Artur Zembowicz

Summary

Publications

  1. ncbi Loss of expression of protein kinase a regulatory subunit 1alpha in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesions
    Artur Zembowicz
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 31:1764-75. 2007
  2. ncbi Histological spectrum of cutaneous reactions to aspirin in chronic idiopathic urticaria
    Artur Zembowicz
    Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Warren 820, 55 Fruit Street, Boston, MA 02114, USA
    J Cutan Pathol 31:323-9. 2004
  3. doi Correlation between histologic assessment and fluorescence in situ hybridization using MelanoSITE in evaluation of histologically ambiguous melanocytic lesions
    Artur Zembowicz
    Department of Pathology, Harvard Vanguard Medical Associates, Boston, Massachusetts, USA
    Arch Pathol Lab Med 136:1571-9. 2012
  4. ncbi Case records of the Massachusetts General Hospital. Case 25-2007. A 60-year-old man with fever, odynophagia, weight loss, and rash
    Mandakolathur R Murali
    Department of Medicine, Massachusetts General Hospital, USA
    N Engl J Med 357:692-701. 2007
  5. ncbi Atypical genital nevi. A clinicopathologic analysis of 56 cases
    Briana C Gleason
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Am J Surg Pathol 32:51-7. 2008
  6. doi Pigmented epithelioid melanocytoma: favorable outcome after 5-year follow-up
    Rajni V Mandal
    Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 33:1778-82. 2009
  7. doi Nevus/Melanocytoma/Melanoma: an emerging paradigm for classification of melanocytic neoplasms?
    Artur Zembowicz
    Department of Pathology, Lahey Clinic, Burlington, Massachusetts, USA
    Arch Pathol Lab Med 135:300-6. 2011
  8. pmc Expression of soluble adenylyl cyclase in lentigo maligna: use of immunohistochemistry with anti-soluble adenylyl cyclase antibody (R21) in diagnosis of lentigo maligna and assessment of margins
    Cynthia M Magro
    Department of Pathology, Weill Medical College of Cornell University, New York, New York, USA
    Arch Pathol Lab Med 136:1558-64. 2012
  9. ncbi Endocrine mucin-producing sweat gland carcinoma: twelve new cases suggest that it is a precursor of some invasive mucinous carcinomas
    Artur Zembowicz
    Dermatopathology Unit, Department of Pathology, Warren 820, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 29:1330-9. 2005
  10. ncbi Low-risk and high-risk histologic features in conjunctival primary acquired melanosis with atypia: Clinicopathologic analysis of 29 cases
    Mitsuhiro Sugiura
    Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 31:185-92. 2007

