Abdel Rahman Zekri

Summary

Publications

  1. pmc Genetic distance and heterogenecity between quasispecies is a critical predictor to IFN response in Egyptian patients with HCV genotype-4
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Virol J 4:16. 2007
  2. doi request reprint Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in Egyptian liver disease patients associated with HCV-genotype-4
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    J Gastroenterol Hepatol 24:416-28. 2009
  3. ncbi request reprint Disease Progression from Chronic Hepatitis C to Cirrhosis and Hepatocellular Carcinoma is Associated with Increasing DNA Promoter Methylation
    Abd El Rahman Nabawy Zekri
    Virology and Immunology, National Cancer Institute, Cairo University, Cairo, Egypt e mail
    Asian Pac J Cancer Prev 14:6721-6. 2013
  4. pmc Dynamic interplay between CXCL levels in chronic hepatitis C patients treated by interferon
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
    Virol J 10:218. 2013
  5. doi request reprint Epstein-Barr virus and breast cancer: epidemiological and molecular study on Egyptian and Iraqi women
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11976, Egypt
    J Egypt Natl Canc Inst 24:123-31. 2012
  6. pmc Occult HBV infection among Egyptian hepatocellular carcinoma patients
    Zeinab K Hassan
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, 11197 Cairo, Egypt
    Virol J 8:90. 2011
  7. pmc Clinical significance of altered nm23-H1, EGFR, RB and p53 expression in bilharzial bladder cancer
    Hussein M Khaled
    Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    BMC Cancer 9:32. 2009
  8. ncbi request reprint Detection of simian virus 40 DNA sequences in Egyptian patients with different hematological malignancies
    Abdel Rahman Zekri
    Cancer Biology Department, NCI, Cairo University, Egypt
    Leuk Lymphoma 48:1828-34. 2007
  9. pmc Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: preliminary study
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
    BMC Res Notes 1:106. 2008
  10. pmc Consensus siRNA for inhibition of HCV genotype-4 replication
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
    Virol J 6:13. 2009

