Lun Yang

Summary

Publications

  1. pmc DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical-protein interactome
    Heng Luo
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    Nucleic Acids Res 39:W492-8. 2011
  2. pmc Systematic drug repositioning based on clinical side-effects
    Lun Yang
    Computational Biology, Quantitative Sciences, Medicines Discovery and Development, GlaxoSmithKline, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e28025. 2011
  3. pmc Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case study
    Lun Yang
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    PLoS Comput Biol 7:e1002016. 2011
  4. doi request reprint Chemical-protein interactome and its application in off-target identification
    Lun Yang
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China
    Interdiscip Sci 3:22-30. 2011
  5. doi request reprint Systematic screening for polymorphisms within the UGT1A6 gene in three Chinese populations and function prediction through structural modeling
    Yi Xing
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Pharmacogenomics 10:741-52. 2009
  6. pmc Genetic polymorphisms in CYP2E1: association with schizophrenia susceptibility and risperidone response in the Chinese Han population
    Ran Huo
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 7:e34809. 2012
  7. pmc SePreSA: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical-protein interactome
    Lun Yang
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Nucleic Acids Res 37:W406-12. 2009
  8. pmc Identifying unexpected therapeutic targets via chemical-protein interactome
    Lun Yang
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    PLoS ONE 5:e9568. 2010
  9. pmc Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome
    Lun Yang
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    PLoS Comput Biol 5:e1000441. 2009
  10. pmc Metabolomic analysis reveals metabolic disturbance in the cortex and hippocampus of subchronic MK-801 treated rats
    Liya Sun
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, PR China
    PLoS ONE 8:e60598. 2013

