Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expressionGang Yue
Department of Molecular Genetics, Microbiology and Immunology The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
BMC Genomics 9:608. 2008
..These observations make it difficult to understand the role of LPS in brain parenchymal injury...
- BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility
Ning Zhang
Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, PR China
BMC Med Genet 12:48. 2011
..Furthermore, we also studied the effects of this SNP on Bcl-2 expression in vitro...
Loss of Msh2 is not associated with FHIT deletion in breast carcinomasQifeng Yang
Department of Surgery, Qilu Hospital, Shandong University, Ji Nan, People s Republic of China
Anticancer Res 22:2591-5. 2002
..Our results suggest that this mismatch repair protein may play little role in maintaining the integrity of the common fragile locus with the FHIT gene...
- BRCA1 in non-inherited breast carcinomas (Review)
Qifeng Yang
Department of General Surgery, Qilu Hospital, Shandong University, Ji Nan, Shandong Province, P R China
Oncol Rep 9:1329-33. 2002
..The decreased expression of BRCA1 in sporadic breast cancer is thought to be caused by other mechanisms, such as CpG methylation. BRCA1 expression may play an important role in the pathogenesis and prognosis of sporadic breast carcinoma...
Huaier aqueous extract inhibits proliferation of breast cancer cells by inducing apoptosisNing Zhang
Department of Breast Surgery Obstetrics and Gynecology, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, Shandong, China
Cancer Sci 101:2375-83. 2010
..Based on our findings, Huaier can induce cell apoptosis in both ER-positive and ER-negative breast cancer cell lines and is an effective complementary agent for breast cancer treatment...
- Identification of novel variants of metadherin in breast cancer
Xianqiang Liu
Department of Breast Surgery, Qilu Hospital, School of Medicine, Shandong University, Ji Nan, Shandong, People s Republic of China
PLoS ONE 6:e17582. 2011
..However, additional studies need to be conducted in larger sample sizes to validate these findings and to further investigate whether these variants are prognostic in breast cancer patients...
- Prognostic value of Bcl-2 in invasive breast cancer receiving chemotherapy and endocrine therapy
Qifeng Yang
Department of General Surgery, Qilu Hospital, Shandong University, Ji Nan, Shandong Province, PR China
Oncol Rep 10:121-5. 2003
..0242) after consideration of other prognostic factors. Our results imply that Bcl-2 is a significant favorable prognostic factor for breast cancer with chemotherapy and endocrine therapy...
- Metadherin regulates radioresistance in cervical cancer cells
Ying Zhao
Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji Nan, Shandong 250012, PR China
Oncol Rep 27:1520-6. 2012
..These results indicate that MTDH affects the radiosensitivity of cervical cancer cells and that MTDH may be a novel target to improve cervical cancer radiation response...
- Hepatocyte growth factor enhances ovarian cancer cell invasion through downregulation of thrombospondin-1
Wei Wei
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji nan 250012, Shandong, China
Cancer Biol Ther 9:79-87. 2010
..This study enhances our understanding of the mechanisms of signaling transduction in the HGF-induced invasion and progression of ovarian cancer...
- 53BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathway
Shuhui Hong
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji Nan, Shandong 250012, PR China
Oncol Rep 27:1251-7. 2012
..Collectively, our data suggest that 53BP1 is involved in several important steps in controlling cell proliferation and growth and preventing tumor development...
- Thio-glucose bound gold nanoparticles enhance radio-cytotoxic targeting of ovarian cancer
Feng Geng
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, People s Republic of China
Nanotechnology 22:285101. 2011
..48% for 90 kVp and 26.88% for 6 MV irradiation. The interaction of x-ray radiation with GNPs induced elevated levels of ROS production, which is one of the mechanisms by which GNPs can enhance radiotherapy on ovarian cancer...
- Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer
Haifeng Qiu
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, China
Cancer Sci 101:1255-60. 2010
..Our findings suggest that the TES gene functions as a tumor suppressor gene and is frequently silenced by hypermethylation and loss of heterozygosity in ovarian cancers...
- The hormonal receptor status in breast cancer can be altered by neoadjuvant chemotherapy: a meta-analysis
Ning Zhang
Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, Shandong, P R China
Cancer Invest 29:594-8. 2011
....