Collaborators

Detail Information

Publications30

  1. pmc Genetic distance and heterogenecity between quasispecies is a critical predictor to IFN response in Egyptian patients with HCV genotype-4
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Virol J 4:16. 2007
    ..HCV is one of the major health problems in Egypt, where it is highly prevalent. Genotype 4 is the most common genotype of HCV and its response to treatment is still a controversy...
  2. doi request reprint Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in Egyptian liver disease patients associated with HCV-genotype-4
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    J Gastroenterol Hepatol 24:416-28. 2009
    ..Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide strongly linked to hepatitis C virus (HCV) infection. However, the exact pathogenetic mechanisms are still unclear...
  3. ncbi request reprint Disease Progression from Chronic Hepatitis C to Cirrhosis and Hepatocellular Carcinoma is Associated with Increasing DNA Promoter Methylation
    Abd El Rahman Nabawy Zekri
    Virology and Immunology, National Cancer Institute, Cairo University, Cairo, Egypt e mail
    Asian Pac J Cancer Prev 14:6721-6. 2013
    ..We can conclude that methylation processes are not just early events in hepatocarcinogenesis but accumulate with progression to cancer. ..
  4. pmc Dynamic interplay between CXCL levels in chronic hepatitis C patients treated by interferon
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
    Virol J 10:218. 2013
    ..Pretreatment predictors of SVR to interferon therapy have not been fully investigated yet. The current study assesses a group of chemokines that may predict treatment response in Egyptian patients with chronic HCV infection...
  5. doi request reprint Epstein-Barr virus and breast cancer: epidemiological and molecular study on Egyptian and Iraqi women
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo 11976, Egypt
    J Egypt Natl Canc Inst 24:123-31. 2012
    ..The aim of the current study is to unravel the association between EBV and primary invasive breast cancer (PIBC) in two different Arab populations (Egyptian and Iraqi women)...
  6. pmc Occult HBV infection among Egyptian hepatocellular carcinoma patients
    Zeinab K Hassan
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, 11197 Cairo, Egypt
    Virol J 8:90. 2011
    ..Occult HBV infection accelerates the progression of liver fibrosis, cirrhosis, and finally leading to hepatocellular carcinoma (HCC). This study analyzed the occult HBV-genotypes in HCC patients...
  7. pmc Clinical significance of altered nm23-H1, EGFR, RB and p53 expression in bilharzial bladder cancer
    Hussein M Khaled
    Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    BMC Cancer 9:32. 2009
    ..We assessed the correlation between nm23-H1, Rb, EGFR and p53 in relation to the clinical outcome of patients with muscle invasive bilharzial bladder cancer (MI-BBC)...
  8. ncbi request reprint Detection of simian virus 40 DNA sequences in Egyptian patients with different hematological malignancies
    Abdel Rahman Zekri
    Cancer Biology Department, NCI, Cairo University, Egypt
    Leuk Lymphoma 48:1828-34. 2007
    ..This could lead to new diagnostic, therapeutic, and preventive approaches...
  9. pmc Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: preliminary study
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
    BMC Res Notes 1:106. 2008
    ..Hepatocellular carcinoma (HCC) is a preventable disease rather than a curable one, since there is no well-documented effective treatment modality until now, making the molecular study of this disease mandatory...
  10. pmc Consensus siRNA for inhibition of HCV genotype-4 replication
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
    Virol J 6:13. 2009
    ..The current study was conducted to assess whether siRNA can inhibit different HCV genotypes with many quasispecies and to assess whether consensus siRNA have the same effect as regular siRNA...
  11. doi request reprint Disease progression from chronic hepatitis C to cirrhosis and hepatocellular carcinoma is associated with repression of interferon regulatory factor-1
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Eur J Gastroenterol Hepatol 22:450-6. 2010
    ..This study has been performed to show the expression profile of IRF-1, IRF-3, and IRF-7 in Egyptian patients with HCV-related liver diseases and hepatocellular carcinoma (HCC)...
  12. pmc Characterization of chronic HCV infection-induced apoptosis
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Egypt
    Comp Hepatol 10:4. 2011
    ..abstract:..
  13. pmc Hepatitis B virus (HBV) genotypes in Egyptian pediatric cancer patients with acute and chronic active HBV infection
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Virol J 4:74. 2007
    ..Several methods have been developed and used for HBV genotyping. This study was undertaken to determine the HBV genotypes in Egyptian pediatric cancer patients with acute and chronic liver disease...
  14. ncbi request reprint p53 mutation in HCV-genotype-4 associated hepatocellular carcinoma in Egyptian patients
    Abdel Rahman N Zekri
    The Department of Virology and Immunology Unit, National Cancer Institute, El Menoufia School of Medicine, El Menoufia University, Egypt
    J Egypt Natl Canc Inst 18:17-29. 2006
    ..However, no specific pattern for p53 mutations was observed in HCV genotype 4-associated HCC and no significant relation between p53 mutations, HCV-NS3 expressions or any HCV sub-genotype-4 sequence...
  15. ncbi request reprint Genetic profiling of non-Hodgkin's lymphoma with or without hepatitis C virus infection
    Abdel Rahman Zekri
    Department of Virology and Immunology, National Cancer Institute, Cairo University, Egypt
    Egypt J Immunol 17:81-90. 2010
    ..We conclude that the upregulated and the downregulated genes identified through the studied expression profiles of NHL with HCV infection may shed light on the mechanisms of HCV lymphomagenesis...
