High levels of glucose induce "metabolic memory" in cardiomyocyte via epigenetic histone H3 lysine 9 methylationXi Yong Yu
Guangdong Provincial Cardiovascular Institute, Medical Research Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, People s Republic of China
Mol Biol Rep 39:8891-8. 2012
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- Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1
Xi Yong Yu
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong 510080, PR China
Biochem Biophys Res Commun 376:548-52. 2008
..In conclusion, our data demonstrate that IGF-1 inhibits glucose-induced mitochondrial dysfunction, cytochrome-c release and apoptosis and IGF-1's effect is regulated by miR-1...
- The effects of mesenchymal stem cells on c-kit up-regulation and cell-cycle re-entry of neonatal cardiomyocytes are mediated by activation of insulin-like growth factor 1 receptor
Xi Yong Yu
Medical Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People s Republic of China
Mol Cell Biochem 332:25-32. 2009
..These findings provide a new paradigm for the biological effects of IGF-1 and have significant implications for understanding the beneficial effects of MSCs on myocardial regeneration...
Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabraXi Yong Yu
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, 510080, China
Pharm Res 24:1668-90. 2007
..Recently, we have found that glabridin is a substrate of P-glycoprotein (PgP/MDR1). This study aimed to investigate the role of PgP in glabridin penetration across the blood-brain barrier (BBB) using several in vitro and in vivo models...
Hyperglycemic myocardial damage is mediated by proinflammatory cytokine: macrophage migration inhibitory factorXi Yong Yu
Medical Research Center, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People s Republic of China
PLoS ONE 6:e16239. 2011
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- Evidence for coexistence of three beta-adrenoceptor subtypes in human peripheral lymphocytes
Xi Yong Yu
Department of Clinical Pharmacology, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, China, and School of Life Sciences, Queensland University of Technology, Brisbane, Australia
Clin Pharmacol Ther 81:654-8. 2007
..Our study, for the first time, indicates that human peripheral lymphocytes coexpress ADRB1, ADRB2, and ADRB3, which has important implications for precisely predicting clinical response to drug therapy in congestive heart failure...
- High levels of glucose induce apoptosis in cardiomyocyte via epigenetic regulation of the insulin-like growth factor receptor
Xi Yong Yu
Medical Research Center, Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P R China
Exp Cell Res 316:2903-9. 2010
..These studies may help delineate the complex pathways regulating diabetic cardiomyopathy, and have implications for the development of novel therapeutic strategies to prevent diabetic cardiomyopathy by epigenetic regulation of IGF-1R...
- Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra
Jie Cao
Department of Pharmacy, School of Life Sciences, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4001 Australia
Drug Metab Dispos 35:539-53. 2007
..8-fold higher than that in wild-type mice. These findings indicate that glabridin is a substrate for PgP and that both PgP/MDR1-mediated efflux and first-pass metabolism contribute to the low oral bioavailability of glabridin...
- Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice
Jiu Chang Zhong
Research Center of Medicine Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong, and Department of Physiology, Chinese University of Hong Kong, Shatin, China
Cardiovasc Res 74:388-95. 2007
..Our aim here was to explore the regulatory role of apelin in the aortic vascular tone in diabetic mice...
- Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier
Xi Yong Yu
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China
Curr Drug Metab 8:365-78. 2007
..Further studies are needed to explore the role of other drug transporters in restricting the brain penetration of CTS and the clinical relevance...
- Integrating interacting drugs and genetic variations to improve the predictability of warfarin maintenance dose in Chinese patients
Shi long Zhong
Medical Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Institute of Clinical Pharmacology, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People s Republic of China
Pharmacogenet Genomics 22:176-82. 2012
..This study sought to systematically investigate the effects of VKORC1, STX4A, CYP2C9, CYP4F2, CYP3A4, and GGCX gene polymorphisms and interacting drugs on warfarin maintenance dose...
- Induced bone marrow mesenchymal stem cells improve cardiac performance of infarcted rat hearts
Xiao Hong Li
Medical Research Center, Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, 96 Dongchuan Road, Weilun Bldg, Guangzhou 510080, People s Republic of China
Mol Biol Rep 39:1333-42. 2012
..It will open new promising therapeutic opportunities for patients with post-infarction heart failure...
- Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats
Xi Yong Yu
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, and Department of Biological Science and Biotechnology, College of Bioengineering, Nanchang University, China
Neurosci Lett 417:261-5. 2007
..This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB...
- MicroRNA 16 enhances differentiation of human bone marrow mesenchymal stem cells in a cardiac niche toward myogenic phenotypes in vitro
Ju Li Liu
Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Life Sci 90:1020-6. 2012
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- [Distribution of variant alleles association with warfarin pharmacokinetics and pharmacodynamics in the Han population in China]
Yuan Liu
Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Beijing Da Xue Xue Bao 43:798-803. 2011
..To investigate distribution of CYP2C9, CYP3A4, VKORC1 and GGCX gene polymorphisms in the Han population of Guangdong...
- Allitridi inhibits transient outward potassium currents in human atrial myocytes
Chun yu Deng
Department of Cardiology, Guangdong Cardiovascular Institute and Guangdong Academy of Medical Sciences, Research Centre of Guangdong General Hospital, Guangzhou, China
Clin Exp Pharmacol Physiol 38:323-7. 2011
..4. The results of the present study indicate that allitridi inhibits I(to), but not I(Kur) and I(Ca), and prolongs the action potential duration in human atrial myocytes...
- miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes
Zhi xin Shan
Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
FEBS Lett 584:3592-600. 2010
..These results revealed that miR-1 and miR-206 regulate Hsp60 expression, contributing to high glucose-mediated apoptosis in cardiomyocytes...
- Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge
Xi Yong Yu
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China
Curr Drug Metab 8:325-40. 2007
..Further studies are needed to explore the role of other drug transporters and first-pass metabolism in the low bioavailability of TSA...
- Cardioprotective effect of a hemoglobin-based oxygen carrier on cold ischemia/reperfusion injury
Li Wei
Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Cardiology 120:73-83. 2011
..The aim of this study was to investigate the protective effect of a hemoglobin-based oxygen carrier (HBOC) on cold I/R heart and to explore the underlying mechanisms...
- Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction
Zhi xin Shan
Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, China
Biochem Biophys Res Commun 381:597-601. 2009
..05, p<0.01). Together, our results indicate that miR-1 and miR-206 are involved in apoptotic cell death in MI by post-transcriptional repression of IGF-1...
- [Plasmid-mediated miRNA-1-2 specifically inhibits Hand2 protein expression in H9C2 cells]
Zhi xin Shan
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou, China
Nan Fang Yi Ke Da Xue Xue Bao 28:1559-61, 1567. 2008
..To construct an eukaryotic expression vector for miRNA-1-2 that can be expressed in rat H9C2 cardiomyocytes...
- Involvement of Src in L-type Ca2+ channel depression induced by macrophage migration inhibitory factor in atrial myocytes
Fang Rao
Department of Cardiology, Guangdong Cardiovascular Institute, 96 Dongchuan Road, Guangzhou 510080, PR China
J Mol Cell Cardiol 47:586-94. 2009
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- Improved liquid chromatography-tandem mass spectrometry method for the analysis of eptifibatide in human plasma
Zhi Ling Zhou
Medical Research Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
J Chromatogr B Analyt Technol Biomed Life Sci 878:2094-100. 2010
..The validated LC-MS/MS method was successfully applied for the evaluation of pharmacokinetic parameters of eptifibatide after intravenous (i.v.) administration of a 45 microg/kg bolus of eptifibatide to 8 healthy volunteers...
- [MicroRNAs can be expressed in cardiomyocyte-like cells differentiated from human mesenchymal stem cells]
Zhi xin Shan
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Diseases Institute, Guangzhou 510080, China
Nan Fang Yi Ke Da Xue Xue Bao 27:1813-6. 2007
..To investigate the expression of representative heart-specific primary microRNAs (pri-miRNAs) in the cardiomyocyte-like cells differentiated from human mesenchymal stem cells (hMSCs)...
