Alfeu Zanotto-Filho

Summary

Publications

  1. doi request reprint Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Rio Grande do Sul, Brasil
    Invest New Drugs 30:2252-62. 2012
  2. doi request reprint The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Rio Grande do Sul, Brasil
    J Nutr Biochem 23:591-601. 2012
  3. doi request reprint NFκB inhibitors induce cell death in glioblastomas
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Biochem Pharmacol 81:412-24. 2011
  4. ncbi request reprint Retinol induces the ERK1/2-dependent phosphorylation of CREB through a pathway involving the generation of reactive oxygen species in cultured Sertoli cells
    Daniel P Gelain
    Centro de Estudos em Estresse Oxidativo, Brazil
    Cell Signal 18:1685-94. 2006
  5. doi request reprint The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, UFRGS, Rio Grande do Sul, Brazil
    Cancer Lett 288:192-203. 2010
  6. doi request reprint In vitro optimization of retinoic acid-induced neuritogenesis and TH endogenous expression in human SH-SY5Y neuroblastoma cells by the antioxidant Trolox
    Mario Luiz Conte da Frota Junior
    Center of Oxidative Stress Research, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rio Grande do Sul, Rua Ramiro Barcelos 2600 anexo, Porto Alegre, RS 90035 003, Brazil
    Mol Cell Biochem 358:325-34. 2011
  7. ncbi request reprint Retinoic acid induces apoptosis by a non-classical mechanism of ERK1/2 activation
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Toxicol In Vitro 22:1205-12. 2008
  8. doi request reprint Retinol increases catalase activity and protein content by a reactive species-dependent mechanism in Sertoli cells
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Chem Biol Interact 174:38-43. 2008
  9. ncbi request reprint Retinol and retinoic acid increase MMP-2 activity by different pathways in cultured Sertoli cells
    Rodrigo J S Dalmolin
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil
    Free Radic Res 41:1338-47. 2007
  10. ncbi request reprint Retinol and retinoic acid modulate catalase activity in Sertoli cells by distinct and gene expression-independent mechanisms
    Matheus A B Pasquali
    CEEO, Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Laboratório 32, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 anexo, CEP 90035003, Porto Alegre, RS, Brazil
    Toxicol In Vitro 22:1177-83. 2008

Collaborators

  • Fabio Klamt
  • Daniel Pens Gelain
  • Elizandra Braganhol
  • Felipe Dal-Pizzol
  • Rodrigo J S Dalmolin
  • Ana Maria O Battastini
  • Martin Cammarota
  • Guilherme Antonio Behr
  • Fernanda Freitas Caregnato
  • Andressa Bernardi
  • Clarissa Severino Gama
  • Fares Zeidán-Chuliá
  • Rodrigo Lorenzi
  • Diego Bonatto
  • Ivan Izquierdo
  • Marcio Soares
  • Jose Claudio Fonseca Moreira
  • Fabrício Figueiró
  • Daniéli Gerhardt
  • Christianne G Salbego
  • Karine Zortea
  • Mario Luiz Conte da Frota Junior
  • Mauro Antonio Alves Castro
  • Iuri Marques de Oliveira
  • Matheus Augusto de Bittencourt Pasquali
  • Matheus A B Pasquali
  • Evandro Gomes da Silva
  • Mara Regina Netto Benetti
  • Gabriela Bertola
  • Fabrícia Dietrich
  • Fernanda Bueno Morrone
  • Carlos Henrique Barrios
  • José Cláudio Moreira Fonseca
  • Maria I Edelweiss
  • Adriana R Pohlmann
  • Thatiana Terroso
  • Jose Claudio F Moreira
  • Elisa H F Jandrey
  • Rudimar L Frozza
  • Silvia S Guterres
  • Camila Lersch
  • Paulo Silva Belmonte-de-Abreu
  • Maria Inês Rodrigues Lobato
  • José Cláudio Moreira
  • Lísia Rejane Guimarães
  • Lenise Petter Francesconi
  • Brisa Simões Fernandes
  • Rafael Schroeder
  • Ivi Juliana Bristot
  • Fernanda M Lopes
  • André Simões Pires
  • Emily Shacter
  • Carolina Beatriz Muller
  • Stephanie Zdanov
  • Fernanda Martins Lopes
  • Marilda da Cruz Fernandes
  • João Antonio Pêgas Henriques
  • Jose C F Moreira
  • Ramatis B de Oliveira
  • Luiz F de Souza
  • Flávio Henrique Reginatto
  • Francilene Amaral da Silva
  • Ana Lúcia Aboy
  • Adriana Coitinho
  • Luis Gustavo Ravazolo
  • Martina Rudnicki
  • Andréa Gisiane Kurek
  • Valquiria Linck Bassani
  • Gilberto Schwartsmann
  • Marcos Roberto de Oliveira
  • Celso Luis Bordignon
  • Amélia Teresinha Henriques

