Genetic distance and heterogenecity between quasispecies is a critical predictor to IFN response in Egyptian patients with HCV genotype-4Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
Virol J 4:16. 2007
..HCV is one of the major health problems in Egypt, where it is highly prevalent. Genotype 4 is the most common genotype of HCV and its response to treatment is still a controversy...
- Occult HBV infection among Egyptian hepatocellular carcinoma patients
Zeinab K Hassan
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, 11197 Cairo, Egypt
Virol J 8:90. 2011
..Occult HBV infection accelerates the progression of liver fibrosis, cirrhosis, and finally leading to hepatocellular carcinoma (HCC). This study analyzed the occult HBV-genotypes in HCC patients...
- Clinical significance of altered nm23-H1, EGFR, RB and p53 expression in bilharzial bladder cancer
Hussein M Khaled
Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
BMC Cancer 9:32. 2009
..We assessed the correlation between nm23-H1, Rb, EGFR and p53 in relation to the clinical outcome of patients with muscle invasive bilharzial bladder cancer (MI-BBC)...
- Hepatitis B virus (HBV) genotypes in Egyptian pediatric cancer patients with acute and chronic active HBV infection
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
Virol J 4:74. 2007
..Several methods have been developed and used for HBV genotyping. This study was undertaken to determine the HBV genotypes in Egyptian pediatric cancer patients with acute and chronic liver disease...
Detection of simian virus 40 DNA sequences in Egyptian patients with different hematological malignanciesAbdel Rahman Zekri
Cancer Biology Department, NCI, Cairo University, Egypt
Leuk Lymphoma 48:1828-34. 2007
..This could lead to new diagnostic, therapeutic, and preventive approaches...
- Genetic profile of Egyptian hepatocellular-carcinoma associated with hepatitis C virus Genotype 4 by 15 K cDNA microarray: preliminary study
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
BMC Res Notes 1:106. 2008
..Hepatocellular carcinoma (HCC) is a preventable disease rather than a curable one, since there is no well-documented effective treatment modality until now, making the molecular study of this disease mandatory...
Expression of pro- and anti-inflammatory cytokines in relation to apoptotic genes in Egyptian liver disease patients associated with HCV-genotype-4Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
J Gastroenterol Hepatol 24:416-28. 2009
..Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide strongly linked to hepatitis C virus (HCV) infection. However, the exact pathogenetic mechanisms are still unclear...
- Consensus siRNA for inhibition of HCV genotype-4 replication
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, 1st Kasr El Aini st, Cairo, Egypt
Virol J 6:13. 2009
..The current study was conducted to assess whether siRNA can inhibit different HCV genotypes with many quasispecies and to assess whether consensus siRNA have the same effect as regular siRNA...
- Disease progression from chronic hepatitis C to cirrhosis and hepatocellular carcinoma is associated with repression of interferon regulatory factor-1
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
Eur J Gastroenterol Hepatol 22:450-6. 2010
..This study has been performed to show the expression profile of IRF-1, IRF-3, and IRF-7 in Egyptian patients with HCV-related liver diseases and hepatocellular carcinoma (HCC)...
- Characterization of chronic HCV infection-induced apoptosis
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Egypt
Comp Hepatol 10:4. 2011
..abstract:..
- p53 mutation in HCV-genotype-4 associated hepatocellular carcinoma in Egyptian patients
Abdel Rahman N Zekri
The Department of Virology and Immunology Unit, National Cancer Institute, El Menoufia School of Medicine, El Menoufia University, Egypt
J Egypt Natl Canc Inst 18:17-29. 2006
..However, no specific pattern for p53 mutations was observed in HCV genotype 4-associated HCC and no significant relation between p53 mutations, HCV-NS3 expressions or any HCV sub-genotype-4 sequence...
- Genetic profiling of non-Hodgkin's lymphoma with or without hepatitis C virus infection
Abdel Rahman Zekri
Department of Virology and Immunology, National Cancer Institute, Cairo University, Egypt
Egypt J Immunol 17:81-90. 2010
..We conclude that the upregulated and the downregulated genes identified through the studied expression profiles of NHL with HCV infection may shed light on the mechanisms of HCV lymphomagenesis...
- Autologous hematopoietic stem cell transplantation in 48 patients with end-stage chronic liver diseases
Hosny Salama
Hepatology Department, Cairo University Hospital, Cairo, Egypt
Cell Transplant 19:1475-86. 2010
..003). These results suggest that autologous CD34(+) stem cell transplantation may be safely administered and appears to offer some therapeutic benefit to patients with both viral and autoimmune-induced end-stage liver disease...
