Ryan Zarychanski

Summary

Publications

  1. ncbi request reprint Plasma homocysteine concentration is not associated with activated protein C resistance in patients investigated for hypercoagulability
    Ryan Zarychanski
    Section of Haematology Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Thromb Haemost 91:1115-22. 2004
  2. pmc Erythropoietin-receptor agonists in critically ill patients: a meta-analysis of randomized controlled trials
    Ryan Zarychanski
    Department of Epidemiology and Community Medicine, University of Ottawa, and the Ottawa Health Research Institute, Ottawa, Ont
    CMAJ 177:725-34. 2007
  3. pmc Anemia of chronic disease: a harmful disorder or an adaptive, beneficial response?
    Ryan Zarychanski
    Section of Hematology Medical Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Man
    CMAJ 179:333-7. 2008
  4. doi request reprint Early intravenous unfractionated heparin and mortality in septic shock
    Ryan Zarychanski
    Section of Critical Care Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 36:2973-9. 2008
  5. pmc Frequency of colorectal cancer screening and the impact of family physicians on screening behaviour
    Ryan Zarychanski
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 177:593-7. 2007
  6. doi request reprint The benefits of 24/7 in-house intensivist coverage for prolonged-stay cardiac surgery patients
    Kanwal Kumar
    Cardiac Sciences Program, St Boniface General Hospital I H Asper Clinical Research Institute, Winnipeg, Manitoba, Canada
    J Thorac Cardiovasc Surg 148:290-297.e6. 2014
  7. doi request reprint The PRECISE RCT: evolution of an early septic shock fluid resuscitation trial
    Lauralyn McIntyre
    The Clinical Epidemiology Program, Ottawa Hospital Research Institute OHRI, The Ottawa Hospital, Ottawa, Ontario, Canada
    Transfus Med Rev 26:333-41. 2012
  8. doi request reprint The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis
    Ryan Zarychanski
    1Section of Critical Care, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada 2Department of Haematology and Medical Oncology, CancerCare Manitoba, Winnipeg, MB, Canada 3George and Fay Yee Center for Healthcare Innovation, University of Manitoba Winnipeg Regional Health Authority, Winnipeg, MB, Canada 4Clinical Epidemiology Program, Ottawa Hospital Research Institute, Department of Pharmacy, The Ottawa Hospital, Ottawa, ON, Canada 5Division of Critical Care Medicine, Department of Anesthesiology, Centre de recherche CHU de Québec CHU de Québec Research Center Enfant Jésus Hospital, Axe Santé des populations et pratiques optimales en santé Population Health and Optimal Health Practices Unit, Universite Laval, Quebec City, QC, Canada 6Department of Internal Medicine, University of Toronto, ON, Canada 7Clinical Epidemiology Program, Ottawa Hospital Research Institute, Department of Medicine, University of Ottawa, ON, Canada 8Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada 9Department of Medicine, McMaster University, Hamilton, ON, Canada 10Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton
    Crit Care Med 43:511-8. 2015
  9. pmc The efficacy and safety of plasma exchange in patients with sepsis and septic shock: a systematic review and meta-analysis
    Emily Rimmer
    Department of Internal Medicine, University of Manitoba, GC425 820 Sherbrook Street, HSC, Winnipeg, R3A 1R9, Canada
    Crit Care 18:699. 2014
  10. doi request reprint Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis
    Ryan Zarychanski
    University of Manitoba, Department of Internal Medicine, Section of Critical Care, University of Manitoba, ON2056 675 McDermot Ave, Winnipeg, Manitoba R3E 0V9, Canada
    JAMA 309:678-88. 2013

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Plasma homocysteine concentration is not associated with activated protein C resistance in patients investigated for hypercoagulability
    Ryan Zarychanski
    Section of Haematology Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Thromb Haemost 91:1115-22. 2004
    ..In these patients, elevated plasma homocysteine levels is not associated with aPC resistance regardless of FV Leiden genotype suggesting that this is not the mechanism by which homocysteine exerts a prothrombotic effect...
  2. pmc Erythropoietin-receptor agonists in critically ill patients: a meta-analysis of randomized controlled trials
    Ryan Zarychanski
    Department of Epidemiology and Community Medicine, University of Ottawa, and the Ottawa Health Research Institute, Ottawa, Ont
    CMAJ 177:725-34. 2007
    ..We evaluated the effect of erythropoietin-receptor agonists on clinically important outcomes, including mortality, length of stay in hospital or intensive care unit, ventilator use, transfusion requirements and major adverse events...