Detail Information

Publications21

  1. doi request reprint Proteasome inhibitor MG132 induces selective apoptosis in glioblastoma cells through inhibition of PI3K/Akt and NFkappaB pathways, mitochondrial dysfunction, and activation of p38-JNK1/2 signaling
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Rio Grande do Sul, Brasil
    Invest New Drugs 30:2252-62. 2012
    ..In summary, MG132 exerted profound and selective toxicity in GBMs, being a potential agent for further testing in animal models of the disease...
  2. doi request reprint The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, Rio Grande do Sul, Brasil
    J Nutr Biochem 23:591-601. 2012
    ..In summary, data presented here suggest curcumin as a potential agent for therapy of GBMs...
  3. doi request reprint NFκB inhibitors induce cell death in glioblastomas
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Biochem Pharmacol 81:412-24. 2011
    ..These findings support NFκB as a potential target to cell death induction in GBMs, and that the NFκB inhibitors may be considered for in vivo testing on animal models and possibly on GBM therapy...
  4. ncbi request reprint Retinol induces the ERK1/2-dependent phosphorylation of CREB through a pathway involving the generation of reactive oxygen species in cultured Sertoli cells
    Daniel P Gelain
    Centro de Estudos em Estresse Oxidativo, Brazil
    Cell Signal 18:1685-94. 2006
    ....
  5. doi request reprint The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, UFRGS, Rio Grande do Sul, Brazil
    Cancer Lett 288:192-203. 2010
    ..Data suggest that the NFkappaB inhibitors MG132 and BAY117082 are potential anti-leukemia agents...
  6. doi request reprint In vitro optimization of retinoic acid-induced neuritogenesis and TH endogenous expression in human SH-SY5Y neuroblastoma cells by the antioxidant Trolox
    Mario Luiz Conte da Frota Junior
    Center of Oxidative Stress Research, Department of Biochemistry, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Rio Grande do Sul, Rua Ramiro Barcelos 2600 anexo, Porto Alegre, RS 90035 003, Brazil
    Mol Cell Biochem 358:325-34. 2011
    ..Therefore, our data demonstrate that concomitant decreases in basal reactive oxygen species (ROS) production could exert a positive effect on the neuritogenic process of RA-treated SH-SY5Y cells...
  7. ncbi request reprint Retinoic acid induces apoptosis by a non-classical mechanism of ERK1/2 activation
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Toxicol In Vitro 22:1205-12. 2008
    ..The non-canonical RA signaling presented in this work evokes new perspectives of RA action, which may play an important role in mediating early biological effects of RA modulating cell death in normal and tumor cells...
  8. doi request reprint Retinol increases catalase activity and protein content by a reactive species-dependent mechanism in Sertoli cells
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil
    Chem Biol Interact 174:38-43. 2008
    ....
  9. ncbi request reprint Retinol and retinoic acid increase MMP-2 activity by different pathways in cultured Sertoli cells
    Rodrigo J S Dalmolin
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil
    Free Radic Res 41:1338-47. 2007
    ..Our findings suggested that retinol-induced MMP-2 activity, but not retinoic acid-induced MMP-2 activity, was related to ERK1/2 phosphorylation and ROS production...
  10. ncbi request reprint Retinol and retinoic acid modulate catalase activity in Sertoli cells by distinct and gene expression-independent mechanisms
    Matheus A B Pasquali
    CEEO, Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Laboratório 32, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600 anexo, CEP 90035003, Porto Alegre, RS, Brazil
    Toxicol In Vitro 22:1177-83. 2008
    ..In vitro incubation of purified CAT with retinol or RA did not alter enzyme activity...
  11. doi request reprint The role of two putative nitroreductases, Frm2p and Hbn1p, in the oxidative stress response in Saccharomyces cerevisiae
    Iuri Marques de Oliveira
    Departamento de Biofisica Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av Bento Goncalves 9500, 91507 970 Porto Alegre, RS, Brazil
    Yeast 27:89-102. 2010
    ..In summary, the Frm1p and Hbn1p nitroreductases influence the response to oxidative stress in S. cerevisae yeast by modulating the GSH contents and antioxidant enzymatic activities, such as SOD, CAT and GPx...
