Biao Yan



  1. Yan B. Research progress on Livin protein: an inhibitor of apoptosis. Mol Cell Biochem. 2011;357:39-45 pubmed publisher
    ..In this review, we introduce Livin structure, biological function, and its role in cancer formation and progression and the possible interventions for cancer therapy. ..
  2. Liu C, Ge H, Liu B, Dong R, Shan K, Chen X, et al. Targeting pericyte-endothelial cell crosstalk by circular RNA-cPWWP2A inhibition aggravates diabetes-induced microvascular dysfunction. Proc Natl Acad Sci U S A. 2019;116:7455-7464 pubmed publisher
    ..Collectively, this study unveils a mechanism by which pericytes and ECs communicate. Intervention of cPWWP2A or miR-579 expression may offer opportunities for treating diabetic microvascular complications. ..
  3. Yan B, Yao J, Liu J, Li X, Wang X, Li Y, et al. lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA. Circ Res. 2015;116:1143-56 pubmed publisher
    ..This study highlights the involvement of lncRNA-MIAT in pathological angiogenesis and facilitates the development of lncRNA-directed diagnostics and therapeutics against neovascular diseases. ..
  4. Wang Y, Shan K, Yao M, Yao J, Wang J, Li X, et al. Long Noncoding RNA-GAS5: A Novel Regulator of Hypertension-Induced Vascular Remodeling. Hypertension. 2016;68:736-48 pubmed publisher
    ..This study identified GAS5 as a critical regulator in hypertension and demonstrated the potential of gene therapy and drug development for treating hypertension. ..
  5. Shan K, Liu C, Liu B, Chen X, Dong R, Liu X, et al. Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus. Circulation. 2017;136:1629-1642 pubmed publisher
    ..These data suggest that circular RNA is a potential target to control diabetic proliferative retinopathy. ..
  6. Yan B, Wang Z, Guo J. The research strategies for probing the function of long noncoding RNAs. Genomics. 2012;99:76-80 pubmed publisher
    ..The transcripts of lncRNAs are easy to find, but sorting out what they do remains the biggest challenge in lncRNAs' research field. In the paper, we highlight recent progress regarding the methods to explore the roles of lncRNAs. ..
  7. Yan B, Kong M, Chen Y. Prevention of apoptosis by the interaction between FIH1 and Bax. Mol Cell Biochem. 2011;348:1-9 pubmed publisher
    ..Overall, there results unveil a novel role of FIH1 in the regulation of Bax-mediated apoptosis. ..
  8. Zhou R, Wang X, Yao J, Shen Y, Chen S, Yang H, et al. Identification and characterization of proliferative retinopathy-related long noncoding RNAs. Biochem Biophys Res Commun. 2015;465:324-30 pubmed publisher
    ..This study suggests that lncRNAs are the potential regulators of PVR pathology. MALAT1 is a potential prognostic indicator and a target for the diagnosis and gene therapy for PVR diseases. ..
  9. Dong L, Yao J, Wang X, Shan K, Yang H, Yan B, et al. Lenalidomide, an anti-tumor drug, regulates retinal endothelial cell function: Implication for treating ocular neovascular disorder. Biochem Biophys Res Commun. 2015;465:678-84 pubmed publisher
    ..Collectively, lenalidomide is a promising drug for treating ocular angiogenesis through its anti-proliferative and anti-inflammatory property. ..

More Information


  1. Wang J, Shan K, Liu B, Liu C, Zhou R, Li X, et al. Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration. Cell Death Dis. 2018;9:540 pubmed publisher
    ..cZRANB1 acts as miRNA sponge to regulate Müller cell function through cZRANB1/miR-217/RUNX2 network. Intervention of cZRANB1 expression would become an effective strategy for treating retinal neurodegeneration. ..
  2. Chen X, Sheng X, Liu Y, Li Z, Sun X, Jiang C, et al. Distinct mutations with different inheritance mode caused similar retinal dystrophies in one family: a demonstration of the importance of genetic annotations in complicated pedigrees. J Transl Med. 2018;16:145 pubmed publisher
  3. Wu Z, Ding N, Yu M, Wang K, Luo S, Zou W, et al. Identification of Potential Biomarkers for Rhegmatogenous Retinal Detachment Associated with Choroidal Detachment by Vitreous iTRAQ-Based Proteomic Profiling. Int J Mol Sci. 2016;17: pubmed
    ..This study may provide novel insights into the pathogenesis of RRDCD and offer potential opportunities for the diagnosis and treatment of RRDCD. ..
  4. Yan B, Kong M, Chen S, Chen Y. VEGF stimulation enhances Livin protein synthesis through mTOR signaling. J Cell Biochem. 2010;111:1114-24 pubmed publisher
    ..Pharmacologic inhibition of VEGF/mTOR/Livin signaling may provide a novel strategy for cancer treatment. ..
  5. Yan B, Zhao J. miR-1228 prevents cellular apoptosis through targeting of MOAP1 protein. Apoptosis. 2012;17:717-24 pubmed publisher
    ..Taken together, this study provides evidences that miR-1228 plays an inhibitory role in stress-induced cellular apoptosis. miR-1228 may become a critical therapeutic target for apoptosis relevant diseases in the future. ..