Loss of expression of protein kinase a regulatory subunit 1alpha in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesionsArtur Zembowicz
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Am J Surg Pathol 31:1764-75. 2007
..Loss of expression of R1alpha offers a useful diagnostic test that helps to distinguish PEM from lesions that mimic it histologically...
- Histological spectrum of cutaneous reactions to aspirin in chronic idiopathic urticaria
Artur Zembowicz
Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Warren 820, 55 Fruit Street, Boston, MA 02114, USA
J Cutan Pathol 31:323-9. 2004
..This presented the rare opportunity to evaluate histological features of a series of skin eruptions induced by a drug acting through a defined mechanism in a controlled experimental setting...
Pigmented epithelioid melanocytoma: favorable outcome after 5-year follow-upRajni V Mandal
Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
Am J Surg Pathol 33:1778-82. 2009
..These findings provide further evidence that PEM is a unique low-grade melanocytic tumor with limited metastatic potential (to lymph nodes), but a favorable long-term clinical course...
- Case records of the Massachusetts General Hospital. Case 25-2007. A 60-year-old man with fever, odynophagia, weight loss, and rash
Mandakolathur R Murali
Department of Medicine, Massachusetts General Hospital, USA
N Engl J Med 357:692-701. 2007
- Atypical genital nevi. A clinicopathologic analysis of 56 cases
Briana C Gleason
Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
Am J Surg Pathol 32:51-7. 2008
..Awareness and recognition of this group of melanocytic lesions is important to avoid over diagnosis as melanoma with subsequent wide excision and possibly sentinel lymph node biopsy...
- Nevus/Melanocytoma/Melanoma: an emerging paradigm for classification of melanocytic neoplasms?
Artur Zembowicz
Department of Pathology, Lahey Clinic, Burlington, Massachusetts, USA
Arch Pathol Lab Med 135:300-6. 2011
..Such lesions have been referred to as borderline or melanocytic tumors of uncertain malignant potential...
- Endocrine mucin-producing sweat gland carcinoma: twelve new cases suggest that it is a precursor of some invasive mucinous carcinomas
Artur Zembowicz
Dermatopathology Unit, Department of Pathology, Warren 820, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Am J Surg Pathol 29:1330-9. 2005
..Although the data from this series support the notion that the prognosis of EMPSGC and mucinous carcinoma is good, longer follow-up is needed for better understanding of their pathogenesis and clinical behavior...
- Endocrine mucin-producing sweat gland carcinoma of the eyelid
Sonia Mehta
Boston University School of Medicine, Massachusetts General Hospital, Boston, MA, USA
Ophthal Plast Reconstr Surg 24:164-5. 2008
..She underwent Mohs surgery and reconstruction of the resulting defect. Clinicians should be aware of this entity given its association with invasive mucinous adenocarcinoma, a locally aggressive tumor with metastatic potential...
- Low-risk and high-risk histologic features in conjunctival primary acquired melanosis with atypia: Clinicopathologic analysis of 29 cases
Mitsuhiro Sugiura
Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
Am J Surg Pathol 31:185-92. 2007
..Our findings offer a practical approach for prognostically useful subclassification of PAM with atypia, which emphasizes cytologic features of intraepithelial conjunctival melanocytic proliferation...
- Melanocytic lesions of the conjunctiva
Artur Zembowicz
Department of Pathology, Lahey Clinic, Burlington, Massachusetts, USA
Arch Pathol Lab Med 134:1785-92. 2010
..They often represent challenging lesions for pathologists unfamiliar with unique histologic features of melanocytic proliferations in this location and with nomenclature used by ophthalmologists...
- Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 7-2004. A 48-year-old woman with multiple pigmented lesions and a personal and family history of melanoma
Hensin Tsao
Wellman Center for Photomedicine, Massachusetts General Hospital, USA
N Engl J Med 350:924-32. 2004
- Pigmented epithelioid melanocytoma: a low-grade melanocytic tumor with metastatic potential indistinguishable from animal-type melanoma and epithelioid blue nevus
Artur Zembowicz
Dermatopathology Unit, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Am J Surg Pathol 28:31-40. 2004
..We suggest that PEM be considered as a provisional histologic entity encompassing both animal-type melanoma and epithelioid blue nevus...
- Subcutaneous thrombotic vasculopathy syndrome: an ominous condition reminiscent of calciphylaxis: calciphylaxis sine calcifications?
Artur Zembowicz
Department of Pathology, Lahey Clinic, Burlington, MA 01805, USA
Am J Dermatopathol 33:796-802. 2011
..This conclusion is in keeping with increasing appreciation of importance of thrombosis and vascular injury in calciphylaxis...