  12. ncbi request reprint Differential effects of retinol and retinoic acid on cell proliferation: a role for reactive species and redox-dependent mechanisms in retinol supplementation
    Alfeu Zanotto-Filho
    Departamento de Bioquimica, Centro de Estudos em Estresse Oxidativo, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brasil
    Free Radic Res 42:778-88. 2008
    ..RA decreased DNA synthesis and increased p21 leading to cell arrest. Overall, data show that ROH, but not RA, is able to induce proliferation through non-classical and redox-dependent mechanisms...
  13. ncbi request reprint Xanthine oxidase-dependent ROS production mediates vitamin A pro-oxidant effects in cultured Sertoli cells
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil
    Free Radic Res 42:593-601. 2008
    ..The data show that xanthine oxidase may play a role on vitamin A pro-oxidant effects...
  14. ncbi request reprint Evaluation of antioxidant effect of extracts of Symphyopappus casarettoi
    Mara Regina Netto Benetti
    Curso de Pós Graduação em Ciências Biológicas Bioquímica, Instituto de Ciências Básicas de Saúde, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos, 2600 Anexo, Porto Alegre, RS, CEP 90035 003, Brazil
    Fitoterapia 78:232-4. 2007
    ..These findings suggest that the ethanolic extract of S. casarettoi inflorescence and its methanolic fraction have in vitro and ex vivo antioxidant properties...
  15. ncbi request reprint Retinol up-regulates the receptor for advanced glycation endproducts (RAGE) by increasing intracellular reactive species
    Daniel Pens Gelain
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Laboratório 32, Rua Ramiro Barcelos 2600 anexo, CEP 90035 003, Porto Alegre, RS, Brazil
    Toxicol In Vitro 22:1123-7. 2008
    ....
  16. ncbi request reprint Resveratrol-loaded lipid-core nanocapsules treatment reduces in vitro and in vivo glioma growth
    Fabrício Figueiró
    Departamento de Bioquimica, Institute de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, 90035 003, Brasil
    J Biomed Nanotechnol 9:516-26. 2013
    ....
  17. doi request reprint Reduced serum non-enzymatic antioxidant defense and increased lipid peroxidation in schizophrenic patients on a hypocaloric diet
    Karine Zortea
    Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Neurosci Lett 512:43-7. 2012
    ..Therefore, we aimed to study the effect of a hypocaloric dietary intervention on OS in subjects with SZ...
  18. pmc CFL1 expression levels as a prognostic and drug resistance marker in nonsmall cell lung cancer
    Mauro Antonio Alves Castro
    Department of Biochemistry, ICBS Federal University of Rio Grande do Sul, Porto Alegre, Brazil
    Cancer 116:3645-55. 2010
    ....
  19. ncbi request reprint Antioxidant activities and free radical scavenging potential of Bauhinia microstachya (RADDI) MACBR. (Caesalpinaceae) extracts linked to their polyphenol content
    Evandro Gomes da Silva
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Universidade Federal do Rio Grande do Sul, Rua Ramiro Barcelos 2600, 90035 003 Porto Alegre, RS, Brazil
    Biol Pharm Bull 30:1488-96. 2007
    ..B. microstachya extracts may be considered an interesting source of natural antioxidants as well as other phenolic-rich plants...
  20. doi request reprint Boldine induces cell cycle arrest and apoptosis in T24 human bladder cancer cell line via regulation of ERK, AKT, and GSK-3β
    Daniéli Gerhardt
    Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul UFRGS, Porto Alegre, RS, Brasil Electronic address
    Urol Oncol 32:36.e1-9. 2014
    ..The objective of the present study was to evaluate the effect and underlying mechanisms of boldine, an aporphine alkaloid of Peumus boldus, on bladder cancer proliferation and cell death...
  21. doi request reprint The NF kappa B-mediated control of RS and JNK signaling in vitamin A-treated cells: duration of JNK-AP-1 pathway activation may determine cell death or proliferation
    Alfeu Zanotto-Filho
    Centro de Estudos em Estresse Oxidativo, Departamento de Bioquimica, Instituto de Ciencias Basicas da Saude, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Biochem Pharmacol 77:1291-301. 2009
    ..Taken together, data presented here show that NFkappaB mediates cellular resistance to the pro-oxidant effects of vitamin A by inhibiting RS accumulation and the persistent and redox-dependent activation of JNK-AP-1 cascade...