Z A Zakaria

Summary

Publications

  1. pmc Antinociceptive Activity of Methanol Extract of Muntingia calabura Leaves and the Mechanisms of Action Involved
    M H Mohd Sani
    Department of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Selangor, 43400 Serdang, Malaysia
    Evid Based Complement Alternat Med 2012:890361. 2012
  2. pmc Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review
    S Mohd Joffry
    Departments of Pharmaceutics and Pharmaceutical Sciences, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Selangor, 42300 Bandar Puncak Alam, Malaysia
    Evid Based Complement Alternat Med 2012:258434. 2012
  3. pmc Hepatoprotective activity of dried- and fermented-processed virgin coconut oil
    Z A Zakaria
    Department of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Evid Based Complement Alternat Med 2011:142739. 2011
  4. pmc Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses
    N J Yob
    Department of Pharmaceutics, Faculty of Pharmacy, MARA University of Technology, Puncak Alam Campus, Bandar Puncak Alam, 42300 Selangor, Malaysia
    Evid Based Complement Alternat Med 2011:543216. 2011
  5. pmc Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of the possible mechanisms
    Zainul Amiruddin Zakaria
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    BMC Complement Altern Med 14:63. 2014
  6. doi request reprint Mechanism(s) of action involved in the gastroprotective activity of Muntingia calabura
    Zainul Amiruddin Zakaria
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia Electronic address
    J Ethnopharmacol 151:1184-93. 2014
  7. pmc Methanol extract of Melastoma malabathricum leaves exerted antioxidant and liver protective activity in rats
    Siti Syariah Mamat
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    BMC Complement Altern Med 13:326. 2013
  8. pmc Complementary alternative medicine use among patients with type 2 diabetes mellitus in the primary care setting: a cross-sectional study in Malaysia
    Siew Mooi Ching
    Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia
    BMC Complement Altern Med 13:148. 2013
  9. pmc Chemical constituents and antihistamine activity of Bixa orellana leaf extract
    Yoke Keong Yong
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    BMC Complement Altern Med 13:32. 2013
  10. doi request reprint In vitro antiproliferative and antioxidant activities and total phenolic contents of the extracts of Melastoma malabathricum leaves
    Z A Zakaria
    Department of Biomedical Science, Universiti Putra Malaysia, Selangor, Malaysia
    J Acupunct Meridian Stud 4:248-56. 2011

Collaborators

  • L K Teh
  • M R Sulaiman
  • D A Israf
  • A S Mohamad
  • M N Somchit
  • N H Lajis
  • Siew Mooi Ching
  • M Z Salleh
  • N J Yob
  • A Zuraini
  • S Khalid
  • E K Perimal
  • M N Akhtar
  • W M Shaik Mossadeq
  • Z Bannur
  • N D Mahmood
  • H O Dyary
  • N Mohtarrudin
  • F H Kamisan
  • Siti Syariah Mamat
  • F Yahya
  • S S Mamat
  • Yoke Keong Yong
  • A K Arifah
  • S Mohd Joffry
  • M H Mohd Sani
  • Z Zabidi
  • M M R Meor Mohd Affandi
  • M H Khalid
  • L T Merawin
  • M Adilius
  • M Ismail
  • F Mokhtar
  • M T Hidayat
  • S Moin
  • H S Chiong
  • Y Adam
  • T Hennesy
  • N Mohamad
  • N Nasir
  • A Nasir
  • W R W Rosli
  • A Baba
  • R Ankathil
  • S F Md Tohid
  • M S Mohd-Aspollah
  • R S Sharma
  • A Rasedee
  • M F F Kamarolzaman
  • Farhana Yahya
  • Mohamad Fauzi Fahmi Kamarolzaman
  • Muhammad Nazrul Somchit
  • Deny Susanti
  • Nur Diyana Mahmood
  • Zuraini Ahmad
  • Arifah Abdul Kadir
  • Norhafizah Mohtarrudin
  • Muhammad Syahmi Shahril
  • Gwendoline Ee Cheng Lian
  • Muhammad Taher
  • Mehrdad Jalalian
  • Krystal Feredoline Jakius
  • Fuziah Paimin
  • T Balan
  • A Md Akim
  • H Hassan
  • F Othman
  • M N M Desa
  • N A Ismail
  • Z Suhaili
  • R Rodzi
  • S Shamsahal Din
  • M S Rofiee
  • W N Wan Zainulddin
  • S Mohd Jofrry
  • N A Tasrip
  • S Rejab
  • A Syahida
  • A Abdul Rahman
  • C L Tham
  • P Hashim
  • P A Mohd
  • R A Sani
  • J Stanslas
  • M N Desa
  • S Ganabadi
  • A M Shaberi
  • A A Bustamam
  • T A Tengku Mohamad
  • M L Jabit

Detail Information

Publications47

  1. pmc Antinociceptive Activity of Methanol Extract of Muntingia calabura Leaves and the Mechanisms of Action Involved
    M H Mohd Sani
    Department of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Selangor, 43400 Serdang, Malaysia
    Evid Based Complement Alternat Med 2012:890361. 2012
    ..05) change in the intensity of the MEMC antinociception. In conclusion, the MEMC antinociceptive activity involves activation of the peripheral and central mechanisms, and modulation via, partly, the opioid receptors and NO/cGMP pathway...
