Structure-dependent response of a chemiluminescence nitrogen detector for organic compounds with adjacent nitrogen atoms connected by a single bondBing Yan
School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China Bristol Myers Squibb Pharmaceutical Research Institute, Wallingford, Connecticut 06492, USA
Anal Chem 79:718-26. 2007
..5/nitrogen atom for compounds with adjacent nitrogen atoms connected by a single bond should be abandoned. Compounds with similar structures should be used to generate calibration curves for quantification of this class of compounds...
A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune responseHongyu Zhou
St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
Nano Lett 8:859-65. 2008
..Our results demonstrated the general utility of the nanocombinatorial library approach in nanomedicine and nanotoxicity research...
- Leading neuroblastoma cells to die by multiple premeditated attacks from a multifunctionalized nanoconstruct
Peifu Jiao
School of Pharmaceutical Sciences, Shandong University, Jinan, China
J Am Chem Soc 133:13918-21. 2011
..The success of this multipronged attack approach launched by cell-embedded nanoconstructs demonstrates the power and flexibility of nanotechnology in treating cancer, a difficult task for a small molecule...
Exploring the immunotoxicity of carbon nanotubesYanmei Yu
School of Pharmaceutical Sciences, Shandong University, Jinan, China
Nanoscale Res Lett 3:271-7. 2008
..This article reviews some existing studies assessing carbon nanotubes' toxicity to immune system and provides the potential mechanistic explanation...
- Cell cycle regulation by carboxylated multiwalled carbon nanotubes through p53-independent induction of p21 under the control of the BMP signaling pathway
Yi Zhang
School of Pharmaceutical Sciences, Shandong University, Jinan 250100, China
Chem Res Toxicol 25:1212-21. 2012
..Hypophosphorylation of Rb prevents the release of E2F factors and causes cell cycle arrest. These findings provide valuable insight into a mechanistic understanding of carbon nanotubes' effects on cellular functions...
- Steering carbon nanotubes to scavenger receptor recognition by nanotube surface chemistry modification partially alleviates NFκB activation and reduces its immunotoxicity
Ningning Gao
School of Pharmaceutical Sciences, Shandong University, Jinan 250100, China
ACS Nano 5:4581-91. 2011
..The modified MWCNTs change their preferred binding pattern from mannose receptor to scavenger receptor. This switch significantly alleviates NFκB activation and reduces immunotoxicity of MWCNTs...
- Characterizing the surface chemistry of nanoparticles: an analogy to solid-phase synthesis samples
Yin Liu
School of Chemistry and Chemical Engineering, Shandong University, Jinan, China
Comb Chem High Throughput Screen 14:191-7. 2011
..FTIR, NMR, MS and other analytical methods have been used as effective methods to analyze surface bound molecules and monitor organic reactions directly, or indirectly, on a solid phase of a resin or a NPs...
- Nanoparticle-based strategies for detection and remediation of environmental pollutants
Yanyan Liu
School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, China
Analyst 136:872-7. 2011
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- Tumor cellular proteasome inhibition and growth suppression by 8-hydroxyquinoline and clioquinol requires their capabilities to bind copper and transport copper into cells
Shumei Zhai
School of Chemistry and Chemical Engineering, Shandong University, Jinan, China
J Biol Inorg Chem 15:259-69. 2010
..In contrast, the non-copper-binding analogs of 8-OHQ or CQ blocked the very first step-copper binding-in this chain of events mediated by 8-OHQ-Cu or CQ-Cu...
- Microwave-assisted fluorous synthesis of a 1,4-benzodiazepine-2,5-dione library
Aifeng Liu
School of Pharmaceutical Sciences, Shandong University, Jinan, China
J Comb Chem 11:1083-93. 2009
..The fluorous tag facilitated the intermediate purifications using fluorous solid-phase extraction (F-SPE) and had no negative impact on the reactivity of the Ugi reactions and postcondensation reactions...
- Evaluation of copper-dependent proteasome-inhibitory and apoptosis-inducing activities of novel pyrrolidine dithiocarbamate analogues
Zhiyong Yu
The Prevention Program, Barbara Ann Karmanos Cancer Institute, Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201 2013, USA
Int J Mol Med 20:919-25. 2007
..Our data further support the novel concept of using accumulated copper in human cancer cells as a selective approach for chemotherapy...
- A kinetic study of product cleavage reactions from the solid phase by a biocompatible and removable cleaving reagent, HCl
Bing Yan
St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
J Comb Chem 9:684-9. 2007
..Therefore, our kinetic studies establish HCl as a biocompatible, removable, and effective substitute for TFA when final compounds are used for biological screening and drug discovery...
- Photophysical properties of novel ternary lanthanide complexes with long chain mono-L cis-butene dicarboxylate (L = hexadecyl, octadecyl and eicosyl) and 2,2'-bipyridyl (or 1,10-phenanthroline)
Bing Yan
Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, China
J Fluoresc 17:331-7. 2007
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- [Refractivity of C60 composite material]
Bing Yan
Hebei Medical College for Continuing Education, Baoding 071000, China
Guang Pu Xue Yu Guang Pu Fen Xi 22:548-9. 2002
..A comparison is made between the above three cases. The result shows that: under different circumstances, the change in refractivity with the change of temperature differ...