  3. pmc Anemia of chronic disease: a harmful disorder or an adaptive, beneficial response?
    Ryan Zarychanski
    Section of Hematology Medical Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Man
    CMAJ 179:333-7. 2008
  4. doi request reprint Early intravenous unfractionated heparin and mortality in septic shock
    Ryan Zarychanski
    Section of Critical Care Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 36:2973-9. 2008
    ..Unfractionated heparin is a known anticoagulant, which also possesses anti-inflammatory properties. Unfractionated heparin has been shown to increase survival in experimental models of septic shock...
  5. pmc Frequency of colorectal cancer screening and the impact of family physicians on screening behaviour
    Ryan Zarychanski
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ont
    CMAJ 177:593-7. 2007
    ..We examined the frequency of colorectal cancer screening in 4 Canadian provinces and the influence of patient contact with a family physician on the uptake of cancer screening...
  6. doi request reprint The benefits of 24/7 in-house intensivist coverage for prolonged-stay cardiac surgery patients
    Kanwal Kumar
    Cardiac Sciences Program, St Boniface General Hospital I H Asper Clinical Research Institute, Winnipeg, Manitoba, Canada
    J Thorac Cardiovasc Surg 148:290-297.e6. 2014
    ..The objective of our study was to evaluate the efficacy of 24/7 in-house intensivist care for patients requiring prolonged intensive care unit (ICU) stay following cardiac surgery...
  7. doi request reprint The PRECISE RCT: evolution of an early septic shock fluid resuscitation trial
    Lauralyn McIntyre
    The Clinical Epidemiology Program, Ottawa Hospital Research Institute OHRI, The Ottawa Hospital, Ottawa, Ontario, Canada
    Transfus Med Rev 26:333-41. 2012
    ....
  8. doi request reprint The efficacy and safety of heparin in patients with sepsis: a systematic review and metaanalysis
    Ryan Zarychanski
    1Section of Critical Care, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada 2Department of Haematology and Medical Oncology, CancerCare Manitoba, Winnipeg, MB, Canada 3George and Fay Yee Center for Healthcare Innovation, University of Manitoba Winnipeg Regional Health Authority, Winnipeg, MB, Canada 4Clinical Epidemiology Program, Ottawa Hospital Research Institute, Department of Pharmacy, The Ottawa Hospital, Ottawa, ON, Canada 5Division of Critical Care Medicine, Department of Anesthesiology, Centre de recherche CHU de Québec CHU de Québec Research Center Enfant Jésus Hospital, Axe Santé des populations et pratiques optimales en santé Population Health and Optimal Health Practices Unit, Universite Laval, Quebec City, QC, Canada 6Department of Internal Medicine, University of Toronto, ON, Canada 7Clinical Epidemiology Program, Ottawa Hospital Research Institute, Department of Medicine, University of Ottawa, ON, Canada 8Department of Medicine, Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, ON, Canada 9Department of Medicine, McMaster University, Hamilton, ON, Canada 10Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton
    Crit Care Med 43:511-8. 2015
    ..To evaluate the efficacy and safety of heparin in patients with sepsis, septic shock, or disseminated intravascular coagulation associated with infection...
  9. pmc The efficacy and safety of plasma exchange in patients with sepsis and septic shock: a systematic review and meta-analysis
    Emily Rimmer
    Department of Internal Medicine, University of Manitoba, GC425 820 Sherbrook Street, HSC, Winnipeg, R3A 1R9, Canada
    Crit Care 18:699. 2014
    ..The objective of this study is to evaluate the efficacy and safety of plasma exchange in patients with sepsis...
  10. doi request reprint Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis
    Ryan Zarychanski
    University of Manitoba, Department of Internal Medicine, Section of Critical Care, University of Manitoba, ON2056 675 McDermot Ave, Winnipeg, Manitoba R3E 0V9, Canada
    JAMA 309:678-88. 2013
    ..Clinical trials of hydroxyethyl starch are conflicting. Moreover, multiple trials from one investigator have been retracted because of scientific misconduct...
  11. pmc Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
    Ryan Zarychanski
    Department of Internal Medicine, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba
    CMAJ 182:257-64. 2010
    ..The objective of this study was to identify factors correlated with severity of disease in confirmed cases of pandemic H1N1 influenza...