  2. pmc Melastoma malabathricum (L.) Smith Ethnomedicinal Uses, Chemical Constituents, and Pharmacological Properties: A Review
    S Mohd Joffry
    Departments of Pharmaceutics and Pharmaceutical Sciences, Faculty of Pharmacy, Universiti Teknologi MARA, Puncak Alam Campus, Selangor, 42300 Bandar Puncak Alam, Malaysia
    Evid Based Complement Alternat Med 2012:258434. 2012
    ..malabathricum. Thus, the aim of the present review is to present comprehensive information on ethnomedicinal uses, phytochemical constituents, and pharmacological activities of M. malabathricum...
  3. pmc Hepatoprotective activity of dried- and fermented-processed virgin coconut oil
    Z A Zakaria
    Department of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Evid Based Complement Alternat Med 2011:142739. 2011
    ..05) reduced the liver damage caused by the administration of paracetamol, which is further confirmed by the histological findings. In conclusion, VCO possessed hepatoprotective effect that requires further in-depth study...
  4. pmc Zingiber zerumbet (L.) Smith: A Review of Its Ethnomedicinal, Chemical, and Pharmacological Uses
    N J Yob
    Department of Pharmaceutics, Faculty of Pharmacy, MARA University of Technology, Puncak Alam Campus, Bandar Puncak Alam, 42300 Selangor, Malaysia
    Evid Based Complement Alternat Med 2011:543216. 2011
    ..The active pharmacological component of Z. zerumbet rhizomes most widely studied is zerumbone. This paper presents the botany, traditional uses, chemistry, and pharmacology of this medicinal plant...
  5. pmc Antinociceptive activity of methanolic extract of Muntingia calabura leaves: further elucidation of the possible mechanisms
    Zainul Amiruddin Zakaria
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    BMC Complement Altern Med 14:63. 2014
    ..Following the recent establishment of antinociceptive activity of M. calabura leaf, the present study was performed to further elucidate on the possible mechanisms of antinociception involved...
  6. doi request reprint Mechanism(s) of action involved in the gastroprotective activity of Muntingia calabura
    Zainul Amiruddin Zakaria
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia Electronic address
    J Ethnopharmacol 151:1184-93. 2014
    ..The present study aimed to investigate the mechanism(s) of gastroprotective effect of methanol extract of Muntingia calabura leaves (MEMC) using the pylorus ligation induced gastric ulceration in rats...
  7. pmc Methanol extract of Melastoma malabathricum leaves exerted antioxidant and liver protective activity in rats
    Siti Syariah Mamat
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    BMC Complement Altern Med 13:326. 2013
    ..The present study was carried out to determine the hepatoprotective activity of methanol extract of M. malabathricum leaves (MEMM) against the paracetamol-induced liver toxicity in rats model...
  8. pmc Complementary alternative medicine use among patients with type 2 diabetes mellitus in the primary care setting: a cross-sectional study in Malaysia
    Siew Mooi Ching
    Department of Family Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia
    BMC Complement Altern Med 13:148. 2013
    ..This study seeks to understand the prevalence, types, expenditures, attitudes, beliefs, and perceptions of CAM use among patients with DM visiting outpatient primary care clinics...
  9. pmc Chemical constituents and antihistamine activity of Bixa orellana leaf extract
    Yoke Keong Yong
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    BMC Complement Altern Med 13:32. 2013
    ..The current study aimed to determine the major chemical constituents of the aqueous extract of B. orellana (AEBO) and to evaluate the antihistamine activity of AEBO during acute inflammation induced in rats...
  10. doi request reprint In vitro antiproliferative and antioxidant activities and total phenolic contents of the extracts of Melastoma malabathricum leaves
    Z A Zakaria
    Department of Biomedical Science, Universiti Putra Malaysia, Selangor, Malaysia
    J Acupunct Meridian Stud 4:248-56. 2011
    ..1, 3055.1 ± 8.7, and 92.5 ± 7.3 mg/100 g of gallic acid, respectively. The M malabathricum leaves possessed potential antiproliferative and antioxidant activities that could be attributed to its high content of phenolic compounds...
