Xi Yong Yu

Summary

Publications

  1. pmc Smad3 Inactivation and MiR-29b Upregulation Mediate the Effect of Carvedilol on Attenuating the Acute Myocardium Infarction-Induced Myocardial Fibrosis in Rat
    Jie Ning Zhu
    Medical Research Department of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, China
    PLoS ONE 8:e75557. 2013
  2. pmc Ischemic Preconditioning Potentiates the Protective Effect of Stem Cells through Secretion of Exosomes by Targeting Mecp2 via miR-22
    Yuliang Feng
    Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Cardiovascular Institute, Southern Medical University, Guangzhou, China Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e88685. 2014
  3. doi request reprint High levels of glucose induce "metabolic memory" in cardiomyocyte via epigenetic histone H3 lysine 9 methylation
    Xi Yong Yu
    Guangdong Provincial Cardiovascular Institute, Medical Research Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, People s Republic of China
    Mol Biol Rep 39:8891-8. 2012
  4. ncbi request reprint Evidence for coexistence of three beta-adrenoceptor subtypes in human peripheral lymphocytes
    Xi Yong Yu
    Department of Clinical Pharmacology, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, China, and School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Clin Pharmacol Ther 81:654-8. 2007
  5. doi request reprint Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong 510080, PR China
    Biochem Biophys Res Commun 376:548-52. 2008
  6. doi request reprint The effects of mesenchymal stem cells on c-kit up-regulation and cell-cycle re-entry of neonatal cardiomyocytes are mediated by activation of insulin-like growth factor 1 receptor
    Xi Yong Yu
    Medical Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People s Republic of China
    Mol Cell Biochem 332:25-32. 2009
  7. doi request reprint High levels of glucose induce apoptosis in cardiomyocyte via epigenetic regulation of the insulin-like growth factor receptor
    Xi Yong Yu
    Medical Research Center, Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P R China
    Exp Cell Res 316:2903-9. 2010
  8. pmc Hyperglycemic myocardial damage is mediated by proinflammatory cytokine: macrophage migration inhibitory factor
    Xi Yong Yu
    Medical Research Center, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People s Republic of China
    PLoS ONE 6:e16239. 2011
  9. ncbi request reprint Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, 510080, China
    Pharm Res 24:1668-90. 2007
  10. ncbi request reprint Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra
    Jie Cao
    Department of Pharmacy, School of Life Sciences, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4001 Australia
    Drug Metab Dispos 35:539-53. 2007

Collaborators

Detail Information

Publications63

  1. pmc Smad3 Inactivation and MiR-29b Upregulation Mediate the Effect of Carvedilol on Attenuating the Acute Myocardium Infarction-Induced Myocardial Fibrosis in Rat
    Jie Ning Zhu
    Medical Research Department of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, China
    PLoS ONE 8:e75557. 2013
    ..Taken together, we found that smad3 inactivation and miR-29b upregulation contributed to the cardioprotective activity of carvedilol against AMI-induced myocardial fibrosis. ..
  2. pmc Ischemic Preconditioning Potentiates the Protective Effect of Stem Cells through Secretion of Exosomes by Targeting Mecp2 via miR-22
    Yuliang Feng
    Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangdong Provincial Cardiovascular Institute, Southern Medical University, Guangzhou, China Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio, United States of America
    PLoS ONE 9:e88685. 2014
    ..In vivo data showed that delivery of Exo(IPC) significantly reduced cardiac fibrosis. Our data identified a significant benefit of Exo(IPC) for the treatment of cardiac diseases by targeting Mecp2 via miR-22. ..
  3. doi request reprint High levels of glucose induce "metabolic memory" in cardiomyocyte via epigenetic histone H3 lysine 9 methylation
    Xi Yong Yu
    Guangdong Provincial Cardiovascular Institute, Medical Research Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, Guangdong, People s Republic of China
    Mol Biol Rep 39:8891-8. 2012
    ....