Collaborators

Detail Information

Publications43

  1. ncbi Loss of expression of protein kinase a regulatory subunit 1alpha in pigmented epithelioid melanocytoma but not in melanoma or other melanocytic lesions
    Artur Zembowicz
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 31:1764-75. 2007
    ..Loss of expression of R1alpha offers a useful diagnostic test that helps to distinguish PEM from lesions that mimic it histologically...
  2. ncbi Histological spectrum of cutaneous reactions to aspirin in chronic idiopathic urticaria
    Artur Zembowicz
    Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Warren 820, 55 Fruit Street, Boston, MA 02114, USA
    J Cutan Pathol 31:323-9. 2004
    ..This presented the rare opportunity to evaluate histological features of a series of skin eruptions induced by a drug acting through a defined mechanism in a controlled experimental setting...
  3. doi Correlation between histologic assessment and fluorescence in situ hybridization using MelanoSITE in evaluation of histologically ambiguous melanocytic lesions
    Artur Zembowicz
    Department of Pathology, Harvard Vanguard Medical Associates, Boston, Massachusetts, USA
    Arch Pathol Lab Med 136:1571-9. 2012
    ..Thus far, use of MelanoSITE as a diagnostic adjunct in the diagnosis of melanocytic lesions has not, to our knowledge, been reported in the literature...
  4. ncbi Case records of the Massachusetts General Hospital. Case 25-2007. A 60-year-old man with fever, odynophagia, weight loss, and rash
    Mandakolathur R Murali
    Department of Medicine, Massachusetts General Hospital, USA
    N Engl J Med 357:692-701. 2007
  5. ncbi Atypical genital nevi. A clinicopathologic analysis of 56 cases
    Briana C Gleason
    Department of Pathology, Brigham and Women s Hospital, Boston, MA, USA
    Am J Surg Pathol 32:51-7. 2008
    ..Awareness and recognition of this group of melanocytic lesions is important to avoid over diagnosis as melanoma with subsequent wide excision and possibly sentinel lymph node biopsy...
  6. doi Pigmented epithelioid melanocytoma: favorable outcome after 5-year follow-up
    Rajni V Mandal
    Department of Pathology, Massachusetts General Hospital, Boston, MA, USA
    Am J Surg Pathol 33:1778-82. 2009
    ..These findings provide further evidence that PEM is a unique low-grade melanocytic tumor with limited metastatic potential (to lymph nodes), but a favorable long-term clinical course...
  7. doi Nevus/Melanocytoma/Melanoma: an emerging paradigm for classification of melanocytic neoplasms?
    Artur Zembowicz
    Department of Pathology, Lahey Clinic, Burlington, Massachusetts, USA
    Arch Pathol Lab Med 135:300-6. 2011
    ..Such lesions have been referred to as borderline or melanocytic tumors of uncertain malignant potential...
  8. pmc Expression of soluble adenylyl cyclase in lentigo maligna: use of immunohistochemistry with anti-soluble adenylyl cyclase antibody (R21) in diagnosis of lentigo maligna and assessment of margins
    Cynthia M Magro
    Department of Pathology, Weill Medical College of Cornell University, New York, New York, USA
    Arch Pathol Lab Med 136:1558-64. 2012
    ..R21, a mouse monoclonal antibody against sAC, shows a striking pan-nuclear staining in lentigo maligna, indicating possible utility for diagnosis and margin assessment...
  9. ncbi Endocrine mucin-producing sweat gland carcinoma: twelve new cases suggest that it is a precursor of some invasive mucinous carcinomas
    Artur Zembowicz
    Dermatopathology Unit, Department of Pathology, Warren 820, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Am J Surg Pathol 29:1330-9. 2005
    ..Although the data from this series support the notion that the prognosis of EMPSGC and mucinous carcinoma is good, longer follow-up is needed for better understanding of their pathogenesis and clinical behavior...
  10. ncbi Low-risk and high-risk histologic features in conjunctival primary acquired melanosis with atypia: Clinicopathologic analysis of 29 cases
    Mitsuhiro Sugiura
    Department of Pathology, Massachusetts General Hospital Harvard Medical School, Boston, MA, USA
    Am J Surg Pathol 31:185-92. 2007
    ..Our findings offer a practical approach for prognostically useful subclassification of PAM with atypia, which emphasizes cytologic features of intraepithelial conjunctival melanocytic proliferation...
  11. doi Melanocytic lesions of the conjunctiva
    Artur Zembowicz
    Department of Pathology, Lahey Clinic, Burlington, Massachusetts, USA
    Arch Pathol Lab Med 134:1785-92. 2010
    ..They often represent challenging lesions for pathologists unfamiliar with unique histologic features of melanocytic proliferations in this location and with nomenclature used by ophthalmologists...
  12. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 7-2004. A 48-year-old woman with multiple pigmented lesions and a personal and family history of melanoma
    Hensin Tsao
    Wellman Center for Photomedicine, Massachusetts General Hospital, USA
    N Engl J Med 350:924-32. 2004
  13. ncbi Pigmented epithelioid melanocytoma: a low-grade melanocytic tumor with metastatic potential indistinguishable from animal-type melanoma and epithelioid blue nevus
    Artur Zembowicz
    Dermatopathology Unit, Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Surg Pathol 28:31-40. 2004
    ..We suggest that PEM be considered as a provisional histologic entity encompassing both animal-type melanoma and epithelioid blue nevus...