- [Effect of adenoviral vectors on the differentiation potential of human bone marrow mesenchymal stem cells]
Zhi xin Shan
Research Center of Medical Sciences, Guangdong Provincial People s Hospital Guangdong Provincial Cardiovascular Diseases Institute, Guangzhou 510080, China
Nan Fang Yi Ke Da Xue Xue Bao 28:1132-5. 2008
..To investigate the effect of adenoviral vector infection on the differentiation potential of human bone marrow mesenchymal stem cells (hMSCs)...
- The influence of genetic polymorphisms and interacting drugs on initial response to warfarin in Chinese patients with heart valve replacement
Shi long Zhong
Guangdong Provincial Cardiovascular Institute, Medical Research Center of Guangdong General Hospital, Guangdong Institute of Clinical Pharmacology, Guangdong Academy of Medical Sciences, 96 Dongchuan Road, Guangzhou, GD 510080, People s Republic of China
Eur J Clin Pharmacol 67:581-90. 2011
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- Effect of ranolazine on rat intrarenal arteries in vitro
Chun yu Deng
Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, PR China
Eur J Pharmacol 683:211-6. 2012
..Therefore it can be said that ranolazine has significant α₁-adrenergic receptor and weak calcium channel antagonistic effects in rat intrarenal arteries...
- [Differentiation of rabbit bone marrow mesenchymal stem cells into myogenic cells in vitro and expression of vascular endothelial growth factor gene after transfection]
Xiao gang Sheng
Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangzhou 510100, China
Di Yi Jun Yi Da Xue Xue Bao 24:290-4. 2004
..To induce the differentiation of rabbit bone marrow mesenchymal stem cells (MSCs) into myogenic cells in vitro, and to investigate the expression of vascular endothelial growth factor (VEGF) gene in AdTrackCMV-hVEGF165- transfected MSCs...
- [Association of the polymorphism of macrophage migration inhibitory factor gene with coronary heart disease in Chinese population]
Zhi xin Shan
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Diseases Institute, Guangzhou, Guangdong, 510080 PR China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:548-50. 2006
..The present study is to investigate the association of the -173 G/C polymorphism of MIF gene with the outcome of the CHD...
- Transcription factor Ap-1 mediates proangiogenic MIF expression in human endothelial cells exposed to Angiotensin II
Zhi xin Shan
Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Cytokine 53:35-41. 2011
..Our results suggest that AP-1 mediates Ang II-induced MIF expression which contributes to atherosclerotic plaque destabilization in human endothelial cells...
- Association between polymorphisms of the renin-angiotensin system and coronary artery disease in Chinese patients with type 2 diabetes
He Ping Lei
Medical Research Center, Guangdong General Hospital, Guangzhou, Guangdong, China
J Renin Angiotensin Aldosterone Syst 13:305-13. 2012
..In this study, we investigated associations of the five genetic polymorphisms in the RAS and presence of coronary artery disease (CAD) in type 2 diabetes...
- [Effect of ketamine on transient outward potassium current of isolated human atrial myocytes]
Su juan Kuang
Medical Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Yao Xue Xue Bao 45:849-52. 2010
..The I(to) activation curve, inactivation curve and the recovery curve were not altered by ketamine. So, ketamine concentration-dependently decreased I(to) of human atrial myocytes...
- High glucose induces apoptosis in AC16 human cardiomyocytes via macrophage migration inhibitory factor and c-Jun N-terminal kinase
Jia Liang Liang
Medical Research Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Clin Exp Pharmacol Physiol 37:969-73. 2010
..The identification of a high glucose-MIF-JNK pathway will help determine potential new targets in the treatment of diabetic cardiomyopathy...
- Mechanism of macrophage migration inhibitory factor-induced decrease of T-type Ca(2+) channel current in atrium-derived cells
Fang Rao
Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, 96 Dongchuan Road, Guangzhou 510080, PR China
Exp Physiol 98:172-82. 2013
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- Rapid and sensitive HPLC-MS/MS method for pharmacokinetic assessment of ribavirin in healthy Chinese
Zhi Ling Zhou
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou 510080, People s Republic of China
Biomed Chromatogr 22:1409-15. 2008
..The mean elimination half-life was 43.6 h. The present study describes a simple, specific, sensitive HPLC-MS/MS method for measuring plasma drug concentration and analyzing human pharmacokinetics of ribavirin...