  11. doi request reprint In vivo antinociceptive and anti-inflammatory activities of dried and fermented processed virgin coconut oil
    Z A Zakaria
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia
    Med Princ Pract 20:231-6. 2011
    ..The present study was carried out to investigate the antinociceptive and anti-inflammatory activities of virgin coconut oil (VCO) produced by the Malaysian Agriculture Research and Development Institute (MARDI) using various in vivo models...
  12. doi request reprint Antinociceptive, antiinflammatory and antipyretic properties of Channa striatus fillet aqueous and lipid-based extracts in rats
    Z A Zakaria
    Faculty of Pharmacy, Science and Technology Complex, Universiti Teknologi MARA, Shah Alam, Malaysia
    Methods Find Exp Clin Pharmacol 30:355-62. 2008
    ..05) activity in the pyrexia test. In conclusion, the present study demonstrated that C. striatus extracts possess antinociceptive, antiinflammatory and antipyretic activities...
  13. doi request reprint Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract
    M R Sulaiman
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Fitoterapia 79:557-61. 2008
    ..deltoidea leaves aqueous extract contains pharmacologically active constituents which possess antinociceptive activity justifying its popular therapeutic use in treating conditions associated with the painful conditions...
  14. doi request reprint Preliminary analysis of the antinociceptive activity of zerumbone
    M R Sulaiman
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Fitoterapia 80:230-2. 2009
    ..In addition, the antinociceptive effect of 1 in the hot plate test was reversed by the non-selective opioid receptor antagonist naloxone, suggesting that the opioid system is involved in its analgesic mechanism of action...
  15. ncbi request reprint Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals
    Z A Zakaria
    Faculty of Biotechnology and Life Sciences, Universiti Industri Selangor, Jalan Zirkon A 7 A, Seksyen 7, 40000 Shah Alam, Selangor, Malaysia
    Can J Physiol Pharmacol 84:1291-9. 2006
    ..Our findings that the aqueous extract of M. malabathricum possesses antinociceptive, anti-inflammatory, and antipyretic activities supports previous claims on its traditional uses to treat various ailments...
  16. doi request reprint Antinociceptive and anti-inflammatory activities of the aqueous extract of Kaempferia galanga leaves in animal models
    M R Sulaiman
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    J Nat Med 62:221-7. 2008
    ..galanga leaves possessed antinociceptive and anti-inflammatory activities and thus supports the Malay's traditional uses of the plant for treatments of mouth ulcer, headache, sore throat, etc...
  17. doi request reprint Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice
    M R Sulaiman
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    Fitoterapia 81:855-8. 2010
    ..It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test...
  18. ncbi request reprint In vitro antiproliferative and antioxidant activities of the extracts of Muntingia calabura leaves
    Z A Zakaria
    Department of Biomedical Sciences, Faculty of Medicine and Health Science, Universiti Putra Malaysia, Selangor, Malaysia
    Am J Chin Med 39:183-200. 2011
    ..In conclusion, the M. calabura leaves possess potential antiproliferative and antioxidant activities that could be attributed to its high content of phenolic compounds, and thus, needs to be further explored...
  19. ncbi request reprint Anti-inflammatory and antinociceptive effects of Mitragyna speciosa Korth methanolic extract
    W M Shaik Mossadeq
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Med Princ Pract 18:378-84. 2009
    ..To determine the anti-inflammatory and antinociceptive activities of Mitragyna speciosa Korth methanol extract in rodents. Materials and..
  20. ncbi request reprint The influences of temperature and naloxone on the antinociceptive activity of Corchorus olitorius L. in mice
    Z A Zakaria
    School of Biotechnology and Life Sciences, Universiti Industri Selangor, Jalan Zirkon A7 A, Seksyen 7, 40000, Shah Alam, Selangor, Malaysia
    Naunyn Schmiedebergs Arch Pharmacol 372:55-62. 2005
    ..Based on this observation, we conclude that the antinociceptive activity exhibited by C. olitorius is enhanced by the increase in temperature and may be mediated peripherally, but not centrally, at least in part, via an opioid receptor...
  21. doi request reprint Antinociceptive, anti-inflammatory and antipyretic effects of Solanum nigrum aqueous extract in animal models
    Z A Zakaria
    Pharmacogenomics Center, Faculty of Pharmacy, Universiti Teknologi MARA, Selangor, Malaysia
    Methods Find Exp Clin Pharmacol 31:81-8. 2009
    ..In conclusion, the present study demonstrated that S. nigrum leaves possessed antinociceptive, anti-inflammatory and antipyretic effects and thus supported traditional claims of its medicinal uses...
