Qifeng Yang

Summary

Publications

  1. pmc Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression
    Gang Yue
    Department of Molecular Genetics, Microbiology and Immunology The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    BMC Genomics 9:608. 2008
  2. pmc BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, PR China
    BMC Med Genet 12:48. 2011
  3. ncbi request reprint Loss of Msh2 is not associated with FHIT deletion in breast carcinomas
    Qifeng Yang
    Department of Surgery, Qilu Hospital, Shandong University, Ji Nan, People s Republic of China
    Anticancer Res 22:2591-5. 2002
  4. pmc The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, Wenhua Xi Road 107, Jinan 250012, Shandong Province, China
    J Biol Chem 288:9396-407. 2013
  5. doi request reprint A genetic variant in pre-miR-27a is associated with a reduced breast cancer risk in younger Chinese population
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, Shandong, China
    Gene 529:125-30. 2013
  6. doi request reprint 53BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-κB through miR-146a
    Xiaoyan Li
    Department of Breast Surgery, Qilu Hospital, Shandong University, Wenhua Xi Road No 107, Jinan 250012, China
    Carcinogenesis 33:2593-600. 2012
  7. ncbi request reprint BRCA1 in non-inherited breast carcinomas (Review)
    Qifeng Yang
    Department of General Surgery, Qilu Hospital, Shandong University, Ji Nan, Shandong Province, P R China
    Oncol Rep 9:1329-33. 2002
  8. pmc Identification of novel variants of metadherin in breast cancer
    Xianqiang Liu
    Department of Breast Surgery, Qilu Hospital, School of Medicine, Shandong University, Ji Nan, Shandong, People s Republic of China
    PLoS ONE 6:e17582. 2011
  9. doi request reprint Huaier aqueous extract inhibits proliferation of breast cancer cells by inducing apoptosis
    Ning Zhang
    Department of Breast Surgery Obstetrics and Gynecology, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, Shandong, China
    Cancer Sci 101:2375-83. 2010
  10. pmc LAPTM4B allele *2 is associated with breast cancer susceptibility and prognosis
    Xiaoyan Li
    Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People s Republic of China
    PLoS ONE 7:e44916. 2012

Collaborators

Detail Information

Publications49

  1. pmc Lipopolysaccharide (LPS) potentiates hydrogen peroxide toxicity in T98G astrocytoma cells by suppression of anti-oxidative and growth factor gene expression
    Gang Yue
    Department of Molecular Genetics, Microbiology and Immunology The Cancer Institute of New Jersey, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    BMC Genomics 9:608. 2008
    ..These observations make it difficult to understand the role of LPS in brain parenchymal injury...
  2. pmc BCL-2 (-938C > A) polymorphism is associated with breast cancer susceptibility
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, PR China
    BMC Med Genet 12:48. 2011
    ..Furthermore, we also studied the effects of this SNP on Bcl-2 expression in vitro...
  3. ncbi request reprint Loss of Msh2 is not associated with FHIT deletion in breast carcinomas
    Qifeng Yang
    Department of Surgery, Qilu Hospital, Shandong University, Ji Nan, People s Republic of China
    Anticancer Res 22:2591-5. 2002
    ..Our results suggest that this mismatch repair protein may play little role in maintaining the integrity of the common fragile locus with the FHIT gene...
  4. pmc The oncogene metadherin modulates the apoptotic pathway based on the tumor necrosis factor superfamily member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in breast cancer
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, Wenhua Xi Road 107, Jinan 250012, Shandong Province, China
    J Biol Chem 288:9396-407. 2013
    ....
  5. doi request reprint A genetic variant in pre-miR-27a is associated with a reduced breast cancer risk in younger Chinese population
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, Shandong, China
    Gene 529:125-30. 2013
    ..In conclusion, our results suggest that the SNP rs895819 may serve as a risk factor for breast cancer in younger Chinese populations; however, larger population-based studies are needed to validate these findings. ..
  6. doi request reprint 53BP1 functions as a tumor suppressor in breast cancer via the inhibition of NF-κB through miR-146a
    Xiaoyan Li
    Department of Breast Surgery, Qilu Hospital, Shandong University, Wenhua Xi Road No 107, Jinan 250012, China
    Carcinogenesis 33:2593-600. 2012
    ..Together, our findings demonstrated that 53BP1 has a potent tumor suppressor activity in breast cancer, and it may serve as a novel target for breast cancer prevention and treatment...