- [High glucose up-regulates GRK2 gene expression in H9C2 cardiomyoblasts in vitro]
Hong mei Chen
Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
Nan Fang Yi Ke Da Xue Xue Bao 30:472-4. 2010
..To study the effect of high glucose on GRK2 gene expression in H9C2 cardiomyoblasts in vitro...
- Effect of impaired glucose tolerance on cardiac dysfunction in a rat model of prediabetes
Jia Liang Liang
Medical Research Center, Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Institute of Clinical Pharmacology, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China
Chin Med J (Engl) 124:734-9. 2011
..This study was designed to observe cardiac dysfunction in prediabetic rats with IGT and to determine whether glucose metabolic abnormalities, inflammation and apoptosis are linked to it...
- [An method for small hairpin RNA expression vector reconstruction for easy single restriction endonuclease identification]
Zhi xin Shan
Research Center of Medical Sciences, People s Hospital of Guangdong Province, Guangzhou 510080, China
Nan Fang Yi Ke Da Xue Xue Bao 27:1341-4. 2007
..To develop an effective method for screening recombinant hairpin RNA expression plasmids using single restriction endonuclease analysis...
- Electrophysiological effects of ketamine on human atrial myocytes at therapeutically relevant concentrations
Chun yu Deng
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou, China
Clin Exp Pharmacol Physiol 35:1465-70. 2008
..5. In conclusion, ketamine, at a clinically relevant concentration, shortens the action potential duration of the human atrial myocytes, probably by inhibiting I(Ca)...
- [Identification of the interactions between the truncated fragments of macrophage migration inhibitory factor and CD74 using a yeast two-hybrid system]
Zhi Xi Shan
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou Guangdong Provincial Cardiovascular Disease Institute, Guangzhou 510080, China
Nan Fang Yi Ke Da Xue Xue Bao 29:2383-6, 2390. 2009
..To investigate the interaction domains between macrophage migration inhibitory factors (MIF) and the extracellular segment of type-II trans-membrane protein CD74 using a yeast two-hybrid system...
- [Effects of macrophage migration inhibitory factor on collagen I and III mRNA expression in vascular smooth muscle cells in vitro]
Jun Li
Institute of Cardiovascular Diseases, Guangdong People s Hospital, Guangzhou 510080, China
Di Yi Jun Yi Da Xue Xue Bao 25:684-6. 2005
..To investigate the association between macrophage migration inhibitory factor (MIF) and collagen synthesis in vascular smooth muscle cells (VSMCs)...
- [Impact of CYP2C9 and VKORC1 polymorphism on warfarin response during initiation of therapy]
Yuan Liu
Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Zhonghua Xin Xue Guan Bing Za Zhi 39:929-35. 2011
..To investigate potential contributions of genetic variants of cytochrome P-450 2C9 (CYP2C9) and vitamin K expoxide reductase (VKORC1) to the anticoagulation response during the initiation of warfarin therapy in the Han Chinese population...
- A rapid and simple high-performance liquid chromatography method for the determination of human plasma levofloxacin concentration and its application to bioequivalence studies
Zhi Ling Zhou
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou 510080, People s Republic of China
Biomed Chromatogr 21:1045-51. 2007
..The method described herein has been successfully used for the pharmacokinetic and bioequivalence studies of a levofloxacin formulation product after oral administration to healthy Chinese volunteers...
- [Efficacy comparison between transplanting microenvironmental induced and non-induced bone marrow mesenchymal stem cells in ischemic rat hearts]
Xiao Hong Li
Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
Zhonghua Xin Xue Guan Bing Za Zhi 37:680-4. 2009
..To compare the efficacy of transplanting bone marrow mesenchymal stem cell (BMSC) or microenvironmental induced BMSC (iBMSC) into the ischemic myocardium of rats with myocardial infarction...
- Molecular characterization of a Chinese pedigree with beta-thalassemia intermedia
Ge Huang
Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People s Republic of China
Hemoglobin 34:179-83. 2010
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- An efficient method to enhance gene silencing by using precursor microRNA designed small hairpin RNAs
Zhixin Shan
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou, 510080, China
Mol Biol Rep 36:1483-9. 2009
..Together, this study confirmed the efficiency of gene silencing mediated by pre-miRNA-30- and pre-miRNA-155-designed shRNAs, demonstrating that pre-miRNA-designed hairpins are a good strategy for gene silencing...
