Zeng C, Liu Y, Wang Z, He D, Huang L, Yu P, et al
. Activation of D3 dopamine receptor decreases angiotensin II type 1 receptor expression in rat renal proximal tubule cells. Circ Res. 2006;99:494-500 pubmed
..One mechanism of hypertension may be related to increased renal expression of AT(1) receptors due decreased D(3) receptor regulation. ..
Zeng C, Felder R, Jose P. A new approach for treatment of hypertension: modifying D1 dopamine receptor function. Cardiovasc Hematol Agents Med Chem. 2006;4:369-77 pubmed
..We also discuss possible new approaches developing anti-hypertensive medicine by increasing renal dopamine production, enhancing D(1) receptor function, or modifying its interactions with other blood pressure-regulating systems. ..
Yang D, Fu W, Li L, Xia X, Liao Q, Yue R, et al
. Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction. Clin Sci (Lond). 2017;131:2919-2932 pubmed publisher
..In conclusion, porcupine inhibitor CGX1321 reduces MI injury by limiting fibrosis and promoting regeneration. It promotes cardiomyocyte proliferation by stimulating cell cycle regulating genes with a Hippo/YAP-independent pathway. ..
Han Y, Liao X, Gao Z, Yang S, Chen C, Liu Y, et al
. Cardiac troponin I exacerbates myocardial ischaemia/reperfusion injury by inducing the adhesion of monocytes to vascular endothelial cells via a TLR4/NF-κB-dependent pathway. Clin Sci (Lond). 2016;130:2279-2293 pubmed publisher
..Inhibition of TLR4 may be an alternative strategy to reduce cTnI-induced myocardial I/R injury. ..
Zeng C, Wang Z, Li H, Yu P, Zheng S, Wu L, et al
. D3 dopamine receptor directly interacts with D1 dopamine receptor in immortalized renal proximal tubule cells. Hypertension. 2006;47:573-9 pubmed
Guan W, Wang Z, Liu Y, Han Y, Ren H, Eric Wang W, et al
. Protective effects of tirofiban on ischemia/reperfusion-induced renal injury in vivo and in vitro. Eur J Pharmacol. 2015;761:144-52 pubmed publisher
..The present in vivo and in vitro study indicated that tirofiban pretreatment exerts a protective effect on I/R injury in kidney through regulation of eNOS/iNOS balance. ..
Zeng C, Villar V, Yu P, Zhou L, Jose P. Reactive oxygen species and dopamine receptor function in essential hypertension. Clin Exp Hypertens. 2009;31:156-78 pubmed publisher
..Decreased dopamine receptor function and increased ROS production, working in concert or independent of each other, contribute to the pathogenesis of essential hypertension. ..
Zeng C, Zhang M, Asico L, Eisner G, Jose P. The dopaminergic system in hypertension. Clin Sci (Lond). 2007;112:583-97 pubmed
..This review summarizes the physiology of the different dopamine receptors in the regulation of blood pressure, and the relationship between dopamine receptor subtypes and hypertension. ..
Zeng C, Luo Y, Asico L, Hopfer U, Eisner G, Felder R, et al
. Perturbation of D1 dopamine and AT1 receptor interaction in spontaneously hypertensive rats. Hypertension. 2003;42:787-92 pubmed
..This regulation and D1/AT1 receptor interaction are different in RPT cells of WKY and SHR. An altered interaction of D1 and AT1 receptors may play a role in the impaired sodium excretion and enhanced vasoconstriction in hypertension. ..