- Blue nevi and related tumors
Pushkar A Phadke
Department of Pathology, Tufts Medical Center, Tufts University, Boston, MA 02111, USA
Clin Lab Med 31:345-58. 2011
..The differential diagnosis of the main entities and strategies to distinguish them from their melanocytic and nonmelanocytic mimics is also presented...
- Histological evolution of lentiginous melanoma: a report of five new cases
Tracy Davis
Department of Pathology, Massachusetts General Hospital and Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
J Cutan Pathol 34:296-300. 2007
..We report five similar cases...
- Case records of the Massachusetts General Hospital. Case 19-2006. A 22-month-old boy with the rapid growth of subcutaneous nodules
J Patrick Whelan
Pediatric Rheumatology Service, Massachusetts General Hospital, USA
N Engl J Med 354:2697-704. 2006
- Prevalence of melanoma clinically resembling seborrheic keratosis: analysis of 9204 cases
Leonid Izikson
Harvard Medical School, Boston, MA, USA
Arch Dermatol 138:1562-6. 2002
..CONCLUSIONS: Our results confirm that melanoma can mimic seborrheic keratosis. These data strongly support the current policy of submitting for histological examination all specimens that have been removed from patients...
- Combined basal cell carcinoma and Langerhans cell histiocytosis of the scrotum in a patient with occupational exposure to coal tar and dust
Leonid Izikson
Division of Dermatopathology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, and Harvard Vanguard Medical Associates, Boston, MA 02114, USA
Int J Dermatol 43:678-80. 2004
- A comprehensive analysis of a web-based dermatopathology second opinion consultation practice
Artur Zembowicz
Arch Pathol Lab Med 135:379-83. 2011
..The software allowed us to collect data about the current needs and use of a second opinion consultation practice, a topic that has not been addressed in research studies thus far...
- Syringotropic melanoma: a variant of melanoma with prominent involvement of eccrine apparatus and risk of deep dermal invasion
Artur Zembowicz
Department of Pathology, Harvard Vanguard Medical Associates, 133 Brookline Avenue, Boston, MA 02215, USA
Am J Dermatopathol 34:151-6. 2012
....
- Safety of cyclooxygenase 2 inhibitors and increased leukotriene synthesis in chronic idiopathic urticaria with sensitivity to nonsteroidal anti-inflammatory drugs
Artur Zembowicz
Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, USA
Arch Dermatol 139:1577-82. 2003
..Sensitivity to NSAIDs in CIU is associated with overproduction of cysteinyl leukotrienes and mast cell activation and most likely depends on inhibition of cyclooxygenase 1...
- Juvenile conjunctival nevus: clinicopathologic analysis of 33 cases
Sureka Thiagalingam
Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
Am J Surg Pathol 32:399-406. 2008
..Recognition of JCN as a distinct morphologic variant of a conjunctival nevus with characteristic histologic features may help to distinguish this benign lesion from melanoma...
- Warfarin-induced skin necrosis
Rosalynn M Nazarian
Department of Pathology and Dermatopathology Unit, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Am Acad Dermatol 61:325-32. 2009
..Herein, we review the clinical and histologic features helpful for differentiating warfarin-induced skin necrosis and report a case illustrative of the diagnostic difficulty that may at times be encountered in clinical practice...
- Blue nevi and variants: an update
Artur Zembowicz
Department of Pathology, Lahey Clinic, Burlington, Massachusetts, USA
Arch Pathol Lab Med 135:327-36. 2011
..They are common specimens in a general pathology practice, but some of their rare variants may pose diagnostic difficulty. Recent molecular studies provide new insights into genetics of blue nevi...
- Amelanotic cellular blue nevus: a hypopigmented variant of the cellular blue nevus: clinicopathologic analysis of 20 cases
Artur Zembowicz
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
Am J Surg Pathol 26:1493-500. 2002
..In particular, amelanotic cellular blue nevus must be distinguished from malignant cellular blue nevus and other variants of melanoma...
- Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations
David C Wilbur
Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
Arch Pathol Lab Med 133:1949-53. 2009
..Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized...
- Treatment of synchronous mucinous carcinoma and endocrine mucin-producing sweat gland carcinoma with Mohs' micrographic surgery
Zeina S Tannous
Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Dermatol Surg 31:364-7. 2005
..We report a case of an endocrine mucin-producing sweat gland carcinoma associated with mucinous carcinoma treated by Mohs' micrographic surgery...
