Research Topics

Genomes and Genes

Species

Shengqing Yu

Summary

Publications

  1. Malhi K, Wang X, Chen Z, Ding C, Yu S. Riemerella anatipestifer gene AS87_08785 encodes a functional component, GldK, of the type IX secretion system. Vet Microbiol. 2019;231:93-99 pubmed publisher
    ..Our results demonstrated that R. anatipestifer gene AS87_08785 encoded a component of the type IX secretion system, GldK, which functioned in bacterial gliding motility, protein secretion, and bacterial virulence. ..
  2. Tian M, Qu J, Li P, Bao Y, Liu J, Ding C, et al. Identification of novel genes essential for Brucella abortus to establish infection by signature-tagged mutagenesis. Vet Microbiol. 2019;230:130-137 pubmed publisher
    ..These findings provide novel genetic information associated with Brucella infection. ..
  3. Li P, Tian M, Hu H, Yin Y, Guan X, Ding C, et al. Lable-free based comparative proteomic analysis of secretory proteins of rough Brucella mutants. J Proteomics. 2019;195:66-75 pubmed publisher
    ..This study provides novel information of the secretory proteins from the Brucella rough mutants and their effects on the Brucella cytotoxicity. ..
  4. Ren X, Wang X, Shi H, Zhang X, Chen Z, Malhi K, et al. Riemerella anatipestifer AS87_RS09170 gene is responsible for biotin synthesis, bacterial morphology and virulence. Sci Rep. 2018;8:14645 pubmed publisher
    ..These results provide the first evidence that the R. anatipestifer AS87_RS09170 gene is responsible for biotin synthesis, bacterial morphology and virulence. ..
  5. Dou Y, Yu G, Wang X, Wang S, Li T, Tian M, et al. The Riemerella anatipestifer M949_RS01035 gene is involved in bacterial lipopolysaccharide biosynthesis. Vet Res. 2018;49:93 pubmed publisher
    ..This study presents evidence that the M949_RS01035 gene is involved in bacterial phenotype, virulence, and gene regulation in R. anatipestifer. The mutant strain RA1062 could be used as a cross-protective vaccine candidate. ..
  6. Liu J, Cong Y, Yin R, Ding C, Yu S, Liu X, et al. The deletion of an extra six nucleotides in the 5' -untranslated region of the nucleoprotein gene of Newcastle disease virus NA-1 decreases virulence. BMC Vet Res. 2014;10:964 pubmed publisher
    ..However, rNA-1(-) was more virulent in chickens than geese, as seen by the higher intracerebral pathogenicity index value. ..
  7. Tian M, Bao Y, Li P, Hu H, Ding C, Wang S, et al. The putative amino acid ABC transporter substrate-binding protein AapJ2 is necessary for Brucella virulence at the early stage of infection in a mouse model. Vet Res. 2018;49:32 pubmed publisher
    ..These data elucidated that the bab_RS27735 gene is necessary for B. abortus virulence at the early stage of infection in a mouse model. ..
  8. Rehman Z, Qiu X, Sun Y, Liao Y, Tan L, Song C, et al. Vitamin E Supplementation Ameliorates Newcastle Disease Virus-Induced Oxidative Stress and Alleviates Tissue Damage in the Brains of Chickens. Viruses. 2018;10: pubmed publisher
    ..These findings also demonstrate that supplementing vitamin E ameliorates these pathologies in chickens and proposes its supplementation for NDV-induced stresses. ..
  9. Wang X, Ding C, Wang S, Han X, Yu S. Whole-Genome Sequence Analysis and Genome-Wide Virulence Gene Identification of Riemerella anatipestifer Strain Yb2. Appl Environ Microbiol. 2015;81:5093-102 pubmed publisher
    ..The functions of the other 23 genes are poorly characterized or unknown. This genome-wide study identified genes important to the virulence of R. anatipestifer. ..

