Wan Xi Yang



  1. Liang Y, Yang W. Kinesins in MAPK cascade: How kinesin motors are involved in the MAPK pathway?. Gene. 2019;684:1-9 pubmed publisher
    ..This review summarizes the novel roles of kinesins in MAPK cascade and tries to discuss the mechanism of the interaction between them using mammalian and plant cells as models. ..
  2. Sheng L, Hao S, Yang W, Sun Y. The multiple functions of kinesin-4 family motor protein KIF4 and its clinical potential. Gene. 2018;678:90-99 pubmed publisher
    ..Here, we summarize KIF4 functions in normal cells and in various cancers, and provide an overview on the association between KIF4 disorders and disease progression. ..
  3. Su Y, Hou C, Yang W. Control of hair cell development by molecular pathways involving Atoh1, Hes1 and Hes5. Gene. 2015;558:6-24 pubmed publisher
    ..Thereby, we presented a complex regulatory network involving these three genes, which might be crucial for proliferation and differentiation of inner ear hair cells. ..
  4. Dong W, Tan F, Yang W. Wnt signaling in testis development: Unnecessary or essential?. Gene. 2015;565:155-65 pubmed publisher
    ..We evaluate the outcomes of current studies in the field and suggest future research directions. ..
  5. Xu Y, Wang G, Zhou Y, Yang W. The characterization and potential roles of bone morphogenetic protein 7 during spermatogenesis in Chinese mitten crab Eriocheir sinensis. Gene. 2018;673:119-129 pubmed publisher
  6. Jin J, Yang W. Molecular regulation of hypothalamus-pituitary-gonads axis in males. Gene. 2014;551:15-25 pubmed publisher
    ..This article systematically introduces the basic knowledge of the HPG axis and provides information of the current advances relating to reproductive hormones. ..
  7. Dong W, Hou C, Yang W. Mitochondrial prohibitin and its ubiquitination during crayfish Procambarus clarkii spermiogenesis. Cell Tissue Res. 2015;359:679-692 pubmed publisher
    ..clarkii. In addition, it might possess a more profound role in mediating mitochondrial ubiquitination. For the first time this study uncovers the role of PHB in the spermiogenesis of macrura crustacean species. ..
  8. Hu J, Liu M, Hou C, She Z, Wang D, Hao S, et al. Gene expression pattern of KIFC3 during spermatogenesis of the skink Eumeces chinensis. Gene. 2015;556:206-12 pubmed publisher
    ..From the results of in situ hybridization and previous researches, we speculated that ec-KIFC3 may play a role in nuclear morphogenesis and acrosome formation during spermiogenesis of E. chinensis. ..
  9. Wei Y, Yang W. The acroframosome-acroplaxome-manchette axis may function in sperm head shaping and male fertility. Gene. 2018;660:28-40 pubmed publisher
    ..The hypothesis of the acroframosome-acroplaxome-manchette (AAM) cytoskeletal system is likely to be the axis of head-to-tail spermiogenesis. ..

More Information


  1. Zhu H, Hou C, Luo L, Hu Y, Yang W. Endometrial stromal cells and decidualized stromal cells: origins, transformation and functions. Gene. 2014;551:1-14 pubmed publisher
  2. Jin J, Hou C, Tan F, Yang W. The potential function of prohibitin during spermatogenesis in Chinese fire-bellied newt Cynops orientalis. Cell Tissue Res. 2016;363:805-22 pubmed publisher
    ..This is the first time that the relationship between mitochondria and prohibitin in different stages of the sperm cells in Cynops orientalis has been examined, which also revealed that Sertoli cells have abundant prohibitins. ..
  3. Xu Y, Dong H, Yang W. Regulators in the apoptotic pathway during spermatogenesis: Killers or guards?. Gene. 2016;582:97-111 pubmed publisher
  4. Luo L, Hou C, Yang W. Small non-coding RNAs and their associated proteins in spermatogenesis. Gene. 2016;578:141-57 pubmed publisher
    ..We also show that male germ granules are seen to have a close relationship with a considerable number of mRNAs and small RNAs. Those special structures may also participate in sperm development. ..
  5. Li Y, Yang W. Myosin superfamily: The multi-functional and irreplaceable factors in spermatogenesis and testicular tumors. Gene. 2016;576:195-207 pubmed publisher
  6. She Z, Yang W. SOX family transcription factors involved in diverse cellular events during development. Eur J Cell Biol. 2015;94:547-63 pubmed publisher
    ..We particularly emphasize the representative roles of the SOX group proteins in major tissues during developmental and physiological processes. ..
  7. Zhong A, Tan F, Yang W. Chromokinesin: Kinesin superfamily regulating cell division through chromosome and spindle. Gene. 2016;589:43-48 pubmed publisher
    ..Furthermore, we have also introduced some new-found but unconfirmed kinesins which may have a relationship with chromosomes or the cell cycle. ..
  8. Xu Y, Yang W. SOX-mediated molecular crosstalk during the progression of tumorigenesis. Semin Cell Dev Biol. 2017;63:23-34 pubmed publisher
    ..We believe that SOX family proteins may be used as prognostic markers for human clinical therapy, and novel therapy strategies targeting SOX factors should be explored in future clinical applications. ..
  9. She Z, Yang W. Sry and SoxE genes: How they participate in mammalian sex determination and gonadal development?. Semin Cell Dev Biol. 2017;63:13-22 pubmed publisher
    ..We also briefly summarize the dedicate balances between male and female sex-determining genes in mammalian sex development, with particular highlights on the molecular actions of Sry and Sox9 transcription factors. ..
  10. Shen H, Xiao Y, She Z, Tan F, Yang W. A novel role of KIF3b in the seminoma cell cycle. Exp Cell Res. 2017;352:95-103 pubmed publisher
    ..In this way we demonstrate that KIF3b functions importantly in mitosis and may be essential to seminoma cell division and proliferation as well as being necessary for normal cell division. ..
  11. Xu Y, Fan Y, Yang W. Mitochondrial prohibitin and its ubiquitination during spermatogenesis of the swimming crab Charybdis japonica. Gene. 2017;627:137-148 pubmed publisher
    ..We conclude that PHB is indispensable in the spermatogenesis of the swimming crab Charybdis japonica through different testis developmental stages. ..
  12. Ma D, Pan M, Hou C, Tan F, Yang W. KIFC1 and myosin Va: two motors for acrosomal biogenesis and nuclear shaping during spermiogenesis of Portunus trituberculatus. Cell Tissue Res. 2017;369:625-640 pubmed publisher
    ..The above results provide a preliminary illustration of the essential roles of KIFC1 and myosin Va in the spermiogenesis of the swimming crab P. trituberculatus. ..