Plasma homocysteine concentration is not associated with activated protein C resistance in patients investigated for hypercoagulabilityRyan Zarychanski
Section of Haematology Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
Thromb Haemost 91:1115-22. 2004
..In these patients, elevated plasma homocysteine levels is not associated with aPC resistance regardless of FV Leiden genotype suggesting that this is not the mechanism by which homocysteine exerts a prothrombotic effect...
Erythropoietin-receptor agonists in critically ill patients: a meta-analysis of randomized controlled trialsRyan Zarychanski
Department of Epidemiology and Community Medicine, University of Ottawa, and the Ottawa Health Research Institute, Ottawa, Ont
CMAJ 177:725-34. 2007
..We evaluated the effect of erythropoietin-receptor agonists on clinically important outcomes, including mortality, length of stay in hospital or intensive care unit, ventilator use, transfusion requirements and major adverse events...
- Anemia of chronic disease: a harmful disorder or an adaptive, beneficial response?
Ryan Zarychanski
Section of Hematology Medical Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Man
CMAJ 179:333-7. 2008
Early intravenous unfractionated heparin and mortality in septic shockRyan Zarychanski
Section of Critical Care Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care Med 36:2973-9. 2008
..Unfractionated heparin is a known anticoagulant, which also possesses anti-inflammatory properties. Unfractionated heparin has been shown to increase survival in experimental models of septic shock...
- Frequency of colorectal cancer screening and the impact of family physicians on screening behaviour
Ryan Zarychanski
Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ont
CMAJ 177:593-7. 2007
..We examined the frequency of colorectal cancer screening in 4 Canadian provinces and the influence of patient contact with a family physician on the uptake of cancer screening...
- The PRECISE RCT: evolution of an early septic shock fluid resuscitation trial
Lauralyn McIntyre
The Clinical Epidemiology Program, Ottawa Hospital Research Institute OHRI, The Ottawa Hospital, Ottawa, Ontario, Canada
Transfus Med Rev 26:333-41. 2012
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- Association of hydroxyethyl starch administration with mortality and acute kidney injury in critically ill patients requiring volume resuscitation: a systematic review and meta-analysis
Ryan Zarychanski
University of Manitoba, Department of Internal Medicine, Section of Critical Care, University of Manitoba, ON2056 675 McDermot Ave, Winnipeg, Manitoba R3E 0V9, Canada
JAMA 309:678-88. 2013
..Clinical trials of hydroxyethyl starch are conflicting. Moreover, multiple trials from one investigator have been retracted because of scientific misconduct...
- Correlates of severe disease in patients with 2009 pandemic influenza (H1N1) virus infection
Ryan Zarychanski
Department of Internal Medicine, University of Manitoba, CancerCare Manitoba, Winnipeg, Manitoba
CMAJ 182:257-64. 2010
..The objective of this study was to identify factors correlated with severity of disease in confirmed cases of pandemic H1N1 influenza...
- Activated protein C and septic shock: a propensity-matched cohort study*
Emily Rimmer
Department of Internal Medicine, University of Manitoba, Winnipeg, Canada
Crit Care Med 40:2974-81. 2012
..Further clinical trials, including a recently completed trial in patients with septic shock, failed to reproduce these results...
- Enteric absorption and pharmacokinetics of oseltamivir in critically ill patients with pandemic (H1N1) influenza
Robert E Ariano
Department of Pharmacy, St Boniface General Hospital, and Department of Internal Medicine, The Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba
CMAJ 182:357-63. 2010
..We documented the pharmacokinetic profile of oseltamivir in patients admitted to intensive care units (ICUs) with suspected or confirmed pandemic (H1N1) influenza...
- Sedation and analgesia usage in severe pandemic H1N1 (2009) infection: a comparison to respiratory failure secondary to other infectious pneumonias
Kendiss Olafson
Section of Critical Care, Department of Medicine, University of Manitoba, Winnipeg, MB, Canada
Ann Pharmacother 46:9-20. 2012
..During the 2009 H1N1 pandemic (pH1N1), patients requiring mechanical ventilation for respiratory failure received high doses of sedation and analgesia...
- Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada
Darren H Freed
Surgical Heart Failure Program, Cardiac Sciences Program, St Boniface General Hospital, CR3030 Asper Clinical Research Building, 369 Tache Ave, Winnipeg, Manitoba R2H 2A6, Canada
Can J Anaesth 57:240-7. 2010
..In this report, we describe characteristics, treatment, and outcomes of critically ill patients in Canada who had H1N1-2009 infection and were treated with extracorporeal lung support (ECLS)...
- Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis
Anand Kumar
Section of Critical Care Medicine, Health Sciences Centre St Boniface Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
Crit Care Med 38:1773-85. 2010
..Current guidelines do not recommend combination therapy except for the express purpose of broadening coverage when resistant pathogens are a concern...
- Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A(H1N1): report from a Canadian Province
Manish M Sood
St Boniface General Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
Am J Kidney Dis 55:848-55. 2010
..2009 pandemic influenza A(H1N1) has led to a global increase in severe respiratory illness. Little is known about kidney outcomes and dialytic requirements in critically ill patients infected with pandemic H1N1...
- Perinatal and maternal outcomes in critically ill obstetrics patients with pandemic H1N1 Influenza A
Titilayo Oluyomi-Obi
Department of Obstetrics, Gynaecology and Reproductive Sciences, University of Manitoba, Winnipeg MB, Canada
J Obstet Gynaecol Can 32:443-7, 448-52. 2010
..Information about these cases will be useful to help us understand the potential impact of future outbreaks and review critical illness in pregnancy...
- Preoperative anemia does not increase the risks of early surgical revascularization after myocardial infarction
Li Zhang
Cardiac Sciences Program, St Boniface Hospital I H Asper Clinical Research Institute, University of Manitoba, Winnipeg, Manitoba, Canada
Ann Thorac Surg 95:542-7. 2013
..The objective of this study was to investigate the impact of preoperative anemia on short-term outcomes after coronary bypass surgery in patients with a recent MI...
- Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock: a pilot randomized, controlled trial
Lauralyn A McIntyre
Department of Medicine Division of Critical Care, Ottawa Hospital Research Institute OHRI, University of Ottawa, Ottawa, Ontario, Canada
J Crit Care 27:317.e1-6. 2012
..We describe the Fluid Resuscitation with 5% albumin versus Normal Saline in Early Septic Shock (PRECISE) pilot trial study design and report feasibility of patient recruitment...
- Clinical review: a review and analysis of heart rate variability and the diagnosis and prognosis of infection
Saif Ahmad
Ottawa Hospital Research Institute, Ottawa, Ontario, K1Y 4E9, Canada
Crit Care 13:232. 2009
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- Impact of 24-hour in-house intensivists on a dedicated cardiac surgery intensive care unit
Kanwal Kumar
Cardiovascular Health Research in Manitoba Investigator Group, Cardiac Sciences Program, St Boniface General Hospital IH Asper Clinical Research Institute, Winnipeg, Manitoba, Canada
Ann Thorac Surg 88:1153-61. 2009
..Clinical outcomes associated with 24-hour, in-house intensivists working in a dedicated post-cardiac surgical unit has not been previously investigated. We sought to examine the safety and efficacy of such a model...
- Historical perspectives in critical care medicine: blood transfusion, intravenous fluids, inotropes/vasopressors, and antibiotics
Ryan Zarychanski
Section of Critical Care Medicine, University of Manitoba, JJ399 700 William Avenue, Winnipeg, Manitoba, Canada
Crit Care Clin 25:201-20, x. 2009
..Prominent medical and social pressures that have catalyzed research and innovation in each domain are also addressed, as well as current and future challenges...
- Rates of colorectal cancer screening
Ryan Zarychanski
CMAJ 178:1465. 2008