  4. ncbi request reprint Evidence for coexistence of three beta-adrenoceptor subtypes in human peripheral lymphocytes
    Xi Yong Yu
    Department of Clinical Pharmacology, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, China, and School of Life Sciences, Queensland University of Technology, Brisbane, Australia
    Clin Pharmacol Ther 81:654-8. 2007
    ..Our study, for the first time, indicates that human peripheral lymphocytes coexpress ADRB1, ADRB2, and ADRB3, which has important implications for precisely predicting clinical response to drug therapy in congestive heart failure...
  5. doi request reprint Glucose induces apoptosis of cardiomyocytes via microRNA-1 and IGF-1
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong 510080, PR China
    Biochem Biophys Res Commun 376:548-52. 2008
    ..In conclusion, our data demonstrate that IGF-1 inhibits glucose-induced mitochondrial dysfunction, cytochrome-c release and apoptosis and IGF-1's effect is regulated by miR-1...
  6. doi request reprint The effects of mesenchymal stem cells on c-kit up-regulation and cell-cycle re-entry of neonatal cardiomyocytes are mediated by activation of insulin-like growth factor 1 receptor
    Xi Yong Yu
    Medical Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, 510080, People s Republic of China
    Mol Cell Biochem 332:25-32. 2009
    ..These findings provide a new paradigm for the biological effects of IGF-1 and have significant implications for understanding the beneficial effects of MSCs on myocardial regeneration...
  7. doi request reprint High levels of glucose induce apoptosis in cardiomyocyte via epigenetic regulation of the insulin-like growth factor receptor
    Xi Yong Yu
    Medical Research Center, Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, P R China
    Exp Cell Res 316:2903-9. 2010
    ..These studies may help delineate the complex pathways regulating diabetic cardiomyopathy, and have implications for the development of novel therapeutic strategies to prevent diabetic cardiomyopathy by epigenetic regulation of IGF-1R...
  8. pmc Hyperglycemic myocardial damage is mediated by proinflammatory cytokine: macrophage migration inhibitory factor
    Xi Yong Yu
    Medical Research Center, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People s Republic of China
    PLoS ONE 6:e16239. 2011
    ....
  9. ncbi request reprint Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, 510080, China
    Pharm Res 24:1668-90. 2007
    ..Recently, we have found that glabridin is a substrate of P-glycoprotein (PgP/MDR1). This study aimed to investigate the role of PgP in glabridin penetration across the blood-brain barrier (BBB) using several in vitro and in vivo models...
  10. ncbi request reprint Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra
    Jie Cao
    Department of Pharmacy, School of Life Sciences, Queensland University of Technology, 2 George Street, Brisbane, Queensland 4001 Australia
    Drug Metab Dispos 35:539-53. 2007
    ..8-fold higher than that in wild-type mice. These findings indicate that glabridin is a substrate for PgP and that both PgP/MDR1-mediated efflux and first-pass metabolism contribute to the low oral bioavailability of glabridin...
  11. ncbi request reprint Transport of cryptotanshinone, a major active triterpenoid in Salvia miltiorrhiza Bunge widely used in the treatment of stroke and Alzheimer's disease, across the blood-brain barrier
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China
    Curr Drug Metab 8:365-78. 2007
    ..Further studies are needed to explore the role of other drug transporters in restricting the brain penetration of CTS and the clinical relevance...
  12. ncbi request reprint Tanshinone IIB, a primary active constituent from Salvia miltiorrhza, exhibits neuro-protective activity in experimentally stroked rats
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, and Department of Biological Science and Biotechnology, College of Bioengineering, Nanchang University, China
    Neurosci Lett 417:261-5. 2007
    ..This study demonstrated that TSB was effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development. Further mechanistic studies are needed for the neuron-protective activity of TSB...
  13. doi request reprint Integrating interacting drugs and genetic variations to improve the predictability of warfarin maintenance dose in Chinese patients
    Shi long Zhong
    Medical Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Institute of Clinical Pharmacology, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, People s Republic of China
    Pharmacogenet Genomics 22:176-82. 2012
    ..This study sought to systematically investigate the effects of VKORC1, STX4A, CYP2C9, CYP4F2, CYP3A4, and GGCX gene polymorphisms and interacting drugs on warfarin maintenance dose...