  22. doi request reprint Antinociceptive and anti-inflammatory effects of the ethanol extract of Alpinia conchigera rhizomes in various animal models
    M R Sulaiman
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Pharm Biol 48:861-8. 2010
    ..conchigera rhizomes possessed a peripheral and central antinociceptive activity that was mediated, in part, via the opioid receptor, as well as anti-inflammatory activity...
  23. ncbi request reprint In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits
    S Khalid
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia
    Med Princ Pract 19:255-9. 2010
    ..To study the effects of Tamarindus indica L. aqueous fruit extract on the antinociceptive activities in rodent models...
  24. ncbi request reprint Antiinflammatory and antinociceptive activities of Zingiber zerumbet methanol extract in experimental model systems
    Z A Zakaria
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Med Princ Pract 19:287-94. 2010
    ..Objective: The present study was carried out to determine the antiinflammatory and antinociceptive activities of a methanol extract of Zingiber zerumbet rhizomes (MEZZ) using various experimental model systems...
  25. doi request reprint Antinociceptive and anti-inflammatory effects of Stachytarpheta jamaicensis (L.) Vahl (Verbenaceae) in experimental animal models
    M R Sulaiman
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia
    Med Princ Pract 18:272-9. 2009
    ..Vahl (EESJ) using 3 models of nociception and 2 models of inflammation in experimental animals...
  26. doi request reprint Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice
    A S Mohamad
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia
    Eur J Pharmacol 647:103-9. 2010
    ..The present results indicate that FKB produced pronounced antinociception effect against both chemical and thermal models of pain in mice that exhibited both peripheral and central analgesic activity...
  27. doi request reprint In vivo anti-nociceptive and anti-inflammatory activities of the aqueous extract of the leaves of Piper sarmentosum
    Z A Zakaria
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
    J Ethnopharmacol 128:42-8. 2010
    ..Piper sarmentosum (Piperaceae) is a medicinal plant traditionally used by the Malays to treat headaches, toothaches, coughs, asthma and fever...
  28. doi request reprint Methanol extract of Bauhinia purpurea leaf possesses anti-ulcer activity
    Z A Zakaria
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Med Princ Pract 21:476-82. 2012
    ..The aim of the present study was to determine the anti-ulcer activity of a methanol extract of Bauhinia purpurea leaf (MEBP)...
  29. ncbi request reprint Antinociceptive and anti-inflammatory effects of the ethanol extract of Alpinia conchigera Griff. leaves in various animal models
    M R Sulaiman
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia
    Methods Find Exp Clin Pharmacol 31:241-7. 2009
    ..These findings suggest that EACL presents notable analgesic and anti-inflammatory activities, which support its folkloric use for painful and inflammatory conditions...
  30. doi request reprint Antinociceptive and antiedematogenic activities of andrographolide isolated from Andrographis paniculata in animal models
    M R Sulaiman
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Biol Res Nurs 11:293-301. 2010
    ..05) antiedematogenic activity. In conclusion, the results obtained suggest that andrographolide has antinociceptive and antiedematogenic activities; it may be useful for treating pain and inflammation once human studies are conducted...
  31. ncbi request reprint Effects of various nonopioid receptor antagonists on the antinociceptive activity of Muntingia calabura extracts in mice
    Z A Zakaria
    Faculty of Pharmacy, Science and Technology Complex, Universiti Teknologi MARA, Selangor, Malaysia
    Methods Find Exp Clin Pharmacol 29:515-20. 2007
    ....
  32. doi request reprint Antiulcer activity of methanol extract of Melastoma malabathricum leaves in rats
    Z Zabidi
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia
    Med Princ Pract 21:501-3. 2012
    ..To determine the potential antiulcer activity of methanol extract of Melastoma malabathricum leaves (MEMM) using various established rat models...
  33. doi request reprint Anti-inflammatory activity of the aqueous extract of ficus deltoidea
    Z A Zakaria
    Department of Biomedical Science, Universiti Putra Malaysia, Selangor, Malaysia
    Biol Res Nurs 14:90-7. 2012
    ..These findings justify the traditional uses of F. deltoidea leaves for treatment of inflammatory-mediated ailments...
  34. doi request reprint In vivo antiulcer activity of the aqueous extract of Bauhinia purpurea leaf
    Z A Zakaria
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    J Ethnopharmacol 137:1047-54. 2011
    ..In order to establish pharmacological properties of the leaf of Bauhinia purpurea, studies were performed on antiulcer activity of the plant's aqueous extract...