- Risk factors for cytomegalovirus, hepatitis B and C virus reactivation after bone marrow transplantation
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Fom El Khalig, Cairo 11796, Egypt
Transpl Immunol 13:305-11. 2004
..In conclusion, previous exposure to CMV, HBV, and HCV infections in the recipients of BMT patients were found to influence the risk of developing those viral infections...
- Evaluation of blood units with isolated anti HBC for the presence of HBV DNA
Abdel-Rahman N Zekri
Virology and immunology Unit Cancer biology Department and Clinical Pathology Department National Cancer Institute, Cairo, Egypt
Dis Markers 18:107-10. 2002
..We found only one specimen positive with incidence of 1.25%. So we recommended restricting transfusion from the previously mentioned donors to emergencies...
- Cyclin A and cyclin D1 as significant prognostic markers in colorectal cancer patients
Abeer A Bahnassy
Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
BMC Gastroenterol 4:22. 2004
..Colorectal cancer is a common cancer all over the world. Aberrations in the cell cycle checkpoints have been shown to be of prognostic significance in colorectal cancer...
- Human papillomavirus infection in Egyptian esophageal carcinoma: correlation with p53, p21, mdm2, C-erbB2 and impact on survival
Abeer A Bahnassy
Department of Pathology, National Cancer Institute, Kaser El-Aini School of Medicine, Cairo University, Fom El-Khalig, Cairo 11796, Egypt
Pathol Int 55:53-62. 2005
..mdm2 and c-erbB2 are possible targets for HPV in the p53-independent pathway. However, only advanced stage and aberrant expression of p53 and p21(waf) are independent prognostic markers...
- Application of refractory fragment amplification system for detection of Egyptian variant of Familial Mediterranean Fever
Abdel Rahman N Zekri
Department of Cancer Biology, Virology and Immunology Unit, National Cancer Institute, Cairo University, Egypt
Egypt J Immunol 11:103-10. 2004
..No false positive or false negative results were obtained by using the three sets of primers for each sample, indicating a sensitivity and specificity of 100% of this assay...
- Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Fom El Khalig, Cairo 11796, Egypt
World J Gastroenterol 11:6624-30. 2005
..To observe the imbalance between T helper cell Th1 and Th2 cytokines in several chronic hepatitis disease at different stages of disease progression...
- Evaluation of simian virus-40 as a biological prognostic factor in Egyptian patients with malignant pleural mesothelioma
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Cairo, Egypt
Pathol Int 57:493-501. 2007
..Combined positivity for SV40 and asbestos exposure is an independent prognostic factor in MPM, having a detrimental effect on OS...
- Mismatch repair genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6, hMSH2) in the pathogenesis of hepatocellular carcinoma
Abdel Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Cancer Institute, Cairo University, Kasr El Aini St, Fom El Khaig, Cairo 11796, Egypt
World J Gastroenterol 11:3020-6. 2005
..Abnormalities in one or more MMR genes are implicated in the development of many cancers. We investigated the role of expression of MMR genes (hMLH1, hPMS1, hPMS2, GTBP/hMSH6, hMSH2) in hepatocellular carcinogenesis...
- Alterations of the fragile histidine triad gene in hepatitis C virus-associated hepatocellular carcinoma
Abdel Rahman N Zekri
Virology and Immunology Unit, Cairo University, Cairo, Egypt
J Gastroenterol Hepatol 20:87-94. 2005
....
- Hepatitis C virus-NS3P in relation to p53, p21waf, mdm2, p21-ras and c-erbB2 in hepatocarcinogenesis
Abeer A Bahnassi
Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt
J Gastroenterol Hepatol 20:1731-40. 2005
..In contrast, p53, p21ras and mdm2 alterations are late events in hepatocarcinogenesis and are usually associated with an aggressive phenotype...
- Correlation between p53 mutations and HPV in bilharzial bladder cancer
Hussein M Khaled
Medical Oncology Department, Cairo University, Cairo, Egypt
Urol Oncol 21:334-41. 2003
..However, both HPV infection and p53 gene abnormalities may contribute to Bilharzial bladder carcinogenesis in an independent way...
- HLA alleles in Egyptian HCV genotype-4 carriers
Abdel-Rahman N Zekri
Virology and Immunology Unit, Cancer Biology Department, National Institute, Cairo University, Cairo, Egypt
Egypt J Immunol 12:77-86. 2005
..We conclude that, there is a possible impact of both class I and class II alleles on HCV infection, resistance, clearance and intrafamilial transmission...