  7. ncbi request reprint BRCA1 in non-inherited breast carcinomas (Review)
    Qifeng Yang
    Department of General Surgery, Qilu Hospital, Shandong University, Ji Nan, Shandong Province, P R China
    Oncol Rep 9:1329-33. 2002
    ..The decreased expression of BRCA1 in sporadic breast cancer is thought to be caused by other mechanisms, such as CpG methylation. BRCA1 expression may play an important role in the pathogenesis and prognosis of sporadic breast carcinoma...
  8. pmc Identification of novel variants of metadherin in breast cancer
    Xianqiang Liu
    Department of Breast Surgery, Qilu Hospital, School of Medicine, Shandong University, Ji Nan, Shandong, People s Republic of China
    PLoS ONE 6:e17582. 2011
    ..However, additional studies need to be conducted in larger sample sizes to validate these findings and to further investigate whether these variants are prognostic in breast cancer patients...
  9. doi request reprint Huaier aqueous extract inhibits proliferation of breast cancer cells by inducing apoptosis
    Ning Zhang
    Department of Breast Surgery Obstetrics and Gynecology, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, Shandong, China
    Cancer Sci 101:2375-83. 2010
    ..Based on our findings, Huaier can induce cell apoptosis in both ER-positive and ER-negative breast cancer cell lines and is an effective complementary agent for breast cancer treatment...
  10. pmc LAPTM4B allele *2 is associated with breast cancer susceptibility and prognosis
    Xiaoyan Li
    Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People s Republic of China
    PLoS ONE 7:e44916. 2012
    ..This study aimed to investigate the polymorphism of LAPTM4B in breast cancer by analysis the correlation of LAPTM4B genotype with breast cancer susceptibility, clinicopathologic features and prognosis...
  11. doi request reprint Testin is a tumor suppressor and prognostic marker in breast cancer
    Jiang Zhu
    Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, China
    Cancer Sci 103:2092-101. 2012
    ..TES may be an effective novel target in breast cancer prevention and treatment...
  12. ncbi request reprint Prognostic value of Bcl-2 in invasive breast cancer receiving chemotherapy and endocrine therapy
    Qifeng Yang
    Department of General Surgery, Qilu Hospital, Shandong University, Ji Nan, Shandong Province, PR China
    Oncol Rep 10:121-5. 2003
    ..0242) after consideration of other prognostic factors. Our results imply that Bcl-2 is a significant favorable prognostic factor for breast cancer with chemotherapy and endocrine therapy...
  13. doi request reprint Fulvestrant radiosensitizes human estrogen receptor-positive breast cancer cells
    Jing Wang
    Department of Breast Surgery, Qilu Hospital, Shandong Univeristy, Wenhua Xi Road 107, Shandong Province, PR China
    Biochem Biophys Res Commun 431:146-51. 2013
    ..Thus, our findings suggest that F+RT increases breast cancer cell radiosensitivity compared with radiation alone. These findings have salient implications for designing clinical trials using fulvestrant and radiation therapy...
  14. doi request reprint Metadherin regulates radioresistance in cervical cancer cells
    Ying Zhao
    Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji Nan, Shandong 250012, PR China
    Oncol Rep 27:1520-6. 2012
    ..These results indicate that MTDH affects the radiosensitivity of cervical cancer cells and that MTDH may be a novel target to improve cervical cancer radiation response...
  15. ncbi request reprint Hepatocyte growth factor enhances ovarian cancer cell invasion through downregulation of thrombospondin-1
    Wei Wei
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji nan 250012, Shandong, China
    Cancer Biol Ther 9:79-87. 2010
    ..This study enhances our understanding of the mechanisms of signaling transduction in the HGF-induced invasion and progression of ovarian cancer...
  16. doi request reprint A genetic variant in p63 (rs17506395) is associated with breast cancer susceptibility and prognosis
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, Shandong, China
    Gene 535:170-6. 2014
    ..The present study aimed to evaluate the association of rs17506395 genotypes with breast cancer susceptibility, clinicopathological characteristics and prognosis...
