Jian Yu

Summary

Publications

  1. pmc Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma
    Jian Yu
    Cancer Epigenetics and Gene Therapy, State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, LN 2200 25, Xie Tu Road, Shanghai 200032, China
    BMC Cancer 4:65. 2004
  2. ncbi request reprint Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma
    Sheng Ding
    The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University, LN 2200 25, Xie Tu Road, Shanghai 200032, China
    World J Gastroenterol 10:3433-40. 2004
  3. ncbi request reprint Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development
    Lingling Zhang
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China
    Dev Biol 387:64-72. 2014
  4. ncbi request reprint Correlation between methylation profile of promoter cpg islands of seven metastasis-associated genes and their expression states in six cell lines of liver origin
    Jian Liang Li
    State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, 200032, PR China
    Ai Zheng 23:985-91. 2004
  5. ncbi request reprint A novel protein-DNA interaction involved with the CpG dinucleotide at -30 upstream is linked to the DNA methylation mediated transcription silencing of the MAGE-A1 gene
    Jie Zhang
    The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, LN 2200 25, Xietu Road, Shanghai 200032, China
    Cell Res 14:283-94. 2004
  6. pmc Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
    Jian Yu
    The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, LN 2200 25, Xie Tu Road, Shanghai 200032, China
    BMC Cancer 2:29. 2002
  7. ncbi request reprint Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis
    Jian Yu
    The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University, LN 2200 25, Xietu Road, Shanghai 200032, China
    Cell Res 13:319-33. 2003
  8. ncbi request reprint Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis
    Xiao Li Xu
    The State Key Laboratory for Oncogenes and Related Genes, Cancer Institute of Shanghai Jiaotong University, Shanghai 200032, China
    World J Gastroenterol 10:3441-54. 2004
  9. ncbi request reprint The DNA methylation profile within the 5'-regulatory region of DRD2 in discordant sib pairs with schizophrenia
    Ai ping Zhang
    Bio X Center, Shanghai Jiao Tong University, Shanghai 200030, China
    Schizophr Res 90:97-103. 2007
  10. pmc Methylcap-seq reveals novel DNA methylation markers for the diagnosis and recurrence prediction of bladder cancer in a Chinese population
    Yangxing Zhao
    State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 7:e35175. 2012

