Zhang Y, Yin F, Liu J, Liu Z, Guo L, Xia Z, et al
. Geniposide attenuates insulin-deficiency-induced acceleration of Î²-amyloidosis in an APP/PS1 transgenic model of Alzheimer's disease. Neurochem Int. 2015;89:7-16 pubmed publisher
Liu J, Liu Z, Zhang Y, Yin F. Leptin signaling plays a critical role in the geniposide-induced decrease of tau phosphorylation. Acta Biochim Biophys Sin (Shanghai). 2015;47:1018-22 pubmed publisher
..All these results indicate that geniposide may regulate tau phosphorylation through leptin signaling, and geniposide may be a promising therapeutic compound for the treatment of Alzheimer's disease in the future. ..
Cui H, Deng M, Zhang Y, Yin F, Liu J. Geniposide Increases Unfolded Protein Response-Mediating HRD1 Expression to Accelerate APP Degradation in Primary Cortical Neurons. Neurochem Res. 2018;43:669-680 pubmed publisher
..These data suggest that geniposide might be benefit to re-establish proteostasis by enhancing the UPR to decrease the load of APP in neurons challenged by high glucose. ..
Liu C, Hao Y, Yin F, Zhang Y, Liu J. Geniposide accelerates proteasome degradation of Txnip to inhibit insulin secretion in pancreatic β-cells. J Endocrinol Invest. 2017;40:505-512 pubmed publisher
..Txnip protein played an essential role in glucose uptake, metabolism and GSIS, and geniposide could accelerate the degradation via proteasome pathway in high-glucose-treated pancreatic INS-1 cells. ..
Liu Z, Zhang Y, Liu J, Yin F. Geniposide attenuates the level of A?1-42 via enhancing leptin signaling in cellular and APP/PS1 transgenic mice. Arch Pharm Res. 2017;40:571-578 pubmed publisher
..The results of this study suggest that geniposide may regulate the production of A?1-42 via leptin signaling. ..