  14. doi request reprint Induced bone marrow mesenchymal stem cells improve cardiac performance of infarcted rat hearts
    Xiao Hong Li
    Medical Research Center, Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, 96 Dongchuan Road, Weilun Bldg, Guangzhou 510080, People s Republic of China
    Mol Biol Rep 39:1333-42. 2012
    ..It will open new promising therapeutic opportunities for patients with post-infarction heart failure...
  15. ncbi request reprint Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice
    Jiu Chang Zhong
    Research Center of Medicine Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong, and Department of Physiology, Chinese University of Hong Kong, Shatin, China
    Cardiovasc Res 74:388-95. 2007
    ..Our aim here was to explore the regulatory role of apelin in the aortic vascular tone in diabetic mice...
  16. doi request reprint MicroRNA 16 enhances differentiation of human bone marrow mesenchymal stem cells in a cardiac niche toward myogenic phenotypes in vitro
    Ju Li Liu
    Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
    Life Sci 90:1020-6. 2012
    ....
  17. doi request reprint Upregulated expression of miR-1/miR-206 in a rat model of myocardial infarction
    Zhi xin Shan
    Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, China
    Biochem Biophys Res Commun 381:597-601. 2009
    ..05, p<0.01). Together, our results indicate that miR-1 and miR-206 are involved in apoptotic cell death in MI by post-transcriptional repression of IGF-1...
  18. doi request reprint Mechanism of macrophage migration inhibitory factor-induced decrease of T-type Ca(2+) channel current in atrium-derived cells
    Fang Rao
    Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Academy of Medical Sciences, 96 Dongchuan Road, Guangzhou 510080, PR China
    Exp Physiol 98:172-82. 2013
    ....
  19. ncbi request reprint [Distribution of variant alleles association with warfarin pharmacokinetics and pharmacodynamics in the Han population in China]
    Yuan Liu
    Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
    Beijing Da Xue Xue Bao 43:798-803. 2011
    ..To investigate distribution of CYP2C9, CYP3A4, VKORC1 and GGCX gene polymorphisms in the Han population of Guangdong...
  20. doi request reprint Allitridi inhibits transient outward potassium currents in human atrial myocytes
    Chun yu Deng
    Department of Cardiology, Guangdong Cardiovascular Institute and Guangdong Academy of Medical Sciences, Research Centre of Guangdong General Hospital, Guangzhou, China
    Clin Exp Pharmacol Physiol 38:323-7. 2011
    ..4. The results of the present study indicate that allitridi inhibits I(to), but not I(Kur) and I(Ca), and prolongs the action potential duration in human atrial myocytes...
  21. doi request reprint miR-1/miR-206 regulate Hsp60 expression contributing to glucose-mediated apoptosis in cardiomyocytes
    Zhi xin Shan
    Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
    FEBS Lett 584:3592-600. 2010
    ..These results revealed that miR-1 and miR-206 regulate Hsp60 expression, contributing to high glucose-mediated apoptosis in cardiomyocytes...
  22. ncbi request reprint Role of P-glycoprotein in the intestinal absorption of tanshinone IIA, a major active ingredient in the root of Salvia miltiorrhiza Bunge
    Xi Yong Yu
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China
    Curr Drug Metab 8:325-40. 2007
    ..Further studies are needed to explore the role of other drug transporters and first-pass metabolism in the low bioavailability of TSA...
  23. doi request reprint Cardioprotective effect of a hemoglobin-based oxygen carrier on cold ischemia/reperfusion injury
    Li Wei
    Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
    Cardiology 120:73-83. 2011
    ..The aim of this study was to investigate the protective effect of a hemoglobin-based oxygen carrier (HBOC) on cold I/R heart and to explore the underlying mechanisms...
  24. ncbi request reprint [Plasmid-mediated miRNA-1-2 specifically inhibits Hand2 protein expression in H9C2 cells]
    Zhi xin Shan
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:1559-61, 1567. 2008
    ..To construct an eukaryotic expression vector for miRNA-1-2 that can be expressed in rat H9C2 cardiomyocytes...
