Xue Fu You

Summary

Publications

  1. pmc In vivo antibacterial activity of vertilmicin, a new aminoglycoside antibiotic
    Xue Fu You
    Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Antimicrob Agents Chemother 53:4525-8. 2009
  2. pmc Susceptibility of vertilmicin to modifications by three types of recombinant aminoglycoside-modifying enzymes
    Min Yuan
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Antimicrob Agents Chemother 55:3950-3. 2011
  3. ncbi request reprint In vitro activity of recombinant lysostaphin against Staphylococcus aureus isolates from hospitals in Beijing, China
    Xin Yi Yang
    Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China
    J Med Microbiol 56:71-6. 2007
  4. ncbi request reprint Berberine analogue IMB-Y53 improves glucose-lowering efficacy by averting cellular efflux especially P-glycoprotein efflux
    Yong Qiang Shan
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Metabolism 62:446-56. 2013
  5. doi request reprint Host apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3G is an innate defensive factor and drug target against hepatitis C virus
    Zong Gen Peng
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Hepatology 53:1080-9. 2011
  6. doi request reprint Protein kinase D activation stimulates the transcription of the insulin receptor gene
    Hao Zhang
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, 1 Tiantan Xili, Beijing 100050, China
    Mol Cell Endocrinol 330:25-32. 2010
  7. doi request reprint Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA
    Zong Gen Peng
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Hepatology 52:845-53. 2010
  8. doi request reprint In vitro antibacterial activity of chinfloxacin, a new fluoroquinolone antibiotic
    Guo Qing Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    Chemotherapy 58:175-84. 2012
  9. pmc Heat stress cognate 70 host protein as a potential drug target against drug resistance in hepatitis B virus
    Yu Ping Wang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, China
    Antimicrob Agents Chemother 54:2070-7. 2010
  10. pmc In vitro antibacterial activity of vertilmicin and its susceptibility to modifications by the recombinant AAC6'-APH2'' enzyme
    Cong Ran Li
    Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Antimicrob Agents Chemother 52:3875-82. 2008

