Molecular changes in the Ki-ras and APC genes in colorectal adenomas and carcinomas arising in the same patientN P Zauber
Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ, USA
J Pathol 193:303-9. 2001
..The development of LOH of the APC gene is a slightly more consistent finding between the pair, but is not always allelic-specific...
The characterization of somatic APC mutations in colonic adenomas and carcinomas in Ashkenazi Jews with the APC I1307K variant using linkage disequilibriumN Peter Zauber
Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ, USA
J Pathol 199:146-51. 2003
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Molecular changes in the Ki-ras and APC genes in primary colorectal carcinoma and synchronous metastases compared with the findings in accompanying adenomasP Zauber
Saint Barnabas Medical Center, 22 Old Short Hill Road, Livingstone, NJ 07039, USA
Mol Pathol 56:137-40. 2003
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The Adenomatous Polyposis Coli (APC) gene microsatellite marker D5S1385 is equally informative for loss of heterozygosity as the marker D5S346N Peter Zauber
Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ 07039, USA
Exp Mol Pathol 75:144-7. 2003
..D5S1385 detected LOH in 39 of 41 lesions, or 95%, for which D5S346 detected LOH. D5S1385 is moderately polymorphic and is informative at least as often as D5S346...
Ki-ras gene mutations, LOH of the APC and DCC genes, and microsatellite instability in primary colorectal carcinoma are not associated with micrometastases in pericolonic lymph nodes or with patients' survivalN P Zauber
Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ 07039, USA
J Clin Pathol 57:938-42. 2004
..The secondary aim was to correlate the data on these molecular genetic changes and micrometastases with survival...
Comparative molecular pathology of sporadic hyperplastic polyps and neoplastic lesions from the same individualP Zauber
Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ 07039, USA
J Clin Pathol 57:1084-8. 2004
..The aim of this study was to assess and compare the clinical and molecular characteristics of hyperplastic polyps and neoplastic lesions removed from patients without the hyperplastic polyposis syndrome...
Clinical and genetic findings in an Ashkenazi Jewish population with colorectal neoplasmsN Peter Zauber
Department of Medicine, Saint Barnabas Medical Center, Livingston, New Jersey, USA
Cancer 104:719-29. 2005
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Adequacy of colonoscopic biopsy specimens for molecular analysis: a comparative study with colectomy tissueNeil P Zauber
Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ 07039, USA
Diagn Mol Pathol 15:162-8. 2006
..93, respectively) but less so for DCC LOH (kappa=0.62). Colonoscopic biopsies are an acceptable source of neoplastic DNA for studies of KRAS, APC LOH, and MSI, but less so for DCC LOH, primarily resulting from technical considerations...
Molecular genetic changes associated with colorectal carcinogenesis are not prognostic for tumor regression following preoperative chemoradiation of rectal carcinomaN Peter Zauber
Department of Medicine, Saint Barnabas Medical Center, Livingston, NJ, USA
Int J Radiat Oncol Biol Phys 74:472-6. 2009
..We assessed a series of rectal cancers for the molecular changes of loss of heterozygosity of the APC and DCC genes, K-ras mutations, and microsatellite instability, changes that have clearly been associated with rectal carcinogenesis...