Song Yu Yang

Summary

Publications

  1. ncbi request reprint Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Steroid Biochem Mol Biol 87:191-8. 2003
  2. ncbi request reprint 3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease
    Song Yu Yang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    FEBS J 272:4874-83. 2005
  3. pmc Mental retardation linked to mutations in the HSD17B10 gene interfering with neurosteroid and isoleucine metabolism
    Song Yu Yang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Proc Natl Acad Sci U S A 106:14820-4. 2009
  4. ncbi request reprint Type 10 17beta-hydroxysteroid dehydrogenase catalyzing the oxidation of steroid modulators of gamma-aminobutyric acid type A receptors
    Xue Ying He
    Department of Neuropharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Mol Cell Endocrinol 229:111-7. 2005
  5. ncbi request reprint Multiple functions of type 10 17beta-hydroxysteroid dehydrogenase
    Song Yu Yang
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Trends Endocrinol Metab 16:167-75. 2005
  6. ncbi request reprint HSD17B10: a gene involved in cognitive function through metabolism of isoleucine and neuroactive steroids
    Song Yu Yang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Mol Genet Metab 92:36-42. 2007
  7. doi request reprint Hydroxysteroid (17β) dehydrogenase X in human health and disease
    Song Yu Yang
    Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Mol Cell Endocrinol 343:1-6. 2011
  8. ncbi request reprint Abundant type 10 17 beta-hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease model
    Xue Ying He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Brain Res Mol Brain Res 99:46-53. 2002
  9. pmc Transcription start sites and epigenetic analysis of the HSD17B10 proximal promoter
    Song Yu Yang
    Department of Developmental Biochemistry, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    BMC Biochem 14:17. 2013
  10. ncbi request reprint Intracellular oxidation of allopregnanolone by human brain type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Brain Res 1040:29-35. 2005

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Oxidative 3alpha-hydroxysteroid dehydrogenase activity of human type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    J Steroid Biochem Mol Biol 87:191-8. 2003
    ..The experimental results lead to the conclusion that mitochondrial 17beta-HSD10 plays a significant part in a non-classical androgen synthesis pathway along with microsomal retinol dehydrogenases...
  2. ncbi request reprint 3-Hydroxyacyl-CoA dehydrogenase and short chain 3-hydroxyacyl-CoA dehydrogenase in human health and disease
    Song Yu Yang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, 10314, USA
    FEBS J 272:4874-83. 2005
    ....
  3. pmc Mental retardation linked to mutations in the HSD17B10 gene interfering with neurosteroid and isoleucine metabolism
    Song Yu Yang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Proc Natl Acad Sci U S A 106:14820-4. 2009
    ..The results support the theory that an imbalance in neurosteroid metabolism could be a major cause of the neurological handicap associated with hydroxysteroid (17beta) dehydrogenase 10 deficiency...
  4. ncbi request reprint Type 10 17beta-hydroxysteroid dehydrogenase catalyzing the oxidation of steroid modulators of gamma-aminobutyric acid type A receptors
    Xue Ying He
    Department of Neuropharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Mol Cell Endocrinol 229:111-7. 2005
    ..Immunoreactivity against 17beta-HSD10 was found in a number of neuronal populations. Taken together, evidence suggests that 17beta-HSD10 is the brain enzyme capable of catalyzing the oxidation of steroid modulators of GABA(A) receptors...
  5. ncbi request reprint Multiple functions of type 10 17beta-hydroxysteroid dehydrogenase
    Song Yu Yang
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Trends Endocrinol Metab 16:167-75. 2005
    ..This versatile enzyme might provide a new drug target for neuronal excitability control and for intervention in Alzheimer's disease and certain cancers...
  6. ncbi request reprint HSD17B10: a gene involved in cognitive function through metabolism of isoleucine and neuroactive steroids
    Song Yu Yang
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Mol Genet Metab 92:36-42. 2007
    ....
  7. doi request reprint Hydroxysteroid (17β) dehydrogenase X in human health and disease
    Song Yu Yang
    Department of Neurochemistry, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Mol Cell Endocrinol 343:1-6. 2011
    ..The investigation of HSD10 may lead to a better understanding of AD pathogenesis...
  8. ncbi request reprint Abundant type 10 17 beta-hydroxysteroid dehydrogenase in the hippocampus of mouse Alzheimer's disease model
    Xue Ying He
    Department of Pharmacology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Brain Res Mol Brain Res 99:46-53. 2002
    ..High levels of this enzyme may disrupt steroid hormone homeostasis in synapses and contribute to synapse loss in the hippocampus of the mouse Alzheimer's disease model...
  9. pmc Transcription start sites and epigenetic analysis of the HSD17B10 proximal promoter
    Song Yu Yang
    Department of Developmental Biochemistry, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    BMC Biochem 14:17. 2013
    ....
  10. ncbi request reprint Intracellular oxidation of allopregnanolone by human brain type 10 17beta-hydroxysteroid dehydrogenase
    Xue Ying He
    Department of Neurochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Brain Res 1040:29-35. 2005
    ..The elevated level of 17beta-HSD10 in activated astrocytes is a new feature found in brains of people with AD, and it may have important impact on AD pathogenesis...
  11. doi request reprint A 5-methylcytosine hotspot responsible for the prevalent HSD17B10 mutation
    Song Yu Yang
    Department of Developmental Biochemistry, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Gene 515:380-4. 2013
    ..This is significantly lower than in cells of patients with other, clinically milder mutations and suggests that the loss of HSD10/MHBD activity is a marker for the disorder...
  12. doi request reprint Re: Hadh2 and 3-hydroxyacyl-CoA dehydrogenase
    Song Yu Yang
    Am J Physiol Endocrinol Metab 295:E987. 2008
  13. ncbi request reprint HSD17B10 replaces HADH2 as the approved designation for the gene mutated in 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency
    Stanley H Korman
    Mol Genet Metab 91:115. 2007
  14. ncbi request reprint 3-hydroxyacyl-CoA dehydrogenase (HAD) deficiency replaces short-chain hydroxyacyl-CoA dehydrogenase (SCHAD) deficiency as well as medium- and short-chain hydroxyacyl-CoA dehydrogenase (M/SCHAD) deficiency as the consensus name of this fatty acid oxidation
    Xue Ying He
    Mol Genet Metab 91:205-6. 2007