  25. doi request reprint Fn14 promotes differentiation of human mesenchymal stem cells into heart valvular interstitial cells by phenotypic characterization
    Wei Huang
    Medical Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China
    J Cell Physiol 229:580-7. 2014
    ..These new findings of the effect of Fn14 on VIC-like cell differentiation may provide a novel therapeutic strategy for heart valve disease treatment...
  26. ncbi request reprint Involvement of Src in L-type Ca2+ channel depression induced by macrophage migration inhibitory factor in atrial myocytes
    Fang Rao
    Department of Cardiology, Guangdong Cardiovascular Institute, 96 Dongchuan Road, Guangzhou 510080, PR China
    J Mol Cell Cardiol 47:586-94. 2009
    ....
  27. ncbi request reprint [MicroRNAs can be expressed in cardiomyocyte-like cells differentiated from human mesenchymal stem cells]
    Zhi xin Shan
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Diseases Institute, Guangzhou 510080, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:1813-6. 2007
    ..To investigate the expression of representative heart-specific primary microRNAs (pri-miRNAs) in the cardiomyocyte-like cells differentiated from human mesenchymal stem cells (hMSCs)...
  28. ncbi request reprint [Effect of adenoviral vectors on the differentiation potential of human bone marrow mesenchymal stem cells]
    Zhi xin Shan
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital Guangdong Provincial Cardiovascular Diseases Institute, Guangzhou 510080, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:1132-5. 2008
    ..To investigate the effect of adenoviral vector infection on the differentiation potential of human bone marrow mesenchymal stem cells (hMSCs)...
  29. ncbi request reprint Improved liquid chromatography-tandem mass spectrometry method for the analysis of eptifibatide in human plasma
    Zhi Ling Zhou
    Medical Research Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
    J Chromatogr B Analyt Technol Biomed Life Sci 878:2094-100. 2010
    ..The validated LC-MS/MS method was successfully applied for the evaluation of pharmacokinetic parameters of eptifibatide after intravenous (i.v.) administration of a 45 microg/kg bolus of eptifibatide to 8 healthy volunteers...
  30. doi request reprint Association of PON1 genotype and haplotype with susceptibility to coronary artery disease and clinical outcomes in dual antiplatelet-treated Han Chinese patients
    Yan hong Kang
    Medical Research Center, Guangdong General Hospital, Guangzhou, Guangdong 510080, China
    Eur J Clin Pharmacol 69:1511-9. 2013
    ....
  31. ncbi request reprint A rapid and simple high-performance liquid chromatography method for the determination of human plasma levofloxacin concentration and its application to bioequivalence studies
    Zhi Ling Zhou
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou 510080, People s Republic of China
    Biomed Chromatogr 21:1045-51. 2007
    ..The method described herein has been successfully used for the pharmacokinetic and bioequivalence studies of a levofloxacin formulation product after oral administration to healthy Chinese volunteers...
  32. doi request reprint The influence of genetic polymorphisms and interacting drugs on initial response to warfarin in Chinese patients with heart valve replacement
    Shi long Zhong
    Guangdong Provincial Cardiovascular Institute, Medical Research Center of Guangdong General Hospital, Guangdong Institute of Clinical Pharmacology, Guangdong Academy of Medical Sciences, 96 Dongchuan Road, Guangzhou, GD 510080, People s Republic of China
    Eur J Clin Pharmacol 67:581-90. 2011
    ....
  33. doi request reprint Effect of ranolazine on rat intrarenal arteries in vitro
    Chun yu Deng
    Medical Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, PR China
    Eur J Pharmacol 683:211-6. 2012
    ..Therefore it can be said that ranolazine has significant α₁-adrenergic receptor and weak calcium channel antagonistic effects in rat intrarenal arteries...
  34. ncbi request reprint [Association of the polymorphism of macrophage migration inhibitory factor gene with coronary heart disease in Chinese population]
    Zhi xin Shan
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Diseases Institute, Guangzhou, Guangdong, 510080 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 23:548-50. 2006
    ..The present study is to investigate the association of the -173 G/C polymorphism of MIF gene with the outcome of the CHD...
