;36:353-61 pubmed
    ..This indicated that lowered plasma NPY concentration and decreased NPY receptor in VSMCs, might play some roles in the anti-hypertensive mechanisms mediated by ACE inhibitor and beta-adrenergic blockers. ..
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    Zeng C, Wang Z, Hopfer U, Asico L, Eisner G, Felder R, et al. Rat strain effects of AT1 receptor activation on D1 dopamine receptors in immortalized renal proximal tubule cells. Hypertension. 2005;46:799-805 pubmed
    ..It is possible that an angiotensin II-mediated increase in D1 receptors and dissociation of AT1 from D1 receptors serve to counter regulate the long-term action of angiotensin II in WKY rats; different effects are seen in SHRs. ..
  4. Zeng C, Armando I, Luo Y, Eisner G, Felder R, Jose P. Dysregulation of dopamine-dependent mechanisms as a determinant of hypertension: studies in dopamine receptor knockout mice. Am J Physiol Heart Circ Physiol. 2008;294:H551-69 pubmed
  5. Zeng C, Han Y, Huang H, Yu C, Ren H, Shi W, et al. D1-like receptors inhibit insulin-induced vascular smooth muscle cell proliferation via down-regulation of insulin receptor expression. J Hypertens. 2009;27:1033-41 pubmed publisher
    ..The inhibitory effect of D1-like receptors on insulin-mediated VSMC proliferation may play an important role in the regulation of blood pressure. ..
  6. request reprint
    Zeng C, Wang Z, Asico L, Hopfer U, Eisner G, Felder R, et al. Aberrant ETB receptor regulation of AT receptors in immortalized renal proximal tubule cells of spontaneously hypertensive rats. Kidney Int. 2005;68:623-31 pubmed
    ..ETB receptors regulate AT(1) receptors by direct physical receptor interaction and receptor expression. An impaired ETB receptor regulation of the AT(1) receptor may participate in the pathogenesis of high blood pressure in the SHR. ..
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    Zeng C, Yang Z, Wang Z, Jones J, Wang X, Altea J, et al. Interaction of angiotensin II type 1 and D5 dopamine receptors in renal proximal tubule cells. Hypertension. 2005;45:804-10 pubmed
    ..18+/-0.08 versus 0.84+/-0.07; n=4; P<0.05). We conclude that D5 and AT1 receptors interact with each other. Altered interactions between AT1 and dopamine receptors may play a role in the pathogenesis of hypertension. ..
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    Zeng C, Wang D, Asico L, Welch W, Wilcox C, Hopfer U, et al. Aberrant D1 and D3 dopamine receptor transregulation in hypertension. Hypertension. 2004;43:654-60 pubmed
    ..Altered interactions between D(1) and D(3) receptors may play a role in the pathogenesis of genetic hypertension, including human hypertension, because these receptors also interact in human vascular smooth muscle cells. ..