More Information

Publications23

  1. Zou J, Wang X, Tian M, Cao S, Hou W, Wang S, et al. The M949_1556 gene plays a role on the bacterial antigenicity and pathogenicity of Riemerella anatipestifer. Vet Microbiol. 2015;177:193-200 pubmed publisher
    ..anatipestifer serotypes 1, 2 and 10 strains. Our results demonstrated that the M949_1556 gene plays a role on the bacterial antigenicity and pathogenicity of R. anatipestifer. ..
  2. Wang X, Ding C, Han X, Wang S, Yue J, Hou W, et al. Complete Genome Sequence of Riemerella anatipestifer Serotype 1 Strain CH3. Genome Announc. 2015;3: pubmed publisher
    ..Here, we present the complete genome sequence of R. anatipestifer strain CH3, the serotype 1 prevalent in China. ..
  3. Wang X, Liu B, Dou Y, Fan H, Wang S, Li T, et al. The Riemerella anatipestifer AS87_01735 Gene Encodes Nicotinamidase PncA, an Important Virulence Factor. Appl Environ Microbiol. 2016;82:5815-23 pubmed publisher
    ..Altogether, these results suggest that PncA contributes to the virulence of R. anatipestifer and that the Yb2ΔpncA mutant can be used as a novel live vaccine candidate. ..
  4. Gao J, Tian M, Bao Y, Li P, Liu J, Ding C, et al. Pyruvate kinase is necessary for Brucella abortus full virulence in BALB/c mouse. Vet Res. 2016;47:87 pubmed publisher
    ..abortus virulence in a mouse infection model. Our results elucidated the role of the Pyk in B. abortus virulence and provided information for further investigation of Brucella virulence associated carbon metabolism. ..
  5. Zou J, Wang X, Ding C, Tian M, Han X, Wang S, et al. Characterization and cross-protection evaluation of M949_1603 gene deletion Riemerella anatipestifer mutant RA-M1. Appl Microbiol Biotechnol. 2015;99:10107-16 pubmed publisher
    ..These results suggested that M949_1603 gene is associated with serotype 1 O-antigen biosynthesis, and mutant RA-M1 could be used as a novel cross-protection vaccine candidate to protect ducks against R. anatipestifer infection. ..
  6. Tian M, Qu J, Bao Y, Gao J, Liu J, Wang S, et al. Construction of pTM series plasmids for gene expression in Brucella species. J Microbiol Methods. 2016;123:18-23 pubmed publisher
    ..The constructed pTM series plasmids will play an important role in the functional investigation of Brucella spp. ..
  7. Jiang W, Xue J, Liu Y, Li T, Han X, Wang S, et al. Identification and characterization of an immunogenic antigen, enolase 2, among excretory/secretory antigens (ESA) of Toxoplasma gondii. Protein Expr Purif. 2016;127:88-97 pubmed publisher
    ..Our findings indicate that enolase 2 could play important roles in metabolism, immunogenicity and pathogenicity and that it may serve as a novel drug target and candidate vaccine against T. gondii infection. ..
  8. Han X, Bai H, Tu J, Yang L, Xu D, Wang S, et al. Deletion of luxS further attenuates the virulence of the avian pathogenic Escherichia coli aroA mutant. Microb Pathog. 2015;88:39-47 pubmed publisher
  9. Wang Y, Yi L, Zhang F, Qiu X, Tan L, Yu S, et al. Identification of genes involved in Mycoplasma gallisepticum biofilm formation using mini-Tn4001-SGM transposon mutagenesis. Vet Microbiol. 2017;198:17-22 pubmed publisher
    ..This study adds to our understanding of the molecular mechanisms involved in MG biofilm formation and may shed light on the persistence of MG infections. ..
  10. Dou Y, Wang X, Yu G, Wang S, Tian M, Qi J, et al. Disruption of the M949_RS01915 gene changed the bacterial lipopolysaccharide pattern, pathogenicity and gene expression of Riemerella anatipestifer. Vet Res. 2017;48:6 pubmed publisher
    ..Our findings demonstrate that the M949_RS01915 gene is associated to bacterial antigenicity, pathogenicity and gene regulation of R. anatipestifer. ..
  11. Bao Y, Tian M, Li P, Liu J, Ding C, Yu S. Characterization of Brucella abortus mutant strain Δ22915, a potential vaccine candidate. Vet Res. 2017;48:17 pubmed publisher
    ..Therefore, mutant strain ∆22915 could be used as a novel vaccine candidate in the future to protect animals against B. abortus infection. ..
  12. Han X, Liu L, Fan G, Zhang Y, Xu D, Zuo J, et al. Riemerella anatipestifer lacks luxS, but can uptake exogenous autoinducer-2 to regulate biofilm formation. Res Microbiol. 2015;166:486-93 pubmed publisher
    ..These findings will benefit future studies on AI-2 regulation in RA. ..
  13. Cao S, Han X, Ding C, Wang S, Tian M, Wang X, et al. Molecular cloning of the duck mitogen-activated protein kinase 1 (MAPK1) gene and the development of a quantitative real-time PCR assay to detect its expression. Poult Sci. 2014;93:2158-67 pubmed publisher
    ..Our results provide ground work to warrant further studies of the duck MAPK1 gene in bacterial pathogenesis. ..
  14. Zhang Y, Qi K, Jing Y, Zuo J, Hu J, Lv X, et al. LsrB-based and temperature-dependent identification of bacterial AI-2 receptor. AMB Express. 2017;7:188 pubmed publisher
    ..These findings will be beneficial for screening of new AI-2 receptors in different bacterial species. ..