Junying Yu

Summary

Publications

  1. pmc Human induced pluripotent stem cells free of vector and transgene sequences
    Junying Yu
    Morgridge Institute for Research, Madison, WI 53707 7365, USA
    Science 324:797-801. 2009
  2. pmc Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells
    Kejin Hu
    Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, WI 53715, USA
    Blood 117:e109-19. 2011
  3. ncbi request reprint Induced pluripotent stem cell lines derived from human somatic cells
    Junying Yu
    Genome Center of Wisconsin, Madison, WI 53706 1580, USA
    Science 318:1917-20. 2007
  4. pmc A mesoderm-derived precursor for mesenchymal stem and endothelial cells
    Maxim A Vodyanik
    National Primate Research Center, University of Wisconsin Graduate School, Madison, 53715, USA
    Cell Stem Cell 7:718-29. 2010
  5. pmc Generation of red blood cells from human induced pluripotent stem cells
    Jessica Dias
    Department of Pathology and Laboratory Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin 53715, USA
    Stem Cells Dev 20:1639-47. 2011
  6. pmc Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method
    Jianhua Zhang
    Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Circ Res 111:1125-36. 2012
  7. pmc Functional cardiomyocytes derived from human induced pluripotent stem cells
    Jianhua Zhang
    Department of Medicine, University of Wisconsin, WiCell Research Institute, Madison, WI 53792 3248, USA
    Circ Res 104:e30-41. 2009
  8. pmc Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells
    Xuezhu Feng
    Genome Center of Wisconsin, University of Wisconsin Madison, Madison, WI, USA
    Stem Cells 30:461-70. 2012
  9. pmc FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation
    Pengzhi Yu
    Morgridge Institute for Research, Madison, WI 53715 7365, USA
    Cell Stem Cell 8:326-34. 2011
  10. doi request reprint Human lymphoblastoid B-cell lines reprogrammed to EBV-free induced pluripotent stem cells
    Deepika Rajesh
    Cellular Dynamics International Inc, Madison, WI 53711 1018, USA
    Blood 118:1797-800. 2011