  12. doi request reprint Activated protein C and septic shock: a propensity-matched cohort study*
    Emily Rimmer
    Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
    Crit Care Med 40:2974-81. 2012
    ..Further clinical trials, including a recently completed trial in patients with septic shock, failed to reproduce these results...
  13. pmc Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza
    Robert E Ariano
    Department of Pharmacy, St Boniface General Hospital, and Department of Internal Medicine, The Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba
    CMAJ 182:357-63. 2010
    ..We documented the pharmacokinetic profile of oseltamivir in patients admitted to intensive care units (ICUs) with suspected or confirmed pandemic (H1N1) influenza...
  14. doi request reprint Sedation and analgesia usage in severe pandemic H1N1 (2009) infection: a comparison to respiratory failure secondary to other infectious pneumonias
    Kendiss Olafson
    Section of Critical Care, Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Ann Pharmacother 46:9-20. 2012
    ..During the 2009 H1N1 pandemic (pH1N1), patients requiring mechanical ventilation for respiratory failure received high doses of sedation and analgesia...
  15. doi request reprint Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada
    Darren H Freed
    Surgical Heart Failure Program, Cardiac Sciences Program, St Boniface General Hospital, CR3030 Asper Clinical Research Building, 369 Tache Ave, Winnipeg, Manitoba R2H 2A6, Canada
    Can J Anaesth 57:240-7. 2010
    ..In this report, we describe characteristics, treatment, and outcomes of critically ill patients in Canada who had H1N1-2009 infection and were treated with extracorporeal lung support (ECLS)...
  16. doi request reprint The use of higher platelet: RBC transfusion ratio in the acute phase of trauma resuscitation: a systematic review
    Julie Hallet
    1Centre de recherche du CHU de Québec, Santé des populations et pratiques optimales en santé, Universite Laval, Quebec, Quebec, Canada 2Department of Surgery, Universite Laval, Quebec City, Quebec, Canada 3Department of Medicine, Universite Laval, Quebec City, Quebec, Canada 4Division of Critical Care Medicine, Department of Anesthesiology, Universite Laval, Quebec City, Quebec, Canada 5Department of Family Medicine and Emergency Medicine, Universite Laval, Quebec City, Quebec, Canada 6CancerCare Manitoba, Winnipeg, Manitoba, Canada 7Department of Internal Medicine, Sections of Critical Care and Hematology Medical Oncology, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 41:2800-11. 2013
    ..The overall benefit of this strategy remains controversial. Our objective was to compare the effects of a liberal use of platelet (higher platelet:RBC ratios) with a conservative approach (lower ratios) in trauma resuscitation...
  17. doi request reprint Preoperative anemia does not increase the risks of early surgical revascularization after myocardial infarction
    Li Zhang
    Cardiac Sciences Program, St Boniface Hospital I H Asper Clinical Research Institute, Winnipeg, Manitoba, Canada
    Ann Thorac Surg 95:542-7. 2013
    ..The objective of this study was to investigate the impact of preoperative anemia on short-term outcomes after coronary bypass surgery in patients with a recent MI...
  18. doi request reprint Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A(H1N1): report from a Canadian Province
    Manish M Sood
    St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Kidney Dis 55:848-55. 2010
    ..2009 pandemic influenza A(H1N1) has led to a global increase in severe respiratory illness. Little is known about kidney outcomes and dialytic requirements in critically ill patients infected with pandemic H1N1...
  19. doi request reprint Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis
    Anand Kumar
    Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Crit Care Med 38:1773-85. 2010
    ..Current guidelines do not recommend combination therapy except for the express purpose of broadening coverage when resistant pathogens are a concern...
  20. doi request reprint Failure of anticoagulant thromboprophylaxis: risk factors in medical-surgical critically ill patients*
    Wendy Lim
    1Department of Medicine, McMaster University, Hamilton, ON, Canada 2Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada 3Research Center of the CHU de Québec, Population Health and Optimal Health Practices Research Unit, Quebec, QC, Canada 4Division of Critical Care, Department of Medicine, Quebec, QC, Canada 5Section of Critical Care, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada 6Section of Hematology Medical Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada 7Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada 8Division of Critical Care, Department of Medicine, Centre de Recherche Clinique Étiene Le Bel, Universite de Sherbrooke, Sherbrooke, QC, Canada 9Division of Critical Care Medicine and Center for Health Evaluation and Outcome Sciences, St Paul s Hospital and University of British Columbia, Vancouver, BC, Canada 10Department of Critical Care, University of Ottawa, Ottawa, ON, Canada 11Department of Anesthesia, Queen Elizabeth II Health Sciences Centre, 12Department of Critical Care, University of Michigan
    Crit Care Med 43:401-10. 2015
    ..To identify risk factors for failure of anticoagulant thromboprophylaxis in critically ill patients in the ICU...