Collaborators

Detail Information

Publications33

  1. pmc Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma
    Jian Yu
    Cancer Epigenetics and Gene Therapy, State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, LN 2200 25, Xie Tu Road, Shanghai 200032, China
    BMC Cancer 4:65. 2004
    ..Therefore, DNA methylation status as such may serve as an epigenetic biomarker for both diagnosis and prognosis of human tumors, including astrocytoma...
  2. ncbi request reprint Methylation profile of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma
    Sheng Ding
    The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University, LN 2200 25, Xie Tu Road, Shanghai 200032, China
    World J Gastroenterol 10:3433-40. 2004
    ..To establish the DNA methylation patterns of the promoter CpG islands of 14 "drug-resistance" genes in hepatocellular carcinoma (HCC)...
  3. ncbi request reprint Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development
    Lingling Zhang
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200240, China
    Dev Biol 387:64-72. 2014
    ....
  4. ncbi request reprint Correlation between methylation profile of promoter cpg islands of seven metastasis-associated genes and their expression states in six cell lines of liver origin
    Jian Liang Li
    State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University, Shanghai, 200032, PR China
    Ai Zheng 23:985-91. 2004
    ..This study was to assess the correlation between methylation state of promoter CpG islands of metastasis-associated genes and their expression in 6 liver cell lines, including 5 cancerous...
  5. ncbi request reprint A novel protein-DNA interaction involved with the CpG dinucleotide at -30 upstream is linked to the DNA methylation mediated transcription silencing of the MAGE-A1 gene
    Jie Zhang
    The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, LN 2200 25, Xietu Road, Shanghai 200032, China
    Cell Res 14:283-94. 2004
    ....
  6. pmc Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
    Jian Yu
    The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, LN 2200 25, Xie Tu Road, Shanghai 200032, China
    BMC Cancer 2:29. 2002
    ..Changes in the methylation profile of the promoters represent an alternative to genetic lesions as causative factors for the tumor-specific aberrant expression of the genes...
  7. ncbi request reprint Methylation profiling of twenty four genes and the concordant methylation behaviours of nineteen genes that may contribute to hepatocellular carcinogenesis
    Jian Yu
    The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiaotong University, LN 2200 25, Xietu Road, Shanghai 200032, China
    Cell Res 13:319-33. 2003
    ....
  8. ncbi request reprint Methylation profile of the promoter CpG islands of 31 genes that may contribute to colorectal carcinogenesis
    Xiao Li Xu
    The State Key Laboratory for Oncogenes and Related Genes, Cancer Institute of Shanghai Jiaotong University, Shanghai 200032, China
    World J Gastroenterol 10:3441-54. 2004
    ..To establish the methylation profile of the promoter CpG islands of 31 genes that might play etiological roles in colon carcinogenesis...
  9. ncbi request reprint The DNA methylation profile within the 5'-regulatory region of DRD2 in discordant sib pairs with schizophrenia
    Ai ping Zhang
    Bio X Center, Shanghai Jiao Tong University, Shanghai 200030, China
    Schizophr Res 90:97-103. 2007
    ..Our study did not support the hypothesis that site-specific cytosine methylation of DRD2 plays a role in the psychopathology of schizophrenia...
  10. pmc Methylcap-seq reveals novel DNA methylation markers for the diagnosis and recurrence prediction of bladder cancer in a Chinese population
    Yangxing Zhao
    State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 7:e35175. 2012
    ..We aimed to identify novel DNA methylation markers for BC through genome-wide profiling of BC cell lines and subsequent methylation-specific PCR (MSP) screening of clinical urine samples...
  11. ncbi request reprint [Correlation of the methylation status of CpG islands in the promoter region of 10 genes with the 5-Fu chemosensitivity in 3 breast cancer cell lines]
    Xiao Yu Zhou
    Fudan University School of Medicine, Shanghai 200032, China
    Zhonghua Zhong Liu Za Zhi 32:328-33. 2010
    ....
  12. ncbi request reprint A novel set of DNA methylation markers in urine sediments for sensitive/specific detection of bladder cancer
    Jian Yu
    Cancer Genetics and Gene Therapy Program, The State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Shanghai Jiao Tong University, Shanghai, China
    Clin Cancer Res 13:7296-304. 2007
    ..This study aims to provide a better set of DNA methylation markers in urine sediments for sensitive and specific detection of bladder cancer...
  13. ncbi request reprint [The clinical analysis of 62 cases of the urothelial inverted papilloma]
    Jian Yu
    Department of Urology, First Affiliated Hospital of China Medical University, Shenyang 110001, China
    Zhonghua Wai Ke Za Zhi 47:1400-2. 2009
    ..To investigate the clinical manifestation, biological behavior, diagnosis and treatment of the urothelial inverted papilloma...
  14. doi request reprint Effect of nourishing "Yin"-removing "Fire" Chinese herbal mixture on hypothalamic kisspeptin expression in female precocious rats
    Yan Sun
    Department of Neurobiology and Integrative Medicine, Shanghai Medical College of Fudan University, PO Box 291, 138 Yi Xue Yuan Road, 200032 Shanghai, PR China
    J Ethnopharmacol 127:274-9. 2010
    ..The present study aims to investigate the effect of nourishing "Yin"-removing "Fire" herbal mixture, a Chinese herb-based formulation, on hypothalamic kisspeptin expression in danazol-induced female precocious model rats...
  15. pmc Misexpression of Pknox2 in mouse limb bud mesenchyme perturbs zeugopod development and deltoid crest formation
    Wenrong Zhou
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    PLoS ONE 8:e64237. 2013
    ....
  16. ncbi request reprint [Gene expression related to growth axis and gonadal axis in puberty rats]
    Jia Min Wu
    Paediatric Research Institute, Children s Hospital, Fudan University, Shanghai 200032, China
    Zhong Xi Yi Jie He Xue Bao 1:35-8. 2003
    ..To elucidate the effect and effective mechanism of gonadotropin-releasing hormone analog (GnRHa) on growth axis and gonadal axis in puberty rats...
  17. pmc Selection against PUMA gene expression in Myc-driven B-cell lymphomagenesis
    Sean P Garrison
    Department of Biochemistry, St Jude Children s Research Hospital, 332 N Lauderdale, Memphis, TN 38105, USA
    Mol Cell Biol 28:5391-402. 2008
    ..These findings establish that PUMA is silenced in human malignancies, and they suggest PUMA as a target for the development of novel chemotherapeutics...
