Teresa Zelante

Summary

Publications

  1. doi request reprint Th17 cells in the setting of Aspergillus infection and pathology
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Med Mycol 47:S162-9. 2009
  2. ncbi request reprint Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Adv Exp Med Biol 590:209-21. 2007
  3. doi request reprint Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Microbes Infect 11:133-41. 2009
  4. ncbi request reprint IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Eur J Immunol 37:2695-706. 2007
  5. ncbi request reprint Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism
    Claudia Montagnoli
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Italy
    J Immunol 176:1712-23. 2006
  6. doi request reprint Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease
    Carmen D'Angelo
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 183:4609-18. 2009
  7. ncbi request reprint Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection
    Silvia Bozza
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 180:4022-31. 2008
  8. doi request reprint Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    Luigina Romani
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nature 451:211-5. 2008
  9. ncbi request reprint Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc
    Antonella De Luca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 179:5999-6008. 2007
  10. ncbi request reprint Thymosin alpha1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo
    Silvia Bozza
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Perugia, Italy
    Int Immunol 19:1261-70. 2007

Collaborators

Detail Information

Publications28

  1. doi request reprint Th17 cells in the setting of Aspergillus infection and pathology
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Med Mycol 47:S162-9. 2009
    ..Thus, modulation of the inflammatory response represents a potential strategy to stimulate protective immune responses to Aspergillus...
  2. ncbi request reprint Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Adv Exp Med Biol 590:209-21. 2007
  3. doi request reprint Indoleamine 2,3-dioxygenase in infection: the paradox of an evasive strategy that benefits the host
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Microbes Infect 11:133-41. 2009
    ..This review deals with recent findings that could gain IDO a reputation of Jack-of-all-trades in mammalian host/microbe interactions...
  4. ncbi request reprint IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Eur J Immunol 37:2695-706. 2007
    ..As IL-23-driven inflammation promotes infection and impairs antifungal resistance, modulation of the inflammatory response represents a potential strategy to stimulate protective immune responses to fungi...
  5. ncbi request reprint Immunity and tolerance to Aspergillus involve functionally distinct regulatory T cells and tryptophan catabolism
    Claudia Montagnoli
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Italy
    J Immunol 176:1712-23. 2006
    ..Thus, regulation is an essential component of the host response in infection and allergy to the fungus, and its manipulation may allow the pathogen to overcome host resistance and promote disease...
  6. doi request reprint Exogenous pentraxin 3 restores antifungal resistance and restrains inflammation in murine chronic granulomatous disease
    Carmen D'Angelo
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 183:4609-18. 2009
    ..Thus, PTX3 could be therapeutically used for the exploitation of NADPH-independent mechanism(s) of antifungal immune protection with limited immunopathology in CGD...
  7. ncbi request reprint Lack of Toll IL-1R8 exacerbates Th17 cell responses in fungal infection
    Silvia Bozza
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 180:4022-31. 2008
    ..TIR8 may contribute toward fine-tuning the balance between protective immunity and immunopathology in infection...
  8. doi request reprint Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    Luigina Romani
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nature 451:211-5. 2008
    ..Yet, this condition can be reverted by reactivating the pathway downstream of the superoxide-dependent step...
  9. ncbi request reprint Functional yet balanced reactivity to Candida albicans requires TRIF, MyD88, and IDO-dependent inhibition of Rorc
    Antonella De Luca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 179:5999-6008. 2007
    ..This is the first study to show that the same tryptophan catabolites can foster dendritic cell-supported generation of Foxp3(+) cells and mediate, at the same time, inhibition of RORgammat-expressing T cells...
  10. ncbi request reprint Thymosin alpha1 activates the TLR9/MyD88/IRF7-dependent murine cytomegalovirus sensing for induction of anti-viral responses in vivo
    Silvia Bozza
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Perugia, Italy
    Int Immunol 19:1261-70. 2007
    ....
  11. ncbi request reprint Thymosin alpha1: an endogenous regulator of inflammation, immunity, and tolerance
    Luigina Romani
    Microbiology Section, Department of Experimental Medicine, and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Ann N Y Acad Sci 1112:326-38. 2007
    ....
  12. doi request reprint Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO
    Antonella De Luca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Cell Mol Immunol 7:459-70. 2010
    ..Thus, distinct immune pathways contribute to resistance and tolerance to the fungus, to which the hematopoietic/non-hematopoietic compartments contribute through distinct, yet complementary, roles...
  13. doi request reprint Indoleamine 2,3-dioxygenase (IDO) in inflammation and allergy to Aspergillus
