Individual space-time activity-based modelling of infectious disease transmission within a cityYong Yang
School of Geography, University of Southampton, Southampton SO17 1BJ, UK
J R Soc Interface 5:759-72. 2008
..The model was calibrated and examples of simulation results such as dynamics of the population during a whole day, infection distribution and network analysis are presented...
Simultaneous knockdown of p18INK4C, p27Kip1 and MAD1 via RNA interference results in the expansion of long-term culture-initiating cells of murine bone marrow cells in vitroYan Y I Wang
Department of Pharmaceutical Engineering, College of Life Science, Guizhou University, Guiyang 550025, China
Acta Biochim Biophys Sin (Shanghai) 40:711-20. 2008
..Thus, the simultaneous knockdown of p18, p27 and MAD1 with a medium of only SCF can induce LTC-IC expansion despite the loss of engraftment ability...
- Profilin 1 obtained by proteomic analysis in all-trans retinoic acid-treated hepatocarcinoma cell lines is involved in inhibition of cell proliferation and migration
Nan Wu
Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, P R China
Proteomics 6:6095-106. 2006
..Furthermore, RNAi-based PFN1 knockdown could rescue the inhibitory effect of ATRA on cell proliferation and migration. In conclusion, ATRA inhibited cell proliferation and migration through up-regulation of PFN1...
- Phosphorylation of HsMis13 by Aurora B kinase is essential for assembly of functional kinetochore
Yong Yang
Hefei National Laboratory for Physical Sciences at Micro scale and University of Science and Technology of China, Hefei 230027, China
J Biol Chem 283:26726-36. 2008
..Thus, we reason that HsMis13 phosphorylation by Aurora B is required for organizing a stable bi-oriented microtubule kinetochore attachment that is essential for faithful chromosome segregation in mitosis...
Microtubule depolymerization and phosphorylation of c-Jun N-terminal kinase-1 and p38 were involved in gambogic acid induced cell cycle arrest and apoptosis in human breast carcinoma MCF-7 cellsJing Chen
Jiangsu Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University, Nanjing, PR China
Life Sci 83:103-9. 2008
..Taken together, our results suggested that GA depolymerized microtubules and elevated the phosphorylation levels of JNK1 and p38, which caused G2/M cell cycle arrest and apoptosis in MCF-7 cells...
- Inhibition of alpha(4) integrin mediated adhesion was involved in the reduction of B16-F10 melanoma cells lung colonization in C57BL/6 mice treated with gambogic acid
Jie Zhao
Jiangsu Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University, Nanjing, PR China
Eur J Pharmacol 589:127-31. 2008
..Thus we concluded for the first time that gambogic acid could inhibit the adhesion and migration of B16-F10 cells in vitro and in vivo, in which down-regulation of alpha(4) integrin expression was involved...
- Wogonin induces the granulocytic differentiation of human NB4 promyelocytic leukemia cells and up-regulates phospholipid scramblase 1 gene expression
Kun Zhang
Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China
Cancer Sci 99:689-95. 2008
..Taken together, the results reported here demonstrated that wogonin could promote the granulocytic differentiation of NB4 cells by up-regulating the expression of PLSCR1 gene...
- Phytoene desaturase is present in a large protein complex in the plastid membrane
Alex B Lopez
United States Department of Agriculture Agriculture Research Service, Plant, Soil and Nutrition Laboratory, Cornell University, Ithaca, NY 14853, USA
Physiol Plant 133:190-8. 2008
..The plastid membrane form was present in a large protein complex of approximately 350 kDa, whereas the stroma version was in an approximately 660 kDa complex...
- N-glycosylation at Asn residues 554 and 566 of E-cadherin affects cell cycle progression through extracellular signal-regulated protein kinase signaling pathway
Hongbo Zhao
Key Laboratory of Glycoconjugate Research, Ministry of Health, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Acta Biochim Biophys Sin (Shanghai) 40:140-8. 2008
..These findings implied that N-glycosylation might be crucial for E-cadherin-mediated suppression of cell cycle progression...
- Involvement of bax/bcl-2 in wogonin-induced apoptosis of human hepatoma cell line SMMC-7721
Wei Wang
Department of Physiology, China Pharmaceutical University, Nanjing, PRC
Anticancer Drugs 17:797-805. 2006
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- Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment
Dan Liu
Laboratory of Cellular Dynamics, University of Science and Technology of China and the National Laboratory for Physical Sciences, Hefei 230027, China
J Biol Chem 282:21415-24. 2007
..Our results indicate that HsNUF2 and CENP-E are required for organization of stable microtubule-kinetochore attachment that is essential for faithful chromosome segregation in mitosis...
- D-box is required for the degradation of human Shugoshin and chromosome alignment
Guosheng Fu
Laboratory of Cellular Dynamics, University of Science and Technology of China, Hefei National Laboratory, Hefei 230027, China
Biochem Biophys Res Commun 357:672-8. 2007
..These results provide a link between sister centromere cohesion and bipolar attachment of kinetochores...
- Combination of integrin siRNA and irradiation for breast cancer therapy
Qizhen Cao
Molecular Imaging Program at Stanford and Bio-X, Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA
Biochem Biophys Res Commun 351:726-32. 2006
..This study, with further optimization, may provide a simple and highly efficient treatment strategy for breast cancer as well as other integrin alpha(v)beta(3)-positive cancer types...
- [Intrathecal administration of HSV-I amplicon vector-mediated HPPE gene therapy of nocicepion in rats with formalin pain]
Hui-ning Liu
Department of Obstetrics and Gynecology, Xiangya Hospital, Central South University, Changsha 410008, China
Zhong Nan Da Xue Xue Bao Yi Xue Ban 31:742-6. 2006
..Intrathecal delivery SHPZ demonstrated antinociceptive effects on formalin induced pain...
- Identification of a novel mutation and a de novo mutation in DKC1 in two Chinese pedigrees with Dyskeratosis congenita
Ying-guo Ding
Department of Dermatology and Venereology, Peking University First Hospital, Beijing 100 034, China
J Invest Dermatol 123:470-3. 2004
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