  16. doi request reprint Autologous hematopoietic stem cell transplantation in 48 patients with end-stage chronic liver diseases
    Hosny Salama
    Hepatology Department, Cairo University Hospital, Cairo, Egypt
    Cell Transplant 19:1475-86. 2010
    ..003). These results suggest that autologous CD34(+) stem cell transplantation may be safely administered and appears to offer some therapeutic benefit to patients with both viral and autoimmune-induced end-stage liver disease...
  17. ncbi request reprint Caspase recruitment domains. New potential markers for diagnosis of hepatocellular carcinoma associated with HCV in Egyptian patients
    Abdel Rahman Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Ann Hepatol 12:774-81. 2013
    ....
  18. pmc Repressed induction of interferon-related microRNAs miR-146a and miR-155 in peripheral blood mononuclear cells infected with HCV genotype 4
    Nada El-Ekiaby
    The Molecular Pathology Research Group, Pharmacology and Toxicology Department, German University in Cairo, Cairo, Egypt
    FEBS Open Bio 2:179-86. 2012
    ..In conclusion, HCV infection might repress the induction of miR-146a and miR-155 by interfering with TLR-7 signaling...
  19. ncbi request reprint Risk factors for cytomegalovirus, hepatitis B and C virus reactivation after bone marrow transplantation
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Fom El Khalig, Cairo 11796, Egypt
    Transpl Immunol 13:305-11. 2004
    ..In conclusion, previous exposure to CMV, HBV, and HCV infections in the recipients of BMT patients were found to influence the risk of developing those viral infections...
  20. pmc Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients
    Abeer A Bahnassy
    Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    BMC Gastroenterol 4:22. 2004
    ..Colorectal cancer is a common cancer all over the world. Aberrations in the cell cycle checkpoints have been shown to be of prognostic significance in colorectal cancer...
  21. ncbi request reprint Evaluation of simian virus-40 as a biological prognostic factor in Egyptian patients with malignant pleural mesothelioma
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    Pathol Int 57:493-501. 2007
    ..Combined positivity for SV40 and asbestos exposure is an independent prognostic factor in MPM, having a detrimental effect on OS...
  22. ncbi request reprint Human papillomavirus infection in Egyptian esophageal carcinoma: correlation with p53, p21, mdm2, C-erbB2 and impact on survival
    Abeer A Bahnassy
    Department of Pathology, National Cancer Institute, Kaser El Aini School of Medicine, Cairo University, Fom El Khalig, Cairo 11796, Egypt
    Pathol Int 55:53-62. 2005
    ..mdm2 and c-erbB2 are possible targets for HPV in the p53-independent pathway. However, only advanced stage and aberrant expression of p53 and p21(waf) are independent prognostic markers...
  23. ncbi request reprint Application of refractory fragment amplification system for detection of Egyptian variant of Familial Mediterranean Fever
    Abdel Rahman N Zekri
    Department of Cancer Biology, Virology and Immunology Unit, National Cancer Institute, Cairo University, Egypt
    Egypt J Immunol 11:103-10. 2004
    ..No false positive or false negative results were obtained by using the three sets of primers for each sample, indicating a sensitivity and specificity of 100% of this assay...
  24. ncbi request reprint Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Fom El Khalig, Cairo 11796, Egypt
    World J Gastroenterol 11:6624-30. 2005
    ..To observe the imbalance between T helper cell Th1 and Th2 cytokines in several chronic hepatitis disease at different stages of disease progression...
  25. pmc Evaluation of blood units with isolated anti HBC for the presence of HBV DNA
    Abdel Rahman N Zekri
    Virology and immunology Unit Cancer biology Department and Clinical Pathology Department National Cancer Institute, Cairo, Egypt
    Dis Markers 18:107-10. 2002
    ..We found only one specimen positive with incidence of 1.25%. So we recommended restricting transfusion from the previously mentioned donors to emergencies...
  26. ncbi request reprint Alterations of the fragile histidine triad gene in hepatitis C virus-associated hepatocellular carcinoma
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cairo University, Cairo, Egypt
    J Gastroenterol Hepatol 20:87-94. 2005
    ....
  27. ncbi request reprint Mismatch repair genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6, hMSH2) in the pathogenesis of hepatocellular carcinoma
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Kasr El Aini St, Fom El Khaig, Cairo 11796, Egypt
    World J Gastroenterol 11:3020-6. 2005
    ..Abnormalities in one or more MMR genes are implicated in the development of many cancers. We investigated the role of expression of MMR genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6, hMSH2) in hepatocellular carcinogenesis...
  28. ncbi request reprint Hepatitis C virus-NS3P in relation to p53, p21waf, mdm2, p21-ras and c-erbB2 in hepatocarcinogenesis
    Abeer A Bahnassi
    Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
    J Gastroenterol Hepatol 20:1731-40. 2005
    ..However, the exact mechanisms involved in this process are unidentified yet, especially in the Egyptian population where the commonest type is genotype 4...
  29. ncbi request reprint Correlation between p53 mutations and HPV in bilharzial bladder cancer
    Hussein M Khaled
    Medical Oncology Department, Cairo University, Cairo, Egypt
    Urol Oncol 21:334-41. 2003
    ..However, both HPV infection and p53 gene abnormalities may contribute to Bilharzial bladder carcinogenesis in an independent way...
  30. ncbi request reprint HLA alleles in Egyptian HCV genotype-4 carriers
    Abdel Rahman N Zekri
    Virology and Immunology Unit, Cancer Biology Department, National Institute, Cairo University, Cairo, Egypt
    Egypt J Immunol 12:77-86. 2005
    ..We conclude that, there is a possible impact of both class I and class II alleles on HCV infection, resistance, clearance and intrafamilial transmission...