Collaborators

Detail Information

Publications24

  1. pmc DRAR-CPI: a server for identifying drug repositioning potential and adverse drug reactions via the chemical-protein interactome
    Heng Luo
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    Nucleic Acids Res 39:W492-8. 2011
    ..This server is freely available at http://cpi.bio-x.cn/drar/...
  2. pmc Systematic drug repositioning based on clinical side-effects
    Lun Yang
    Computational Biology, Quantitative Sciences, Medicines Discovery and Development, GlaxoSmithKline, Philadelphia, Pennsylvania, United States of America
    PLoS ONE 6:e28025. 2011
    ..7. This suggests that closer attention should be paid to the SEs observed in trials not just to evaluate the harmful effects, but also to rationally explore the repositioning potential based on this "clinical phenotypic assay"...
  3. pmc Exploring off-targets and off-systems for adverse drug reactions via chemical-protein interactome--clozapine-induced agranulocytosis as a case study
    Lun Yang
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    PLoS Comput Biol 7:e1002016. 2011
    ....
  4. doi request reprint Chemical-protein interactome and its application in off-target identification
    Lun Yang
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, China
    Interdiscip Sci 3:22-30. 2011
    ..Such studies present prospect of large scale in silico methodologies for off-target discovery with low cost and high efficiency...
  5. doi request reprint Systematic screening for polymorphisms within the UGT1A6 gene in three Chinese populations and function prediction through structural modeling
    Yi Xing
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Pharmacogenomics 10:741-52. 2009
    ..The present study was designed to determine the allele frequencies and haplotypes of this gene in the population and predict the candidate functional mutations...
  6. pmc Genetic polymorphisms in CYP2E1: association with schizophrenia susceptibility and risperidone response in the Chinese Han population
    Ran Huo
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 7:e34809. 2012
    ..We investigated the possible association of CYP2E1 polymorphisms with susceptibility to schizophrenia in the Chinese Han Population as well as the relationship with response to risperidone in schizophrenia patients...
  7. pmc SePreSA: a server for the prediction of populations susceptible to serious adverse drug reactions implementing the methodology of a chemical-protein interactome
    Lun Yang
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Nucleic Acids Res 37:W406-12. 2009
    ..The server is freely available at http://SePreSA.Bio-X.cn/...
  8. pmc Identifying unexpected therapeutic targets via chemical-protein interactome
    Lun Yang
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    PLoS ONE 5:e9568. 2010
    ....
  9. pmc Harvesting candidate genes responsible for serious adverse drug reactions from a chemical-protein interactome
    Lun Yang
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    PLoS Comput Biol 5:e1000441. 2009
    ..In conclusion, SADR targets and the patient-specific off-targets could be identified through a systematic investigation of the CPI, generating important hypotheses for prospective experimental validation of the candidate genes...
  10. pmc Metabolomic analysis reveals metabolic disturbance in the cortex and hippocampus of subchronic MK-801 treated rats
    Liya Sun
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, PR China
    PLoS ONE 8:e60598. 2013
    ..This prompted us to further investigate metabolite levels in the same rat model to better delineate the metabolism dysfunctions and provide insights into the pathology of schizophrenia...
  11. ncbi request reprint Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China
    Shengying Qin
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, Shanghai 200030, China
    Genomics 92:152-8. 2008
    ..Tag SNP selection and haplotype distributions showed differences across the four populations. This is the first large-scale study to analyze polymorphisms systematically across the whole CYP2D6 gene in the Chinese Han population...
  12. doi request reprint HLA-B*58:01 allele is associated with augmented risk for both mild and severe cutaneous adverse reactions induced by allopurinol in Han Chinese
    Zhi Hao Cao
    Huashan Hospital, Fudan University, Shanghai, China
    Pharmacogenomics 13:1193-201. 2012
    ..The results indicated that the prospective use of a genetic test of HLA-B*58:01 might reduce the prevalence of allopurinol-induced cADRs. Original submitted 7 March 2012; Revision submitted 21 May 2012...
  13. ncbi request reprint Label-free quantitative proteomic analysis reveals dysfunction of complement pathway in peripheral blood of schizophrenia patients: evidence for the immune hypothesis of schizophrenia
    Yang Li
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, China
    Mol Biosyst 8:2664-71. 2012
    ..The protein interaction network enhances the interpretation of proteomic data and provides evidence that the immune system may contribute to schizophrenia...
  14. doi request reprint Metabolomic profiling to identify potential serum biomarkers for schizophrenia and risperidone action
    Jiekun Xuan
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, China
    J Proteome Res 10:5433-43. 2011
    ..Further study of these metabolites may facilitate the development of noninvasive biomarkers and more efficient therapeutic strategies for schizophrenia...
  15. doi request reprint Quantitative assessment of the effect of LRRK2 exonic variants on the risk of Parkinson's disease: a meta-analysis
    Xi Wu
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Parkinsonism Relat Disord 18:722-30. 2012
    ..Within its limitations, this meta-analysis demonstrated that the G2019S, G2385R, R1628P and A419V variations are risk factors associated with increased PD susceptibility. However, these associations vary in different ethnicities...
  16. doi request reprint Association analysis of serotonin receptor 7 gene (HTR7) and risperidone response in Chinese schizophrenia patients
    Zhiyun Wei
    Bio X Center, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 33:547-51. 2009
    ..These results demonstrate that variations in the HTR7 gene may not be good genetic markers for predicting the therapeutic efficacy of risperidone...
  17. pmc Prediction of drug-target interactions for drug repositioning only based on genomic expression similarity
    Kejian Wang
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai, China
    PLoS Comput Biol 9:e1003315. 2013
    ..We believe the success in CMap can be further translated into other public and commercial data of genomic expression, thus increasing research productivity towards valid drug repositioning and minimal side effects. ..
  18. ncbi request reprint DDI-CPI, a server that predicts drug-drug interactions through implementing the chemical-protein interactome
    Heng Luo
    Bio X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China University of Arkansas at Little Rock University of Arkansas for Medical Sciences, Little Rock, AR 72204, USA
    Nucleic Acids Res 42:W46-52. 2014
    ..A 3D visualization of the drug-protein interaction will be provided as well. The DDI-CPI is freely accessible at http://cpi.bio-x.cn/ddi/. ..
  19. pmc Systematic prediction of pharmacodynamic drug-drug interactions through protein-protein-interaction network
    Jialiang Huang
    Key laboratory of Computational Biology, Chinese Academy of Sciences Max Planck Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    PLoS Comput Biol 9:e1002998. 2013
    ..Importantly, our algorithm provided opportunities for better understanding the potential molecular mechanisms or physiological effects underlying DDIs, as illustrated by the case studies...
  20. doi request reprint A CitationRank algorithm inheriting Google technology designed to highlight genes responsible for serious adverse drug reaction
    Lun Yang
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Bioinformatics 25:2244-50. 2009
    ....
  21. pmc Accurate quantification of microRNA via single strand displacement reaction on DNA origami motif
    Jie Zhu
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, China
    PLoS ONE 8:e69856. 2013
    ....
  22. doi request reprint Characterization of a novel missense mutation on murine Pax3 through ENU mutagenesis
    Yue Xiao
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, China
    J Genet Genomics 38:333-9. 2011
    ..The characterization of the new mutation expanded our understanding the transactivation and DNA-binding structure of Pax3 protein...
  23. pmc ReCGiP, a database of reproduction candidate genes in pigs based on bibliomics
    Lun Yang
    School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, 200240, China
    Reprod Biol Endocrinol 8:96. 2010
    ..So we have developed a database providing candidate genes for reproductive researches in pig by mining and processing existing biological literatures in human and pigs, named as ReCGiP...
  24. doi request reprint Genetic polymorphism analysis of CYP2C19 in Chinese Han populations from different geographic areas of mainland China
    Lingling Chen
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, Shanghai 200030, China
    Pharmacogenomics 9:691-702. 2008
    ..A comprehensive search for genetic polymorphisms of the CYP2C19 gene in the Chinese Han population has rarely been conducted. The present study was designed to determine the genetic basis of CYP2C19 polymorphisms...