  35. doi request reprint Transcription factor Ap-1 mediates proangiogenic MIF expression in human endothelial cells exposed to Angiotensin II
    Zhi xin Shan
    Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
    Cytokine 53:35-41. 2011
    ..Our results suggest that AP-1 mediates Ang II-induced MIF expression which contributes to atherosclerotic plaque destabilization in human endothelial cells...
  36. doi request reprint Association between polymorphisms of the renin-angiotensin system and coronary artery disease in Chinese patients with type 2 diabetes
    He Ping Lei
    Medical Research Center, Guangdong General Hospital, Guangzhou, Guangdong, China
    J Renin Angiotensin Aldosterone Syst 13:305-13. 2012
    ..In this study, we investigated associations of the five genetic polymorphisms in the RAS and presence of coronary artery disease (CAD) in type 2 diabetes...
  37. ncbi request reprint [Effect of ketamine on transient outward potassium current of isolated human atrial myocytes]
    Su juan Kuang
    Medical Research Center of Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
    Yao Xue Xue Bao 45:849-52. 2010
    ..The I(to) activation curve, inactivation curve and the recovery curve were not altered by ketamine. So, ketamine concentration-dependently decreased I(to) of human atrial myocytes...
  38. doi request reprint High glucose induces apoptosis in AC16 human cardiomyocytes via macrophage migration inhibitory factor and c-Jun N-terminal kinase
    Jia Liang Liang
    Medical Research Center, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
    Clin Exp Pharmacol Physiol 37:969-73. 2010
    ..The identification of a high glucose-MIF-JNK pathway will help determine potential new targets in the treatment of diabetic cardiomyopathy...
  39. ncbi request reprint [Differentiation of rabbit bone marrow mesenchymal stem cells into myogenic cells in vitro and expression of vascular endothelial growth factor gene after transfection]
    Xiao gang Sheng
    Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangzhou 510100, China
    Di Yi Jun Yi Da Xue Xue Bao 24:290-4. 2004
    ..To induce the differentiation of rabbit bone marrow mesenchymal stem cells (MSCs) into myogenic cells in vitro, and to investigate the expression of vascular endothelial growth factor (VEGF) gene in AdTrackCMV-hVEGF165- transfected MSCs...
  40. ncbi request reprint Rapid and sensitive HPLC-MS/MS method for pharmacokinetic assessment of ribavirin in healthy Chinese
    Zhi Ling Zhou
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou 510080, People s Republic of China
    Biomed Chromatogr 22:1409-15. 2008
    ..The mean elimination half-life was 43.6 h. The present study describes a simple, specific, sensitive HPLC-MS/MS method for measuring plasma drug concentration and analyzing human pharmacokinetics of ribavirin...
  41. doi request reprint Molecular characterization of a Chinese pedigree with beta-thalassemia intermedia
    Ge Huang
    Research Center of Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People s Republic of China
    Hemoglobin 34:179-83. 2010
    ....
  42. ncbi request reprint [High glucose up-regulates GRK2 gene expression in H9C2 cardiomyoblasts in vitro]
    Hong mei Chen
    Department of Endocrinology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:472-4. 2010
    ..To study the effect of high glucose on GRK2 gene expression in H9C2 cardiomyoblasts in vitro...
  43. ncbi request reprint Effect of impaired glucose tolerance on cardiac dysfunction in a rat model of prediabetes
    Jia Liang Liang
    Medical Research Center, Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangdong Institute of Clinical Pharmacology, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080, China
    Chin Med J (Engl) 124:734-9. 2011
    ..This study was designed to observe cardiac dysfunction in prediabetic rats with IGT and to determine whether glucose metabolic abnormalities, inflammation and apoptosis are linked to it...
  44. ncbi request reprint [Identification of the interactions between the truncated fragments of macrophage migration inhibitory factor and CD74 using a yeast two-hybrid system]
    Zhi Xi Shan
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou Guangdong Provincial Cardiovascular Disease Institute, Guangzhou 510080, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:2383-6, 2390. 2009
    ..To investigate the interaction domains between macrophage migration inhibitory factors (MIF) and the extracellular segment of type-II trans-membrane protein CD74 using a yeast two-hybrid system...