Collaborators

Detail Information

Publications16

  1. pmc Human induced pluripotent stem cells free of vector and transgene sequences
    Junying Yu
    Morgridge Institute for Research, Madison, WI 53707 7365, USA
    Science 324:797-801. 2009
    ..These results demonstrate that reprogramming human somatic cells does not require genomic integration or the continued presence of exogenous reprogramming factors and removes one obstacle to the clinical application of human iPS cells...
  2. pmc Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells
    Kejin Hu
    Wisconsin National Primate Research Center, University of Wisconsin, 1220 Capitol Court, Madison, WI 53715, USA
    Blood 117:e109-19. 2011
    ..This approach provides an opportunity to explore banked normal and diseased CB and BM samples without the limitations associated with virus-based methods...
  3. ncbi request reprint Induced pluripotent stem cell lines derived from human somatic cells
    Junying Yu
    Genome Center of Wisconsin, Madison, WI 53706 1580, USA
    Science 318:1917-20. 2007
    ....
  4. pmc A mesoderm-derived precursor for mesenchymal stem and endothelial cells
    Maxim A Vodyanik
    National Primate Research Center, University of Wisconsin Graduate School, Madison, 53715, USA
    Cell Stem Cell 7:718-29. 2010
    ..Together, these studies identified a common precursor of mesenchymal and endothelial cells, mesenchymoangioblast, as the source of mesoderm-derived MSCs...
  5. pmc Generation of red blood cells from human induced pluripotent stem cells
    Jessica Dias
    Department of Pathology and Laboratory Medicine, University of Wisconsin, School of Medicine and Public Health, Madison, Wisconsin 53715, USA
    Stem Cells Dev 20:1639-47. 2011
    ..Since RBCs generated from transgene-free hiPSCs lack genomic integration and background expression of reprogramming genes, they would be a preferable cell source for modeling of diseases and for gene function studies...
  6. pmc Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method
    Jianhua Zhang
    Department of Medicine, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Circ Res 111:1125-36. 2012
    ..However, extracellular matrix is also fundamentally involved in cardiac development from the earliest morphogenetic events, such as gastrulation...
  7. pmc Functional cardiomyocytes derived from human induced pluripotent stem cells
    Jianhua Zhang
    Department of Medicine, University of Wisconsin, WiCell Research Institute, Madison, WI 53792 3248, USA
    Circ Res 104:e30-41. 2009
    ..We conclude that human iPS cells can differentiate into functional cardiomyocytes, and thus iPS cells are a viable option as an autologous cell source for cardiac repair and a powerful tool for cardiovascular research...
  8. pmc Protein kinase C mediated extraembryonic endoderm differentiation of human embryonic stem cells
    Xuezhu Feng
    Genome Center of Wisconsin, University of Wisconsin Madison, Madison, WI, USA
    Stem Cells 30:461-70. 2012
    ..We further confirmed that this differentiation is through the activation of protein kinase C (PKC) pathway and demonstrated that a particular PKC subtype, PKC-δ, is most responsible for this transition...
  9. pmc FGF2 sustains NANOG and switches the outcome of BMP4-induced human embryonic stem cell differentiation
    Pengzhi Yu
    Morgridge Institute for Research, Madison, WI 53715 7365, USA
    Cell Stem Cell 8:326-34. 2011
    ..Together, our results demonstrate that FGF2 signaling switches the outcome of BMP4-induced differentiation of human ESCs by maintaining NANOG levels through the MEK-ERK pathway...
  10. doi request reprint Human lymphoblastoid B-cell lines reprogrammed to EBV-free induced pluripotent stem cells
    Deepika Rajesh
    Cellular Dynamics International Inc, Madison, WI 53711 1018, USA
    Blood 118:1797-800. 2011
    ..Thus, reprogramming LCLs could offer an unlimited source for patient-specific iPSCs...
  11. pmc Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
    Bao Yang Hu
    Department of Anatomy, School of Medicine and Public Health, University of Wisconsin, Waisman Center, Madison, WI 53705, USA
    Proc Natl Acad Sci U S A 107:4335-40. 2010
    ..These findings, which show a need for improving differentiation potency of iPSCs, suggest the possibility of employing human iPSCs in pathological studies, therapeutic screening, and autologous cell transplantation...
  12. pmc Induced pluripotent stem cells from a spinal muscular atrophy patient
    Allison D Ebert
    The Waisman Center, The Stem Cell and Regenerative Medicine Center, University of Wisconsin Madison, 1500 Highland Avenue, Madison, Wisconsin 53705, USA
    Nature 457:277-80. 2009
    ..As such, it represents a promising resource to study disease mechanisms, screen new drug compounds and develop new therapies...
  13. pmc Pluripotent stem cell lines
    Junying Yu
    Genome Center of Wisconsin, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Genes Dev 22:1987-97. 2008
    ..Here we review the family of pluripotent cell lines derived from early embryos and from germ cells, and compare them with the more recently described induced pluripotent stem cells...
  14. ncbi request reprint Feeder-independent culture of human embryonic stem cells
    Tenneille E Ludwig
    Genome Center of Wisconsin, University of Wisconsin Madison, 425 Henry Mall, Madison, Wisconsin 53706, USA
    Nat Methods 3:637-46. 2006
  15. pmc Hematopoietic and endothelial differentiation of human induced pluripotent stem cells
    Kyung Dal Choi
    Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, 53715, USA
    Stem Cells 27:559-67. 2009
    ....
  16. ncbi request reprint Human embryonic stem cells reprogram myeloid precursors following cell-cell fusion
    Junying Yu
    Wisconsin National Primate Research Center, University of Wisconsin, Madison, WI 53706, USA
    Stem Cells 24:168-76. 2006
    ..These results indicate that hESCs are capable of reprogramming nuclei from differentiated cells and that hESC hybrid cells provide a new model system for studying the mechanisms of nuclear reprogramming...