- Case records of the Massachusetts General Hospital. Case 14-2007. A 59-year-old man with fever and pain and swelling of both eyes and the right ear
Joan R Butterton
Infectious Disease Division, Massachusetts General Hospital, USA
N Engl J Med 356:1980-8. 2007
- Clinical and pathologic findings of paraneoplastic dermatoses
Vinh Q Chung
Harvard Medical School, Boston, Massachusetts, USA
J Am Acad Dermatol 54:745-62; quiz 763-6. 2006
..LEARNING OBJECTIVE: At the conclusion of this leaning activity, participants should be able to recognize, diagnose, and describe the clinical and pathologic findings of paraneoplastic dermatoses...
- Phakomatous choristoma of the eyelid: a report of a case
Katherine Szyfelbein
Harvard Medical School, Boston, MA 02114, USA
J Cutan Pathol 31:506-8. 2004
..Our case illustrates unique histological features of this entity which has to be included in differential diagnosis of skin lesions of the inferonasal eyelid...
- Fine-needle aspiration biopsy of a cystic pleomorphic adenoma with extensive adnexa-like differentiation: differential diagnostic pitfall with mucoepidermoid carcinoma
Elena F Brachtel
Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Diagn Cytopathol 28:100-3. 2003
....
- Non-bullous neutrophilic dermatosis: an uncommon dermatologic manifestation in patients with lupus erythematosus
Briana C Gleason
Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Cutan Pathol 33:721-5. 2006
..Rare cases of a non-bullous neutrophilic dermatosis occurring in patients with lupus erythematosus (LE) have been reported, often as the presenting manifestation of the disease...
- Linear ectodermal cutaneous hamartoma
Rebecca Campen
Department of Dermatology, Harvard Medical School, Boston, MA, USA
Int J Dermatol 42:376-9. 2003
- CD20+ T-cell lymphoma: clinicopathologic analysis of 9 cases and a review of the literature
Aliyah Rahemtullah
James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA
Am J Surg Pathol 32:1593-607. 2008
..Knowledge of the unusual phenomenon of CD20 expression in TCL, in conjunction with careful morphologic analysis, the use of a panel of antibodies, and molecular genetic studies, is important in avoiding a misdiagnosis of BCL...
- Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 5-2003 - a 16-year-old girl with a rash and chest pain
Ivor Caro
Dermatology Clinical Investigations Unit, Department of Dermatology, Massachusetts General Hospital, Boston, USA
N Engl J Med 348:630-7. 2003
- Lues maligna in early HIV infection case report and review of the literature
Joseph D Tucker
Division of Infection Diseases, Massachusetts General Hospital, 55 Fruit St, GRJ 504, Boston, MA 02114, USA
Sex Transm Dis 36:512-4. 2009
..The classic lesion of lues maligna is an oval, papulopustular skin lesion with well demarcated borders sometimes covered with a lamellar crust, but myriad clinical presentations of this disease also exist...
- Androgen receptor expression helps to differentiate basal cell carcinoma from benign trichoblastic tumors
Leonid Izikson
Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
Am J Dermatopathol 27:91-5. 2005
..These results confirm the lack of expression of androgen receptor in benign trichoblastic neoplasms and indicate that androgen receptor expression by tumor cells points to basal cell carcinoma as the most likely diagnosis...
- Case records of the Massachusetts General Hospital. Case 32-2008. A 10-year-old girl with recurrent oral lesions and cutaneous bullae
James G H Dinulos
Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA
N Engl J Med 359:1718-24. 2008
- Cutaneous metastases of follicular thyroid carcinoma: a report of four cases and a review of the literature
Timothy R Quinn
Pathology Services, Inc, Cambridge, Massachusetts, USA
Am J Dermatopathol 27:306-12. 2005
..Awareness of the varied morphologies of metastatic follicular thyroid carcinoma to the skin may prompt immunohistochemical analysis and the request for a complete clinical history, ultimately preventing misdiagnosis...
- Adnexal clear cell carcinoma with comedonecrosis: clinicopathologic analysis of 12 cases
Iskander H Chaudhry
Department of Pathology, Leeds General Infirmary, Leeds, United Kingdom
Arch Pathol Lab Med 131:1655-64. 2007
..Cutaneous clear cell tumors can pose a diagnostic challenge even to the experienced dermatopathologist; this is partly because of limitations of existing diagnostic categories...
- Case records of the Massachusetts General Hospital. Case 2-2007. A 49-year-old woman with a pigmented lesion on the arm
John F Thompson
Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia
N Engl J Med 356:285-92. 2007