  45. doi request reprint Electrophysiological effects of ketamine on human atrial myocytes at therapeutically relevant concentrations
    Chun yu Deng
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou, China
    Clin Exp Pharmacol Physiol 35:1465-70. 2008
    ..5. In conclusion, ketamine, at a clinically relevant concentration, shortens the action potential duration of the human atrial myocytes, probably by inhibiting I(Ca)...
  46. ncbi request reprint [An method for small hairpin RNA expression vector reconstruction for easy single restriction endonuclease identification]
    Zhi xin Shan
    Research Center of Medical Sciences, People s Hospital of Guangdong Province, Guangzhou 510080, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:1341-4. 2007
    ..To develop an effective method for screening recombinant hairpin RNA expression plasmids using single restriction endonuclease analysis...
  47. ncbi request reprint [Human bone marrow mesenchymal stem cells cocultured with semi-permeable membrane separated neonatal rat ventricular myocytes differentiated into cardiomyocyte phenotype]
    Xiao Hong Li
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou 510080, China
    Zhonghua Xin Xue Guan Bing Za Zhi 36:651-4. 2008
    ..To investigate the ability of human bone marrow mesenchymal stem cells (hBMSCs), cocultured with semi-permeable membrane separated neonatal rat ventricular myocytes, to differentiate into cardiomyocytes...
  48. doi request reprint An efficient method to enhance gene silencing by using precursor microRNA designed small hairpin RNAs
    Zhixin Shan
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou, 510080, China
    Mol Biol Rep 36:1483-9. 2009
    ..Together, this study confirmed the efficiency of gene silencing mediated by pre-miRNA-30- and pre-miRNA-155-designed shRNAs, demonstrating that pre-miRNA-designed hairpins are a good strategy for gene silencing...
  49. ncbi request reprint [Relationship between macrophage migration inhibitory factor and cardiac function in patients with congestive heart failure]
    Yuan Liu
    Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangzhou 510080, China
    Di Yi Jun Yi Da Xue Xue Bao 23:1169-70. 2003
    ..To examine the level of plasma macrophage migration inhibitory factor (MIF) in patients with congestive heart failure (CHF) and its relationship with cardiac function...
  50. ncbi request reprint [Impact of CYP2C9 and VKORC1 polymorphism on warfarin response during initiation of therapy]
    Yuan Liu
    Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
    Zhonghua Xin Xue Guan Bing Za Zhi 39:929-35. 2011
    ..To investigate potential contributions of genetic variants of cytochrome P-450 2C9 (CYP2C9) and vitamin K expoxide reductase (VKORC1) to the anticoagulation response during the initiation of warfarin therapy in the Han Chinese population...
  51. ncbi request reprint [Efficacy comparison between transplanting microenvironmental induced and non-induced bone marrow mesenchymal stem cells in ischemic rat hearts]
    Xiao Hong Li
    Guangdong Provincial Cardiovascular Institute, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:680-4. 2009
    ..To compare the efficacy of transplanting bone marrow mesenchymal stem cell (BMSC) or microenvironmental induced BMSC (iBMSC) into the ischemic myocardium of rats with myocardial infarction...
  52. doi request reprint Plasma miR-126 as a potential marker predicting major adverse cardiac events in dual antiplatelet-treated patients after percutaneous coronary intervention
    Xi Yong Yu
    Medical Research Center of Guangdong General Hospital, Guangzhou, Guangdong, China
    EuroIntervention 9:546-54. 2013
    ..Conclusions: Based on these results, we suggest that plasma miR-126 could be a potential marker for predicting major adverse cardiac events in patients after PCI. ..
  53. ncbi request reprint [An efficient method for screening effective siRNAs using dual-luciferase reporter assay system]
    Zhi xin Shan
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital Guangdong Provincial Cardiovascular Diseases Institute, Guangzhou 510080, China
    Nan Fang Yi Ke Da Xue Xue Bao 29:1577-81. 2009
    ..To establish an efficient method for screening effective small interference RNA (siRNA) using dual-luciferase reporter assay system...