  17. pmc 53BP1 suppresses tumor growth and promotes susceptibility to apoptosis of ovarian cancer cells through modulation of the Akt pathway
    Shuhui Hong
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji Nan, Shandong 250012, PR China
    Oncol Rep 27:1251-7. 2012
    ..Collectively, our data suggest that 53BP1 is involved in several important steps in controlling cell proliferation and growth and preventing tumor development...
  18. doi request reprint Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer
    Haifeng Qiu
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, China
    Cancer Sci 101:1255-60. 2010
    ..Our findings suggest that the TES gene functions as a tumor suppressor gene and is frequently silenced by hypermethylation and loss of heterozygosity in ovarian cancers...
  19. doi request reprint Thio-glucose bound gold nanoparticles enhance radio-cytotoxic targeting of ovarian cancer
    Feng Geng
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, People s Republic of China
    Nanotechnology 22:285101. 2011
    ..48% for 90 kVp and 26.88% for 6 MV irradiation. The interaction of x-ray radiation with GNPs induced elevated levels of ROS production, which is one of the mechanisms by which GNPs can enhance radiotherapy on ovarian cancer...
  20. doi request reprint The hormonal receptor status in breast cancer can be altered by neoadjuvant chemotherapy: a meta-analysis
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, Shandong, P R China
    Cancer Invest 29:594-8. 2011
    ....
  21. ncbi request reprint Mammographic features are associated with clinicopathological characteristics in invasive breast cancer
    Liyu Jiang
    Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, Shandong 250012, PR China
    Anticancer Res 31:2327-34. 2011
    ..To assess the correlation between mammographic features and clinicopathologic characteristics of invasive breast carcinoma...
  22. ncbi request reprint Involvement of mitochondria-caspase pathway in Hemoporfin-mediated cell death
    Yongqing Wei
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China
    Photochem Photobiol 83:1319-24. 2007
    ..Understanding the mechanisms involved in PDT-mediated apoptosis may improve its therapeutic efficacy and facilitate its transition into the clinic...
  23. doi request reprint A Genetic Polymorphism (rs17251221) in the Calcium-Sensing Receptor is Associated with Breast Cancer Susceptibility and Prognosis
    Xiaoyan Li
    Department of Breast Surgery, Qilu Hospital, Shandong University, Shandong, P R China
    Cell Physiol Biochem 33:165-72. 2014
    ..Our data suggest that rs17251221 may be a potential therapeutic target in breast cancer. © 2014 S. Karger AG, Basel. ..
  24. doi request reprint Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling
    Xiaolong Wang
    Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P R China
    Int J Oncol 43:321-8. 2013
    ..Our study provides evidence that Huaier extract is a novel estrogen receptor modulator and is a promising drug for the prevention and treatment of ERα-positive human breast cancers...
  25. doi request reprint A multiplex methylation-specific PCR assay for the detection of early-stage ovarian cancer using cell-free serum DNA
    Qing Zhang
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Ji Nan, Shandong 250012, PR China
    Gynecol Oncol 130:132-9. 2013
    ..In this study, we established a multiplex methylation-specific PCR (MSP) assay to improve the early detection of ovarian cancer, via identification of the methylation status of cell-free serum DNA...
  26. doi request reprint Inhibition of metadherin sensitizes breast cancer cells to AZD6244
    Xiaoli Kong
    Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Shandong, China
    Cancer Biol Ther 13:43-9. 2012
    ..These indicate us that MTDH is a candidate marker to predict the clinical efficacy of AZD6244 and targeting MTDH could overcome the resistance to AZD6244 in breast cancer cells...
  27. doi request reprint The p53-HDM2 gene-gene polymorphism interaction is associated with the development of missed abortion
    Yan Fang
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Shandong, China
    Hum Reprod 26:1252-8. 2011
    ..In this study, we investigated whether p53 codon 72 and HDM2 promoter (SNP309) polymorphisms were associated with the development of missed abortion...
  28. pmc Effects of ambient particulate matter on human breast cancer: is xenogenesis responsible?
    Qiang Huo
    Department of Breast Surgery, Qilu Hospital of Shandong University, Shandong, China School of Medicine, Shandong University, Shandong, China
    PLoS ONE 8:e76609. 2013
    ..However, to date, the underlying mechanism remains largely unclear. Considering the high prevalence of air pollution and breast cancer in China, it is necessary to understand how air pollution may affect breast cancer...