- Involvement of mitochondria-caspase pathway in Hemoporfin-mediated cell death
Yongqing Wei
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China
Photochem Photobiol 83:1319-24. 2007
..Understanding the mechanisms involved in PDT-mediated apoptosis may improve its therapeutic efficacy and facilitate its transition into the clinic...
- Mammographic features are associated with clinicopathological characteristics in invasive breast cancer
Liyu Jiang
Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, Shandong 250012, PR China
Anticancer Res 31:2327-34. 2011
..To assess the correlation between mammographic features and clinicopathologic characteristics of invasive breast carcinoma...
- Inhibition of metadherin sensitizes breast cancer cells to AZD6244
Xiaoli Kong
Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Shandong, China
Cancer Biol Ther 13:43-9. 2012
..These indicate us that MTDH is a candidate marker to predict the clinical efficacy of AZD6244 and targeting MTDH could overcome the resistance to AZD6244 in breast cancer cells...
- The p53-HDM2 gene-gene polymorphism interaction is associated with the development of missed abortion
Yan Fang
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China
Hum Reprod 26:1252-8. 2011
..In this study, we investigated whether p53 codon 72 and HDM2 promoter (SNP309) polymorphisms were associated with the development of missed abortion...
- Testin is a tumor suppressor and prognostic marker in breast cancer
Jiang Zhu
Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, China
Cancer Sci 103:2092-101. 2012
..TES may be an effective novel target in breast cancer prevention and treatment...
- LAPTM4B allele *2 is associated with breast cancer susceptibility and prognosis
Xiaoyan Li
Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People s Republic of China
PLoS ONE 7:e44916. 2012
..This study aimed to investigate the polymorphism of LAPTM4B in breast cancer by analysis the correlation of LAPTM4B genotype with breast cancer susceptibility, clinicopathologic features and prognosis...
- 53BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-κB through miR-146a
Xiaoyan Li
Department of Breast Surgery, Qilu Hospital, Shandong University, Wenhua Xi Road No 107, Jinan 250012, China
Carcinogenesis 33:2593-600. 2012
..Together, our findings demonstrated that 53BP1 has a potent tumor suppressor activity in breast cancer, and it may serve as a novel target for breast cancer prevention and treatment...
- Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial-mesenchymal transition
Xin Zhang
Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, School of Medicine, West Wenhua Road No 107, Ji Nan, Shandong 250012, PR China
Biochem Biophys Res Commun 412:188-92. 2011
..These findings may ultimately provide a new targeted approach for improving the therapeutic effectiveness of radiation in breast cancer...
- Epstein-Barr virus infection and sporadic breast cancer risk: a meta-analysis
Qiang Huo
Department of Breast Surgery, School of Medicine, Shandong University, Qilu Hospital, Ji Nan, Shandong, People s Republic of China
PLoS ONE 7:e31656. 2012
..A large number of epidemiological studies have evaluated the association between Epstein-Barr virus infection and breast carcinoma risk but results have been inconsistent...
- The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility
Cunzhong Yuan
Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji Nan, Shandong, China
PLoS ONE 7:e51561. 2012
..038). These data suggest that MTDH (-470G>A) could be a useful molecular marker for assessing ovarian cancer risk and for predicting ovarian cancer patient prognosis...
- Meta-analysis confirms achieving pathological complete response after neoadjuvant chemotherapy predicts favourable prognosis for breast cancer patients
Xiangnan Kong
Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Wenhua West Road No 107, Ji Nan, Shandong 250012, PR China
Eur J Cancer 47:2084-90. 2011
..This meta-analysis confirms that pathologic response is a prognostic indicator for RFS, DFS and OS and suggests that patients achieving pCR after NAC have favourable outcomes...
- MDM2 SNP309 is associated with endometrial cancer susceptibility: a meta-analysis
Yan Li
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, People s Republic of China
Hum Cell 24:57-64. 2011
..29, P = 0.29; for recessive model, OR = 1.65, 95% CI = 1.33-2.04, P < 0.00001). Overall, the meta-analysis suggested that the GG genotype of MDM2 SNP309 was significantly associated with the increased endometrial cancer risk...
- CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer
Qin Yao
Department of Obstetrics and Gynaecology, Qilu Hospital, Shandong University, Ji nan 250012, Shandong, PR China
Oncol Rep 22:541-8. 2009
....