  14. doi Endocrine mucin-producing sweat gland carcinoma of the eyelid
    Sonia Mehta
    Boston University School of Medicine, Massachusetts General Hospital, Boston, MA, USA
    Ophthal Plast Reconstr Surg 24:164-5. 2008
    ..She underwent Mohs surgery and reconstruction of the resulting defect. Clinicians should be aware of this entity given its association with invasive mucinous adenocarcinoma, a locally aggressive tumor with metastatic potential...
  15. doi Subcutaneous thrombotic vasculopathy syndrome: an ominous condition reminiscent of calciphylaxis: calciphylaxis sine calcifications?
    Artur Zembowicz
    Department of Pathology, Lahey Clinic, Burlington, MA 01805, USA
    Am J Dermatopathol 33:796-802. 2011
    ..This conclusion is in keeping with increasing appreciation of importance of thrombosis and vascular injury in calciphylaxis...
  16. ncbi Histological evolution of lentiginous melanoma: a report of five new cases
    Tracy Davis
    Department of Pathology, Massachusetts General Hospital and Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Cutan Pathol 34:296-300. 2007
    ..We report five similar cases...
  17. ncbi Prevalence of melanoma clinically resembling seborrheic keratosis: analysis of 9204 cases
    Leonid Izikson
    Harvard Medical School, Boston, MA, USA
    Arch Dermatol 138:1562-6. 2002
    ..To estimate the prevalence of melanoma clinically mimicking seborrheic keratosis...
  18. ncbi Case records of the Massachusetts General Hospital. Case 19-2006. A 22-month-old boy with the rapid growth of subcutaneous nodules
    J Patrick Whelan
    Pediatric Rheumatology Service, Massachusetts General Hospital, USA
    N Engl J Med 354:2697-704. 2006
  19. ncbi Combined basal cell carcinoma and Langerhans cell histiocytosis of the scrotum in a patient with occupational exposure to coal tar and dust
    Leonid Izikson
    Division of Dermatopathology, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, and Harvard Vanguard Medical Associates, Boston, MA 02114, USA
    Int J Dermatol 43:678-80. 2004
  20. doi Blue nevi and related tumors
    Pushkar A Phadke
    Department of Pathology, Tufts Medical Center, Tufts University, Boston, MA 02111, USA
    Clin Lab Med 31:345-58. 2011
    ..The differential diagnosis of the main entities and strategies to distinguish them from their melanocytic and nonmelanocytic mimics is also presented...
  21. doi A comprehensive analysis of a web-based dermatopathology second opinion consultation practice
    Artur Zembowicz
    Arch Pathol Lab Med 135:379-83. 2011
    ..The software allowed us to collect data about the current needs and use of a second opinion consultation practice, a topic that has not been addressed in research studies thus far...
  22. doi Syringotropic melanoma: a variant of melanoma with prominent involvement of eccrine apparatus and risk of deep dermal invasion
    Artur Zembowicz
    Department of Pathology, Harvard Vanguard Medical Associates, 133 Brookline Avenue, Boston, MA 02215, USA
    Am J Dermatopathol 34:151-6. 2012
    ....
  23. doi Warfarin-induced skin necrosis
    Rosalynn M Nazarian
    Department of Pathology and Dermatopathology Unit, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Am Acad Dermatol 61:325-32. 2009
    ..Herein, we review the clinical and histologic features helpful for differentiating warfarin-induced skin necrosis and report a case illustrative of the diagnostic difficulty that may at times be encountered in clinical practice...
  24. ncbi Safety of cyclooxygenase 2 inhibitors and increased leukotriene synthesis in chronic idiopathic urticaria with sensitivity to nonsteroidal anti-inflammatory drugs
    Artur Zembowicz
    Department of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, USA
    Arch Dermatol 139:1577-82. 2003
    ..Nonsteroidal anti-inflammatory drugs (NSAIDs) exacerbate various forms of urticaria by a nonallergic mechanism involving inhibition of cyclooxygenases...
  25. doi Juvenile conjunctival nevus: clinicopathologic analysis of 33 cases
    Sureka Thiagalingam
    Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, MA, USA
    Am J Surg Pathol 32:399-406. 2008
    ..Recognition of JCN as a distinct morphologic variant of a conjunctival nevus with characteristic histologic features may help to distinguish this benign lesion from melanoma...
  26. ncbi Fine-needle aspiration biopsy of a cystic pleomorphic adenoma with extensive adnexa-like differentiation: differential diagnostic pitfall with mucoepidermoid carcinoma
    Elena F Brachtel
    Department of Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Diagn Cytopathol 28:100-3. 2003
    ....
  27. ncbi Phakomatous choristoma of the eyelid: a report of a case
    Katherine Szyfelbein
    Harvard Medical School, Boston, MA 02114, USA
    J Cutan Pathol 31:506-8. 2004
    ..Our case illustrates unique histological features of this entity which has to be included in differential diagnosis of skin lesions of the inferonasal eyelid...
  28. ncbi Amelanotic cellular blue nevus: a hypopigmented variant of the cellular blue nevus: clinicopathologic analysis of 20 cases
    Artur Zembowicz
    Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Am J Surg Pathol 26:1493-500. 2002
    ..In particular, amelanotic cellular blue nevus must be distinguished from malignant cellular blue nevus and other variants of melanoma...
  29. doi Blue nevi and variants: an update
    Artur Zembowicz
    Department of Pathology, Lahey Clinic, Burlington, Massachusetts, USA