  29. doi request reprint Prognostic significance of mammalian sterile 20-like kinase 1 in breast cancer
    Xiaoyan Lin
    Department of Oncology, Qilu Hospital, Shandong University, Jinan, 250012, Shandong, China
    Tumour Biol 34:3239-43. 2013
    ..030). Our results presented the tumor suppressive role of Mst1, and confirmed Mst1 was a prognostic factor in human breast cancer...
  30. pmc Enforced effect of tk-MCP-1 fusion gene in ovarian cancer
    Shuhui Hong
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Ji nan 250012, People s Republic of China
    J Exp Clin Cancer Res 31:74. 2012
    ..The present study was designed to assess the antitumor efficacy of tk-MCP-1 on ovarian cancer in vitro and vivo...
  31. pmc Polymorphisms in the p63 and p73 genes are associated with ovarian cancer risk and clinicopathological variables
    Xiao Guan
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107, Wenhua Xi Road, Jinan, PR China
    J Exp Clin Cancer Res 31:89. 2012
    ..In the present study, we aimed to evaluate the relationship between these SNPs and ovarian cancer susceptibility and clinical pathology...
  32. doi request reprint Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial-mesenchymal transition
    Xin Zhang
    Department of Chemotherapy, Cancer Center, Qilu Hospital, Shandong University, School of Medicine, West Wenhua Road No 107, Ji Nan, Shandong 250012, PR China
    Biochem Biophys Res Commun 412:188-92. 2011
    ..These findings may ultimately provide a new targeted approach for improving the therapeutic effectiveness of radiation in breast cancer...
  33. pmc 53BP1 sensitizes breast cancer cells to 5-fluorouracil
    Xiaoyan Li
    Department of Breast Surgery, Qilu Hospital, Shandong University, Jinan, Shandong, People s Republic of China
    PLoS ONE 8:e74928. 2013
    ..The present studies provide a new clue that combination of 5-Fu and 53BP1 could be a potential novel targeted strategy for overcoming breast cancer chemoresistance. ..
  34. pmc Epstein-Barr virus infection and sporadic breast cancer risk: a meta-analysis
    Qiang Huo
    Department of Breast Surgery, School of Medicine, Shandong University, Qilu Hospital, Ji Nan, Shandong, People s Republic of China
    PLoS ONE 7:e31656. 2012
    ..A large number of epidemiological studies have evaluated the association between Epstein-Barr virus infection and breast carcinoma risk but results have been inconsistent...
  35. pmc The MTDH (-470G>A) polymorphism is associated with ovarian cancer susceptibility
    Cunzhong Yuan
    Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Ji Nan, Shandong, China
    PLoS ONE 7:e51561. 2012
    ..038). These data suggest that MTDH (-470G>A) could be a useful molecular marker for assessing ovarian cancer risk and for predicting ovarian cancer patient prognosis...
  36. doi request reprint MDM2 SNP309 is associated with endometrial cancer susceptibility: a meta-analysis
    Yan Li
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, Jinan, Shandong, People s Republic of China
    Hum Cell 24:57-64. 2011
    ..29, P = 0.29; for recessive model, OR = 1.65, 95% CI = 1.33-2.04, P < 0.00001). Overall, the meta-analysis suggested that the GG genotype of MDM2 SNP309 was significantly associated with the increased endometrial cancer risk...
  37. ncbi request reprint Retinoid, retinoic acid receptor beta and breast cancer
    Qifeng Yang
    Department of General Surgery, Qilu Hospital, Shandong University, Ji Nan, People s Republic of China
    Breast Cancer Res Treat 76:167-73. 2002
    ..This paper will briefly discuss basic aspects of retinoids and retinoid acid receptor. In particular, we review what is now known for inactivation mechanism of RARbeta2 and its role in tumor cell growth inhibition...
  38. doi request reprint Meta-analysis confirms achieving pathological complete response after neoadjuvant chemotherapy predicts favourable prognosis for breast cancer patients
    Xiangnan Kong
    Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Wenhua West Road No 107, Ji Nan, Shandong 250012, PR China
    Eur J Cancer 47:2084-90. 2011
    ..This meta-analysis confirms that pathologic response is a prognostic indicator for RFS, DFS and OS and suggests that patients achieving pCR after NAC have favourable outcomes...