- Retinoid, retinoic acid receptor beta and breast cancer
Qifeng Yang
Department of General Surgery, Qilu Hospital, Shandong University, Ji'nan, People's Republic of China
Breast Cancer Res Treat 76:167-73. 2002
..This paper will briefly discuss basic aspects of retinoids and retinoid acid receptor. In particular, we review what is now known for inactivation mechanism of RARbeta2 and its role in tumor cell growth inhibition...
- MDM2 309 polymorphism is associated with missed abortion
Yan Fang
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Ji nan 250012, Shandong, People s Republic of China
Hum Reprod 24:1346-9. 2009
..In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion...
- Enforced effect of tk-MCP-1 fusion gene in ovarian cancer
Shuhui Hong
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Ji nan 250012, People s Republic of China
J Exp Clin Cancer Res 31:74. 2012
..The present study was designed to assess the antitumor efficacy of tk-MCP-1 on ovarian cancer in vitro and vivo...
- Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue
Peng Su
Department of Pathology, Qilu Hospital, Shandong University School of Medicine, Ji Nan, China
Diagn Pathol 5:38. 2010
....
- Role of AIB1 for tamoxifen resistance in estrogen receptor-positive breast cancer cells
Qingbo Su
Department of General Surgery, Qilu Hospital, Shandong University, Jinan, PR China
Oncology 75:159-68. 2008
..The present study aimed to investigate the role of AIB1 in tamoxifen resistance of breast cancer cells...
- Polymorphisms in the p63 and p73 genes are associated with ovarian cancer risk and clinicopathological variables
Xiao Guan
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107, Wenhua Xi Road, Jinan, PR China
J Exp Clin Cancer Res 31:89. 2012
..In the present study, we aimed to evaluate the relationship between these SNPs and ovarian cancer susceptibility and clinical pathology...
- Anti-angiogenic and antitumor activities of Huaier aqueous extract
Xiaolong Wang
Department of Breast Surgery, Qilu Hospital, Shandong Univeristy School of Medicine, Jinan, Shandong 250012, PR China
Oncol Rep 28:1167-75. 2012
..These data suggest that Huaier extract may serve as a potent anti-angiogenic and antitumor agent...
- Intraperitoneal photodynamic therapy for an ovarian cancer ascite model in Fischer 344 rat using hematoporphyrin monomethyl ether
Kun Song
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Ji Nan, 250012, Shandong, China
Cancer Sci 98:1959-64. 2007
..Thus, this study provides evidence that HMME-based photodynamic therapy is an effective adjuvant therapy for ovarian cancer...
- Primary tumor resection may improve prognosis for nonoperable advanced breast cancer
Ning Zhang
Department of Breast Surgery, Qilu Hospital, Shandong University School of Medicine, Wenhua West Road No 107, Ji Nan, Shandong 250012, PR China
Med Hypotheses 73:1058-9. 2009
..Based on the cancer stem cells niche theory, we hypothesized that resection of the primary tumor may be a new avenue to improve the survival and the quality of life for advanced breast cancer patients...
- Radiosensitization effects of berberine on human breast cancer cells
Jing Wang
Department of Oncology, Qilu Hospital, Shandong University School of Medicine, Jinan, PR China
Int J Mol Med 30:1166-72. 2012
..Berberine may be a promising radiosensitizer for the treatment of breast cancer...
- P53-binding protein 1: a new player for tumorigenesis and a new target for breast cancer treatment
Qiang Huo
Department of Breast Surgery, Qilu Hospital, Shandong University School of Medicine, West Wenhua Road No 107, Ji Nan, Shandong 250012, PR China
Med Hypotheses 77:359-63. 2011
..Furthermore, 53BP1 gene therapy will be a potential therapeutic strategy for breast cancer...
- Two-hit inactivation of FHIT by loss of heterozygosity and hypermethylation in breast cancer
Qifeng Yang
Department of General Surgery, Qilu Hospital, Shandong University, Ji Nan, Shandong Province, People s Republic of China
Clin Cancer Res 8:2890-3. 2002
..The FHIT gene, which spans the FRA3B fragile site at chromosome 3p14.2, is a candidate tumor suppressor gene in breast carcinomas. In this study, we would like to delineate more precisely its role in breast tumorigenesis...