    Luigina Romani
    Department of Experimental Medicine and Biochemical Sciences and Fondazione, Istituto di Ricovero e Cura per le Biotecnologie Trapiantologiche, Perugia, Italy
    Med Mycol 47:S154-61. 2009
    ....
  14. doi request reprint Thymosin alpha1: the regulator of regulators?
    Bonifazi Pierluigi
    Department of Experimental Medicine and Biochemical Science, University of Perugia, Perugia, Italy
    Ann N Y Acad Sci 1194:1-5. 2010
    ..We will discuss recent molecular mechanisms underlying the ability of Talpha1 to activate or inhibit immune responses...
  15. ncbi request reprint Provision of antifungal immunity and concomitant alloantigen tolerization by conditioned dendritic cells in experimental hematopoietic transplantation
    Claudia Montagnoli
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Blood Cells Mol Dis 40:55-62. 2008
    ..Thus, transplantation tolerance and concomitant pathogen clearance could be achieved through the therapeutic induction of antigen-specific Treg cells via instructive immunotherapy with pathogen- or TLR-conditioned donor DC...
  16. doi request reprint IDO mediates TLR9-driven protection from experimental autoimmune diabetes
    Francesca Fallarino
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 183:6303-12. 2009
    ..Thus, our data suggest that the TLR9-IDO axis may represent a valuable target in the prevention/therapy of type 1 diabetes...
  17. ncbi request reprint Immunity and tolerance to Aspergillus fumigatus
    Claudia Montagnoli
    Department of Experimental Medicine and Biochemical Science, University of Perugia, 06126 Perugia, Italy
    Novartis Found Symp 279:66-77; discussion 77-9, 216-9. 2006
    ..Thus, regulation is an essential component of the host response in infection and allergy to the fungus, and its manipulation may allow the pathogen to overcome host resistance and promote disease...
  18. ncbi request reprint IL-17 and therapeutic kynurenines in pathogenic inflammation to fungi
    Luigina Romani
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 180:5157-62. 2008
    ..Recent data support a view in which IL-23/IL-17 antagonistic strategies, including the administration of synthetic kynurenines, could represent a new means of harnessing progressive or potentially harmful inflammation...
  19. doi request reprint Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity
    Cristina Cunha
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Blood 116:5394-402. 2010
    ....
  20. doi request reprint IL-17/Th17 in anti-fungal immunity: what's new?
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, Microbiology Section, University of Perugia, Perugia, Italy
    Eur J Immunol 39:645-8. 2009
    ..Here we discuss how recent findings in experimental candidiasis and aspergillosis shed new lights on the contribution of Th17 cells to resistance and pathology to fungi...
  21. doi request reprint Th17/Treg imbalance in murine cystic fibrosis is linked to indoleamine 2,3-dioxygenase deficiency but corrected by kynurenines
    Rossana G Iannitti
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, Perugia, Italy
    Am J Respir Crit Care Med 187:609-20. 2013
    ..The appreciation of whether such fungi are primarily responsible for or a consequence of ineffective airway inflammation is important for future therapeutics development...
  22. ncbi request reprint Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation
    Silvia Bozza
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Blood 108:3387-96. 2006
    ....
  23. ncbi request reprint A crucial role for tryptophan catabolism at the host/Candida albicans interface
    Silvia Bozza
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 174:2910-8. 2005
    ..The production of IFN-gamma may be squarely placed at this interface, where IDO activation probably exerts a fine control over fungal morphology as well as inflammatory and adaptive antifungal responses...
  24. pmc The danger signal S100B integrates pathogen- and danger-sensing pathways to restrain inflammation
    Guglielmo Sorci
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    PLoS Pathog 7:e1001315. 2011
    ....
  25. doi request reprint Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia 06132, Italy
    Immunity 39:372-85. 2013
    ..Thus, the microbiota-AhR axis might represent an important strategy pursued by coevolutive commensalism for fine tuning host mucosal reactivity contingent on Trp catabolism. ..
  26. doi request reprint Genetic susceptibility to aspergillosis in allogeneic stem-cell transplantation
    Cristina Cunha
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Med Mycol 49:S137-43. 2011
    ..This suggests that understanding host-pathogen interactions at the level of host genetic susceptibility will allow the formulation of new targeted and patient-tailored antifungal therapeutics, including improved donor screening...
  27. doi request reprint Sensing of mammalian IL-17A regulates fungal adaptation and virulence
    Teresa Zelante
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia 06122, Italy
    Nat Commun 3:683. 2012
    ..This might exemplify a mechanism whereby fungi have evolved a means of sensing host immunity to ensure their own persistence in an immunologically dynamic environment...
  28. doi request reprint IL-22 in antifungal immunity
    Teresa Zelante
    Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Eur J Immunol 41:270-5. 2011
    ..The fact that IL-22 production is driven by commensals points to the need of an integrated, systems biology approach to improve our understanding of the inherent and intimate mechanisms underlying multilevel host-fungus interactions...