Lili Yang

Summary

Publications

  1. pmc Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver
    Lili Yang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Free Radic Biol Med 53:1170-80. 2012
  2. pmc Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 54:1753-66. 2011
  3. pmc Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy
    Defeng Wu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 53:1346-57. 2012
  4. pmc Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 63:175-86. 2013
  5. pmc Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells
    Lili Yang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 51:185-96. 2011
  6. pmc CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases
    Arthur I Cederbaum
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, P O Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Int J Hepatol 2012:582790. 2012

Collaborators

Detail Information

Publications6

  1. pmc Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver
    Lili Yang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Free Radic Biol Med 53:1170-80. 2012
    ..The results show that acute alcohol elevation of CYP2E1, oxidative stress, and activation of JNK interact to lower autophagy and increase lipogenic SREBP resulting in fatty liver...
  2. pmc Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Hepatology 54:1753-66. 2011
    ..Electron microscopy showed altered mitochondrial structure in the jnk2(-/-) and WT mice, but not the jnk1(-/-) mice...
  3. pmc Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy
    Defeng Wu
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 53:1346-57. 2012
    ..Inhibition of autophagy promotes binge ethanol induced hepatotoxicity, steatosis and oxidant stress via CYP2E1...
  4. pmc Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo
    Xiaodong Wang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 63:175-86. 2013
    ..Blocking HIF-1α activation and actions may have therapeutic implications for protection against ethanol/CYP2E1-induced oxidative stress, steatosis, and liver injury. ..
  5. pmc Depletion of cytosolic or mitochondrial thioredoxin increases CYP2E1-induced oxidative stress via an ASK-1-JNK1 pathway in HepG2 cells
    Lili Yang
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA
    Free Radic Biol Med 51:185-96. 2011
    ..In conclusion, knockdown of TRX-1 or TRX-2 sensitizes cells to CYP2E1-induced oxidant stress partially via ASK-1 and JNK1 signaling pathways. Both TRX-1 and TRX-2 are important for defense against CYP2E1-induced oxidative stress...
  6. pmc CYP2E1 Sensitizes the Liver to LPS- and TNF α-Induced Toxicity via Elevated Oxidative and Nitrosative Stress and Activation of ASK-1 and JNK Mitogen-Activated Kinases
    Arthur I Cederbaum
    Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, P O Box 1603, One Gustave L Levy Place, New York, NY 10029, USA
    Int J Hepatol 2012:582790. 2012
    ..We hypothesize that similar interactions occur as a result of ethanol induction of CYP2E1 and TNFα...