Collaborators

Detail Information

Publications28

  1. pmc In vivo antibacterial activity of vertilmicin, a new aminoglycoside antibiotic
    Xue Fu You
    Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Antimicrob Agents Chemother 53:4525-8. 2009
    ..coli 9612 and E. faecalis HH22 infections. The therapeutic efficacy of vertilmicin was further confirmed in local infection models of rabbit skin burn infection and mouse ascending urinary tract infection...
  2. pmc Susceptibility of vertilmicin to modifications by three types of recombinant aminoglycoside-modifying enzymes
    Min Yuan
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Antimicrob Agents Chemother 55:3950-3. 2011
    ..8- to 7.5-fold lower for ANT(2'')-Ia adenylation (except that shown by amikacin) while relatively comparable for AAC(6')-Ib acetylation, AAC(6')-Ib-cr acetylation, APH(2'')-Ia phosphorylation, and AAC(6')-Ie-APH(2'')-Ia phosphorylation...
  3. ncbi request reprint In vitro activity of recombinant lysostaphin against Staphylococcus aureus isolates from hospitals in Beijing, China
    Xin Yi Yang
    Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China
    J Med Microbiol 56:71-6. 2007
    ..aureus and meticillin-resistant S. aureus. Its activity at > or =0.5 MIC was sustained for at least 6 h. These results will be informative for the clinical application and evaluation of lysostaphin...
  4. ncbi request reprint Berberine analogue IMB-Y53 improves glucose-lowering efficacy by averting cellular efflux especially P-glycoprotein efflux
    Yong Qiang Shan
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Metabolism 62:446-56. 2013
    ..Cellular efflux transporters, especially P-glycoprotein (P-gp), impel berberine (BBR) out of cells, and therefore reduce bioavailability of the compound. This study was designed to overcome efflux of BBR using P-gp as a target...
  5. doi request reprint Host apolipoprotein B messenger RNA-editing enzyme catalytic polypeptide-like 3G is an innate defensive factor and drug target against hepatitis C virus
    Zong Gen Peng
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Hepatology 53:1080-9. 2011
    ..However, G/A hypermutation in the HCV genome were not detected, suggesting a new antiviral mechanism of hA3G in HCV, different from that in HIV-1. Stabilization of hA3G by RN-5 was safe in vivo...
  6. doi request reprint Protein kinase D activation stimulates the transcription of the insulin receptor gene
    Hao Zhang
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, 1 Tiantan Xili, Beijing 100050, China
    Mol Cell Endocrinol 330:25-32. 2010
    ..These results suggest that the PKD family is involved in the transcriptional regulation of the InsR gene; we consider it to be a potential new target to discover drugs for sugar-related disorders in the future...
  7. doi request reprint Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA
    Zong Gen Peng
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Hepatology 52:845-53. 2010
    ..IMB-DM122 showed considerable good safety in vitro as well as in vivo with no indication of harmful effect on liver and kidney functions...
  8. doi request reprint In vitro antibacterial activity of chinfloxacin, a new fluoroquinolone antibiotic
    Guo Qing Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    Chemotherapy 58:175-84. 2012
    ..Chinfloxacin is a novel synthetic fluoroquinolone with a structure similar to moxifloxacin. The in vitro activity of chinfloxacin was evaluated in the current study...
  9. pmc Heat stress cognate 70 host protein as a potential drug target against drug resistance in hepatitis B virus
    Yu Ping Wang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Beijing, China
    Antimicrob Agents Chemother 54:2070-7. 2010
    ..As the target is not a viral protein, OMTR is active for either wild-type HBV or strains resistant to reverse transcriptase (RT) inhibitors...
  10. pmc In vitro antibacterial activity of vertilmicin and its susceptibility to modifications by the recombinant AAC6'-APH2'' enzyme
    Cong Ran Li
    Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Antimicrob Agents Chemother 52:3875-82. 2008
    ....
  11. doi request reprint In vivo antibacterial activity of nemonoxacin, a novel non-fluorinated quinolone
    Cong Ran Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    J Antimicrob Chemother 65:2411-5. 2010
    ..To evaluate the in vivo antibacterial efficacy of nemonoxacin, a novel C8-methoxy non-fluorinated quinolone in murine systemic and local infection models...
  12. doi request reprint Toxicokinetic study of melamine in the presence and absence of cyanuric acid in rats
    Jing Pang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China
    J Appl Toxicol 33:444-50. 2013
    ..In conclusion, co-administration with CYA leads to the alteration of the kinetic characteristics of MEL, which provides an additional explanation for renal toxicity...
  13. ncbi request reprint [Overexpression of synuclein-gamma confers resistance to antimicrotubule drugs against human hepatoma cells]
    Shi Xiang Cheng
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 45:724-9. 2010
    ....
  14. doi request reprint In vivo antibacterial activity of chinfloxacin, a new fluoroquinolone antibiotic
    Guo Qing Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    J Antimicrob Chemother 67:955-61. 2012
    ..To evaluate the in vivo antibacterial efficacy of chinfloxacin, a novel fluoroquinolone, in murine systemic and local infection models...