- [An efficient method for screening effective siRNAs using dual-luciferase reporter assay system]
Zhi xin Shan
Research Center of Medical Sciences, Guangdong Provincial People s Hospital Guangdong Provincial Cardiovascular Diseases Institute, Guangzhou 510080, China
Nan Fang Yi Ke Da Xue Xue Bao 29:1577-81. 2009
..To establish an efficient method for screening effective small interference RNA (siRNA) using dual-luciferase reporter assay system...
- [Human bone marrow mesenchymal stem cells cocultured with semi-permeable membrane separated neonatal rat ventricular myocytes differentiated into cardiomyocyte phenotype]
Xiao Hong Li
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou 510080, China
Zhonghua Xin Xue Guan Bing Za Zhi 36:651-4. 2008
..To investigate the ability of human bone marrow mesenchymal stem cells (hBMSCs), cocultured with semi-permeable membrane separated neonatal rat ventricular myocytes, to differentiate into cardiomyocytes...
- [Clinical application of anticoagulation treatment with warfarin after prosthetic heart valve replacement: a single center-based survey]
Yuan Liu
Department of Cardiology, Medical Research Center, Guangdong Cardiovascular Institute, People s Hospital of Guangdong Province, Guangzhou 510081, China
Nan Fang Yi Ke Da Xue Xue Bao 30:2242-5. 2010
..To investigate the clinical application of anticoagulation treatment with warfarin after prosthetic heart valve replacement and compare the effect and safety of different anticoagulant intensities...
- Polymerised placenta haemoglobin attenuates cold ischaemia/reperfusion injury in isolated rat heart
Li Wei
Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 96 Dongchuan Road, Guangzhou 510080, China
Microvasc Res 82:430-8. 2011
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- [Identification and tissue localization of intermediate filament protein in Angiostrongylus cantonensis]
Jin xiu Meng
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou 510080, China
Nan Fang Yi Ke Da Xue Xue Bao 27:1141-4. 2007
..To identify the type of the intermediate filament (IF) protein of Angiostrongylus cantonensis and analyze its tissue localization...
- [Progress in genetic and epigenetic research on in-stent restenosis after percutaneous coronary interventions]
Yan hong Kang
Research Center of Guangdong General Hospital, Guangzhou, Guangdong 510080, P R China
Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:38-42. 2012
..In this article, authors have reviewed genetic and epigenetic factors on the progression of ISR, which may help to determine the genetic risk factors in patients with ISR after PCI...
- [Screening and identification of auto-antigen RHDAG1 of rheumatic heart disease]
Jin xiu Meng
Medical Research Center, Guangdong General Hospital Guangdong Academic of Medical Sciences, Guangzhou 510080, China
Nan Fang Yi Ke Da Xue Xue Bao 31:1154-8. 2011
..To identify the candidate auto-antigen of rheumatic heart disease as a molecular marker for this disease...
- [Induced differentiation and signaling factor PTEN expression of 3T3-L1 adipocytes]
Yun xiong Li
Research Center of Medical Sciences, People s Hospital of Guangdong Province, Guangzhou 510089, China
Nan Fang Yi Ke Da Xue Xue Bao 27:259-63. 2007
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- The novel peptide apelin regulates intrarenal artery tone in diabetic mice
Jiu Chang Zhong
Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong, China
Regul Pept 144:109-14. 2007
..Apelin treatment may regulate the balance between Ang II and NO and thereby exert beneficial effects on the diabetic vascular pathophysiology...
- [Effects of C-type natriuretic peptide gene transduction on neointimal hyperplasia and endothelial function after angioplasty]
Xiao yang Pei
Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangzhou 510100, China
Di Yi Jun Yi Da Xue Xue Bao 24:400-3. 2004
..To investigate the effects of C-type natriuretic peptide (CNP) gene transduction on neointimal hyperplasia and endothelial function after angioplasty...
- Mutation of plakophilin-2 gene in arrhythmogenic right ventricular cardiomyopathy
Shu Lin Wu
Department of Cardiology Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong 510080, China
Chin Med J (Engl) 122:403-7. 2009
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