  39. ncbi request reprint CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer
    Qin Yao
    Department of Obstetrics and Gynaecology, Qilu Hospital, Shandong University, Ji nan 250012, Shandong, PR China
    Oncol Rep 22:541-8. 2009
    ....
  40. doi request reprint MDM2 309 polymorphism is associated with missed abortion
    Yan Fang
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Ji nan 250012, Shandong, People s Republic of China
    Hum Reprod 24:1346-9. 2009
    ..In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion...
  41. pmc Post-mastectomy radiotherapy for breast cancer patients with t1-t2 and 1-3 positive lymph nodes: a meta-analysis
    Yaming Li
    Department of Breast Surgery, Qilu Hospital, Shandong University, School of Medicine, Ji Nan, Shandong, P R China
    PLoS ONE 8:e81765. 2013
    ..The role of post-mastectomy radiotherapy (PMRT) in patients with T1-2 and 1-3 positive lymph nodes remains controversial. The aim of this study is to investigate the possible benefits of PMRT for this subgroup...
  42. pmc Anti-angiogenic and antitumor activities of Huaier aqueous extract
    Xiaolong Wang
    Department of Breast Surgery, Qilu Hospital, Shandong Univeristy School of Medicine, Jinan, Shandong 250012, P R China
    Oncol Rep 28:1167-75. 2012
    ..These data suggest that Huaier extract may serve as a potent anti-angiogenic and antitumor agent...
  43. doi request reprint Radiosensitization effects of berberine on human breast cancer cells
    Jing Wang
    Department of Oncology, Qilu Hospital, Shandong University School of Medicine, Jinan, PR China
    Int J Mol Med 30:1166-72. 2012
    ..Berberine may be a promising radiosensitizer for the treatment of breast cancer...
  44. pmc Immunohistochemical analysis of Metadherin in proliferative and cancerous breast tissue
    Peng Su
    Department of Pathology, Qilu Hospital, Shandong University School of Medicine, Ji Nan, China
    Diagn Pathol 5:38. 2010
    ....
  45. doi request reprint Role of AIB1 for tamoxifen resistance in estrogen receptor-positive breast cancer cells
    Qingbo Su
    Department of General Surgery, Qilu Hospital, Shandong University, Jinan, PR China
    Oncology 75:159-68. 2008
    ..The present study aimed to investigate the role of AIB1 in tamoxifen resistance of breast cancer cells...
  46. doi request reprint Primary tumor resection may improve prognosis for nonoperable advanced breast cancer
    Ning Zhang
    Department of Breast Surgery, Qilu Hospital, Shandong University School of Medicine, Wenhua West Road No 107, Ji Nan, Shandong 250012, PR China
    Med Hypotheses 73:1058-9. 2009
    ..Based on the cancer stem cells niche theory, we hypothesized that resection of the primary tumor may be a new avenue to improve the survival and the quality of life for advanced breast cancer patients...
  47. ncbi request reprint Intraperitoneal photodynamic therapy for an ovarian cancer ascite model in Fischer 344 rat using hematoporphyrin monomethyl ether
    Kun Song
    Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Ji Nan, 250012, Shandong, China
    Cancer Sci 98:1959-64. 2007
    ..Thus, this study provides evidence that HMME-based photodynamic therapy is an effective adjuvant therapy for ovarian cancer...
  48. doi request reprint P53-binding protein 1: a new player for tumorigenesis and a new target for breast cancer treatment
    Qiang Huo
    Department of Breast Surgery, Qilu Hospital, Shandong University School of Medicine, West Wenhua Road No 107, Ji Nan, Shandong 250012, PR China
    Med Hypotheses 77:359-63. 2011
    ..Furthermore, 53BP1 gene therapy will be a potential therapeutic strategy for breast cancer...
  49. ncbi request reprint Two-hit inactivation of FHIT by loss of heterozygosity and hypermethylation in breast cancer
    Qifeng Yang
    Department of General Surgery, Qilu Hospital, Shandong University, Ji Nan, Shandong Province, People s Republic of China
    Clin Cancer Res 8:2890-3. 2002
    ..The FHIT gene, which spans the FRA3B fragile site at chromosome 3p14.2, is a candidate tumor suppressor gene in breast carcinomas. In this study, we would like to delineate more precisely its role in breast tumorigenesis...