Le Yu

Summary

Publications

  1. ncbi request reprint Autophagy contributes to modulating the cytotoxicities of Bcl-2 homology domain-3 mimetics
    Le Yu
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China Electronic address
    Semin Cancer Biol 23:553-60. 2013
  2. ncbi request reprint [Cisplatin induces drug resistance in human esophageal squamous carcinoma cell line EC109 by decreasing CTR1 protein expression]
    Le Yu
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:801-4. 2011
  3. ncbi request reprint [Epidermal growth factor stimulates the proliferation of human esophageal squamous cell carcinoma HKESC-1 cells by increasing COX-2 expression]
    Le Yu
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1323-6. 2011
  4. doi request reprint Celecoxib antagonizes the cytotoxic effect of cisplatin in human gastric cancer cells by decreasing intracellular cisplatin accumulation
    Minghui Chen
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
    Cancer Lett 329:189-96. 2013
  5. doi request reprint Celecoxib antagonizes the cytotoxicity of cisplatin in human esophageal squamous cell carcinoma cells by reducing intracellular cisplatin accumulation
    Le Yu
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    Mol Pharmacol 79:608-17. 2011
  6. ncbi request reprint A novel synthetic dibenzocyclooctadiene lignan analog XLYF-104-6 attenuates lipopolysaccharide-induced inflammatory response in RAW264.7 macrophage cells and protects BALB/c mice from sepsis
    Chunping Gu
    School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China
    Eur J Pharmacol 729:22-9. 2014
  7. doi request reprint Synthesis, selective cytotoxicities and probable mechanism of action of 7-methoxy-3-arylflavone-8-acetic acids
    Zhong Zhen Zhou
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China
    Bioorg Med Chem 22:1539-47. 2014
  8. ncbi request reprint [Celecoxib antagonizes the cytotoxic effect of carboplatin in human esophageal cancer cells]
    Lili Shi
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China E mail
    Nan Fang Yi Ke Da Xue Xue Bao 34:792-7. 2014
  9. pmc Sinomenine suppresses osteoclast formation and Mycobacterium tuberculosis H37Ra-induced bone loss by modulating RANKL signaling pathways
    Xiaojuan Li
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    PLoS ONE 8:e74274. 2013
  10. ncbi request reprint [Mechanism of E1A-mediated escape from ras-induced senescence in human fibraoblasts]
    Yi Lei Li
    Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1392-5. 2011

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Autophagy contributes to modulating the cytotoxicities of Bcl-2 homology domain-3 mimetics
    Le Yu
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China Electronic address
    Semin Cancer Biol 23:553-60. 2013
    ..Further exploration of our understanding of the association between autophagy and cellular outcomes in response to BH3 mimetics treatment will likely offer improved therapies for patients with cancer. ..
  2. ncbi request reprint [Cisplatin induces drug resistance in human esophageal squamous carcinoma cell line EC109 by decreasing CTR1 protein expression]
    Le Yu
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:801-4. 2011
    ..To investigate the mechanism of the development of cisplatin resistance in a human esophageal squamous carcinoma cell line...
  3. ncbi request reprint [Epidermal growth factor stimulates the proliferation of human esophageal squamous cell carcinoma HKESC-1 cells by increasing COX-2 expression]
    Le Yu
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1323-6. 2011
    ..To investigate the mechanisms responsible for epidermal growth factor (EGF)-induced proliferation of human esophageal squamous cell carcinoma cells...
  4. doi request reprint Celecoxib antagonizes the cytotoxic effect of cisplatin in human gastric cancer cells by decreasing intracellular cisplatin accumulation
    Minghui Chen
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
    Cancer Lett 329:189-96. 2013
    ..Therefore, treatment strategies with celecoxib in combination with cisplatin should act cautiously...
  5. doi request reprint Celecoxib antagonizes the cytotoxicity of cisplatin in human esophageal squamous cell carcinoma cells by reducing intracellular cisplatin accumulation
    Le Yu
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    Mol Pharmacol 79:608-17. 2011
    ..The combination treatment also shows no beneficial effect compared with cisplatin or celecoxib monotherapy in vivo. Therefore, current clinical trials with celecoxib in combination with cisplatin should be approached with caution...
  6. ncbi request reprint A novel synthetic dibenzocyclooctadiene lignan analog XLYF-104-6 attenuates lipopolysaccharide-induced inflammatory response in RAW264.7 macrophage cells and protects BALB/c mice from sepsis
    Chunping Gu
    School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, China
    Eur J Pharmacol 729:22-9. 2014
    ..These findings suggest XLYF-104-6 could act as a leading compound for developing a potential anti-inflammatory drug. ..
  7. doi request reprint Synthesis, selective cytotoxicities and probable mechanism of action of 7-methoxy-3-arylflavone-8-acetic acids
    Zhong Zhen Zhou
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, PR China
    Bioorg Med Chem 22:1539-47. 2014
    ..In addition, compound 10e was found to be able to induce tumor necrosis factor α (TNF-α) production in human peripheral blood mononuclear cells. ..
  8. ncbi request reprint [Celecoxib antagonizes the cytotoxic effect of carboplatin in human esophageal cancer cells]
    Lili Shi
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China E mail
    Nan Fang Yi Ke Da Xue Xue Bao 34:792-7. 2014
    ..To explore the antagonizing effect of celecoxib against the cytotoxicity of carboplatin in human esophageal cancer cells...
  9. pmc Sinomenine suppresses osteoclast formation and Mycobacterium tuberculosis H37Ra-induced bone loss by modulating RANKL signaling pathways
    Xiaojuan Li
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China
    PLoS ONE 8:e74274. 2013
    ..The protein expression of c-Fos and TRAF6 were also inhibited by SIN after RANKL stimulation. Taken together, SIN could attenuate osteoclast formation and Mt-induced bone loss by mediating RANKL signaling pathways. ..
  10. ncbi request reprint [Mechanism of E1A-mediated escape from ras-induced senescence in human fibraoblasts]
    Yi Lei Li
    Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1392-5. 2011
    ....
  11. ncbi request reprint Protective and antioxidant properties of wasp (Vespa magnifica) honeycomb extract: a potential inhibitor against acidified ethanol-induced gastric lesions
    Xue Qing Xu
    School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 31:1107-10. 2011
    ..To examine the protective effects of wasp (Vespa magnifica) honeycomb extract (WCE) against gastric lesions in rats induced by 60% acidified ethanol, and evaluate its capacity to suppress oxidative stress in the gastric tissue...