  54. ncbi request reprint [Clinical application of anticoagulation treatment with warfarin after prosthetic heart valve replacement: a single center-based survey]
    Yuan Liu
    Department of Cardiology, Medical Research Center, Guangdong Cardiovascular Institute, People s Hospital of Guangdong Province, Guangzhou 510081, China
    Nan Fang Yi Ke Da Xue Xue Bao 30:2242-5. 2010
    ..To investigate the clinical application of anticoagulation treatment with warfarin after prosthetic heart valve replacement and compare the effect and safety of different anticoagulant intensities...
  55. doi request reprint Polymerised placenta haemoglobin attenuates cold ischaemia/reperfusion injury in isolated rat heart
    Li Wei
    Department of Cardiovascular Surgery, Guangdong Cardiovascular Institute, Guangdong General Hospital, Guangdong Academy of Medical Sciences, 96 Dongchuan Road, Guangzhou 510080, China
    Microvasc Res 82:430-8. 2011
    ....
  56. ncbi request reprint [Identification and tissue localization of intermediate filament protein in Angiostrongylus cantonensis]
    Jin xiu Meng
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangzhou 510080, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:1141-4. 2007
    ..To identify the type of the intermediate filament (IF) protein of Angiostrongylus cantonensis and analyze its tissue localization...
  57. ncbi request reprint [Effects of macrophage migration inhibitory factor on collagen I and III mRNA expression in vascular smooth muscle cells in vitro]
    Jun Li
    Institute of Cardiovascular Diseases, Guangdong People s Hospital, Guangzhou 510080, China
    Di Yi Jun Yi Da Xue Xue Bao 25:684-6. 2005
    ..To investigate the association between macrophage migration inhibitory factor (MIF) and collagen synthesis in vascular smooth muscle cells (VSMCs)...
  58. ncbi request reprint [Effects of C-type natriuretic peptide gene transduction on neointimal hyperplasia and endothelial function after angioplasty]
    Xiao yang Pei
    Department of Cardiology, Guangdong Provincial Cardiovascular Institute, Guangzhou 510100, China
    Di Yi Jun Yi Da Xue Xue Bao 24:400-3. 2004
    ..To investigate the effects of C-type natriuretic peptide (CNP) gene transduction on neointimal hyperplasia and endothelial function after angioplasty...
  59. doi request reprint [Progress in genetic and epigenetic research on in-stent restenosis after percutaneous coronary interventions]
    Yan hong Kang
    Research Center of Guangdong General Hospital, Guangzhou, Guangdong 510080, P R China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 29:38-42. 2012
    ..In this article, authors have reviewed genetic and epigenetic factors on the progression of ISR, which may help to determine the genetic risk factors in patients with ISR after PCI...
  60. ncbi request reprint [Screening and identification of auto-antigen RHDAG1 of rheumatic heart disease]
    Jin xiu Meng
    Medical Research Center, Guangdong General Hospital Guangdong Academic of Medical Sciences, Guangzhou 510080, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1154-8. 2011
    ..To identify the candidate auto-antigen of rheumatic heart disease as a molecular marker for this disease...
  61. ncbi request reprint [Induced differentiation and signaling factor PTEN expression of 3T3-L1 adipocytes]
    Yun xiong Li
    Research Center of Medical Sciences, People s Hospital of Guangdong Province, Guangzhou 510089, China
    Nan Fang Yi Ke Da Xue Xue Bao 27:259-63. 2007
    ....
  62. ncbi request reprint The novel peptide apelin regulates intrarenal artery tone in diabetic mice
    Jiu Chang Zhong
    Research Center of Medical Sciences, Guangdong Provincial People s Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong, China
    Regul Pept 144:109-14. 2007
    ..Apelin treatment may regulate the balance between Ang II and NO and thereby exert beneficial effects on the diabetic vascular pathophysiology...
  63. ncbi request reprint Mutation of plakophilin-2 gene in arrhythmogenic right ventricular cardiomyopathy
    Shu Lin Wu
    Department of Cardiology Guangdong General Hospital, Guangdong Provincial Cardiovascular Institute, Guangzhou, Guangdong 510080, China
    Chin Med J (Engl) 122:403-7. 2009
    ....