    Arch Pathol Lab Med 135:327-36. 2011
    ..They are common specimens in a general pathology practice, but some of their rare variants may pose diagnostic difficulty. Recent molecular studies provide new insights into genetics of blue nevi...
  30. ncbi Treatment of synchronous mucinous carcinoma and endocrine mucin-producing sweat gland carcinoma with Mohs' micrographic surgery
    Zeina S Tannous
    Department of Dermatology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Dermatol Surg 31:364-7. 2005
    ..We report a case of an endocrine mucin-producing sweat gland carcinoma associated with mucinous carcinoma treated by Mohs' micrographic surgery...
  31. pmc Whole-slide imaging digital pathology as a platform for teleconsultation: a pilot study using paired subspecialist correlations
    David C Wilbur
    Department of Pathology, James Homer Wright Pathology Laboratories, Massachusetts General Hospital, and the Department of Pathology, Harvard Medical School, Boston, MA 02114, USA
    Arch Pathol Lab Med 133:1949-53. 2009
    ..Before implementation, technical issues, pathologist adaptability, and morphologic pitfalls must be well characterized...
  32. ncbi Clinical and pathologic findings of paraneoplastic dermatoses
    Vinh Q Chung
    Harvard Medical School, Boston, Massachusetts, USA
    J Am Acad Dermatol 54:745-62; quiz 763-6. 2006
    ..Herein are reviewed 16 of the best established paraneoplastic dermatoses that display distinctive clinical and pathologic findings...
  33. ncbi Non-bullous neutrophilic dermatosis: an uncommon dermatologic manifestation in patients with lupus erythematosus
    Briana C Gleason
    Department of Pathology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cutan Pathol 33:721-5. 2006
    ..Rare cases of a non-bullous neutrophilic dermatosis occurring in patients with lupus erythematosus (LE) have been reported, often as the presenting manifestation of the disease...
  34. ncbi Case records of the Massachusetts General Hospital. Case 14-2007. A 59-year-old man with fever and pain and swelling of both eyes and the right ear
    Joan R Butterton
    Infectious Disease Division, Massachusetts General Hospital, USA
    N Engl J Med 356:1980-8. 2007
  35. ncbi Lues maligna in early HIV infection case report and review of the literature
    Joseph D Tucker
    Division of Infection Diseases, Massachusetts General Hospital, 55 Fruit St, GRJ 504, Boston, MA 02114, USA
    Sex Transm Dis 36:512-4. 2009
    ..The classic lesion of lues maligna is an oval, papulopustular skin lesion with well demarcated borders sometimes covered with a lamellar crust, but myriad clinical presentations of this disease also exist...
  36. ncbi Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 5-2003 - a 16-year-old girl with a rash and chest pain
    Ivor Caro
    Dermatology Clinical Investigations Unit, Department of Dermatology, Massachusetts General Hospital, Boston, USA
    N Engl J Med 348:630-7. 2003
  37. ncbi Linear ectodermal cutaneous hamartoma
    Rebecca Campen
    Department of Dermatology, Harvard Medical School, Boston, MA, USA
    Int J Dermatol 42:376-9. 2003
  38. doi CD20+ T-cell lymphoma: clinicopathologic analysis of 9 cases and a review of the literature
    Aliyah Rahemtullah
    James Homer Wright Pathology Laboratories, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Surg Pathol 32:1593-607. 2008
    ..Knowledge of the unusual phenomenon of CD20 expression in TCL, in conjunction with careful morphologic analysis, the use of a panel of antibodies, and molecular genetic studies, is important in avoiding a misdiagnosis of BCL...
  39. ncbi Case records of the Massachusetts General Hospital. Case 2-2007. A 49-year-old woman with a pigmented lesion on the arm
    John F Thompson
    Sydney Melanoma Unit, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia
    N Engl J Med 356:285-92. 2007
  40. ncbi Androgen receptor expression helps to differentiate basal cell carcinoma from benign trichoblastic tumors
    Leonid Izikson
    Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Am J Dermatopathol 27:91-5. 2005
    ..These results confirm the lack of expression of androgen receptor in benign trichoblastic neoplasms and indicate that androgen receptor expression by tumor cells points to basal cell carcinoma as the most likely diagnosis...
  41. doi Case records of the Massachusetts General Hospital. Case 32-2008. A 10-year-old girl with recurrent oral lesions and cutaneous bullae
    James G H Dinulos
    Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA
    N Engl J Med 359:1718-24. 2008
  42. ncbi Cutaneous metastases of follicular thyroid carcinoma: a report of four cases and a review of the literature
    Timothy R Quinn
    Pathology Services, Inc, Cambridge, Massachusetts, USA
    Am J Dermatopathol 27:306-12. 2005
    ..Awareness of the varied morphologies of metastatic follicular thyroid carcinoma to the skin may prompt immunohistochemical analysis and the request for a complete clinical history, ultimately preventing misdiagnosis...
  43. ncbi Adnexal clear cell carcinoma with comedonecrosis: clinicopathologic analysis of 12 cases
    Iskander H Chaudhry
    Department of Pathology, Leeds General Infirmary, Leeds, United Kingdom
    Arch Pathol Lab Med 131:1655-64. 2007
    ..Cutaneous clear cell tumors can pose a diagnostic challenge even to the experienced dermatopathologist; this is partly because of limitations of existing diagnostic categories...