  18. ncbi request reprint Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation
    Wen Yue
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Clin Cancer Res 13:4336-44. 2007
    ..The goal of this study is to identify novel genes frequently silenced by promoter hypermethylation in lung cancer...
  19. pmc Sp1 and p73 activate PUMA following serum starvation
    Lihua Ming
    Department of Pathology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Carcinogenesis 29:1878-84. 2008
    ..Our results suggest that transcription factors Sp1 and p73 mediate p53-independent induction of PUMA following serum starvation to trigger apoptosis in human cancer cells...
  20. ncbi request reprint Up-regulation of DLK1 as an imprinted gene could contribute to human hepatocellular carcinoma
    Jian Huang
    Shanghai Ministry Key Laboratory of Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Shanghai 201203, China
    Carcinogenesis 28:1094-103. 2007
    ..These data suggest that DLK1 as an imprinted gene could be significantly up-regulated in HCC due to certain epigenetic events and contribute to the oncogenesis of this tumor...
  21. pmc p130CAS is required for netrin signaling and commissural axon guidance
    Guofa Liu
    Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Neurosci 27:957-68. 2007
    ..These results demonstrate that p130(CAS) is a key component in the netrin signal transduction pathway and plays an important role in guiding commissural axons in vivo...
  22. pmc Enhanced microtubule-dependent trafficking and p53 nuclear accumulation by suppression of microtubule dynamics
    Paraskevi Giannakakou
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 99:10855-60. 2002
    ..We propose that suppression of MT dynamics by low concentrations of MTCs enhances MT-dependent trafficking toward the minus ends of MTs and facilitates nuclear targeting...
  23. pmc Large-scale cDNA transfection screening for genes related to cancer development and progression
    Dafang Wan
    National Laboratory for Oncogenes and Related Genes, Cancer Institute of Shanghai Jiao Tong University, 25 Ln 2200 Xie Tu Road, Shanghai 200032, People s Republic of China
    Proc Natl Acad Sci U S A 101:15724-9. 2004
    ..It offers a better understanding of the basic machinery of oncogenesis, including previously undescribed systemic regulatory mechanisms, and also provides a tool for gene discovery with potential clinical applications...
  24. ncbi request reprint [Localization of human telomere repeat binding factor 1 in telomerase-positive and-negative cells and its expression during cell cycle]
    Jian Ping Lan
    The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 33:475-80, 495. 2004
    ..To observe the distribution pattern of human telomere repeat binding factor 1(TRF1) in the telomerase-positive (HeLa) and telomerase-negative cells (WI38-2RA) and to investigate its expression level during the cell cycle...
  25. ncbi request reprint [Expression of Pin1 in malignant hematopoietic cells and its relation with cell cycle]
    Yuan Yuan Zhu
    The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 33:500-3, 514. 2004
    ..To study the expression of peptidyl-prolyl cis/trans isomerase (PPIase or Pin1) in malignant hematopoietic cells and its relation with cell cycle...
  26. ncbi request reprint PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells
    Zhihe Liu
    Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131 001, USA
    Cancer Res 65:1647-54. 2005
    ..ROS overproduction and oxidative stress induce proteome-wise alterations, such as stathmin degradation and disorganization of the cell microtubule network, in apoptotic cells...
  27. ncbi request reprint [Mycophenolic acid induced apoptosis in T lymphocytic cells Molt-4 and its mechanism]
    Xiao li Zhu
    The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China
    Zhejiang Da Xue Xue Bao Yi Xue Ban 34:339-43. 2005
    ..To determine whether mycophenolic acid (MPA) exerts an apoptotic effect on human leukemic T cells Molt-4 and to elucidate its possible mechanism...
  28. ncbi request reprint The expression of telomeric proteins and their probable regulation of telomerase during the differentiation of all-trans-retinoic acid-responsive and -resistant acute promyelocytic leukemia cells
    Jie Sun
    Department of Hematology, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
    Int J Hematol 82:215-23. 2005
    ..Thus, our studies provide an outline of the dynamics of telomeric protein expression and the probable regulatory effects of these proteins on telomerase during the differentiation of ATRA-responsive and -resistant APL cells...
  29. doi request reprint SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release
    Alexander Bank
    Department of Pharmacology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Cancer Res 68:276-84. 2008
    ..Together, these results suggest that SMAC is useful as a target for the development of more effective chemopreventive strategies and agents...
  30. pmc BH3 mimetics to improve cancer therapy; mechanisms and examples
    Lin Zhang
    University of Pittsburgh Cancer Institute, Departments of Pharmacology and Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Drug Resist Updat 10:207-17. 2007
    ..This review summarizes recent advances in understanding the mechanisms of action of BH3 domains and several classes of BH3 mimetics, as well as the prospects of using these agents to improve cancer therapy...
  31. pmc p53 independent induction of PUMA mediates intestinal apoptosis in response to ischaemia-reperfusion
    Bin Wu
    University of Pittsburgh Cancer Institute, Hillman Cancer Center, Department of Pharmacology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Gut 56:645-54. 2007
    ..It has been shown that PUMA plays an essential role in apoptosis induced by a variety of stimuli in different tissues through a mitochondrial pathway...
  32. ncbi request reprint A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells
    Wen Xing Ding
    Department of Pathology, University of Pittsburgh School of Medicine, 3550 Terrace Street, Pittsburgh, PA 15231, USA
    Mol Cancer Ther 6:1062-9. 2007
    ..These findings thus strongly indicate the critical involvement of p53-, PUMA-, and Bax-mediated mitochondrial activation in proteasome inhibitor-induced apoptosis in colon cancer cells...
  33. pmc DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities
    Leigh Zawel
    The Howard Hughes Medical Institute and The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA
    Proc Natl Acad Sci U S A 99:2848-53. 2002
    ..However, DEC1 may function in concert with other signaling components to mediate certain biologic effects of TGF-beta...