Caspase-independent cell deathsRichard A Lockshin
Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Curr Opin Cell Biol 14:727-33. 2002
..We do not yet understand the extent to which the pathways are linked, what mechanisms trigger the caspase-independent deaths, and how the choices are made...
Cell death: history and futureZahra Zakeri
Department of Biology, Queens College and the Graduate Center of the City University of New York, 65 30 Kissena Blvd, Flushing, New York 11361, USA
Adv Exp Med Biol 615:1-11. 2008
..A cell that has passed the commitment stage but is blocked from undergoing apoptosis will die by another route. We still must learn much more about how a cell commits to death and what makes it choose a path to die...
Sex of the cell dictates its response: differential gene expression and sensitivity to cell death inducing stress in male and female cellsCarlos Penaloza
Queens College and Graduate Center of the City University of New York, 65 30 Kissena Blvd, Flushing, NY 11367, USA
FASEB J 23:1869-79. 2009
..We conclude that cells differ innately according to sex irrespective of their history of exposure to sex hormones. These differences may have consequences in the course of sexually dimorphic diseases and their therapy...
- Cell death in development: shaping the embryo
Carlos Penaloza
Department of Biology, Queens College and Graduate Center of CUNY, Flushing, NY 11367, USA
Histochem Cell Biol 126:149-58. 2006
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- Detection of autophagy in cell death
Zahra Zakeri
Department of Biology, Queens College and Graduate Center of the City University of New York, Flushing, New York, USA
Methods Enzymol 442:289-306. 2008
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- Activation of cyclin-dependent kinase 5 is a consequence of cell death
Yixia Ye
Department of Biology, Queens College and Graduate Center of the City University of New York, Flushing, NY 11367, USA
J Biomed Biotechnol 2009:805709. 2009
..Thus its activation suggests processes during cell death that will be interesting or important to understand, but activation of Cdk5 is not necessary for cells to die...
- A generalized caspase inhibitor disrupts early mammalian development
Zahra Zakeri
Department of Biology, Queens College and Graduate Center of the City University of New York, New York, USA
Int J Dev Biol 49:43-7. 2005
..Our results indicate that the early deaths are not caspase-dependent and that there is a role for caspase activity in early embryos, which is not related to cell death...
- Flavivirus NS4A-induced autophagy protects cells against death and enhances virus replication
Jeffrey E McLean
Department of Biology, Queens College and Graduate Center of City University of New York, Flushing, New York 11367, USA
J Biol Chem 286:22147-59. 2011
..As autophagy is vital to flavivirus replication in these cells, NS4A is therefore also identified as a critical determinant of flavivirus replication...
- Caspase-independent cell death?
Richard A Lockshin
Department of Biology, Queens College and Graduate Center of the City University of New York, 65 30 Kissena Blvd, Flushing, NY 11367, USA
Oncogene 23:2766-73. 2004
..Experimental and therapeutic procedures must account for this possibility...
- Methods in enzymolology book on cell death
Roya Khosravi-Far
Methods Enzymol 446:xxi-xxii. 2008
- Cell death in health and disease
Richard A Lockshin
Department of Biological Sciences, St John s University, Queens, NY 11439, USA
J Cell Mol Med 11:1214-24. 2007
..In the future, the challenge will be more to understand the challenge to the cell from a more global standpoint, including many more aspects of metabolism, and work toward alleviating or provoking the challenge in a targeted fashion...
- Apoptosis, autophagy, and more
Richard A Lockshin
Department of Biological Sciences, St John s University, 8000 Utopia Parkway, Jamaica, NY 11439, USA
Int J Biochem Cell Biol 36:2405-19. 2004
..Since switching among the alternative pathways to death is relatively common, interpretations based on knockouts or inhibitors, and therapies directed at controlling apoptosis must include these considerations...