  35. ncbi request reprint Effect of various antagonists on the Channa striatus fillet extract antinociception in mice
    Z A Zakaria
    Department of Biomedical Sciences, Faculty of Medical and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    Can J Physiol Pharmacol 83:635-42. 2005
    ....
  36. doi request reprint Preliminary analysis of the anti-inflammatory activity of essential oils of Zingiber zerumbet
    Z A Zakaria
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Selangor, Malaysia
    Biol Res Nurs 13:425-32. 2011
    ..In conclusion, the essential oil of Z. zerumbet possessed anti-inflammatory activity, in addition to its antinociceptive activity, which may explain its traditional uses to treat inflammatory-related ailments...
  37. pmc Amelioration of paracetamol-induced hepatotoxicity in rat by the administration of methanol extract of Muntingia calabura L. leaves
    N D Mahmood
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia UPM, 43400 Serdang, Selangor, Malaysia
    Biomed Res Int 2014:695678. 2014
    ..Moreover, the extract also exhibited good antioxidant activity. In conclusion, MEMC exerts potential hepatoprotective activity that could be partly attributed to its antioxidant activity and, thus warrants further investigations...
  38. doi request reprint Clinical relevance of VKORC1 (G-1639A and C1173T) and CYP2C9*3 among patients on warfarin
    L K Teh
    Pharmacogenomics Centre, Faculty of Pharmacy, Universiti Teknologi MARA, Malaysia
    J Clin Pharm Ther 37:232-6. 2012
    ..However, dose prediction models derived from data obtained in one population may not be applicable to another. We therefore studied the impact of genetic polymorphisms of CYP2C9 and VKORC1 on warfarin dose requirement in Malaysia...
  39. doi request reprint Diuretic properties of Orthosiphon stamineus Benth
    Y Adam
    Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia
    J Ethnopharmacol 124:154-8. 2009
    ..Orthosiphon stamineus has been used in traditional medicine for centuries especially to treat diseases of the urinary system...
  40. pmc Polymorphisms of UGT1A1*6, UGT1A1*27 & UGT1A1*28 in three major ethnic groups from Malaysia
    L K Teh
    Pharmacogenomics Centre PROMISE, Faculty of Pharmacy, Universiti Teknologi MARA, Selangor, Malaysia
    Indian J Med Res 136:249-59. 2012
    ....
  41. doi request reprint Atrovirinone inhibits proinflammatory mediator synthesis through disruption of NF-kappaB nuclear translocation and MAPK phosphorylation in the murine monocytic macrophage RAW 264.7
    D A Israf
    Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia
    Phytomedicine 17:732-9. 2010
    ..We conclude that atrovirinone is a potential anti-inflammatory drug lead that targets both the MAPK and NF-kappaB pathway...
  42. doi request reprint Screening of microfilaricidal effects of plant extracts against Dirofilaria immitis
    L T Merawin
    Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor, Malaysia
    Res Vet Sci 88:142-7. 2010
    ..paniculata and T. crispa Miers. It is speculated that the microfilaricidal mechanism exhibited by these extracts is via spastic paralysis based upon direct observation of the microfilarial motility...
  43. ncbi request reprint Antitrypanosomal screening and cytotoxic effects of selected medicinal plants
    H O Dyary
    Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 UPM, Serdang, Selangor, Malaysia
    Trop Biomed 31:89-96. 2014
    ..It is demonstrated here that the aqueous extract of G. hombroniana has potential antitrypanosomal activity with a high SI, and may be considered as a potential source for the development of new antitrypanosomal compounds. ..
  44. doi request reprint Mutational analysis of CYP2C8 in hypertensive patients using denaturing high performance liquid chromatography
    L K Teh
    Pharmacogenomics Centre PROMISE, Faculty of Pharmacy, Universiti Teknologi MARA, 40450 Shah Alam, Selangor DE, Malaysia
    J Clin Pharm Ther 35:723-8. 2010
    ..We aimed to develop a medium through-put method for screening samples of known and new mutations of CYP2C8 using denaturing high performance liquid chromatography (DHPLC)...
  45. ncbi request reprint The differential metabolite profiles of acute lymphoblastic leukaemic patients treated with 6-mercaptopurine using untargeted metabolomics approach
    Z Bannur
    Integrative Pharmacogenomics Institute iPROMISE, Universiti Teknologi MARA Malaysia, Selangor, Malaysia
    Clin Biochem 47:427-31. 2014
    ..Acute lymphoblastic leukaemia (ALL) has posed challenges to the clinician due to variable patients' responses and late diagnosis. With the advance in metabolomics, early detection and personalised treatment are possible...