  15. ncbi request reprint Antiviral therapeutic efficacy of foscarnet in hepatitis B virus infection
    Yan Xing Han
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, China
    Antiviral Res 68:147-53. 2005
    ..2.15 cells) with reduced amount of HBV RC-DNA and DS-DNA. In the duck HBV-infected ducklings, PFA reduced viral DNA and duck HBsAg in the serum (p<0.01 for both)...
  16. ncbi request reprint Chemomicin A, a new angucyclinone antibiotic produced by Nocardia mediterranei subsp. kanglensis 1747-64
    Cheng Hang Sun
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China
    J Antibiot (Tokyo) 60:211-5. 2007
    ..2 and 20.4 microM, respectively, and showed cytotoxicity against human colorectal cancer HCT116 cells and human esophageal carcinoma YES-2 cells with IC50 values of 127 and 153 microM, respectively...
  17. pmc In vivo antibacterial activity of MRX-I, a new oxazolidinone
    Cong Ran Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People s Republic of China
    Antimicrob Agents Chemother 58:2418-21. 2014
    ..MRX-I showed the same or better efficacy than linezolid in both systemic and local infection models against the tested strains. ..
  18. doi request reprint Combination of simvastatin with berberine improves the lipid-lowering efficacy
    Wei Jia Kong
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Metabolism 57:1029-37. 2008
    ..Our results display the rationale, effectiveness, and safety of the combination therapy for hyperlipidemia using BBR and SIMVA. It could be a new regimen for hypercholesterolemia...
  19. doi request reprint Design, synthesis, and cholesterol-lowering efficacy for prodrugs of berberrubine
    Ying Hong Li
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Bioorg Med Chem 18:6422-8. 2010
    ..Therefore, the design of M1 prodrug appears to be an effective strategy to improve pharmacokinetic feature of BBR for its lipid-lowering efficacy in vivo...
  20. ncbi request reprint [Toxic effects of trimethadione on zebrafish early development]
    Wei Qin
    Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yi Chuan 34:1165-73. 2012
    ....
  21. ncbi request reprint Synthesis and anti-influenza activities of carboxyl alkoxyalkyl esters of 4-guanidino-Neu5Ac2en (zanamivir)
    Zong Ying Liu
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Bioorg Med Chem Lett 17:4851-4. 2007
    ..Oral treatment or intraperitoneal administration of compound 1c showed significantly protective effects in mice infected with influenza A virus with low toxicities...
  22. ncbi request reprint [Zebrafish model for the study on drug ototoxicity of aminoglycoside antibiotics]
    Zhuang Zhao
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Yao Xue Xue Bao 46:928-35. 2011
    ....
  23. doi request reprint Synthesis and in vitro antibacterial activity of 7-(3-alkoxyimino-4-methyl-4-methylaminopiperidin-1-yl)-fluoroquinolone derivatives
    Yi Bin Zhang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P R China
    Arch Pharm (Weinheim) 343:143-51. 2010
    ..In addition, compound 14 exhibits excellent activity (MIC: 0.06 microg/mL) against Acinetobactes calcoaceticus, which is two- to 16-fold more potent than the reference drugs gemifloxacin, levofloxacin, and ciprofloxacin...
  24. pmc Identification of antituberculosis agents that target ribosomal protein interactions using a yeast two-hybrid system
    Yuan Lin
    Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Proc Natl Acad Sci U S A 109:17412-7. 2012
    ..Therefore, our data demonstrate that this yeast two-hybrid system is a useful tool to identify unique antituberculosis agents targeting the ribosomal protein L12-L10 interaction...
  25. doi request reprint N-(2,6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide as a novel tubulin ligand against human cancer
    Yue Ming Wang
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Tiantan Xili, Beijing, People s Republic of China
    Clin Cancer Res 14:6218-27. 2008
    ..We have synthesized a new tubulin ligand N-(2,6-dimethoxypyridine-3-yl)-9-methylcarbazole-3-sulfonamide (IG-105). This work investigates its anticancer effect and mechanism...
  26. pmc Small molecular compounds inhibit HIV-1 replication through specifically stabilizing APOBEC3G
    Shan Cen
    Department of Virology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Science, Beijing 100050, China
    J Biol Chem 285:16546-52. 2010
    ..LD(50) of IMB-26 in mice was >1000 mg/kg (intraperitoneally). Therefore, IMB-26 and IMB-35 are novel anti-HIV leads working through specific stabilization of hA3G...
  27. ncbi request reprint [Advances in molecular biology of extended-spectrum beta-lactamase]
    Qian Xiang
    Department of Pharmacology and Toxicology, Institute of Medicinal Biotechnology, CAMS and PUMC, Beijing 100050, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 28:298-303. 2006
    ..This article reviews recent advances in the classification, characteristics, and other molecular biological aspects of ESBLs...
  28. doi request reprint Berberine reduces insulin resistance through protein kinase C-dependent up-regulation of insulin receptor expression
    Wei Jia Kong
    Department of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    Metabolism 58:109-19. 2009
    ..Our results suggest that BBR is a unique natural medicine against insulin resistance in type 2 diabetes mellitus and metabolic syndrome...