  21. doi request reprint Preoperative therapeutic apheresis for severe medically refractory amiodarone-induced thyrotoxicosis: a case report
    Jennifer Yamamoto
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Clin Apher 29:168-70. 2014
    ..To decrease perioperative thyroid storm and to reduce overall surgical risk, apheresis may be considered preoperatively to restore euthyroidism...
  22. ncbi request reprint Perinatal and maternal outcomes in critically ill obstetrics patients with pandemic H1N1 Influenza A
    Titilayo Oluyomi-Obi
    Department of Obstetrics, Gynaecology and Reproductive Sciences, University of Manitoba, Winnipeg MB, Canada
    J Obstet Gynaecol Can 32:443-7, 448-52. 2010
    ..Information about these cases will be useful to help us understand the potential impact of future outbreaks and review critical illness in pregnancy...
  23. pmc Pain management with acupuncture in osteoarthritis: a systematic review and meta-analysis
    Taru Manyanga
    Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    BMC Complement Altern Med 14:312. 2014
    ..The utility of acupuncture in managing osteoarthritis symptoms is uncertain. Trial results are conflicting and previous systematic reviews may have overestimated the benefits of acupuncture...
  24. pmc The impact of omega-3 polyunsaturated fatty acid supplementation on the incidence of cardiovascular events and complications in peripheral arterial disease: a systematic review and meta-analysis
    Jennifer E Enns
    Department of Physiology, University of Manitoba, Winnipeg, Canada
    BMC Cardiovasc Disord 14:70. 2014
    ..We conducted a systematic review and meta-analysis to determine whether omega-3 PUFA supplementation reduces the incidence of cardiovascular events and complications in adults with peripheral arterial disease...
  25. doi request reprint Is iron deficiency in the absence of anemia associated with fatigue in inflammatory bowel disease?
    Benjamin A Goldenberg
    Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Gastroenterol 108:1392-7. 2013
    ..We explored whether iron deficiency in the absence of anemia is associated with fatigue in inflammatory bowel disease (IBD)...
  26. doi request reprint Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock: a pilot randomized, controlled trial
    Lauralyn A McIntyre
    Department of Medicine Division of Critical Care, Ottawa Hospital Research Institute OHRI, University of Ottawa, Ottawa, Ontario, Canada
    J Crit Care 27:317.e1-6. 2012
    ..We describe the Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock (PRECISE) pilot trial study design and report feasibility of patient recruitment...
  27. pmc Clinical review: a review and analysis of heart rate variability and the diagnosis and prognosis of infection
    Saif Ahmad
    Ottawa Hospital Research Institute, Ottawa, Ontario, K1Y 4E9, Canada
    Crit Care 13:232. 2009
    ....
  28. doi request reprint Historical perspectives in critical care medicine: blood transfusion, intravenous fluids, inotropes/vasopressors, and antibiotics
    Ryan Zarychanski
    Section of Critical Care Medicine, University of Manitoba, JJ399 700 William Avenue, Winnipeg, Manitoba, Canada
    Crit Care Clin 25:201-20, x. 2009
    ..Prominent medical and social pressures that have catalyzed research and innovation in each domain are also addressed, as well as current and future challenges...
  29. doi request reprint Impact of 24-hour in-house intensivists on a dedicated cardiac surgery intensive care unit
    Kanwal Kumar
    Cardiovascular Health Research in Manitoba Investigator Group, Cardiac Sciences Program, St Boniface General Hospital IH Asper Clinical Research Institute, Winnipeg, Manitoba, Canada
    Ann Thorac Surg 88:1153-61. 2009
    ..Clinical outcomes associated with 24-hour, in-house intensivists working in a dedicated post-cardiac surgical unit has not been previously investigated. We sought to examine the safety and efficacy of such a model...
  30. pmc Rates of colorectal cancer screening
    Ryan Zarychanski
    CMAJ 178:1465. 2008